The Experts below are selected from a list of 3807 Experts worldwide ranked by ideXlab platform

Stephen M Schwartz - One of the best experts on this subject based on the ideXlab platform.

  • serum organochlorine pesticide residues and risk of testicular Germ Cell Carcinoma a population based case control study
    Cancer Epidemiology Biomarkers & Prevention, 2008
    Co-Authors: Mary L Biggs, David L. Eaton, Mark D Davis, David R Doody, Sherianne Fish, Larry L Needham, Chu Chen, Noel S Weiss, Dana B. Barr, Stephen M Schwartz
    Abstract:

    Testicular Germ Cell Carcinoma (TGCC) is the most common malignancy among men ages 20 to 34 years. Although the pathogenesis of TGCC is poorly understood, suboptimal androgen levels or impaired androgen signaling may play a role. Some persistent organochlorine pesticides commonly found in human tissue possess antiandrogenic properties. We examined whether the risk of TGCC is associated with serum levels of 11 organochlorine pesticides, including p,p ′-DDE, and whether the p,p ′-DDE-TGCC association is modified by CAG or GGN repeat polymorphisms in the androgen receptor gene. We conducted a population-based case-control study among 18- to 44-year-old male residents of three Washington State counties. Cases ( n = 246) were diagnosed during 1999 to 2003 with a first, primary TGCC. Controls ( n = 630) were men of similar age with no history of TGCC from the same population identified through random-digit telephone dialing. Questionnaires elicited information on demographic, medical, and lifestyle factors. A blood specimen provided serum for gas chromatography-high-resolution mass spectrometry analysis of organochlorine pesticide residues and DNA for genotyping. We observed no clear patterns between TGCC risk and concentrations of any of the organochlorines measured, nor did we observe that the risk associated with p,p ′-DDE was modified by androgen receptor CAG (<23 versus ≥23 repeats) or GGN (<17 versus ≥17 repeats) genotype. This study does not provide support for the hypothesis that adult exposure to organochlorine pesticides is associated with risk of TGCC. Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy. (Cancer Epidemiol Biomarkers Prev 2008;17(8):2012–8)

  • Serum Organochlorine Pesticide Residues and Risk of Testicular Germ Cell Carcinoma: A Population-Based Case-Control Study
    Cancer epidemiology biomarkers & prevention : a publication of the American Association for Cancer Research cosponsored by the American Society of Pre, 2008
    Co-Authors: Mary L Biggs, David L. Eaton, Mark D Davis, David R Doody, Sherianne Fish, Larry L Needham, Chu Chen, Noel S Weiss, Dana B. Barr, Stephen M Schwartz
    Abstract:

    Testicular Germ Cell Carcinoma (TGCC) is the most common malignancy among men ages 20 to 34 years. Although the pathogenesis of TGCC is poorly understood, suboptimal androgen levels or impaired androgen signaling may play a role. Some persistent organochlorine pesticides commonly found in human tissue possess antiandrogenic properties. We examined whether the risk of TGCC is associated with serum levels of 11 organochlorine pesticides, including p,p'-DDE, and whether the p,p'-DDE-TGCC association is modified by CAG or GGN repeat polymorphisms in the androgen receptor gene. We conducted a population-based case-control study among 18- to 44-year-old male residents of three Washington State counties. Cases (n = 246) were diagnosed during 1999 to 2003 with a first, primary TGCC. Controls (n = 630) were men of similar age with no history of TGCC from the same population identified through random-digit telephone dialing. Questionnaires elicited information on demographic, medical, and lifestyle factors. A blood specimen provided serum for gas chromatography-high-resolution mass spectrometry analysis of organochlorine pesticide residues and DNA for genotyping. We observed no clear patterns between TGCC risk and concentrations of any of the organochlorines measured, nor did we observe that the risk associated with p,p'-DDE was modified by androgen receptor CAG ( or =23 repeats) or GGN ( or =17 repeats) genotype. This study does not provide support for the hypothesis that adult exposure to organochlorine pesticides is associated with risk of TGCC. Due to uncertainty regarding how well organochlorine levels measured in adulthood reflect exposures during early life, further research is needed using exposure measurements collected in utero or during infancy.

  • Sequence variation in the human transcription factor gene POU5F1.
    BMC genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark J. Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1, and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED).

