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Christopher Sweeney - One of the best experts on this subject based on the ideXlab platform.

  • craniocaudal retroperitoneal node length as a risk factor for relapse from clinical stage i testicular Germ Cell Tumor
    American Journal of Roentgenology, 2014
    Co-Authors: Stephanie A Howard, Kathryn P Gray, Elizabeth Odonnell, Fiona M Fennessy, Clair J Beard, Christopher Sweeney
    Abstract:

    OBJECTIVE. The purpose of this study was to investigate whether retroperitoneal craniocaudal nodal length or nodal volume predicts relapse risk in stage I testicular cancer. MATERIALS AND METHODS. We retrospectively reviewed 826 testicular cancer patients. Of these 826 patients, 118 had stage I disease and either less than 2 years of surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. These patients formed our analytic cohort, and 3D nodal volumes and craniocaudal nodal length were measured. Association between relapse risk and craniocaudal nodal length and nodal volume was evaluated using univariable or multivariable logistic regression models adjusted for known prognostic factors. RESULTS. Sixty-six (56%) of 118 patients had nonseminomatous Germ Cell Tumor and 52 (44%) had seminomatous Germ Cell Tumor. Craniocaudal nodal length proved to be an independent risk factor in nonseminomatous Germ Cell Tumors using a multivariable logistic regression model adjusting for other p...

  • craniocaudal retroperitoneal node length as a risk factor for relapse from clinical stage i testicular Germ Cell Tumor
    Journal of Clinical Oncology, 2014
    Co-Authors: Stephanie A Howard, Kathryn P Gray, Elizabeth Odonnell, Fiona M Fennessy, Clair J Beard, Christopher Sweeney
    Abstract:

    363 Background: To investigate if retroperitoneal craniocaudal nodal length (CCNL) or nodal volume (NV) predicts relapse risk in clinical stage I testicular cancer. Methods: This institutional review board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant study retrospectively reviewed 826 patients with testicular cancer. One hundred eighteen out of 826 patients forming the analytic cohort had stage I disease and either more than or equal to 2 years surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. 3D NVs and CCNL were measured by two attending physicians in consensus. Association between relapse risk and CCNL/NV was evaluated using univariable/multivariable logistic regression analysis adjusted for known prognostic factors. Results: Sixty six out of 118 patients (56%) had nonseminomatous Germ Cell Tumor (NSGCT) and 52 (44%) had seminomatous Germ Cell Tumor (SGCT). Twenty one percent (25 out of 118) of patients relapsed: 24% (16 out of 66) f...

  • a meta analysis of patient outcomes with subcentimeter disease after chemotherapy for metastatic non seminomatous Germ Cell Tumor
    Annals of Oncology, 2014
    Co-Authors: Praful Ravi, Kathryn P Gray, Elizabeth Odonnell, Christopher Sweeney
    Abstract:

    Background Approximately a quarter of men with metastatic non-seminomatous Germ Cell Tumor (NSGCT) have a residual mass, typically in the retroperitoneum, after chemotherapy. The management of small residual masses (≤1 cm) is controversial, with good outcomes seen with either post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) or surveillance. We sought to review our experience of surveillance and synthesize the cumulative findings with the current literature in the form of a meta-analysis.

Thomas M Ulbright - One of the best experts on this subject based on the ideXlab platform.

  • signet ring Cell carcinoma of the testis clinicopathologic and molecular evidence for Germ Cell Tumor origin a case report
    The American Journal of Surgical Pathology, 2012
    Co-Authors: Sean R Williamson, Thomas M Ulbright, John N Eble, Liang Cheng, Jennifer B Kum, Shilpa R Shah, Lawrence H Einhorn, Muhammad Idrees
    Abstract:

    Development of a somatic-type malignancy from a mixed Germ Cell Tumor is a rare but recognized event and typically represented by sarcoma or, less commonly, by carcinoma. This phenomenon is generally believed to result from progression of a teratomatous component. In many cases, because of intermingling of other Germ Cell Tumor components, the diagnosis is apparent; however, in rare cases, metastatic carcinoma to the testis or a novel primary Tumor may be a diagnostic consideration. In this study, we report the clinicopathologic, immunohistochemical, and molecular features of a 53-year-old man, whose testicular Tumor was composed entirely of signet ring Cells, mimicking metastatic carcinoma. Subsequent retroperitoneal lymph node dissection revealed metastatic deposits composed of teratoma and yolk sac Tumor, in addition to signet ring Cell carcinoma. Fluorescence in situ hybridization for abnormalities of chromosome 12p revealed the presence of i(12p) in both the teratoma and signet ring Cell carcinoma in the metastasis and in signet ring Cells in the testis, supporting a common Germ Cell origin. Our report indicates that signet ring carcinoma Cells in an orchiectomy specimen, although usually strongly suggestive of metastatic adenocarcinoma from a primary Tumor in another organ, may be a primary testicular neoplasm of Germ Cell Tumor origin. This is the first report of testicular signet ring Cell carcinoma of Germ Cell Tumor derivation.

