The Experts below are selected from a list of 228 Experts worldwide ranked by ideXlab platform
Wen Chen - One of the best experts on this subject based on the ideXlab platform.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Puwa Ci, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1005). Low-risk genotypes predominated with a prevalence of 78.1% (785/1005). The most prevalent genotypes were HPV-6 (41.3%) HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients single infections were more frequent (866/891 97.2%) than co-infections (25/891 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025 respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P Genital Warts are HPV-6 HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future. Copyright (c) 2013 Wiley Periodicals Inc.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China, and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1,005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes, geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1,005). Low-risk genotypes predominated, with a prevalence of 78.1% (785/1,005). The most prevalent genotypes were HPV-6 (41.3%), HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients, single infections were more frequent (866/891, 97.2%) than co-infections (25/891, 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025, respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P ≤ 0.001, respectively). The prevalence of HPV-16 in female patients between urban and rural areas showed a marginally significant difference (P = 0.05). In sum, the results provide strong evidence that, in China, the most prevalent HPV genotypes in Genital Warts are HPV-6, HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future.
Lihong Chang - One of the best experts on this subject based on the ideXlab platform.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Puwa Ci, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1005). Low-risk genotypes predominated with a prevalence of 78.1% (785/1005). The most prevalent genotypes were HPV-6 (41.3%) HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients single infections were more frequent (866/891 97.2%) than co-infections (25/891 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025 respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P Genital Warts are HPV-6 HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future. Copyright (c) 2013 Wiley Periodicals Inc.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China, and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1,005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes, geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1,005). Low-risk genotypes predominated, with a prevalence of 78.1% (785/1,005). The most prevalent genotypes were HPV-6 (41.3%), HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients, single infections were more frequent (866/891, 97.2%) than co-infections (25/891, 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025, respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P ≤ 0.001, respectively). The prevalence of HPV-16 in female patients between urban and rural areas showed a marginally significant difference (P = 0.05). In sum, the results provide strong evidence that, in China, the most prevalent HPV genotypes in Genital Warts are HPV-6, HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future.
Timothy Byler - One of the best experts on this subject based on the ideXlab platform.
-
Genital Wart and human papillomavirus prevalence in men in the united states from penile swabs results from national health and nutrition examination surveys
Sexually Transmitted Diseases, 2017Co-Authors: Michael Daugherty, Timothy BylerAbstract:IntroductionHuman papillomavirus (HPV) is a common sexually transmitted infection in the United States that can lead to both malignant (high-risk) and benign (low-risk) findings. These low-risk findings include both Genital condyloma, anal Warts, and adult or juvenile papillomatosis, which are direc
Emmanouil Rampakakis - One of the best experts on this subject based on the ideXlab platform.
-
recurrence of human papillomavirus external Genital Wart infection among high risk adults in montreal canada
Sexually Transmitted Diseases, 2017Co-Authors: Rejean Thomas, Marc Steben, Zoe R Greenwald, Melissa Stutz, Caroline Rodier, Fern Deangelis, Emmanouil RampakakisAbstract:ObjectivesThe incidence of recurrent Genital Warts is not well characterized; this is especially true in a post-human papillomavirus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related external Genital Warts (EGW) episodes in high-risk male and
-
p3 189 recurrence of human papillomavirus external Genital Wart infection among high risk adults in montreal quebec
Sexually Transmitted Infections, 2017Co-Authors: Rejean Thomas, Marc Steben, Zoe R Greenwald, Melissa Stutz, Caroline Rodier, Fern Deangelis, Emmanouil RampakakisAbstract:Introduction External Genital Warts (EGW) are associated with high psychosocial burden and health care costs, may be difficult to treat, and recur frequently. However, the incidence of recurrent EGW is not well characterised; this is especially true in a post-human papilloma virus (HPV) vaccination era. The objectives of this study were to assess the incidence of subsequent HPV-related EGW in high-risk male and female adults, as well as ascertain patient profile and disease characteristics, in a real-world Canadian clinical setting. Methods A retrospective chart review study was conducted at Clinique medicale l’Actuel, a sexual health clinic in Montreal, Quebec, Canada. Eligible patients were 18–45 years of age with a first diagnosis of EGW between July 1, 2006 and June 30, 2012. Results A total of 400 first-episode EGW cases were identified. Up to 6 subsequent episodes were documented, with 194 (48.5%) patients reporting at least 1 subsequent EGW episode. Median time to 1st subsequent EGW episode was 3.97 years, and the incidence density rate for all subsequent episodes was 0.18/100 patient-years. Over 90% of patients reported clearance of the first subsequent episode, with median time to clearance of 0.30 years. Regardless of subsequent episode number, >95% of patients received treatment, primarily cryotherapy, with high-risk sexual behaviour reducing as number of episodes increased. Conclusion Overall, a high rate of subsequent EGW episodes was observed in this high-risk population despite high treatment rates and improvement in high-risk sexual behaviour with increasing number of subsequent episodes. This is the first assessment of the rate of EGW recurrence in a Canadian clinical setting, in addition to proving information related to risk factors, clinical manifestations, and interventions. These data, assessed in a pre-vaccination Quebec healthcare system, may be compared to future EGW rates in order to evaluate the impact of a governmentally-funded HPV vaccination program. Support: R. Thomas has received consulting fees from AbbVie, Gilead, Merck, and ViiV; M. Steben has received speaker honoraria or participated in Advisory Boards for Merck, Paladin, Valeant and Inovio; M. Stutz and E. Rampakakis are both employees of JSS Medical Research; C. Rodier and F. DeAngelis are both employees of Merck Canada Inc.
Xiaoli Feng - One of the best experts on this subject based on the ideXlab platform.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Puwa Ci, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1005). Low-risk genotypes predominated with a prevalence of 78.1% (785/1005). The most prevalent genotypes were HPV-6 (41.3%) HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients single infections were more frequent (866/891 97.2%) than co-infections (25/891 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025 respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P Genital Warts are HPV-6 HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future. Copyright (c) 2013 Wiley Periodicals Inc.
-
distribution of Genital Wart human papillomavirus genotypes in china a multi center study
Journal of Medical Virology, 2013Co-Authors: Lihong Chang, Jufang Shi, Kan Zhai, Xiaoli Feng, Danny V Colombara, Wei Wang, Youlin Qiao, Wen ChenAbstract:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with Genital Warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in Genital Warts across China, and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1,005 Genital Warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes, geographical regions and age groups were assessed. The overall prevalence of HPV DNA in Genital Warts patients was 88.7% (891/1,005). Low-risk genotypes predominated, with a prevalence of 78.1% (785/1,005). The most prevalent genotypes were HPV-6 (41.3%), HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients, single infections were more frequent (866/891, 97.2%) than co-infections (25/891, 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025, respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P ≤ 0.001, respectively). The prevalence of HPV-16 in female patients between urban and rural areas showed a marginally significant difference (P = 0.05). In sum, the results provide strong evidence that, in China, the most prevalent HPV genotypes in Genital Warts are HPV-6, HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of Genital Warts in the future.