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V. Satyanarayana - One of the best experts on this subject based on the ideXlab platform.
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development of colon targeted oral Guar gum matrix tablets of albendazole for the treatment of helminthiasis
Indian Journal of Pharmaceutical Sciences, 2003Co-Authors: Y S R Krishanaiah, K Latha, Nageswara L Rao, R Karthikeyan, P Bhaskar, V. SatyanarayanaAbstract:The objective of the present study is to develop colon targeted drug delivery systems for albendazole using Guar gum as a carrier. Matrix tablets containing various proportions of Guar gum were prepared by wet granulationtechnique using starch paste as a binder. The tablets were evaluated for hardness and drug content, and were subjected to in vitro drug release studies. The amount of albendazole released from the matrix tablets at different time intervals was estimated by HPLC method. Guar gum matrix tablets released 4 to 17% of albendazole in the physiological environment of stomach and small intestine depending on the proportion of Guar gum used in the formulation. When the dissolution study was continued in simulated colonic fluids (rat caecal content medium) the matrix tablets containing 10% of Guar gum released another 83% of albendazole after degradation into 2-3 pieces at the end of 24 h of the study. The matrix tablets containing 20% of Guar gum also released about 44% of albendazole In simulated colonic fluids at the end of 24 h of the study indicating the susceptibility of the Guar gum formulations to the rat caecal contents. The results of the study show that matrix tablets containing either 10% or 20% of Guar gum are most likely to provide targeting of albendazole for local action in the colon. The Guar gum matrix tablets of albendazole showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40°/75 % RH for 6 mo. Differential scanning calorimetry indicated no possibility of interaction between albendazole and Guar gum.
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a three layer Guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate
International Journal of Pharmaceutics, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, V. SatyanarayanaAbstract:Abstract The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of Guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of Guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of Guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer Guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/Guar gum interaction with the formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate.
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a three layer Guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate
International Journal of Pharmaceutics, 2002Co-Authors: Yellela S.r. Krishnaiah, R Karthikeyan, V. SatyanarayanaAbstract:The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of Guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of Guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of Guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer Guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 degrees C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/Guar gum interaction with the formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate.
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three layer Guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride
Journal of Controlled Release, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, Gouri V Sankar, V. SatyanarayanaAbstract:Abstract The present study is carried out to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of three-layer matrix tablets. Trimetazidine dihydrochloride was chosen as a model drug because of its high water solubility. Matrix tablet granules containing 30% (M1), 40% (M2) or 50% (M3) of Guar gum were prepared by the wet granulation technique using starch paste as a binder. Three-layer matrix tablets of trimetazidine dihydrochloride were prepared by compressing on either side of Guar gum matrix tablet granules of trimetazidine dihydrochloride M1, M2 or M3 with 200 mg of Guar gum granules containing either 65% of Guar gum (T1M1, T1M2 or T1M3), 75% of Guar gum (T2M1, T2M2 or T2M3) or 85% of Guar gum (T3M1, T3M2 or T3M3) as release retardant layers. The three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of trimetazidine dihydrochloride released from the matrix and three-layer matrix tablets at different time intervals was estimated using a HPLC method. The three-layer Guar gum matrix tablet (T3M3) provided the required release rate on par with the theoretical release rate for Guar gum formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (T3M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/RH 75% for 6 months. The DSC study did not show any possibility of interaction between trimetazidine dihydrochloride and Guar gum/other formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride.
