The Experts below are selected from a list of 114 Experts worldwide ranked by ideXlab platform
L Danzigerisakov - One of the best experts on this subject based on the ideXlab platform.
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necrotizing Granulomatous Meningoencephalitis due to balamuthia in an immunocompetent child
Neurology, 2011Co-Authors: Partha S Ghosh, Debabrata Ghosh, Tobias Loddenkemper, Richard A Prayson, Tanya Tekautz, C S Sriram, L DanzigerisakovAbstract:A 4-year-old boy presented with headache for 2 months. Neuroimaging revealed a partially calcified left parieto-occipital lesion suspicious for tumor (figure 1, A–C); biopsy showed necrotizing Granulomatous Meningoencephalitis. Postoperative MRI showed rapid progression (figure 1, D–F). He developed fever and seizures and died …
Simone Peletto - One of the best experts on this subject based on the ideXlab platform.
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Isolation and molecular characterisation of Halicephalobus gingivalis in the brain of a horse in Piedmont, Italy
Parasites & Vectors, 2017Co-Authors: Maria Domenica Pintore, Francesco Cerutti, Antonio D’angelo, Cristiano Corona, Paola Gazzuola, Loretta Masoero, Corrado Colombo, Roberto Bona, Carlo Cantile, Simone PelettoAbstract:Background A fatal case of Meningoencephalitis was reported in a 13-year-old Koninklijk Warmbloed Paard Nederland stallion, suspected of West Nile virus (WNV) infection, in the Piedmont region of Italy. Clinical signs included right head tilt and circling, depression alternated with excitability, fever and lateral strabismus. Combined treatment consisting of dimethylsulfoxide, dexamethasone, sulphonamides and sedative was administered, but because of the poor conditions the horse was euthanatized and submitted for necropsy. Results At post-mortem examination no skin lesions were observed, all organs appeared normal on gross evaluation and only head and blood samples were further investigated. Neuropathological findings consisted of Granulomatous Meningoencephalitis and larvae and adult females of Halicephalobus gingivalis were isolated and identified from the digested brain. Frozen brain was submitted to PCR amplification and 220 bp multiple sequence alignment was analysed by Bayesian phylogenetic analysis. Conclusions Phylogenetic inference revealed that the isolate belongs to H. gingivalis Lineage 3. WN surveillance can help to deepen our knowledge of horse neurological disorders investigating their causes and incidence. Moreover, it can help to understand the geographic distribution of the H. gingivalis , to unravel epidemiological information, and to estimate risk for humans.
Partha S Ghosh - One of the best experts on this subject based on the ideXlab platform.
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necrotizing Granulomatous Meningoencephalitis due to balamuthia in an immunocompetent child
Neurology, 2011Co-Authors: Partha S Ghosh, Debabrata Ghosh, Tobias Loddenkemper, Richard A Prayson, Tanya Tekautz, C S Sriram, L DanzigerisakovAbstract:A 4-year-old boy presented with headache for 2 months. Neuroimaging revealed a partially calcified left parieto-occipital lesion suspicious for tumor (figure 1, A–C); biopsy showed necrotizing Granulomatous Meningoencephalitis. Postoperative MRI showed rapid progression (figure 1, D–F). He developed fever and seizures and died …
S. Schöniger - One of the best experts on this subject based on the ideXlab platform.
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Fatal equine Meningoencephalitis in the United Kingdom caused by the panagrolaimid nematode Halicephalobus gingivalis: case report and review of the literature.
