The Experts below are selected from a list of 108 Experts worldwide ranked by ideXlab platform

Laurence E. Becker - One of the best experts on this subject based on the ideXlab platform.

Tomoyuki Takano - One of the best experts on this subject based on the ideXlab platform.

Vanessa J. Auld - One of the best experts on this subject based on the ideXlab platform.

  • Glial processes at the Drosophila larval neuromuscular junction match synaptic growth.
    PloS one, 2012
    Co-Authors: Deidre L. Brink, Mary M. Gilbert, Xiaojun Xie, Lindsay Petley-ragan, Vanessa J. Auld
    Abstract:

    Glia are integral participants in synaptic physiology, remodeling and maturation from blowflies to humans, yet how Glial Structure is coordinated with synaptic growth is unknown. To investigate the dynamics of Glial development at the Drosophila larval neuromuscular junction (NMJ), we developed a live imaging system to establish the relationship between glia, neuronal boutons, and the muscle subsynaptic reticulum. Using this system we observed processes from two classes of peripheral glia present at the NMJ. Processes from the subperineurial glia formed a blood-nerve barrier around the axon proximal to the first bouton. Processes from the perineurial Glial extended beyond the end of the blood-nerve barrier into the NMJ where they contacted synapses and extended across non-synaptic muscle. Growth of the Glial processes was coordinated with NMJ growth and synaptic activity. Increasing synaptic size through elevated temperature or the highwire mutation increased the extent of Glial processes at the NMJ and conversely blocking synaptic activity and size decreased the presence and size of Glial processes. We found that elevated temperature was required during embryogenesis in order to increase Glial expansion at the nmj. Therefore, in our live imaging system, Glial processes at the NMJ are likely indirectly regulated by synaptic changes to ensure the coordinated growth of all components of the tripartite larval NMJ.

Deidre L. Brink - One of the best experts on this subject based on the ideXlab platform.

  • Glial processes at the Drosophila larval neuromuscular junction match synaptic growth.
    PloS one, 2012
    Co-Authors: Deidre L. Brink, Mary M. Gilbert, Xiaojun Xie, Lindsay Petley-ragan, Vanessa J. Auld
    Abstract:

    Glia are integral participants in synaptic physiology, remodeling and maturation from blowflies to humans, yet how Glial Structure is coordinated with synaptic growth is unknown. To investigate the dynamics of Glial development at the Drosophila larval neuromuscular junction (NMJ), we developed a live imaging system to establish the relationship between glia, neuronal boutons, and the muscle subsynaptic reticulum. Using this system we observed processes from two classes of peripheral glia present at the NMJ. Processes from the subperineurial glia formed a blood-nerve barrier around the axon proximal to the first bouton. Processes from the perineurial Glial extended beyond the end of the blood-nerve barrier into the NMJ where they contacted synapses and extended across non-synaptic muscle. Growth of the Glial processes was coordinated with NMJ growth and synaptic activity. Increasing synaptic size through elevated temperature or the highwire mutation increased the extent of Glial processes at the NMJ and conversely blocking synaptic activity and size decreased the presence and size of Glial processes. We found that elevated temperature was required during embryogenesis in order to increase Glial expansion at the nmj. Therefore, in our live imaging system, Glial processes at the NMJ are likely indirectly regulated by synaptic changes to ensure the coordinated growth of all components of the tripartite larval NMJ.

David C. Henshall - One of the best experts on this subject based on the ideXlab platform.

  • Manipulating MicroRNAs in Murine Models: Targeting the Multi-Targeting in Epilepsy.
    Epilepsy currents, 2017
    Co-Authors: David C. Henshall
    Abstract:

    MicroRNAs are small noncoding RNAs that work posttranscriptionally to negatively regulate protein levels. They influence neuronal and Glial Structure and function, neuroinflammatory signaling, cell death, neurogenesis, and other processes relevant to epileptogenesis. Functional studies using oligonucleotide inhibitors (antagomirs) and mimics (agomirs) to modulate microRNAs in rat and mouse models of epilepsy show effects on evoked and spontaneous seizures and attendant neuropathology. The present review summarizes recent findings and points to gaps in our knowledge of the underlying mechanisms and directions for the future.