  • Sequence variation in the human transcription factor gene POU5F1
    BMC Genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1 , and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED). Results A higher number of polymorphisms was observed in the AD (n = 102) versus ED (n = 82) population. Among the 41 observed haplotypes, 21 (51%) and 12 (29%) were unique to the AD and ED populations, respectively, while 8 (20%) were observed in both. The number of tagging polymorphisms necessary to explain at least 80% of common variation (minor allele frequency ≥ 0.10) due to the remaining untyped polymorphisms was 17 for an AD and 10 for an ED population, providing a 4.0- and 7.0-fold gain in genotyping efficiency for characterizing nucleotide variation, respectively. Conclusion POU5F1 is highly polymorphic, however a smaller subset of polymorphisms can tag the observed genetic variation with little loss of information.

  • Abstract B127: Alcohol consumption and risk of testicular Germ Cell Carcinoma
    Epidemiology Lifestyle Factors, 2008
    Co-Authors: Mary L Biggs, David R Doody, Jacqueline R. Starr, Stephen M Schwartz
    Abstract:

    Abstracts: Frontiers in Cancer Prevention Research 2008 B127 The incidence of testicular Germ Cell Carcinoma (TGCC), the most common malignancy among men aged 20-34, has increased several-fold during the past several decades. The etiology of TGCC is poorly understood and the cause of the increased incidence is unknown. Established risk factors include age, race, personal history of undescended testes, and family history of TGCC, none of which is modifiable. Alcohol is an established testicular toxicant, causing testicular atrophy, gynecomastia, and disrupted sexual function in alcoholic men. In both alcoholics and non-alcoholic men with moderate intake, alcohol depresses levels of circulating testosterone and luteinizing hormone. We hypothesized that alcohol consumption, particularly during adolescence, increases the risk of TGCC. A single previous epidemiologic analysis of alcohol intake and TGCC found no association. We conducted a population-based case-control study among 18-44 year-old male residents of three Washington State counties. Cases (n=400) were diagnosed during 1999-2006 with a first, primary TGCC. Controls (n=1,020) were men of similar age with no history of TGCC from the same population identified through random-digit telephone dialing. Questionnaires elicited information on demographic, medical, and lifestyle factors, including usual consumption of beer, wine, and liquor during the 5 years prior to reference date and during grades 7-12. We used logistic regression models to compute odds ratio (OR) estimates and 95% confidence intervals (CI) for TGCC in men that consumed 1-6, 7-13, and 14+ alcoholic beverages per week compared to those that consumed none, adjusting for age, education, smoking, and current marijuana use. A higher proportion of cases than controls (73% vs. 66%) reported drinking 1 or more alcoholic beverages per week during the five years prior to reference date, and during grades 9-12 (44% vs. 37%). Consumption of 14+ alcoholic drinks/week was associated with an approximately 60% increased risk of TGCC (OR=1.62; 95% CI: 1.02-2.58) for consumption during the 5 years prior to reference date, and for consumption during grades 9-12 (OR=1.56; 95% CI: 0.99-2.47). The risk of TGCC appeared to be similar for consumption of beer, wine, or liquor, and for consumption of alcoholic beverages during adolescence versus consumption during adulthood. The risk of TGCC associated with 14+ alcoholic drinks/week was higher among men diagnosed with nonseminomas (OR=2.28; 95% CI: 1.08-4.82) than among men diagnosed with seminomas (OR=1.40 95%CI: 0.80-2.42). Our results indicate that consumption of 14 or more alcoholic beverages per week during adolescence or adulthood may be associated with a doubling of the risk of non-seminomatous TGCC. This is the first study to report an association between alcohol consumption and an increased risk of TGCC. Additional studies are needed to clarify the relationship between alcohol intake and TGCC. Citation Information: Cancer Prev Res 2008;1(7 Suppl):B127.

Shehnaz K. Hussain - One of the best experts on this subject based on the ideXlab platform.

  • Sequence variation in the human transcription factor gene POU5F1.
    BMC genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark J. Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1, and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED).

