The Experts below are selected from a list of 3 Experts worldwide ranked by ideXlab platform
Patrick Pasau - One of the best experts on this subject based on the ideXlab platform.
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New synthetic pathway to diverse 2-substituted quinolines based on a multicomponent Reaction: solution-phase and solid-phase applications.
Journal of combinatorial chemistry, 2004Co-Authors: Thierry Demaude, Laurent Knerr, Patrick PasauAbstract:Using Kobayashi's modification of the Grieco Reaction, we were able to synthesize diverse 4-phenylthio-1,2,3,4-tetrahydroquinolines. These intermediates were oxidized and subsequently pyrolized to provide the corresponding quinolines. This new approach to 2-substituted quinolines was exemplified by liquid-phase production of a 25-member library. This was extended to solid-phase chemistry, starting from (l)-4-nitrophenylalanine on Wang resin, for production of a 16-member library. The latter compounds possess potentially interesting VLA-4 antagonist properties.
Thierry Demaude - One of the best experts on this subject based on the ideXlab platform.
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New synthetic pathway to diverse 2-substituted quinolines based on a multicomponent Reaction: solution-phase and solid-phase applications.
Journal of combinatorial chemistry, 2004Co-Authors: Thierry Demaude, Laurent Knerr, Patrick PasauAbstract:Using Kobayashi's modification of the Grieco Reaction, we were able to synthesize diverse 4-phenylthio-1,2,3,4-tetrahydroquinolines. These intermediates were oxidized and subsequently pyrolized to provide the corresponding quinolines. This new approach to 2-substituted quinolines was exemplified by liquid-phase production of a 25-member library. This was extended to solid-phase chemistry, starting from (l)-4-nitrophenylalanine on Wang resin, for production of a 16-member library. The latter compounds possess potentially interesting VLA-4 antagonist properties.
Laurent Knerr - One of the best experts on this subject based on the ideXlab platform.
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New synthetic pathway to diverse 2-substituted quinolines based on a multicomponent Reaction: solution-phase and solid-phase applications.
Journal of combinatorial chemistry, 2004Co-Authors: Thierry Demaude, Laurent Knerr, Patrick PasauAbstract:Using Kobayashi's modification of the Grieco Reaction, we were able to synthesize diverse 4-phenylthio-1,2,3,4-tetrahydroquinolines. These intermediates were oxidized and subsequently pyrolized to provide the corresponding quinolines. This new approach to 2-substituted quinolines was exemplified by liquid-phase production of a 25-member library. This was extended to solid-phase chemistry, starting from (l)-4-nitrophenylalanine on Wang resin, for production of a 16-member library. The latter compounds possess potentially interesting VLA-4 antagonist properties.
