Granulocyte Antibody

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Robert Weinstein - One of the best experts on this subject based on the ideXlab platform.

  • Transfusion-related acute lung injury after the infusion of IVIG
    Transfusion, 2001
    Co-Authors: André Rizk, Kenneth C. Gorson, Lawrence Kenney, Robert Weinstein
    Abstract:

    BACKGROUND: Transfusion-related acute lung injury (TRALI) is a well-characterized, serious complication of blood component therapy in hospitalized patients. The signs and symptoms are often attributed to other clinical aspects of a patient's condition, and therefore TRALI may go unrecognized. IVIG is a pooled plasma derivative commonly used in the outpatient setting. Respiratory complications of IVIG infusion have typically been attributed to volume overload or allergic and vasomotor reactions. TRALI has never been documented to occur after IVIG infusion. CASE REPORT: A 23-year-old man with multifocal motor neuropathy developed noncardiogenic pulmonary edema 6 hours after receiving 90 g of IVIG by a rapid-infusion protocol. He fully recovered in 5 days with nasal oxygen and bed rest. Granulocyte-associated IgG was detected in his blood 14 and 27 weeks after the event. The lots of IVIG that he received were found to contain a low-titer, panreactive, Granulocyte Antibody, mostly IgG. CONCLUSION: This is the first documented case of TRALI after IVIG infusion. An autoimmune syndrome, including autoAntibody-coated Granulocytes, may have been a priming stimulus for Granulocyte interaction with pulmonary capillary endothelium. Rapid infusion of a large quantity of Granulocyte Antibody may have precipitated TRALI. A pooled plasma product or derivative may result in TRALI.

T. Logan - One of the best experts on this subject based on the ideXlab platform.

  • Transfusion-related acute lung injury following random donor platelet transfusion: a report of two cases.
    Vox sanguinis, 1997
    Co-Authors: Ramesh K. Ramanathan, Darrell J. Triulzi, T. Logan
    Abstract:

    Objectives: Transfusion-related acute lung injury (TRALI) following random donor platelet (RDP) transfusion is a rare complication of transfusion without any well-documented case reported in the English language literature. We describe 2 patients in whom TRALI occurred following RDP transfusion. Methods: Conventional clinical and laboratory methods. Results: Both patients developed acute shortness of breath 30-60 min after completion of RDP transfusion and required mechanical ventilatory support. Chest X-ray (CXR) in both cases revealed bilateral pulmonary infiltrates. Patient 1 required vasopressors for hypotension. Right heart catheterization ruled out fluid overload. Patient 2 remained hemodynamically stable. Both patients improved rapidly with continued respiratory support and were extubated within 48 h. CXR at this time showed clearing of infiltrates. In both cases a Granulocyte Antibody was identified in the plasma of a platelet donor supporting the diagnosis of TRALI. Conclusions: In suspected cases of TRALI, HLA and Granulocyte Antibody testing is indicated for the recipients and for donors of implicated components. Implicated donors need not be excluded from the donor pool, but can be used for fractionated plasma and plasma-free components.

Uday R. Popat - One of the best experts on this subject based on the ideXlab platform.

  • Transfusion-related acute lung injury (TRALI) following allogeneic stem cell transplant for acute myeloid leukemia.
    American journal of hematology, 2003
    Co-Authors: Siddhartha Ganguly, George Carrum, Frank Nizzi, Helen E. Heslop, Uday R. Popat
    Abstract:

    Transfusion-related acute lung injury (TRALI) is a serious complication of transfusion characterized by dyspnea, hypoxemia, hypotension, fever, and bilateral pulmonary infiltrates. Although the frequency is estimated at 1/1,120 to 1/5,000 transfusions, few cases have been reported after hematopoietic stem cell transplant. We report a case occurring in an allogeneic transplant recipient who developed acute respiratory distress and bilateral pulmonary infiltrates 2 hr after a platelet transfusion due to the presence of anti Granulocyte Antibody HNA-3a in the product. As there is a wide differential diagnosis for pulmonary infiltrates developing post transplant, TRALI may be under-recognized and should be considered in this setting.

W.-g. Franke - One of the best experts on this subject based on the ideXlab platform.

  • Bone Marrow Scan Using Tc-99m–labeled Anti-Granulocyte Antibody To Evaluate Hematopoiesis in Osteomyelofibrosis
    Clinical nuclear medicine, 2000
    Co-Authors: Thomas Grüning, W.-g. Franke
    Abstract:

    A 66-year-old woman who had known splenomegaly caused by osteomyelofibrosis for several years was referred for evaluation of hematopoietic bone marrow and extrasplenic hematopoiesis before splenectomy. Bone marrow scanning was performed using a Tc-99m-labeled anti-Granulocyte Antibody. The most prominent uptake was seen in a grossly enlarged spleen. There was normal uptake in the liver, kidneys, and bladder, but no bone marrow uptake. Despite the known limitations of anti-Granulocyte antibodies for evaluating splenic hematopoiesis, the total absence of functioning bone marrow allowed the authors to conclude that any remaining hematopoiesis (a clinical judgment) must be splenic.

Kazuhiko Ito - One of the best experts on this subject based on the ideXlab platform.

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