  • Sequence variation in the human transcription factor gene POU5F1
    BMC Genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1 , and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED). Results A higher number of polymorphisms was observed in the AD (n = 102) versus ED (n = 82) population. Among the 41 observed haplotypes, 21 (51%) and 12 (29%) were unique to the AD and ED populations, respectively, while 8 (20%) were observed in both. The number of tagging polymorphisms necessary to explain at least 80% of common variation (minor allele frequency ≥ 0.10) due to the remaining untyped polymorphisms was 17 for an AD and 10 for an ED population, providing a 4.0- and 7.0-fold gain in genotyping efficiency for characterizing nucleotide variation, respectively. Conclusion POU5F1 is highly polymorphic, however a smaller subset of polymorphisms can tag the observed genetic variation with little loss of information.

Caterina Bertucci - One of the best experts on this subject based on the ideXlab platform.

  • Sequence variation in the human transcription factor gene POU5F1.
    BMC genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark J. Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1, and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED).

  • Sequence variation in the human transcription factor gene POU5F1
    BMC Genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1 , and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED). Results A higher number of polymorphisms was observed in the AD (n = 102) versus ED (n = 82) population. Among the 41 observed haplotypes, 21 (51%) and 12 (29%) were unique to the AD and ED populations, respectively, while 8 (20%) were observed in both. The number of tagging polymorphisms necessary to explain at least 80% of common variation (minor allele frequency ≥ 0.10) due to the remaining untyped polymorphisms was 17 for an AD and 10 for an ED population, providing a 4.0- and 7.0-fold gain in genotyping efficiency for characterizing nucleotide variation, respectively. Conclusion POU5F1 is highly polymorphic, however a smaller subset of polymorphisms can tag the observed genetic variation with little loss of information.

Reynaldo Sequerra - One of the best experts on this subject based on the ideXlab platform.

  • Sequence variation in the human transcription factor gene POU5F1.
    BMC genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark J. Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1, and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED).

  • Sequence variation in the human transcription factor gene POU5F1
    BMC Genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1 , and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED). Results A higher number of polymorphisms was observed in the AD (n = 102) versus ED (n = 82) population. Among the 41 observed haplotypes, 21 (51%) and 12 (29%) were unique to the AD and ED populations, respectively, while 8 (20%) were observed in both. The number of tagging polymorphisms necessary to explain at least 80% of common variation (minor allele frequency ≥ 0.10) due to the remaining untyped polymorphisms was 17 for an AD and 10 for an ED population, providing a 4.0- and 7.0-fold gain in genotyping efficiency for characterizing nucleotide variation, respectively. Conclusion POU5F1 is highly polymorphic, however a smaller subset of polymorphisms can tag the observed genetic variation with little loss of information.

Noel C Hastings - One of the best experts on this subject based on the ideXlab platform.

  • Sequence variation in the human transcription factor gene POU5F1.
    BMC genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark J. Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1, and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED).

  • Sequence variation in the human transcription factor gene POU5F1
    BMC Genetics, 2008
    Co-Authors: Shehnaz K. Hussain, Reynaldo Sequerra, Caterina Bertucci, Noel C Hastings, Mark Rieder, Stephen M Schwartz
    Abstract:

    Background POU5F1 expression is required to maintain stem Cell pluripotency and for primordial Germ Cells to retain proliferative capability in embryonic development. Recent evidence suggests that POU5F1 may also be a testicular Germ Cell Carcinoma (TGCC) oncogene, and POU5F1 variation may influence TGCC risk. As an important first step to a genetic association study, we sought to identify all common sequence variants in an 11.3 kb region containing POU5F1 , and to describe the linkage disequilibrium patterns, using DNA from individuals of African-descent (AD) and European-descent (ED). Results A higher number of polymorphisms was observed in the AD (n = 102) versus ED (n = 82) population. Among the 41 observed haplotypes, 21 (51%) and 12 (29%) were unique to the AD and ED populations, respectively, while 8 (20%) were observed in both. The number of tagging polymorphisms necessary to explain at least 80% of common variation (minor allele frequency ≥ 0.10) due to the remaining untyped polymorphisms was 17 for an AD and 10 for an ED population, providing a 4.0- and 7.0-fold gain in genotyping efficiency for characterizing nucleotide variation, respectively. Conclusion POU5F1 is highly polymorphic, however a smaller subset of polymorphisms can tag the observed genetic variation with little loss of information.