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development of colon targeted drug delivery systems for mebendazole
Journal of Controlled Release, 2001Co-Authors: Yellela S.r. Krishnaiah, P Bhaskar, Veer P Raju, Dinesh B Kumar, V. SatyanarayanaAbstract:Abstract The objective of the present study is to develop colon targeted drug delivery systems for mebendazole using Guar gum as a carrier. Matrix tablets containing various proportions of Guar gum were prepared by wet granulation technique using starch paste as a binder. The tablets were evaluated for drug content uniformity, and were subjected to in vitro drug release studies. The amount of mebendazole released from the matrix tablets at different time intervals was estimated by a high-performance liquid chromatography method. Guar gum matrix tablets released 8–15% of the mebendazole in the physiological environment of stomach and small intestine depending on the proportion of Guar gum used in the formulation. When the dissolution study was continued in simulated colonic fluids the matrix tablets containing 20% of Guar gum released another 83% of mebendazole after degradation into 2–3 pieces. The matrix tablets containing 30% of Guar gum also released about 50% of mebendazole in simulated colonic fluids indicating the susceptibility of the Guar gum formulations to the rat caecal contents. The results of the study show that matrix tablets containing either 20% or 30% of Guar gum are most likely to provide targeting of mebendazole for local action in the colon. The mebendazole matrix tablets containing either 20% or 30% of Guar gum showed no change either in physical appearance, drug content or dissolution pattern after storage at 45°C/75% relative humidity for 3 months. Differential scanning calorimetry indicated no possibility of interaction between mebendazole and Guar gum.
Yellela S.r. Krishnaiah - One of the best experts on this subject based on the ideXlab platform.
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in vitro and in vivo evaluation of Guar gum matrix tablets for oral controlled release of water soluble diltiazem hydrochloride
Aaps Pharmscitech, 2005Co-Authors: S M Alsaidan, Yellela S.r. Krishnaiah, Srinivas S Patro, Vemulapalli SatyanaryanaAbstract:The objective of the study was to develop Guar gum matrix tablets for oral controlled release of water-soluble diltiazem hydrochloride. Matrix tablets of diltiazem hydrochloride, using various viscosity grades of Guar gum in 2 proportions, were prepared by wet granulation method and subjected to in vitro drug release studies. Diltiazem hydrochloride matrix tablets containing either 30% wt/wt lowviscosity (LM1), 40% wt/wt medium-viscosity (MM2), or 50% wt/wt high-viscosity (HM2) Guar gum showed controlled release. The drug release from all Guar gum matrix tablets followed first-order kinetics via Fickian-diffusion. Further, the results of in vitro drug release studies in simulated gastrointestinal and colonic fluids showed that HM2 tablets provided controlled release comparable with marketed sustained release diltiazem hydrochloride tablets (D-SR tablets). Guar gum matrix tablets HM2 showed no change in physical appearance, drug content, or in dissolution pattern after storage at 40°C/relative humidity 75% for 6 months. When subjectd to in vivo pharmacokinetic evaluation in healthy volunteers, the HM2 tablets provided a slow and prolonged drug release when compared with D-SR tablets. Based on the results of in vitro and in vivo studies it was concluded that that Guar gum matrix tablets provided oral controlled release of water-soluble diltiazem hydrochloride.
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a three layer Guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate
International Journal of Pharmaceutics, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, V. SatyanarayanaAbstract:Abstract The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of Guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of Guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of Guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer Guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/Guar gum interaction with the formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate.
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a three layer Guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate
International Journal of Pharmaceutics, 2002Co-Authors: Yellela S.r. Krishnaiah, R Karthikeyan, V. SatyanarayanaAbstract:The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of Guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of Guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of Guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer Guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 degrees C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/Guar gum interaction with the formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate.
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three layer Guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride
Journal of Controlled Release, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, Gouri V Sankar, V. SatyanarayanaAbstract:Abstract The present study is carried out to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of three-layer matrix tablets. Trimetazidine dihydrochloride was chosen as a model drug because of its high water solubility. Matrix tablet granules containing 30% (M1), 40% (M2) or 50% (M3) of Guar gum were prepared by the wet granulation technique using starch paste as a binder. Three-layer matrix tablets of trimetazidine dihydrochloride were prepared by compressing on either side of Guar gum matrix tablet granules of trimetazidine dihydrochloride M1, M2 or M3 with 200 mg of Guar gum granules containing either 65% of Guar gum (T1M1, T1M2 or T1M3), 75% of Guar gum (T2M1, T2M2 or T2M3) or 85% of Guar gum (T3M1, T3M2 or T3M3) as release retardant layers. The three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of trimetazidine dihydrochloride released from the matrix and three-layer matrix tablets at different time intervals was estimated using a HPLC method. The three-layer Guar gum matrix tablet (T3M3) provided the required release rate on par with the theoretical release rate for Guar gum formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (T3M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/RH 75% for 6 months. The DSC study did not show any possibility of interaction between trimetazidine dihydrochloride and Guar gum/other formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride.
