The Experts below are selected from a list of 18603 Experts worldwide ranked by ideXlab platform

Anne Herman - One of the best experts on this subject based on the ideXlab platform.

  • allergic contact dermatitis caused by isobornyl acrylate in the enlite Glucose Sensor and the paradigm minimed quick set insulin infusion set
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Marie Baeck, Laurence De Montjoye, Emil Giertz, An Goossens, Magnus Bruze, Martin Mowitz
    Abstract:

    Background: The FreeStyle Libre Glucose Sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this Sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite Sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting to the Glucose Sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite Glucose Sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the Sensor or the insulin infusion set. IBOA was identified in the Sensor by GC-MS, and its presence was indicated in the infusion set. Conclusions: IBOA is a contact allergen in Enlite Glucose Sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre Sensor. (Less)

  • unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor freestyle libre
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Laurence De Montjoye, Martin Mowitz, An Goossens, Magnus Bruze, Olivier Aerts, Jeroen Pyl, Marie Baeck
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules. (Less)

  • n n dimethylacrylamide a new sensitizer in the freestyle libre Glucose Sensor
    Contact Dermatitis, 2019
    Co-Authors: Martin Mowitz, Anne Herman, Marie Baeck, Marlene Isaksson, Annarita Antelmi, Nils Hamnerius, Ann Ponten, Magnus Bruze
    Abstract:

    Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre Glucose Sensor. Analyses with gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the Sensor. Material and methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the Sensors “as is,” and two patients were tested with acetone extracts of materials from the Sensor. The extracts were analysed with GC-MS. Results: Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch "as is". One patient reacted to both an extract of the adhesive patch and an extract of the Sensor itself. When analysed with GC-MS, IBOA was found in both extracts and DMAA was found in the extract of the Sensor. Conclusion: Both IBOA and DMAA may be present in adhesives used in medical devices such as Glucose Sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated. (Less)

  • allergic contact dermatitis caused by isobornyl acrylate in freestyle libre a newly introduced Glucose Sensor
    Contact Dermatitis, 2017
    Co-Authors: Anne Herman, Marie Baeck, An Goossens, Magnus Bruze, Olivier Aerts, Nils Hamnerius, Christophe De Block, Sara Huygens, Dominique Maiter, Dominique Tennstedt
    Abstract:

    SUMMARYBackground Glucose Sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic Glucose meters, ensuring continuous Glucose monitoring without the disadvantage of regular skin finger pricks. Objectives To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the Glucose Sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the Sensors was performed. Results All patients reacted to the adhesive part of the Sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the Sensors. Conclusions Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

Marie Baeck - One of the best experts on this subject based on the ideXlab platform.

  • allergic contact dermatitis caused by isobornyl acrylate in the enlite Glucose Sensor and the paradigm minimed quick set insulin infusion set
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Marie Baeck, Laurence De Montjoye, Emil Giertz, An Goossens, Magnus Bruze, Martin Mowitz
    Abstract:

    Background: The FreeStyle Libre Glucose Sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this Sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite Sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting to the Glucose Sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite Glucose Sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the Sensor or the insulin infusion set. IBOA was identified in the Sensor by GC-MS, and its presence was indicated in the infusion set. Conclusions: IBOA is a contact allergen in Enlite Glucose Sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre Sensor. (Less)

  • unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor freestyle libre
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Laurence De Montjoye, Martin Mowitz, An Goossens, Magnus Bruze, Olivier Aerts, Jeroen Pyl, Marie Baeck
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules. (Less)

  • n n dimethylacrylamide a new sensitizer in the freestyle libre Glucose Sensor
    Contact Dermatitis, 2019
    Co-Authors: Martin Mowitz, Anne Herman, Marie Baeck, Marlene Isaksson, Annarita Antelmi, Nils Hamnerius, Ann Ponten, Magnus Bruze
    Abstract:

    Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre Glucose Sensor. Analyses with gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the Sensor. Material and methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the Sensors “as is,” and two patients were tested with acetone extracts of materials from the Sensor. The extracts were analysed with GC-MS. Results: Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch "as is". One patient reacted to both an extract of the adhesive patch and an extract of the Sensor itself. When analysed with GC-MS, IBOA was found in both extracts and DMAA was found in the extract of the Sensor. Conclusion: Both IBOA and DMAA may be present in adhesives used in medical devices such as Glucose Sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated. (Less)

