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Mark Noble - One of the best experts on this subject based on the ideXlab platform.

  • redox state is a central modulator of the balance between self renewal and differentiation in a dividing Glial Precursor Cell
    Proceedings of the National Academy of Sciences of the United States of America, 2000
    Co-Authors: Joel Smith, Ena Ladi, Margot Mayerproschel, Mark Noble
    Abstract:

    We have discovered that intraCellular redox state appears to be a necessary and sufficient modulator of the balance between self-renewal and differentiation in dividing oligodendrocyte-type-2 astrocyte progenitor Cells. The intraCellular redox state of freshly isolated progenitors allows prospective isolation of Cells with different self-renewal characteristics. Redox state is itself modulated by Cell-extrinsic signaling molecules that alter the balance between self-renewal and differentiation: growth factors that promote self-renewal cause progenitors to become more reduced, while signaling molecules that promote differentiation cause progenitors to become more oxidized. Moreover, pharmacological antagonists of the redox effects of these Cell-extrinsic signaling molecules antagonize their effects on self-renewal and differentiation, indicating that Cell-extrinsic signaling molecules that modulate this balance converge on redox modulation as a critical component of their effector mechanism.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Mark Noble, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conservation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage. © 1995 Wiley-Liss, Inc.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Mark Noble, Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage.

Steve R Williams - One of the best experts on this subject based on the ideXlab platform.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Mark Noble, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conservation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage. © 1995 Wiley-Liss, Inc.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Mark Noble, Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage.

Karen Bevan - One of the best experts on this subject based on the ideXlab platform.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Mark Noble, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conservation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage. © 1995 Wiley-Liss, Inc.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Mark Noble, Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage.

Ute Engel - One of the best experts on this subject based on the ideXlab platform.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Mark Noble, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conservation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage. © 1995 Wiley-Liss, Inc.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Mark Noble, Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage.

Jutte Urenjak - One of the best experts on this subject based on the ideXlab platform.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Mark Noble, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conservation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage. © 1995 Wiley-Liss, Inc.

  • from rodent Glial Precursor Cell to human Glial neoplasia in the oligodendrocyte type 2 astrocyte lineage
    Glia, 1995
    Co-Authors: Mark Noble, Karen Bevan, Ute Engel, Jutte Urenjak, Kishore K Bhakoo, N. J. Gutowski, Mark E Linskey, Steve R Williams
    Abstract:

    With only a few exceptions, the Precursor Cells representing the normal counterparts of human tumours are unknown. The comparative lack of information about the lineages involved in tissue development, and difficulties in growing many human tumors in a manner suitable for Cellular biological analysis, together often make it difficult to study the differences between normal and tumor Cells and to develop many of the model systems that would be useful in the study of human cancer. By applying techniques previously utilized to study Glial progenitor Cells, we have isolated a human glioblastoma multiforme (GBM)-derived population that expresses many properties otherwise uniquely expressed by oligodendrocyte-type-2 astrocyte (O-2A) progenitor Cells. Hu-O-2A/Gb1 (for Human O-2A lineage Glioblastoma number 1) Cells responded to similar mitogens and differentiation modulators as rodent O-2A progenitors, and generated Cells with features of Precursor Cells, oligodendrocytes and astrocytes. Moreover, 1H-NMR analysis of amino acid composition demonstrated a striking conversation of types and quantities of free amino acids between the human tumour Cells and the rodent primary Cells. Hu-O-2A/Gb1 Cells represent the first human glioma-derived population for which unambiguous lineage assignment has been possible, and our results indicate that the human O-2A lineage can contribute to one of the most malignant of Glial tumours. In addition, the highly diagnostic 1H-NMR spectrum expressed by Hu-O-2A/Gb1 Cells raises the possibility of eventual non-invasive identification of tumors of this lineage.