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development of colon targeted drug delivery systems for mebendazole
Journal of Controlled Release, 2001Co-Authors: Yellela S.r. Krishnaiah, P Bhaskar, Veer P Raju, Dinesh B Kumar, V. SatyanarayanaAbstract:Abstract The objective of the present study is to develop colon targeted drug delivery systems for mebendazole using Guar gum as a carrier. Matrix tablets containing various proportions of Guar gum were prepared by wet granulation technique using starch paste as a binder. The tablets were evaluated for drug content uniformity, and were subjected to in vitro drug release studies. The amount of mebendazole released from the matrix tablets at different time intervals was estimated by a high-performance liquid chromatography method. Guar gum matrix tablets released 8–15% of the mebendazole in the physiological environment of stomach and small intestine depending on the proportion of Guar gum used in the formulation. When the dissolution study was continued in simulated colonic fluids the matrix tablets containing 20% of Guar gum released another 83% of mebendazole after degradation into 2–3 pieces. The matrix tablets containing 30% of Guar gum also released about 50% of mebendazole in simulated colonic fluids indicating the susceptibility of the Guar gum formulations to the rat caecal contents. The results of the study show that matrix tablets containing either 20% or 30% of Guar gum are most likely to provide targeting of mebendazole for local action in the colon. The mebendazole matrix tablets containing either 20% or 30% of Guar gum showed no change either in physical appearance, drug content or dissolution pattern after storage at 45°C/75% relative humidity for 3 months. Differential scanning calorimetry indicated no possibility of interaction between mebendazole and Guar gum.
Harsanto, Thresia Margareth - One of the best experts on this subject based on the ideXlab platform.
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PENGARUH KONSENTRASI JAHE DAN KONSENTRASI STABILIZER Guar GUM TERHADAP SIFAT FISIK DAN ORGANOLEPTIK ES KRIM JAHE
Widya Mandala Catholic University Surabaya, 2019Co-Authors: Harsanto, Thresia Margareth, Utomo, Adrianus RuliantoAbstract:Jahe adalah salah satu tanaman jenis rempah-rempah yang banyak dimanfaatkan oleh ibu-ibu rumah tangga sebagai bumbu untuk memasak. Jahe memiliki kandungan minyak atsiri sebesar 0,25-3,3% yang menimbulkan aroma khas jahe. Aroma dan rasa jahe yang khas membuat jahe potensial digunakan sebagai pemberi flavor pada es krim. Es krim merupakan produk olahan susu dengan penambahan perasa atau pemanis dan disajikan dalam bentuk semi beku. Peningkatan kualitas es krim dapat dilakukan dengan penambahan bahan penstabil, yaitu Guar gum. Guar gum membengkak dan atau larut dalam pelarut polar dan membentuk ikatan hidrogen yang kuat dikarenakan adanya gugus hidroksil dalam molekul Guar gum. Tujuan penelitian ini adalah mengetahui pengaruh konsentrasi jahe dan konsentrasi stabilizer Guar gum terhadap sifat fisik dan organoleptik es krim jahe. Parameter yang diukur adalah parameter fisik meliputi laju pelelehan, persen overrun dan parameter organoleptik yaitu rasa dan mouthfeel. Rancangan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan dua faktor. Masing-masing faktor terdiri dari 3 level yaitu 20%, 35% dan 50% pada faktor konsentrasi jahe dan 0,2%, 0,4% dan 0,6% pada faktor konsentrasi Guar gum dengan 3 kali ulangan. Data dianalisa secara statistik untuk mengetahui apakah terdapat pengaruh konsentrasi jahe dan konsentrasi stabilizer Guar gum terhadap parameter menggunakan uji ANOVA pada α=5%. Jika pengaruh perlakuan terhadap uji parameter teruji nyata maka dilanjutkan dengan Uji DMRT pada α=5% untuk mengetahui perlakuan yang berbeda nyata. Hasil penelitian menunjukkan ada pengaruh perbedaan konsentrasi jahe dan stabilizer Guar gum pada es krim jahe. Semakin tinggi konsentrasi jahe maupun konsentrasi Guar gum menyebabkan penurunan laju leleh dan overrun. Kesukaan rasa es krim jahe paling tinggi pada perlakuan P1K2 dan kesukaan mouthfeel es krim jahe paling tinggi pada perlakuan P2K3
