The Experts below are selected from a list of 7149 Experts worldwide ranked by ideXlab platform
Shizuo Yamada - One of the best experts on this subject based on the ideXlab platform.
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Effects of Ginkgo Biloba Extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats.
The Journal of pharmacy and pharmacology, 2011Co-Authors: Yuko Taki, Eri Hagiwara, Chiemi Hirose, Kazumasa Shinozuka, Keizo Umegaki, Shizuo YamadaAbstract:Objectives Effects of repeated administration of Ginkgo Biloba Extract on pharmacokinetics and pharmacodynamics of tolbutamide were examined in rats fed a low-protein diet. Methods Rats were given a low (7% casein) or control (20% casein) protein diet for 21 days and administered Ginkgo Biloba Extract (100 mg/kg per day) for the last 5 days. Tolbutamide was co-administered on the last day. Blood glucose and plasma tolbutamide concentrations were determined over the subsequent 12 h and the activity of hepatic cytochrome P450s were determined at 12 h after dosing. Key findings There were significant decreases in body weight, the ratio of liver to body weight, and plasma albumin concentrations in rats on the low-protein diet compared with controls. The hypoglycaemic effect of tolbutamide was significantly greater and the concentration of the drug in plasma was higher in the former group. The repeated administration of Ginkgo Biloba Extract had little influence on the hypoglycaemic effect of tolbutamide, but tended to decrease the drug concentration in plasma of control rats, while it reduced significantly the hypoglycaemic action and plasma concentration of tolbutamide in the protein-restricted rats. Conclusions The effects of Ginkgo Biloba Extract on the pharmacokinetics and pharmacodynamics of tolbutamide were significantly enhanced in rats on the low-protein diet.
Edzard Ernst - One of the best experts on this subject based on the ideXlab platform.
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Ginkgo Biloba Extract for the treatment of intermittent claudication a meta analysis of randomized trials
The American Journal of Medicine, 2000Co-Authors: Max H Pittler, Edzard ErnstAbstract:Abstract PURPOSE: The optimal treatment of intermittent claudication has not yet been identified. Ginkgo Biloba Extract has been reported to have beneficial effects. We performed a meta-analysis of the efficacy of Ginkgo Biloba Extract for intermittent claudication based on the results of randomized, placebo-controlled, double-blind trials. METHODS: Literature searches of Medline, Embase, Biosis, AMED, CISCOM, and the Cochrane Library were performed to identify studies on the topic. Manufacturers of commercial Ginkgo Biloba products and authors of original publications and reviews were contacted to provide additional information. No language restrictions were imposed. RESULTS: Eight randomized, placebo-controlled, double-blind trials were included. Meta-analysis found a significant difference in the increase in pain-free walking distance in favor of Ginkgo Biloba (weighted mean difference: 34 meters, 95% confidence interval [CI]: 26 to 43 meters). In studies using similar methodological features (ergometer speed: 3 km/h, inclination: 12%) this difference was 33 meters in favor of Ginkgo Biloba (95% CI: 22 to 43 meters). Adverse effects were rare, mild, and transient. CONCLUSIONS: These results suggest that Ginkgo Biloba Extract is superior to placebo in the symptomatic treatment of intermittent claudication. However, the size of the overall treatment effect is modest and of uncertain clinical relevance.
Juanjuan Ren - One of the best experts on this subject based on the ideXlab platform.
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Ginkgo Biloba Extract for dementia: a systematic review.
Shanghai archives of psychiatry, 2013Co-Authors: Lijuan Jiang, Huiru Cui, Juanjuan RenAbstract:Background Given the increasing burden of dementia internationally and the lack of effective treatments, several countries are already recommending the use of Ginkgo Biloba Extract (GbE) in the treatment of dementia, despite the inconsistent research results about its effectiveness.
J Krieglstein - One of the best experts on this subject based on the ideXlab platform.
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neuroprotective effects of Ginkgo Biloba Extract
Cellular and Molecular Life Sciences, 2003Co-Authors: B Ahlemeyer, J KrieglsteinAbstract:Ginkgo Biloba Extract has been therapeutically used for several decades to increase peripheral and cerebral blood flow as well as for the treatment of dementia. The Extract contains multiple compounds such as flavonoids and terpenoids that are thought to contribute to its neuroprotective and vasotropic effects. In this review, we summarize the experimental results on the mechanism of neuroprotection induced by standardized Extract of Ginkgo Biloba leaves (EGb 761) and its constituents. The effects described mostly in animals include those on cerebral blood flow, neurotransmitter systems, cellular redox state and nitric oxide level. Furthermore, we discuss the current status of clinical trials as well as undesired side effects of EGb 761.
Yuko Taki - One of the best experts on this subject based on the ideXlab platform.
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Effects of Ginkgo Biloba Extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats.
The Journal of pharmacy and pharmacology, 2011Co-Authors: Yuko Taki, Eri Hagiwara, Chiemi Hirose, Kazumasa Shinozuka, Keizo Umegaki, Shizuo YamadaAbstract:Objectives Effects of repeated administration of Ginkgo Biloba Extract on pharmacokinetics and pharmacodynamics of tolbutamide were examined in rats fed a low-protein diet. Methods Rats were given a low (7% casein) or control (20% casein) protein diet for 21 days and administered Ginkgo Biloba Extract (100 mg/kg per day) for the last 5 days. Tolbutamide was co-administered on the last day. Blood glucose and plasma tolbutamide concentrations were determined over the subsequent 12 h and the activity of hepatic cytochrome P450s were determined at 12 h after dosing. Key findings There were significant decreases in body weight, the ratio of liver to body weight, and plasma albumin concentrations in rats on the low-protein diet compared with controls. The hypoglycaemic effect of tolbutamide was significantly greater and the concentration of the drug in plasma was higher in the former group. The repeated administration of Ginkgo Biloba Extract had little influence on the hypoglycaemic effect of tolbutamide, but tended to decrease the drug concentration in plasma of control rats, while it reduced significantly the hypoglycaemic action and plasma concentration of tolbutamide in the protein-restricted rats. Conclusions The effects of Ginkgo Biloba Extract on the pharmacokinetics and pharmacodynamics of tolbutamide were significantly enhanced in rats on the low-protein diet.