The Experts below are selected from a list of 24 Experts worldwide ranked by ideXlab platform

J.w. Lustbader - One of the best experts on this subject based on the ideXlab platform.

  • A Unique Human Chorionic Gonadotropin Antagonist Suppresses Ovarian Hyperstimulation Syndrome in Rats
    Endocrinology, 2009
    Co-Authors: P.a. Vardhana, M.a. Julius, S.v. Pollak, Evan G. Lustbader, Rhonda K. Trousdale, J.w. Lustbader
    Abstract:

    Ovarian hyperstimulation syndrome (OHSS) is a complication of in vitro fertilization associated with physiological changes after hCG administration to induce final oocyte maturation. It presents as widespread increases in vascular permeability and, in rare cases, results in cycle cancellation, multi-organ dysfunction, and pregnancy termination. These physiological changes are due primarily to activation of the vascular endothelial growth factor (VEGF) system in response to exogenous human chorionic Gonadotropin (hCG). An hCG Antagonist (hCG-Ant) could attenuate these effects by competitively binding to the LH/CG receptor, thereby blocking LH activity in vivo. We expressed a form of hCG that lacks three of its four N-linked glycosylation sites and tested its efficacy as an Antagonist. The hCG-Ant binds the LH receptor with an affinity similar to native hCG and inhibits cAMP response in vitro. In a rat model for ovarian stimulation, hCG-Ant dramatically reduces ovulation and steroid hormone production. In a well-established rat OHSS model, vascular permeability and vascular endothelial growth factor (VEGF) expression are dramatically reduced after hCG-Ant treatment. Finally, hCG-Ant does not appear to alter blastocyst development when given after hCG in mice. These studies demonstrate that removing specific glycosylation sites on native hCG can produce an hCG-Ant that is capable of binding without activating the LH receptor and blocking the actions of hCG. Thus hCG-Ant will be investigated as a potential therapy for OHSS.

Fatemeh Mansoori Moghaddam - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of Gynecology and Obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization. Methods 159 poor responder patients were randomized and ovarian stimulation was performed with clomiphene citrate, Gonadotropin and Antagonist (group I) or microdose GnRH agonist flare (group II) protocols. Main outcome was clinical pregnancy rate and secondary outcomes were doses of Gonadotropin administration and duration of stimulation. Results There were no significant differences in age, causes of infertility, basal FSH, BMI, duration of infertility, E_2 level on the day of hCG injection in both groups. Although the cancellation, fertilization, and clinical pregnancy rates were similar in both groups, the endometrial thickness, number of retrieved oocytes, mature oocytes and implantation rate were significantly higher in mild protocol. The doses of Gonadotropin administration and duration of stimulation were significantly lower in mild protocol. Conclusion We recommend mild protocol in assisted reproductive technology cycles for poor responders based on our results regarding less doses of used Gonadotropin and a shorter duration of stimulation.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of gynecology and obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization.

P.a. Vardhana - One of the best experts on this subject based on the ideXlab platform.

  • A Unique Human Chorionic Gonadotropin Antagonist Suppresses Ovarian Hyperstimulation Syndrome in Rats
    Endocrinology, 2009
    Co-Authors: P.a. Vardhana, M.a. Julius, S.v. Pollak, Evan G. Lustbader, Rhonda K. Trousdale, J.w. Lustbader
    Abstract:

    Ovarian hyperstimulation syndrome (OHSS) is a complication of in vitro fertilization associated with physiological changes after hCG administration to induce final oocyte maturation. It presents as widespread increases in vascular permeability and, in rare cases, results in cycle cancellation, multi-organ dysfunction, and pregnancy termination. These physiological changes are due primarily to activation of the vascular endothelial growth factor (VEGF) system in response to exogenous human chorionic Gonadotropin (hCG). An hCG Antagonist (hCG-Ant) could attenuate these effects by competitively binding to the LH/CG receptor, thereby blocking LH activity in vivo. We expressed a form of hCG that lacks three of its four N-linked glycosylation sites and tested its efficacy as an Antagonist. The hCG-Ant binds the LH receptor with an affinity similar to native hCG and inhibits cAMP response in vitro. In a rat model for ovarian stimulation, hCG-Ant dramatically reduces ovulation and steroid hormone production. In a well-established rat OHSS model, vascular permeability and vascular endothelial growth factor (VEGF) expression are dramatically reduced after hCG-Ant treatment. Finally, hCG-Ant does not appear to alter blastocyst development when given after hCG in mice. These studies demonstrate that removing specific glycosylation sites on native hCG can produce an hCG-Ant that is capable of binding without activating the LH receptor and blocking the actions of hCG. Thus hCG-Ant will be investigated as a potential therapy for OHSS.