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Pengaruh konsentrasi jahe dan konsentrasi stabilizer Guar gum terhadap sifat fisik dan organoleptik es krim jahe
2018Co-Authors: Harsanto, Thresia MargarethAbstract:Ginger is one of the kind of spice plants used by housewives as a spice for cooking. Ginger contains 0,25-3,3% of essential oils which gives a distinctive aroma of ginger. Typical scent and ginger flavor makes ginger potentially used as a flavoring agent on ice cream. Ice cream is a diary product with the addition of flavorings or sweeteners and served in semi-frozen form. The ice cream quality improvement can be done with the addition of a stabilizers, that is Guar gum. Guar gum swells and or dissolves in a polar solvent and forms a strong hydrogen bonds due to the presence of hydroxyl groups in Guar gum molecules. The aim of this research is to know the effect of ginger concentration and the concentration of Guar gum stabilizer on physical and organoleptic properties of ginger ice cream. The parameters measured in this study are physical parameters including melting rate, overrun percent and the organoleptic parameters are taste and mouthfeel. The design used was Randomized Block Design (RBD) with two factors. Each factor consisted of 3 levels i.e. 20%, 35% and 50% on the concentration of ginger and 0,2%, 0,4% and 0,6% on Guar gum concentration factor with 3 replications. The data were analyzed statistically to find out if there was any effect of ginger concentration and Guar gum stabilizer concentration on parameter using ANOVA test at α=5%. If the effect of treatment on tested parameter are real then continued with the DMRT test at α=5% to know the treatment is significantly different. The results showed that there was an effect of different concentrations of ginger and Guar gum stabilizer on ginger ice cream. The higher concentrations of ginger and Guar gum concentrations lead to decreased melting and overrun rates. The highest taste of ginger ice cream in P1K2 treatment and mouthfeel highest in P2K3 treatment
R S Karthikeyan - One of the best experts on this subject based on the ideXlab platform.
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a three layer Guar gum matrix tablet for oral controlled delivery of highly soluble metoprolol tartrate
International Journal of Pharmaceutics, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, V. SatyanarayanaAbstract:Abstract The objective of the study is to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of a three-layer matrix tablet. Metoprolol tartrate was chosen as a model drug because of its high water solubility. Matrix tablets containing either 30 (M1), 40 (M2) or 50% (M3) of Guar gum were prepared by wet granulation technique using starch paste as a binder. Three-layer matrix tablets of metoprolol tartrate were prepared by compressing on both sides of Guar gum matrix tablet granules of metoprolol tartrate M1, M2 or M3 with either 50 (TL1M1, TL1M2 or TL1M3) or 75 mg (TL2M1, TL2M2 or TL2M3) of Guar gum granules as release retardant layers. Both the matrix and three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and subjected to in vitro drug release studies. The amount of metoprolol tartrate released from the matrix and three-layer matrix tablets at different time intervals was estimated by using a HPLC method. Matrix tablets of metoprolol tartrate were unable to provide the required drug release rate. However, the three-layer Guar gum matrix tablets (TL2M3) provided the required release rate on par with the theoretical release rate for metoprolol tartrate formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (TL2M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/75% RH for 6 months. The FT-IR study did not show any possibility of metoprolol tartrate/Guar gum interaction with the formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as metoprolol tartrate.
