The Experts below are selected from a list of 285 Experts worldwide ranked by ideXlab platform
Thomas B Dodson - One of the best experts on this subject based on the ideXlab platform.
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s 100 negative Granular Cell Tumor so called primitive polypoid non neural Granular Cell Tumor of the oral cavity
Head and Neck Pathology, 2017Co-Authors: Yeshwant B Rawal, Thomas B DodsonAbstract:Four cases of cutaneous S-100 negative Granular Cell Tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative Granular Cell Tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of Granular Cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative Granular Cell Tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, the lesions consist of sheets, nests, and fascicles of Granular Cells that are S-100 negative. The Granular Cells are non-reactive to SMA, HMB45, Melan A, and CD163. The intracytoplasmic granules are diffusely and strongly positive to NKI/C3. The Cell lineage of the S-100 negative Granular Cell Tumor is obscure. Absence of staining with CD163 excludes a histiocytic lineage. Absence of staining with S-100 excludes a neural origin. Absence of staining with S-100 and key melanoma markers HMB45 and Melan A also excludes a melanocytic origin. In this context, positive reactivity with NKI/C3 is indicative of presence of intracytoplasmic lysosomal granules only. Greater awareness of this lesion in the oral cavity will result in better characterization of its biologic potential.
Ines Velez - One of the best experts on this subject based on the ideXlab platform.
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S-100 Negative Granular Cell Tumor of the Oral Cavity.
Head and neck pathology, 2015Co-Authors: Lynn W. Solomon, Ines VelezAbstract:Classic Granular Cell Tumor is a mesenchymal neoplasm that commonly occurs on the skin, but is not infrequently found in the oral cavity, primarily on the dorsal tongue. Diagnosis is usually straightforward with hematoxylin and eosin stained slides. Immunohistochemical studies on classic Granular Cell Tumor shows positive immunostaining for S-100 and vimentin, while CD68 is variably positive. We report a case of otherwise unremarkable oral Granular Cell Tumor that was immunohistochemically negative for S-100, and positive for vimentin and CD68, and discuss the differential diagnosis. The results of the immunohistochemical studies in our case are compared with those of classic S-100 positive oral Granular Cell Tumors, as well as cutaneous and oral S-100 negative Granular Cell Tumors. Classic S-100 positive Granular Cell Tumors and S-100 negative Granular Cell Tumors of the oral cavity can only be distinguished by immunohistochemical studies; however, the necessity of this distinction is unclear, as both are benign lesions in which recurrence is unlikely.
Walter F Coulson - One of the best experts on this subject based on the ideXlab platform.
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multiple Granular Cell Tumor a case report and review of the literature
Head and Neck-journal for The Sciences and Specialties of The Head and Neck, 1997Co-Authors: Brett Vean Curtis, Thomas C Calcaterra, Walter F CoulsonAbstract:Background Granular Cell Tumor was first described by Abrikossoff in 1926. It is rare and usually presents as a benign solitary lesion. Multifocal and malignant forms are known to occur. Methods This presentation illustrates an additional case of Granular Cell Tumor. Clinical and histological features to distinguish malignant and benign forms are presented. Results Tumor can develop years after therapy for the primary lesion. Treatment recommendations are presented. Conclusions Patients diagnosed with Granular Cell Tumor require close follow-up. Radiographic evaluation for the presence of metastatic disease is necessary if a malignant variant is suspected. © 1997 John Wiley & Sons, Inc. Head Neck19: 634–637, 1997.
Yeshwant B Rawal - One of the best experts on this subject based on the ideXlab platform.
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s 100 negative Granular Cell Tumor so called primitive polypoid non neural Granular Cell Tumor of the oral cavity
Head and Neck Pathology, 2017Co-Authors: Yeshwant B Rawal, Thomas B DodsonAbstract:Four cases of cutaneous S-100 negative Granular Cell Tumor were described in 1991. Until now, only 3 cases of oral involvement have been documented in English literature. Two additional cases of oral S-100 negative Granular Cell Tumor are described. Immunohistochemical markers were applied to exclude other lesions that may show the presence of Granular Cells. The clinical findings were correlated with the histopathological and immunohistochemical features to arrive at the appropriate diagnosis. S-100 negative Granular Cell Tumors are erythematous polypoid masses commonly mistaken for granulation tissue or a pyogenic granuloma. Any part of the oral cavity may be affected. Histopathologically, the lesions consist of sheets, nests, and fascicles of Granular Cells that are S-100 negative. The Granular Cells are non-reactive to SMA, HMB45, Melan A, and CD163. The intracytoplasmic granules are diffusely and strongly positive to NKI/C3. The Cell lineage of the S-100 negative Granular Cell Tumor is obscure. Absence of staining with CD163 excludes a histiocytic lineage. Absence of staining with S-100 excludes a neural origin. Absence of staining with S-100 and key melanoma markers HMB45 and Melan A also excludes a melanocytic origin. In this context, positive reactivity with NKI/C3 is indicative of presence of intracytoplasmic lysosomal granules only. Greater awareness of this lesion in the oral cavity will result in better characterization of its biologic potential.
James Bryant - One of the best experts on this subject based on the ideXlab platform.
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Granular Cell Tumor of penis and scrotum
Urology, 1995Co-Authors: James BryantAbstract:Abstract Two cases of Granular Cell Tumor of the external male genitalia are reported: one on the scrotum and one on the shaft of the penis. No previous reports of Granular Cell Tumor of the scrotum appear in the literature. Each Tumor was treated by simple excision and there was no recurrence. Each Tumor showed cytoplastic S-100 positively. Tumor was seen in close proximity to small nerve fibers, sweet glands, and erectile smooth muscle. These findings are considered encroachments rather than evidence of origin from any of these structures. An immunohistochemical signature for Granular Cell Tumor has developed in recent years, but, from a practical viewpoint, only the S-100 stain should be used for confirmation of the diagnosis.