Farnaz Mohammadian - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of pregnancy outcome after letrozole versus clomiphene treatment for mild ovarian stimulation protocol in poor responders
    Iranian journal of reproductive medicine, 2014
    Co-Authors: Maryam Eftekhar, Farnaz Mohammadian, Robab Davar, Soheila Pourmasumi
    Abstract:

    Background: Poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. Mild ovarian stimulation seems to be preferable to high dose of FSH regimens in women with a history of poor ovarian response in previous protocol. Clomiphene citrate and letrozole alone or in combination with FSH have been used in mild ovarian stimulation protocol. Objective: To compare the efficacy of letrozole and clomiphene citrate for mild ovarian stimulation on assisted reproductive technology outcomes in poor responders. Materials and Methods: In a randomized control study, 184 women aged between 20 and 45 years with the history of poor response to ovarian stimulation who were candidate for ART were randomly subdivided into two groups: group I (n= 80), women who underwent the clomiphene/Gonadotropin/Antagonist protocol; and group II (n= 87), patients who underwent the letrozole/Gonadotropin/Antagonist protocol. Groups were compared regarding implantation, chemical and clinical pregnancy rates. Results: There was a significant difference in the mean endometrial thickness between two groups (9.16±1.2 mm vs. 8.3±0.3 mm). The implantation rate was significantly higher in letrozole group compare to clomiphene group (7.2 vs. 6.6%, p=0.024 respectively). No significant differences were found in chemical and clinical pregnancy rate between two groups. Conclusion: In mild ovarian stimulation protocol, letrozole and clomiphene have similar value for the poor responder. The optimal treatment strategy for these patients remains debated.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of Gynecology and Obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization. Methods 159 poor responder patients were randomized and ovarian stimulation was performed with clomiphene citrate, Gonadotropin and Antagonist (group I) or microdose GnRH agonist flare (group II) protocols. Main outcome was clinical pregnancy rate and secondary outcomes were doses of Gonadotropin administration and duration of stimulation. Results There were no significant differences in age, causes of infertility, basal FSH, BMI, duration of infertility, E_2 level on the day of hCG injection in both groups. Although the cancellation, fertilization, and clinical pregnancy rates were similar in both groups, the endometrial thickness, number of retrieved oocytes, mature oocytes and implantation rate were significantly higher in mild protocol. The doses of Gonadotropin administration and duration of stimulation were significantly lower in mild protocol. Conclusion We recommend mild protocol in assisted reproductive technology cycles for poor responders based on our results regarding less doses of used Gonadotropin and a shorter duration of stimulation.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of gynecology and obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization.

Mohammad Ali Karimzadeh - One of the best experts on this subject based on the ideXlab platform.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of Gynecology and Obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization. Methods 159 poor responder patients were randomized and ovarian stimulation was performed with clomiphene citrate, Gonadotropin and Antagonist (group I) or microdose GnRH agonist flare (group II) protocols. Main outcome was clinical pregnancy rate and secondary outcomes were doses of Gonadotropin administration and duration of stimulation. Results There were no significant differences in age, causes of infertility, basal FSH, BMI, duration of infertility, E_2 level on the day of hCG injection in both groups. Although the cancellation, fertilization, and clinical pregnancy rates were similar in both groups, the endometrial thickness, number of retrieved oocytes, mature oocytes and implantation rate were significantly higher in mild protocol. The doses of Gonadotropin administration and duration of stimulation were significantly lower in mild protocol. Conclusion We recommend mild protocol in assisted reproductive technology cycles for poor responders based on our results regarding less doses of used Gonadotropin and a shorter duration of stimulation.

  • Comparison of mild and microdose GnRH agonist flare protocols on IVF outcome in poor responders
    Archives of gynecology and obstetrics, 2011
    Co-Authors: Mohammad Ali Karimzadeh, Mehri Mashayekhy, Farnaz Mohammadian, Fatemeh Mansoori Moghaddam
    Abstract:

    Purpose To compare the IVF outcome of clomiphene citrate/Gonadotropin/Antagonist (mild protocol) and microdose GnRH agonist flare protocols for poor responders undergoing in vitro fertilization.