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three layer Guar gum matrix tablet formulations for oral controlled delivery of highly soluble trimetazidine dihydrochloride
Journal of Controlled Release, 2002Co-Authors: Yellela S.r. Krishnaiah, R S Karthikeyan, Gouri V Sankar, V. SatyanarayanaAbstract:Abstract The present study is carried out to design oral controlled drug delivery systems for highly water-soluble drugs using Guar gum as a carrier in the form of three-layer matrix tablets. Trimetazidine dihydrochloride was chosen as a model drug because of its high water solubility. Matrix tablet granules containing 30% (M1), 40% (M2) or 50% (M3) of Guar gum were prepared by the wet granulation technique using starch paste as a binder. Three-layer matrix tablets of trimetazidine dihydrochloride were prepared by compressing on either side of Guar gum matrix tablet granules of trimetazidine dihydrochloride M1, M2 or M3 with 200 mg of Guar gum granules containing either 65% of Guar gum (T1M1, T1M2 or T1M3), 75% of Guar gum (T2M1, T2M2 or T2M3) or 85% of Guar gum (T3M1, T3M2 or T3M3) as release retardant layers. The three-layer matrix tablets were evaluated for hardness, thickness, drug content uniformity, and were subjected to in vitro drug release studies. The amount of trimetazidine dihydrochloride released from the matrix and three-layer matrix tablets at different time intervals was estimated using a HPLC method. The three-layer Guar gum matrix tablet (T3M3) provided the required release rate on par with the theoretical release rate for Guar gum formulations meant for twice daily administration. The three-layer Guar gum matrix tablet (T3M3) showed no change either in physical appearance, drug content or in dissolution pattern after storage at 40 °C/RH 75% for 6 months. The DSC study did not show any possibility of interaction between trimetazidine dihydrochloride and Guar gum/other formulation excipients used in the study. The results indicated that Guar gum, in the form of three-layer matrix tablets, is a potential carrier in the design of oral controlled drug delivery systems for highly water-soluble drugs such as trimetazidine dihydrochloride.
Utomo, Adrianus Rulianto - One of the best experts on this subject based on the ideXlab platform.
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PENGARUH KONSENTRASI JAHE DAN KONSENTRASI STABILIZER Guar GUM TERHADAP SIFAT FISIK DAN ORGANOLEPTIK ES KRIM JAHE
Widya Mandala Catholic University Surabaya, 2019Co-Authors: Harsanto, Thresia Margareth, Utomo, Adrianus RuliantoAbstract:Jahe adalah salah satu tanaman jenis rempah-rempah yang banyak dimanfaatkan oleh ibu-ibu rumah tangga sebagai bumbu untuk memasak. Jahe memiliki kandungan minyak atsiri sebesar 0,25-3,3% yang menimbulkan aroma khas jahe. Aroma dan rasa jahe yang khas membuat jahe potensial digunakan sebagai pemberi flavor pada es krim. Es krim merupakan produk olahan susu dengan penambahan perasa atau pemanis dan disajikan dalam bentuk semi beku. Peningkatan kualitas es krim dapat dilakukan dengan penambahan bahan penstabil, yaitu Guar gum. Guar gum membengkak dan atau larut dalam pelarut polar dan membentuk ikatan hidrogen yang kuat dikarenakan adanya gugus hidroksil dalam molekul Guar gum. Tujuan penelitian ini adalah mengetahui pengaruh konsentrasi jahe dan konsentrasi stabilizer Guar gum terhadap sifat fisik dan organoleptik es krim jahe. Parameter yang diukur adalah parameter fisik meliputi laju pelelehan, persen overrun dan parameter organoleptik yaitu rasa dan mouthfeel. Rancangan yang digunakan adalah Rancangan Acak Kelompok (RAK) dengan dua faktor. Masing-masing faktor terdiri dari 3 level yaitu 20%, 35% dan 50% pada faktor konsentrasi jahe dan 0,2%, 0,4% dan 0,6% pada faktor konsentrasi Guar gum dengan 3 kali ulangan. Data dianalisa secara statistik untuk mengetahui apakah terdapat pengaruh konsentrasi jahe dan konsentrasi stabilizer Guar gum terhadap parameter menggunakan uji ANOVA pada α=5%. Jika pengaruh perlakuan terhadap uji parameter teruji nyata maka dilanjutkan dengan Uji DMRT pada α=5% untuk mengetahui perlakuan yang berbeda nyata. Hasil penelitian menunjukkan ada pengaruh perbedaan konsentrasi jahe dan stabilizer Guar gum pada es krim jahe. Semakin tinggi konsentrasi jahe maupun konsentrasi Guar gum menyebabkan penurunan laju leleh dan overrun. Kesukaan rasa es krim jahe paling tinggi pada perlakuan P1K2 dan kesukaan mouthfeel es krim jahe paling tinggi pada perlakuan P2K3
