The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Weidong Zhang - One of the best experts on this subject based on the ideXlab platform.
-
in silico anti inflammatory potential of Guaiane dimers from xylopia vielana targeting cox 2
Journal of Biomolecular Structure & Dynamics, 2020Co-Authors: Syed Shams Ul Hassan, Huizi Jin, Weidong Zhang, Syed Hussain Basha, Sasi PriyaAbstract:Natural products of herbal origin are prodigious to display diverse pharmacological activities. In the present study, five Guaiane-type sesquiterpene dimers, xylopidimers A − E (1–5), isolated from...
-
xylopidimers a e five new Guaiane dimers with various carbon skeletons from the roots of xylopia vielana
ACS omega, 2019Co-Authors: Yigong Guo, Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Five new Guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new Guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 μM in RAW264.7 cells stimulated by lipopolysaccharide.
-
xylopsides a d four rare Guaiane dimers with two unique bridged pentacyclic skeletons from xylopia vielana
Organic and Biomolecular Chemistry, 2018Co-Authors: Yangguo Xie, Yigong Guo, Shenglan Zhu, Taofang Cheng, Yu Zhang, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Four unprecedented Guaiane dimers, xylopsides A–D (1–4), were isolated and identified from the roots of Xylopia vielana. The structures of 1–4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1–4 showed two bridged pentacyclic skeletons between two Guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.
-
vielopsides a e five new Guaiane type sesquiterpenoid dimers from xylopia vielana
Fitoterapia, 2018Co-Authors: Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Abstract Five new Guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct C C bonds (C-2 to C-2′, C-4 to C-1′), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC50 values of 33.8 μM on NO production in RAW 264.7 macrophages.
-
synthesis and structure activity relationships of Guaiane type sesquiterpene lactone derivatives with respect to inhibiting no production in lipopolysaccharide induced raw 264 7 macrophages
European Journal of Medicinal Chemistry, 2014Co-Authors: Hao Chen, Weidong Zhang, Bingyang Chen, Chunting Liu, Zeng Zhao, Wenhao Shao, Hu Yuan, Jiangyun Liu, Qingyan SunAbstract:Abstract A Guaiane framework was scaffolded by photochemical rearrangement reactions using α-santonin 1 as a starting material. Then, using a series of reactions, we synthesized the Guaiane-type sesquiterpene lactone 5 in high yield. The inhibitory activities of compound 5 and of a series of derivatives on nitric oxide (NO) release were evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Compounds 6g, 7h, 7i, 7k and 8g, exhibited significant inhibitory effects on NO production, with IC50 values of 14.8, 22.3, 18.3, 17.4 and 7.0 μM, respectively. Their cytotoxicities were also estimated using an MTT assay. The structure–activity relationships of these compounds were also discussed.
Huizi Jin - One of the best experts on this subject based on the ideXlab platform.
-
three new Guaiane type sesquiterpenoids and a monoterpenoid from litsea lancilimba merr
Natural Product Research, 2020Co-Authors: Ishaq Muhammad, Shikai Yan, Syed Shams Ul Hassan, Yong Zhen Xiao, Xue Xiao, Yuanqiang Guo, Huizi JinAbstract:Three undescribed Guaiane-type sesquiterpenes (1–3), and a monoterpenoid (4) along with eleven known compounds (5 − 15) were isolated from the crude extract of Litsea lancilimba Merr. The structure...
-
in silico anti inflammatory potential of Guaiane dimers from xylopia vielana targeting cox 2
Journal of Biomolecular Structure & Dynamics, 2020Co-Authors: Syed Shams Ul Hassan, Huizi Jin, Weidong Zhang, Syed Hussain Basha, Sasi PriyaAbstract:Natural products of herbal origin are prodigious to display diverse pharmacological activities. In the present study, five Guaiane-type sesquiterpene dimers, xylopidimers A − E (1–5), isolated from...
-
xylopidimers a e five new Guaiane dimers with various carbon skeletons from the roots of xylopia vielana
ACS omega, 2019Co-Authors: Yigong Guo, Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Five new Guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new Guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 μM in RAW264.7 cells stimulated by lipopolysaccharide.
-
xylopsides a d four rare Guaiane dimers with two unique bridged pentacyclic skeletons from xylopia vielana
Organic and Biomolecular Chemistry, 2018Co-Authors: Yangguo Xie, Yigong Guo, Shenglan Zhu, Taofang Cheng, Yu Zhang, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Four unprecedented Guaiane dimers, xylopsides A–D (1–4), were isolated and identified from the roots of Xylopia vielana. The structures of 1–4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1–4 showed two bridged pentacyclic skeletons between two Guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.
-
vielopsides a e five new Guaiane type sesquiterpenoid dimers from xylopia vielana
Fitoterapia, 2018Co-Authors: Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Abstract Five new Guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct C C bonds (C-2 to C-2′, C-4 to C-1′), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC50 values of 33.8 μM on NO production in RAW 264.7 macrophages.