  • nephroblastoma arising in a Germ Cell Tumor of testicular origin
    The American Journal of Surgical Pathology, 2004
    Co-Authors: Robert E Emerson, Thomas M Ulbright, Shaobo Zhang, Richard S Foster, John N Eble, Liang Cheng
    Abstract:

    Abstract:We report a nephroblastoma arising in a Germ Cell Tumor of testicular origin occurring in a 22-year-old man. Orchiectomy demonstrated a malignant mixed Germ Cell Tumor composed of mature and immature teratoma with nephroblastoma and rhabdomyosarcoma. Following chemotherapy, the patient deve

  • update on late relapse of Germ Cell Tumor a clinical and molecular analysis
    Journal of Clinical Oncology, 2003
    Co-Authors: David W George, Thomas M Ulbright, Richard S Foster, Robert A Hromas, Kent A Robertson, Gail H Vance, Troy A Gobbett, Devan J Heiber
    Abstract:

    Purpose: Analysis of patients with late relapse (LR) of Germ Cell Tumor (GCT) with reports on clinical characteristics, outcomes, and molecular and cytogenetic features. Patients and Methods: Eighty-three patients evaluated at Indiana University from 1993 through 2000 for relapse of GCT more than 2 years from initial therapy were reviewed. Available specimens were investigated for expression of the transcription regulator FoxD3 and apurinic/apyrimidinic endonuclease and the presence of chromosome 12 abnormalities. Results: Median interval from initial presentation to LR was 85 months. Forty-three of 49 LR patients who underwent surgery were rendered disease free (NED), and 20 (46.5%) remain continuously NED. Thirty-two patients received chemotherapy, but only six (18.8%) obtained a complete remission. Five of these patients remain continuously NED after chemotherapy alone, including three who were chemotherapy naive. Eighteen of these 32 patients were successfully rendered NED by postchemotherapy surgery,...

Liang Cheng - One of the best experts on this subject based on the ideXlab platform.

  • signet ring Cell carcinoma of the testis clinicopathologic and molecular evidence for Germ Cell Tumor origin a case report
    The American Journal of Surgical Pathology, 2012
    Co-Authors: Sean R Williamson, Thomas M Ulbright, John N Eble, Liang Cheng, Jennifer B Kum, Shilpa R Shah, Lawrence H Einhorn, Muhammad Idrees
    Abstract:

    Development of a somatic-type malignancy from a mixed Germ Cell Tumor is a rare but recognized event and typically represented by sarcoma or, less commonly, by carcinoma. This phenomenon is generally believed to result from progression of a teratomatous component. In many cases, because of intermingling of other Germ Cell Tumor components, the diagnosis is apparent; however, in rare cases, metastatic carcinoma to the testis or a novel primary Tumor may be a diagnostic consideration. In this study, we report the clinicopathologic, immunohistochemical, and molecular features of a 53-year-old man, whose testicular Tumor was composed entirely of signet ring Cells, mimicking metastatic carcinoma. Subsequent retroperitoneal lymph node dissection revealed metastatic deposits composed of teratoma and yolk sac Tumor, in addition to signet ring Cell carcinoma. Fluorescence in situ hybridization for abnormalities of chromosome 12p revealed the presence of i(12p) in both the teratoma and signet ring Cell carcinoma in the metastasis and in signet ring Cells in the testis, supporting a common Germ Cell origin. Our report indicates that signet ring carcinoma Cells in an orchiectomy specimen, although usually strongly suggestive of metastatic adenocarcinoma from a primary Tumor in another organ, may be a primary testicular neoplasm of Germ Cell Tumor origin. This is the first report of testicular signet ring Cell carcinoma of Germ Cell Tumor derivation.