Equine veterinary journal, 2011Co-Authors: C. Hermosilla, K. M. Coumbe, J. Habershon-butcher, S. SchönigerAbstract:Summary A fatal case of eosinophilic and Granulomatous Meningoencephalitis caused by the free-living panagrolaimid nematode Halicephalobus gingivalis is reported in a 10-year-old Welsh gelding in the United Kingdom. Clinical examination first revealed behavioural abnormalities which rapidly progressed to severe ataxia, reduced mentation status and cranial nerve signs. Despite symptomatic treatment no amelioration of neurological signs was achieved and the horse was subjected to euthanasia. A complete post mortem examination revealed eosinophilic and Granulomatous Meningoencephalitis mainly affecting the cerebellum and brain stem with intralesional adult nematodes, larvae and eggs. There was also eosinophilic meningitis of the cervical spinal cord. The intralesional nematodes were morphologically consistent with the panagrolaimid nematode H. gingivalis. Although infection by this facultative neurotropic parasite is extremely rare, it needs to be considered in the differential diagnosis of central nervous signs in horses and, in particular, other equine helminthic infection of the central nervous system. This fatal case is unusual since lesions were locally very extensive and the nematodes did not colonise haematogenously to other organs as seen often in equine halicephalobosis. As the taxonomy of H. gingivalis has changed and some recent reports in the literature still refer to this species as Micronema deletrix or Halicephalobus deletrix, we here provide a short update of the species and some insights on the order Tylenchida, which contains free-living nematodes with parasitic tendencies.
Carlo Cantile - One of the best experts on this subject based on the ideXlab platform.
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Isolation and molecular characterisation of Halicephalobus gingivalis in the brain of a horse in Piedmont, Italy
Parasites & Vectors, 2017Co-Authors: Maria Domenica Pintore, Francesco Cerutti, Antonio D’angelo, Cristiano Corona, Paola Gazzuola, Loretta Masoero, Corrado Colombo, Roberto Bona, Carlo Cantile, Simone PelettoAbstract:Background A fatal case of Meningoencephalitis was reported in a 13-year-old Koninklijk Warmbloed Paard Nederland stallion, suspected of West Nile virus (WNV) infection, in the Piedmont region of Italy. Clinical signs included right head tilt and circling, depression alternated with excitability, fever and lateral strabismus. Combined treatment consisting of dimethylsulfoxide, dexamethasone, sulphonamides and sedative was administered, but because of the poor conditions the horse was euthanatized and submitted for necropsy. Results At post-mortem examination no skin lesions were observed, all organs appeared normal on gross evaluation and only head and blood samples were further investigated. Neuropathological findings consisted of Granulomatous Meningoencephalitis and larvae and adult females of Halicephalobus gingivalis were isolated and identified from the digested brain. Frozen brain was submitted to PCR amplification and 220 bp multiple sequence alignment was analysed by Bayesian phylogenetic analysis. Conclusions Phylogenetic inference revealed that the isolate belongs to H. gingivalis Lineage 3. WN surveillance can help to deepen our knowledge of horse neurological disorders investigating their causes and incidence. Moreover, it can help to understand the geographic distribution of the H. gingivalis , to unravel epidemiological information, and to estimate risk for humans.
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protothecal Granulomatous Meningoencephalitis in a dog
Journal of Small Animal Practice, 2008Co-Authors: Claudia Salvadori, Gualtiero Gandini, A Ballarini, Carlo CantileAbstract:A case of central nervous system protothecosis in a dog is reported. A three-year-old male Maremma sheepdog was referred with a two month history of diarrhoea associated with progressive tetraparesis, depression and right circling. Stupor, severe proprioceptive deficits, bilateral decreased thoracic limb flexor reflexes and bilateral deficit of the menace reaction were detected on neurological examination and a multi-focal neurological localisation was suspected. Histopathological evaluation revealed multi-focal Granulomatous foci in the thalamus, hippocampus and caudal brainstem containing numerous oval-rounded organisms with a thick, periodic acid-Schiff-positive and Gomori's methenamine silver-positive cell wall, a basophilic cytoplasm and one nucleus. Scattered sporangia containing two to four endospores were also observed. Morphological features were consistent with Prototheca species. Ultrastructurally, numerous degenerated algae were present within macrophages mainly lacking nuclei and cytoplasmic organelles. Generally, protothecosis in dogs is characterised by systemic signs because of a multi-organ involvement, and haemorrhagic colitis or ophthalmologic signs are the most frequent presenting signs. However, protothecosis should be added, also in Europe, to the list of the differential diagnoses in adult dogs with a multi-focal neurological localisation even in absence of other clinical signs.
