The Experts below are selected from a list of 246 Experts worldwide ranked by ideXlab platform
Boris Fishman - One of the best experts on this subject based on the ideXlab platform.
-
renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure results of a nationwide cross sectional study of 2 5 million adolescents
Cardiovascular Diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander TenenbaumAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal Glucosuria was conducted. In addition, we assessed the association of renal Glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used. The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal Glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50–0.87) and 0.62 (95% CI 0.43–0.88), respectively. Adolescents afflicted with renal Glucosuria were also less likely to have an elevated systolic blood pressure of 130–139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60–0.90). Renal Glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
-
Renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents.
Cardiovascular diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba, Ehud GrossmanAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and
Gilad Twig - One of the best experts on this subject based on the ideXlab platform.
-
renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure results of a nationwide cross sectional study of 2 5 million adolescents
Cardiovascular Diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander TenenbaumAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal Glucosuria was conducted. In addition, we assessed the association of renal Glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used. The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal Glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50–0.87) and 0.62 (95% CI 0.43–0.88), respectively. Adolescents afflicted with renal Glucosuria were also less likely to have an elevated systolic blood pressure of 130–139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60–0.90). Renal Glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
-
Renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents.
Cardiovascular diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba, Ehud GrossmanAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and
Alexander Tenenbaum - One of the best experts on this subject based on the ideXlab platform.
-
renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure results of a nationwide cross sectional study of 2 5 million adolescents
Cardiovascular Diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander TenenbaumAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal Glucosuria was conducted. In addition, we assessed the association of renal Glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used. The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal Glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50–0.87) and 0.62 (95% CI 0.43–0.88), respectively. Adolescents afflicted with renal Glucosuria were also less likely to have an elevated systolic blood pressure of 130–139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60–0.90). Renal Glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
-
Renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents.
Cardiovascular diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba, Ehud GrossmanAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and
Gadi Shlomai - One of the best experts on this subject based on the ideXlab platform.
-
renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure results of a nationwide cross sectional study of 2 5 million adolescents
Cardiovascular Diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander TenenbaumAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal Glucosuria was conducted. In addition, we assessed the association of renal Glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used. The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal Glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50–0.87) and 0.62 (95% CI 0.43–0.88), respectively. Adolescents afflicted with renal Glucosuria were also less likely to have an elevated systolic blood pressure of 130–139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60–0.90). Renal Glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
-
Renal Glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents.
Cardiovascular diabetology, 2019Co-Authors: Boris Fishman, Gadi Shlomai, Gilad Twig, Estela Derazne, Alexander Tenenbaum, Enrique Z. Fisman, Adi Leiba, Ehud GrossmanAbstract:Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal Glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal Glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal Glucosuria is associated with lower body weight and lower blood pressure values. Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and
J. Mäenpää - One of the best experts on this subject based on the ideXlab platform.
-
Transient incidental Glucosuria in children
European Journal of Pediatrics, 1995Co-Authors: J. Rajantie, J. Mäkelä, J. MäenpääAbstract:A consecutive series of 78 children with transient asymptomatic Glucosuria was studied and followed up for up to 7.3 years. The age at presentation was 0.9–17.6 (median 4.6) years. One third of the patients had random blood glucose levels of >10.0 mmol/l (180 mg/dl). Five patients (6.4%) developed insulin-dependent diabetes mellitus within 2.1 years after the first incident of Glucosuria. These patients presented with higher levels of glycaemia than others, and three out of five were positive for islet cell antibodies with a first-phase insulin response
-
transient incidental Glucosuria in children
European Journal of Pediatrics, 1995Co-Authors: J. Rajantie, J. Mäkelä, J. MäenpääAbstract:A consecutive series of 78 children with transient asymptomatic Glucosuria was studied and followed up for up to 7.3 years. The age at presentation was 0.9–17.6 (median 4.6) years. One third of the patients had random blood glucose levels of >10.0 mmol/l (180 mg/dl). Five patients (6.4%) developed insulin-dependent diabetes mellitus within 2.1 years after the first incident of Glucosuria. These patients presented with higher levels of glycaemia than others, and three out of five were positive for islet cell antibodies with a first-phase insulin response <46 mU/l in all four studied. Of the remaining 73 children, 3 were positive for islet cell antibodies and 12/55 had a first-phase insulin response under 46 mU/l. The insulin response deteriorated in 3 but reverted to normal in 7 patients. For a child with transient Glucosuria and with presence of islet cell antibodies and a subnormal first-phase insulin response, therapeutic attempts to prevent overt insulin-dependent diabetes mellitus should be considered.