The Experts below are selected from a list of 17448 Experts worldwide ranked by ideXlab platform
Xiaoyuan Chen - One of the best experts on this subject based on the ideXlab platform.
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ultrasmall Gold Nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy
Advanced Materials, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:: A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = Gold Nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
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sequential drug release and enhanced photothermal and photoacoustic effect of hybrid reduced graphene oxide loaded ultrasmall Gold Nanorod vesicles for cancer therapy
ACS Nano, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic Gold Nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The hybrid vesicle also exhibits a high loading capacity of doxorubicin (DOX), as both the cavity of the vesicle and the large surface area of the encapsulated rGO can be used for loading DOX, making it an excellent drug carrier. The loaded DOX is released sequentially: near-infrared photothermal heating induces DOX release from the vesicular cavity, and an intracellular acidic environment induces DOX release from the rGO surface. Positron emission tomography imaging showed high passive U87MG tumor accumulation of 64Cu-labeled rGO-AuNRVes (∼9.7% ID/g at 24 h postinjection) and strong PA signal in the tumor region. Single intravenous injection of rGO-AuNRVe-DOX followed by low-power-density 808 nm laser irradiation (0.25 W/cm2) revealed effective inhibition of tumor growth due to the combination of c...
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nir light induced surface enhanced raman scattering for detection and photothermal photodynamic therapy of cancer cells using methylene blue embedded Gold Nanorod sio2 nanocomposites
Biomaterials, 2014Co-Authors: Xiaoyuan Chen, Zhen Cheng, Euesoon JangAbstract:Methylene blue-loaded Gold Nanorod@SiO2 (MB-GNR@SiO2) core@shell nanoparticles are synthesized for use in cancer imaging and photothermal/photodynamic dual therapy. For the preparation of GNR@SiO2 nanoparticles, we found that the silica coating rate of hexadecylcetyltrimethylammonium bromide (CTAB)-capped GNRs is much slower than that of PEGylated GNRs due to the densely coated CTAB bilayer. Encapsulated MB molecules have both monomer and dimer forms that result in an increase in the photosensitizing effect through different photochemical pathways. As a consequence of the excellent plasmonic properties of GNRs at near-infrared (NIR) light, the embedded MB molecules showed NIR light-induced SERS performance with a Raman enhancement factor of 3.0 × 1010, which is enough for the detection of a single cancer cell. Moreover, the MB-GNR@SiO2 nanoparticles exhibit a synergistic effect of photodynamic and photothermal therapies of cancer under single-wavelength NIR laser irradiation.
Zhiyong Tang - One of the best experts on this subject based on the ideXlab platform.
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coordination responsive drug release inside Gold Nanorod metal organic framework core shell nanostructures for near infrared induced synergistic chemo photothermal therapy
Nano Research, 2018Co-Authors: Yantao Li, Dawei Wang, Jiawei Lv, Chunying Chen, Zhiyong TangAbstract:Multifunctional core–shell nanostructures formed by integration of distinct components have received wide attention as promising biological platforms in recent years. In this work, crystalline zeolitic imidazolate framework-8 (ZIF-8), a typical metal-organic framework (MOF), is coated onto single Gold Nanorod(AuNR) core for successful realization of synergistic photothermal and chemotherapy triggered by near-infrared (NIR) light. Impressively, high doxorubicin hydrochloride (DOX) loading capacity followed by pH and NIR light dual stimuli-responsive DOX release can be easily implemented through formation and breakage of coordination bonds in the system. Moreover, under NIR laser irradiation at 808 nm, these novel AuNR@MOF core–shell nanostructures exhibit effective synergistic chemo-photothermal therapy both in vitro and in vivo, confirmed by cell treatment and tumor ablation via intravenous injection.
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Gold Nanorod chiral mesoporous silica core shell nanoparticles with unique optical properties
Journal of the American Chemical Society, 2013Co-Authors: Ke Deng, Zhengtao Li, Yunlong Zhou, Zhiyong TangAbstract:The design and fabrication of chiral nanostructures is a promising approach to realize enantiomeric recognition and separation. In our work, Gold Nanorod@chiral mesoporous silica core–shell nanoparticles (GNR@CMS NPs) have been successfully synthesized. This novel material exhibits strong and tunable circular dichroism signals in the visible and near-infrared regions due to the optical coupling between the CMS shells and the GNR cores. When chiral cysteine molecules are loaded in the porous shells, the corresponding surface enhanced Raman scattering spectroscopy demonstrates a distinct chiral recognition effect, which can be used to semiquantitatively measure the composition of chiral enantiomers. A detailed sensing mechanism has been disclosed by density functional theory calculations.
Jibin Song - One of the best experts on this subject based on the ideXlab platform.
