The Experts below are selected from a list of 312 Experts worldwide ranked by ideXlab platform
Desmond M. Murphy - One of the best experts on this subject based on the ideXlab platform.
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Chronic thromboembolic disease and necrotizing Granulomatous Vasculitis – A case report
Respiratory Medicine CME, 2011Co-Authors: Donall G. Forde, Brian Mccullagh, Michael Henry, Sean Gaine, Desmond M. MurphyAbstract:AbstractA 32 year old male presented to our services with severe, progressive breathlessness. Following a detailed clinical work-up he was found to have severe pulmonary arterial hypertension due to chronic thromboembolic disease. No risk factor for venous thromboembolism,was identified at this time. Vasculitic screen including anti-neutrophil cytoplasmic antibody (ANCA) was normal. He was referred for pulmonary artery endarterectomy which was performed successfully and with good initial improvement in his symptom complex. He represented with breathlessness four months later. He was diagnosed with necrotizing Granulomatous Vasculitis (known formerly as Wegner's Granulomatosis). While an association between necrotizing Granulomatous Vasculitis and venous thromboembolic disease is well described, to our knowledge this is the first case of a patient with chronic thromboembolic pulmonary hypertensive disease subsequently developing fulminant necrotizing Granulomatous Vasculitis
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chronic thromboembolic disease and necrotizing Granulomatous Vasculitis a case report
Respiratory Medicine Cme, 2011Co-Authors: Donall G. Forde, Brian Mccullagh, Sean Gaine, Michael T Henry, Desmond M. MurphyAbstract:A 32 year old male presented to our services with severe, progressive breathlessness. Following a detailed clinical work-up he was found to have severe pulmonary arterial hypertension due to chronic thromboembolic disease. No risk factor for venous thromboembolism,was identified at this time. Vasculitic screen including anti-neutrophil cytoplasmic antibody (ANCA) was normal. He was referred for pulmonary artery endarterectomy which was performed successfully and with good initial improvement in his symptom complex. He represented with breathlessness four months later. He was diagnosed with necrotizing Granulomatous Vasculitis (known formerly as Wegner's Granulomatosis). While an association between necrotizing Granulomatous Vasculitis and venous thromboembolic disease is well described, to our knowledge this is the first case of a patient with chronic thromboembolic pulmonary hypertensive disease subsequently developing fulminant necrotizing Granulomatous Vasculitis.
Om P. Sharma - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary hypertension and Granulomatous Vasculitis in sarcoidosis.
Current opinion in pulmonary medicine, 2007Co-Authors: Hidenobu Shigemitsu, Sonoko Nagai, Om P. SharmaAbstract:Purpose of review To examine the recent advancements of the epidemiology, pathophysiology, clinical characteristics, radiographic studies, diagnostic modalities, treatment, and prognosis of pulmonary hypertension in sarcoidosis. Recent findings A large retrospective study found 73.8% of patients with sarcoidosis listed for transplant had pulmonary hypertension. Several other studies found pulmonary hypertension to be associated mostly with advanced sarcoidosis, although frequencies in nonfibrotic disease were not uncommon. Destruction of vasculature due to fibrotic lung disease is most likely the common cause; however, other mechanisms have been proposed. In a small study, pulmonary venous occlusive disease was observed in the explanted lungs. Several studies have found an association with pulmonary function and the incidence of pulmonary hypertension. Right heart failure was seen in 21-23% of patients. In one study, high-resolution computer tomography findings, such as presence of lymphadenopathy, opacities, and thickened bronchovascular bundles, were not significantly different. Septal lines and ground-glass opacities were found at higher frequency in sarcoidosis-associated pulmonary hypertension. Corticosteroids were effective in treating some patients with sarcoidosis-associated pulmonary hypertension. Inhaled nitric oxide, epoprostenol, and bosentan have been shown to be efficacious in a small number of patients. Summary Pulmonary hypertension is not infrequently observed in sarcoidosis. Further studies are needed to elucidate the epidemiology, mechanisms, treatment, and significance of sarcoidosis-associated pulmonary hypertension.
P. J. R. Shaw - One of the best experts on this subject based on the ideXlab platform.
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Isolated necrotizing Granulomatous Vasculitis of the epididymis and spermatic cords.
World journal of urology, 1994Co-Authors: A. Halim, G. H. Neild, T. Levine, P. J. R. ShawAbstract:A 71-year-old man with a painful scrotal swelling was found to have necrotizing Granulomatous Vasculitis of the epididymis and spermatic cords. No systemic symptom was present, nor was there serological or haematological evidence of systemic Vasculitis.
Donall G. Forde - One of the best experts on this subject based on the ideXlab platform.
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Chronic thromboembolic disease and necrotizing Granulomatous Vasculitis – A case report
Respiratory Medicine CME, 2011Co-Authors: Donall G. Forde, Brian Mccullagh, Michael Henry, Sean Gaine, Desmond M. MurphyAbstract:AbstractA 32 year old male presented to our services with severe, progressive breathlessness. Following a detailed clinical work-up he was found to have severe pulmonary arterial hypertension due to chronic thromboembolic disease. No risk factor for venous thromboembolism,was identified at this time. Vasculitic screen including anti-neutrophil cytoplasmic antibody (ANCA) was normal. He was referred for pulmonary artery endarterectomy which was performed successfully and with good initial improvement in his symptom complex. He represented with breathlessness four months later. He was diagnosed with necrotizing Granulomatous Vasculitis (known formerly as Wegner's Granulomatosis). While an association between necrotizing Granulomatous Vasculitis and venous thromboembolic disease is well described, to our knowledge this is the first case of a patient with chronic thromboembolic pulmonary hypertensive disease subsequently developing fulminant necrotizing Granulomatous Vasculitis
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chronic thromboembolic disease and necrotizing Granulomatous Vasculitis a case report
Respiratory Medicine Cme, 2011Co-Authors: Donall G. Forde, Brian Mccullagh, Sean Gaine, Michael T Henry, Desmond M. MurphyAbstract:A 32 year old male presented to our services with severe, progressive breathlessness. Following a detailed clinical work-up he was found to have severe pulmonary arterial hypertension due to chronic thromboembolic disease. No risk factor for venous thromboembolism,was identified at this time. Vasculitic screen including anti-neutrophil cytoplasmic antibody (ANCA) was normal. He was referred for pulmonary artery endarterectomy which was performed successfully and with good initial improvement in his symptom complex. He represented with breathlessness four months later. He was diagnosed with necrotizing Granulomatous Vasculitis (known formerly as Wegner's Granulomatosis). While an association between necrotizing Granulomatous Vasculitis and venous thromboembolic disease is well described, to our knowledge this is the first case of a patient with chronic thromboembolic pulmonary hypertensive disease subsequently developing fulminant necrotizing Granulomatous Vasculitis.
David Milne - One of the best experts on this subject based on the ideXlab platform.
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Pulmonary hypertension in sarcoidosis, caused by extrinsic compression of major pulmonary vessels
Respiratory Medicine CME, 2010Co-Authors: Paul Sexton, Margaret L. Wilsher, David MilneAbstract:AbstractPulmonary hypertension is an increasingly recognised complication of sarcoidosis that arises from a variety of physiological mechanisms, including pulmonary fibrosis, Granulomatous Vasculitis, and circulating vasoactive mediators. We present the case of a young man with sarcoidosis complicated by fatal pulmonary hypertension due to extrinsic compression of the major pulmonary vessels by mediastinal Granulomatous inflammation and lymphadenopathy