  • nephroblastoma arising in a Germ Cell Tumor of testicular origin
    The American Journal of Surgical Pathology, 2004
    Co-Authors: Robert E Emerson, Thomas M Ulbright, Shaobo Zhang, Richard S Foster, John N Eble, Liang Cheng
    Abstract:

    Abstract:We report a nephroblastoma arising in a Germ Cell Tumor of testicular origin occurring in a 22-year-old man. Orchiectomy demonstrated a malignant mixed Germ Cell Tumor composed of mature and immature teratoma with nephroblastoma and rhabdomyosarcoma. Following chemotherapy, the patient deve

Muhammad Idrees - One of the best experts on this subject based on the ideXlab platform.

  • signet ring Cell carcinoma of the testis clinicopathologic and molecular evidence for Germ Cell Tumor origin a case report
    The American Journal of Surgical Pathology, 2012
    Co-Authors: Sean R Williamson, Thomas M Ulbright, John N Eble, Liang Cheng, Jennifer B Kum, Shilpa R Shah, Lawrence H Einhorn, Muhammad Idrees
    Abstract:

    Development of a somatic-type malignancy from a mixed Germ Cell Tumor is a rare but recognized event and typically represented by sarcoma or, less commonly, by carcinoma. This phenomenon is generally believed to result from progression of a teratomatous component. In many cases, because of intermingling of other Germ Cell Tumor components, the diagnosis is apparent; however, in rare cases, metastatic carcinoma to the testis or a novel primary Tumor may be a diagnostic consideration. In this study, we report the clinicopathologic, immunohistochemical, and molecular features of a 53-year-old man, whose testicular Tumor was composed entirely of signet ring Cells, mimicking metastatic carcinoma. Subsequent retroperitoneal lymph node dissection revealed metastatic deposits composed of teratoma and yolk sac Tumor, in addition to signet ring Cell carcinoma. Fluorescence in situ hybridization for abnormalities of chromosome 12p revealed the presence of i(12p) in both the teratoma and signet ring Cell carcinoma in the metastasis and in signet ring Cells in the testis, supporting a common Germ Cell origin. Our report indicates that signet ring carcinoma Cells in an orchiectomy specimen, although usually strongly suggestive of metastatic adenocarcinoma from a primary Tumor in another organ, may be a primary testicular neoplasm of Germ Cell Tumor origin. This is the first report of testicular signet ring Cell carcinoma of Germ Cell Tumor derivation.

John N Eble - One of the best experts on this subject based on the ideXlab platform.

  • signet ring Cell carcinoma of the testis clinicopathologic and molecular evidence for Germ Cell Tumor origin a case report
    The American Journal of Surgical Pathology, 2012
    Co-Authors: Sean R Williamson, Thomas M Ulbright, John N Eble, Liang Cheng, Jennifer B Kum, Shilpa R Shah, Lawrence H Einhorn, Muhammad Idrees
    Abstract:

    Development of a somatic-type malignancy from a mixed Germ Cell Tumor is a rare but recognized event and typically represented by sarcoma or, less commonly, by carcinoma. This phenomenon is generally believed to result from progression of a teratomatous component. In many cases, because of intermingling of other Germ Cell Tumor components, the diagnosis is apparent; however, in rare cases, metastatic carcinoma to the testis or a novel primary Tumor may be a diagnostic consideration. In this study, we report the clinicopathologic, immunohistochemical, and molecular features of a 53-year-old man, whose testicular Tumor was composed entirely of signet ring Cells, mimicking metastatic carcinoma. Subsequent retroperitoneal lymph node dissection revealed metastatic deposits composed of teratoma and yolk sac Tumor, in addition to signet ring Cell carcinoma. Fluorescence in situ hybridization for abnormalities of chromosome 12p revealed the presence of i(12p) in both the teratoma and signet ring Cell carcinoma in the metastasis and in signet ring Cells in the testis, supporting a common Germ Cell origin. Our report indicates that signet ring carcinoma Cells in an orchiectomy specimen, although usually strongly suggestive of metastatic adenocarcinoma from a primary Tumor in another organ, may be a primary testicular neoplasm of Germ Cell Tumor origin. This is the first report of testicular signet ring Cell carcinoma of Germ Cell Tumor derivation.

  • nephroblastoma arising in a Germ Cell Tumor of testicular origin
    The American Journal of Surgical Pathology, 2004
    Co-Authors: Robert E Emerson, Thomas M Ulbright, Shaobo Zhang, Richard S Foster, John N Eble, Liang Cheng
    Abstract:

    Abstract:We report a nephroblastoma arising in a Germ Cell Tumor of testicular origin occurring in a 22-year-old man. Orchiectomy demonstrated a malignant mixed Germ Cell Tumor composed of mature and immature teratoma with nephroblastoma and rhabdomyosarcoma. Following chemotherapy, the patient deve