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ultrasmall Gold Nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy
Advanced Materials, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:: A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = Gold Nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
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sequential drug release and enhanced photothermal and photoacoustic effect of hybrid reduced graphene oxide loaded ultrasmall Gold Nanorod vesicles for cancer therapy
ACS Nano, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic Gold Nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The hybrid vesicle also exhibits a high loading capacity of doxorubicin (DOX), as both the cavity of the vesicle and the large surface area of the encapsulated rGO can be used for loading DOX, making it an excellent drug carrier. The loaded DOX is released sequentially: near-infrared photothermal heating induces DOX release from the vesicular cavity, and an intracellular acidic environment induces DOX release from the rGO surface. Positron emission tomography imaging showed high passive U87MG tumor accumulation of 64Cu-labeled rGO-AuNRVes (∼9.7% ID/g at 24 h postinjection) and strong PA signal in the tumor region. Single intravenous injection of rGO-AuNRVe-DOX followed by low-power-density 808 nm laser irradiation (0.25 W/cm2) revealed effective inhibition of tumor growth due to the combination of c...
Peng Huang - One of the best experts on this subject based on the ideXlab platform.
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Gold Nanorod embedded large pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer
Nanoscale, 2017Co-Authors: Peng Huang, Qianqian Ni, Zhaogang Teng, Meng Dang, Ying Tian, Yunlei Zhang, Xiaodan Su, Nan LuAbstract:To date, clinicians still lack an effective strategy to treat triple negative breast cancer (TNBC). In this work, we design for the first time a Gold Nanorod embedded large-pore mesoporous organosilica (GNR@LPMO) nanoplatform for gene and photothermal cooperative therapy of TNBC. The synthesized GNR@LPMOs possess a uniform size (175 nm), high surface area (631 m2 g−1), large pore size, excellent photothermal efficiency, and good biocompatibility. Thanks to the large-pore mesoporous organosilica layer, the GNR@LPMO nanoplatforms display much higher loading capacity of siRNA compared with traditional liposome and bare Gold Nanorods. Thus, functional siRNA can be efficiently delivered into TNBC cells by GNR@LPMOs, causing much higher cell apoptosis through knocking down the PLK1 proteins. By combining the effective gene delivery and photothermal abilities, the GNR@LPMO nanoplatforms are further used for gene and photothermal cooperative therapy of TNBC, which induce a 15 fold higher mice tumor inhibition rate than sole therapy modality, indicating the potential clinical use of this novel nanoplatform in treating TNBC.
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ultrasmall Gold Nanorod vesicles with enhanced tumor accumulation and fast excretion from the body for cancer therapy
Advanced Materials, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:: A new kind of ultrasmall dissociable AuNR@PEG/PLGA vesicles (≈60 nm) (AuNR = Gold Nanorod; PEG = poly(ethylene glycol); PLGA = poly(lactic-co-glycolic acid)) assembled from small AuNRs (dimension: ≈8 nm × 2 nm) is reported. They exhibit several striking features: prolonged circulation and prominent tumor accumulation; rapid excretion from the body as AuNR@PEG after therapy; enhanced photoacoustic and photo thermal properties; and high photothermal cancer therapy efficacy.
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sequential drug release and enhanced photothermal and photoacoustic effect of hybrid reduced graphene oxide loaded ultrasmall Gold Nanorod vesicles for cancer therapy
ACS Nano, 2015Co-Authors: Jibin Song, Xiangyu Yang, Orit Jacobson, Peng Huang, Xiaoyuan ChenAbstract:We report a hybrid reduced graphene oxide (rGO)-loaded ultrasmall plasmonic Gold Nanorod vesicle (rGO-AuNRVe) (∼65 nm in size) with remarkably amplified photoacoustic (PA) performance and photothermal effects. The hybrid vesicle also exhibits a high loading capacity of doxorubicin (DOX), as both the cavity of the vesicle and the large surface area of the encapsulated rGO can be used for loading DOX, making it an excellent drug carrier. The loaded DOX is released sequentially: near-infrared photothermal heating induces DOX release from the vesicular cavity, and an intracellular acidic environment induces DOX release from the rGO surface. Positron emission tomography imaging showed high passive U87MG tumor accumulation of 64Cu-labeled rGO-AuNRVes (∼9.7% ID/g at 24 h postinjection) and strong PA signal in the tumor region. Single intravenous injection of rGO-AuNRVe-DOX followed by low-power-density 808 nm laser irradiation (0.25 W/cm2) revealed effective inhibition of tumor growth due to the combination of c...
Yaling Wang - One of the best experts on this subject based on the ideXlab platform.
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fabrication of a graphene oxide Gold Nanorod hybrid material by electrostatic self assembly for surface enhanced raman scattering
Carbon, 2013Co-Authors: Chaofan Hu, Jianhua Rong, Yunhua Yang, Lufeng Yang, Yaling WangAbstract:Abstract An electrostatic self-assembly procedure was used to fabricate graphene oxide (GO) and Gold Nanorod (AuNR) hybrids (GO–AuNR), in which poly ( N -vinyl-2-pyrrolidone) was used as a stabilizing surfactant to prevent the aggregations of GO sheets. AuNRs were loaded onto the surface of GO, which was confirmed by zeta potential measurements, transmission electron microscopy, atomic force microscopy, UV–Vis–NIR and Raman spectroscopy. The GO–AuNR materials show a great increase of Raman signals for adsorbed aromatic dye molecules, which was demonstrated using cationic and anionic aromatic dyes as probe molecules.