Shikai Yan - One of the best experts on this subject based on the ideXlab platform.
-
three new Guaiane type sesquiterpenoids and a monoterpenoid from litsea lancilimba merr
Natural Product Research, 2020Co-Authors: Ishaq Muhammad, Shikai Yan, Syed Shams Ul Hassan, Yong Zhen Xiao, Xue Xiao, Yuanqiang Guo, Huizi JinAbstract:Three undescribed Guaiane-type sesquiterpenes (1–3), and a monoterpenoid (4) along with eleven known compounds (5 − 15) were isolated from the crude extract of Litsea lancilimba Merr. The structure...
-
xylopidimers a e five new Guaiane dimers with various carbon skeletons from the roots of xylopia vielana
ACS omega, 2019Co-Authors: Yigong Guo, Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Five new Guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new Guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 μM in RAW264.7 cells stimulated by lipopolysaccharide.
-
xylopsides a d four rare Guaiane dimers with two unique bridged pentacyclic skeletons from xylopia vielana
Organic and Biomolecular Chemistry, 2018Co-Authors: Yangguo Xie, Yigong Guo, Shenglan Zhu, Taofang Cheng, Yu Zhang, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Four unprecedented Guaiane dimers, xylopsides A–D (1–4), were isolated and identified from the roots of Xylopia vielana. The structures of 1–4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1–4 showed two bridged pentacyclic skeletons between two Guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.
-
vielopsides a e five new Guaiane type sesquiterpenoid dimers from xylopia vielana
Fitoterapia, 2018Co-Authors: Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Abstract Five new Guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct C C bonds (C-2 to C-2′, C-4 to C-1′), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC50 values of 33.8 μM on NO production in RAW 264.7 macrophages.
-
japonicones a d bioactive dimeric sesquiterpenes from inula japonica thunb
Bioorganic & Medicinal Chemistry Letters, 2009Co-Authors: Jiangjiang Qin, Shikai Yan, Huizi Jin, Weidong Zhang, Yan WangAbstract:Abstract Four new dimeric sesquiterpene lactones japonicones A−D (1−4), comprised by eudesmane and Guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1−4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.
Yangguo Xie - One of the best experts on this subject based on the ideXlab platform.
-
xylopidimers a e five new Guaiane dimers with various carbon skeletons from the roots of xylopia vielana
ACS omega, 2019Co-Authors: Yigong Guo, Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Five new Guaiane dimers, xylopidimers A-E (1-5), were isolated and identified from the roots of Xylopia vielana. The structures of 1-5 were elucidated by spectroscopic analysis and further confirmed by single-crystal X-ray diffraction. On the basis of the results of single-crystal X-ray analysis, 1-5 showed different carbon skeletons. Among these compounds, the unique connecting patterns of 1 and 2 caused significant differences on their carbon skeletons, which have not been reported. Moreover, 3-5 were also three new Guaiane dimers. Among these compounds, 4 exhibited potent inhibitory activity against the production of nitric oxide with an IC50 value of 4.59 μM in RAW264.7 cells stimulated by lipopolysaccharide.
-
xylopsides a d four rare Guaiane dimers with two unique bridged pentacyclic skeletons from xylopia vielana
Organic and Biomolecular Chemistry, 2018Co-Authors: Yangguo Xie, Yigong Guo, Shenglan Zhu, Taofang Cheng, Yu Zhang, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Four unprecedented Guaiane dimers, xylopsides A–D (1–4), were isolated and identified from the roots of Xylopia vielana. The structures of 1–4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1–4 showed two bridged pentacyclic skeletons between two Guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC50 value of 25.7 μM in RAW264.7 cells stimulated by LPS.
-
vielopsides a e five new Guaiane type sesquiterpenoid dimers from xylopia vielana
Fitoterapia, 2018Co-Authors: Yangguo Xie, Shenglan Zhu, Taofang Cheng, Shikai Yan, Huizi Jin, Weidong ZhangAbstract:Abstract Five new Guaiane-type sesquiterpenoid dimers vielopsides A-E, connecting patterns through two direct C C bonds (C-2 to C-2′, C-4 to C-1′), were isolated from the roots of Xylopia vielana. Their absolute configurations were established by NOE analysis, the Cu Kα X-ray crystallographic and circular dichroism (CD) experiment. Among them, compound 5 showed moderate activity IC50 values of 33.8 μM on NO production in RAW 264.7 macrophages.
Yeon Su Jeong - One of the best experts on this subject based on the ideXlab platform.
-
a new Guaiane type sesquiterpene from torilis japonica
Archives of Pharmacal Research, 2001Co-Authors: Jaeha Ryu, Yeon Su JeongAbstract:A new Guaiane type sesquiterpene was isolated from the fruit ofTorilis japonica (Umbelliferae). Based on NMR, IR and mass spectroscopy its structure was confirmed as deangeloyloxy torilin, 1s, 7α, 10αH-11 -acetoxy-guaia-4-en-3-one (1). This is the first report showing that this compound can be isolated fromTorilis japonica.