  • allergic contact dermatitis caused by isobornyl acrylate in freestyle libre a newly introduced Glucose Sensor
    Contact Dermatitis, 2017
    Co-Authors: Anne Herman, Marie Baeck, An Goossens, Magnus Bruze, Olivier Aerts, Nils Hamnerius, Christophe De Block, Sara Huygens, Dominique Maiter, Dominique Tennstedt
    Abstract:

    SUMMARYBackground Glucose Sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic Glucose meters, ensuring continuous Glucose monitoring without the disadvantage of regular skin finger pricks. Objectives To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. Patients and Methods Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre. All but 1 were patch tested with a baseline series, and with pieces and/or ultrasonic bath extracts of (the adhesive part of) the Glucose Sensor. Isobornyl acrylate was patch tested, in various concentrations and vehicles, in 13 patients. Gas chromatography–mass spectrometry (GC-MS) of the Sensors was performed. Results All patients reacted to the adhesive part of the Sensor, and 12 patients were shown to be sensitized to isobornyl acrylate. Simultaneous reactions to other allergens were rarely observed. GC-MS showed the presence of isobornyl acrylate in the Sensors. Conclusions Cases of allergic contact dermatitis caused by FreeStyle® Libre are increasingly being observed, and isobornyl acrylate is a relevant culprit allergen. Cross-reactivity to other acrylates was infrequently observed, but other, hitherto unidentified, contact allergens may still be present in the device.

Martin Mowitz - One of the best experts on this subject based on the ideXlab platform.

  • allergic contact dermatitis caused by isobornyl acrylate in the enlite Glucose Sensor and the paradigm minimed quick set insulin infusion set
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Marie Baeck, Laurence De Montjoye, Emil Giertz, An Goossens, Magnus Bruze, Martin Mowitz
    Abstract:

    Background: The FreeStyle Libre Glucose Sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this Sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite Sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting to the Glucose Sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite Glucose Sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the Sensor or the insulin infusion set. IBOA was identified in the Sensor by GC-MS, and its presence was indicated in the infusion set. Conclusions: IBOA is a contact allergen in Enlite Glucose Sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre Sensor. (Less)

  • unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor freestyle libre
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Laurence De Montjoye, Martin Mowitz, An Goossens, Magnus Bruze, Olivier Aerts, Jeroen Pyl, Marie Baeck
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules. (Less)

  • n n dimethylacrylamide a new sensitizer in the freestyle libre Glucose Sensor
    Contact Dermatitis, 2019
    Co-Authors: Martin Mowitz, Anne Herman, Marie Baeck, Marlene Isaksson, Annarita Antelmi, Nils Hamnerius, Ann Ponten, Magnus Bruze
    Abstract:

    Background: Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre Glucose Sensor. Analyses with gas chromatography-mass spectrometry (GC-MS) have indicated the presence of N,N-dimethylacrylamide (DMAA) in the Sensor. Material and methods: Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the Sensors “as is,” and two patients were tested with acetone extracts of materials from the Sensor. The extracts were analysed with GC-MS. Results: Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch "as is". One patient reacted to both an extract of the adhesive patch and an extract of the Sensor itself. When analysed with GC-MS, IBOA was found in both extracts and DMAA was found in the extract of the Sensor. Conclusion: Both IBOA and DMAA may be present in adhesives used in medical devices such as Glucose Sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated. (Less)

An Goossens - One of the best experts on this subject based on the ideXlab platform.

  • allergic contact dermatitis caused by isobornyl acrylate in the enlite Glucose Sensor and the paradigm minimed quick set insulin infusion set
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Marie Baeck, Laurence De Montjoye, Emil Giertz, An Goossens, Magnus Bruze, Martin Mowitz
    Abstract:

    Background: The FreeStyle Libre Glucose Sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this Sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite Sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting to the Glucose Sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite Glucose Sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the Sensor or the insulin infusion set. IBOA was identified in the Sensor by GC-MS, and its presence was indicated in the infusion set. Conclusions: IBOA is a contact allergen in Enlite Glucose Sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre Sensor. (Less)

  • unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor freestyle libre
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Laurence De Montjoye, Martin Mowitz, An Goossens, Magnus Bruze, Olivier Aerts, Jeroen Pyl, Marie Baeck
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules. (Less)

  • Unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor FreeStyle Libre
    'Wiley', 2019
    Co-Authors: Herman Anne, An Goossens, Mowitz Martin, Aerts Olivier, Pyl Jeroen, De Montjoye Laurence, Bruze Magnus, Baeck Marie
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules

  • Unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor FreeStyle Libre
    'Wiley', 2019
    Co-Authors: Herman Anne, An Goossens, Mowitz Martin, Aerts Olivier, Pyl Jeroen, De Montjoye Laurence, Bruze Magnus, Baeck Marie
    Abstract:

    BACKGROUND: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. OBJECTIVES: To compile patch test results of subjects affected, and provide potential explanations for this association. PATIENTS AND METHODS: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. RESULTS: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. CONCLUSION: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist.status: publishe

  • Unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor FreeStyle Libre
    'Wiley', 2019
    Co-Authors: Herman Anne, An Goossens, Mowitz Martin, Aerts Olivier, Pyl Jeroen, De Montjoye Laurence, Bruze Magnus, Baeck Marie
    Abstract:

    BACKGROUND: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. OBJECTIVES: To compile patch test results of subjects affected, and provide potential explanations for this association. PATIENTS AND METHODS: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. RESULTS: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. CONCLUSION: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist

Laurence De Montjoye - One of the best experts on this subject based on the ideXlab platform.

  • allergic contact dermatitis caused by isobornyl acrylate in the enlite Glucose Sensor and the paradigm minimed quick set insulin infusion set
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Marie Baeck, Laurence De Montjoye, Emil Giertz, An Goossens, Magnus Bruze, Martin Mowitz
    Abstract:

    Background: The FreeStyle Libre Glucose Sensor has caused many cases of allergic contact dermatitis, and isobornyl acrylate (IBOA) in this Sensor has been identified as one of the culprit allergens. Objectives: To report on the presence of IBOA in devices produced by Medtronic, namely, Enlite Sensor and insulin infusion set Paradigm MiniMed Quick-set. Patients and Methods: Five patients reacting to the Glucose Sensor Enlite and/or the insulin infusion set Paradigm MiniMed Quick-set observed in three clinics (two Belgian and one Swedish) were patch tested with the baseline and other series, as well as with IBOA; four of them also with pieces of adhesive patches from the devices, and two with a thin layer chromatogram of Enlite Glucose Sensor extracts. Gas chromatography-mass spectrometry (GC-MS) analyses were performed. Results: Four patients reacted to IBOA and one to colophonium, a known allergen in Enlite, and three to the adhesive part of the Sensor or the insulin infusion set. IBOA was identified in the Sensor by GC-MS, and its presence was indicated in the infusion set. Conclusions: IBOA is a contact allergen in Enlite Glucose Sensor, and likely also in the infusion set. Therefore, these devices are not suitable alternatives for patients sensitized to the FreeStyle Libre Sensor. (Less)

  • unexpected positive patch test reactions to sesquiterpene lactones in patients sensitized to the Glucose Sensor freestyle libre
    Contact Dermatitis, 2019
    Co-Authors: Anne Herman, Laurence De Montjoye, Martin Mowitz, An Goossens, Magnus Bruze, Olivier Aerts, Jeroen Pyl, Marie Baeck
    Abstract:

    Background: Most diabetic patients sensitized to FreeStyle Libre react to isobornyl acrylate (IBOA), with a considerable number of them also showing unexpected positive patch test reactions to sesquiterpene lactone (SL) mix (SLM) tested in the baseline series. Objectives: To compile patch test results of subjects affected, and provide potential explanations for this association. Patients and Methods: Fifty-three Freestyle Libre-allergic patients were patch tested with IBOA and/or SLM, and several were also patch tested with the components of SLM. Chromatographic analyses were performed on the Glucose Sensor, IBOA, and the components of SLM. Results: Thirty-three patients reacted positively to the components of SLM, and 11 of 27 patients reacted positively to alantolactone, in particular. Gas chromatography-mass spectrometry (GC-MS) analyses did not detect these chemicals in the different parts of the Glucose Sensor, or in IBOA. Conclusion: Significant co-sensitizations between SLs on the one hand and the Glucose Sensor FreeStyle Libre and/or isobornyl acrylate on the other hand exist, without evidence of the presence of SLs via GC-MS analysis. Cross-reactions between them seem improbable. As a possible hypothesis, a common precursor for both, such as camphene, may exist. Highlights: Of the diabetic patients sensitized to the Glucose Sensor FreeStyle Libre and/or IBOA, 62.3% reacted positively to SLM. Cross-reactions between IBOA and the three components of SLM (alantolactone, costunolide, and dehydrocostus lactone) seem unlikely, because of their different spatial structures. Co-sensitization between IBOA and SLS can be explained by the fact that there is a common precursor, such as camphene, between these two molecules. (Less)