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Mohammad Amin Mohammadifar - One of the best experts on this subject based on the ideXlab platform.

  • physical stability of oil in water emulsions in the presence of gamma irradiated Gum Tragacanth
    Journal of Dispersion Science and Technology, 2017
    Co-Authors: N. Mollakhalili Meybodi, Mohammad Amin Mohammadifar, Mehdi Farhoodi, Jacob Lercke Skytte, Khadije Abdolmaleki
    Abstract:

    ABSTRACTGum Tragacanth (GT) exuded from an Iranian Astragalus species was γ-irradiated at 0, 0.75, 1.5, 3, 5, 7, 10 kGy and used to stabilize a model oil in water emulsion system. Stability and physicochemical properties of emulsion samples were investigated with respect to the effect of irradiation treatment on functional properties of Gum Tragacanth. Particle size distribution, interfacial tension, zeta potential, steady shear and oscillatory rheological measurements were used to characterize and evaluate the emulsion samples and obtain more information about the possible stability mechanism. Emulsions were prepared by homogenizing 10% w/w sun flower oil with 90% w/w aqueous Gum dispersions and stored quiescently at 25°C for 120 days. Results indicated that using 1.5 kGy irradiated GT was more effective in providing optimum values of apparent viscosity, number mean diameter, electrosteric repulsion and structure strength for getting maximum emulsion stability. GT significantly reduced the interfacial te...

  • synthesis and characterization of an in situ forming hydrogel using tyramine conjugated high methoxyl Gum Tragacanth
    Journal of Biomaterials Applications, 2016
    Co-Authors: Moslem Tavakol, Mohammad Amin Mohammadifar, Ebrahim Vasheghanifarahani, Masoud Soleimani, Sameereh Hasheminajafabadi
    Abstract:

    In this study, an enzyme catalyzed in situ forming hydrogel based on tyramine conjugated high methoxyl content Gum Tragacanth (TA-HMGT) was prepared and characterized. TA-HMGT was synthesized via heterogeneous ammonolysis of methyl ester groups of HMGT. Then, the hydrogel was prepared via horseradish peroxidase catalyzed coupling reaction in the presence of hydrogen peroxide. Hydrogel properties, such as gelation time, swelling/degradation behavior and rheological properties could be adjusted by tuning the gelation parameters and extent of tyramine conjugation. This system was a soft elastic hydrogel with appropriate biocompatibility. The fast gelation of the hydrogel is desirable for clinical applications. Also, in vitro bovine serum albumin release from the synthesized hydrogel showed good release profile with limited burst release.

  • Gum Tragacanth dispersions particle size and rheological properties affected by high shear homogenization
    International Journal of Biological Macromolecules, 2015
    Co-Authors: Mina Farzi, Zahra Emamdjomeh, Mohammad Saeed Yarmand, Mohammad Safari, Mohammad Amin Mohammadifar
    Abstract:

    Abstract The effect of high-shear homogenization on the rheological and particle size characteristics of three species of Gum Tragacanth (GT) was detected. Dispersions were subjected to 0–20 min treatment. Static light scattering techniques and rheological tests were used to study the effect of treatment. The results showed that the process caused a decrease in particle size parameters for all three species, but interestingly, the apparent viscosities increased. The highest increase of apparent viscosity was found for solutions containing Astragalus gossypinus, which possessed the highest insoluble fraction. The viscoelastic behaviors of dispersions were also significantly influenced by the process. Homogenization caused an increase in both G′ and G″, in all three species. The alterations seem to be highly dependent on GT species and structure. The results could be of high importance in the industry, since the process will lead to textural modifications of food products containing GT.

  • milk protein Gum Tragacanth mixed gels effect of heat treatment sequence
    Carbohydrate Polymers, 2014
    Co-Authors: Masoud Hatami, Mohammad Amin Mohammadifar, Mohammad Nejatian, Hanieh Pourmand
    Abstract:

    Abstract The aim of this study was to investigate the role of the heat-treatment sequence of biopolymer mixtures as a formulation parameter on the acid-induced gelation of tri-polymeric systems composed of sodium caseinate (Na-caseinate), whey protein concentrate (WPC), and Gum Tragacanth (GT). This was studied by applying four sequences of heat treatment: (A) co-heating all three biopolymers; (B) heating the milk-protein dispersion and the GT dispersion separately; (C) heating the dispersion containing Na-caseinate and GT together and heating whey protein alone; and (D) co-heating whey protein with GT and heating Na-caseinate alone. According to small-deformation rheological measurements, the strength of the mixed-gel network decreased in the order: C > B > D > A samples. SEM micrographs show that the network of sample C is much more homogenous, coarse and dense than sample A, while the networks of samples B and D are of intermediate density. The heat-treatment sequence of the biopolymer mixtures as a formulation parameter thus offers an opportunity to control the microstructure and rheological properties of mixed gels.

  • effect of Gum Tragacanth on rheological and physical properties of a flavored milk drink made with date syrup
    Journal of Dairy Science, 2013
    Co-Authors: Maryam Keshtkaran, Mohammad Amin Mohammadifar, Gholam Hassan Asadi, Reza Azizi Nejad, Sima Balaghi
    Abstract:

    Abstract Date syrup as a nutritional additive and safe alternative to added sugar is one of the best choices for milk flavoring. In this study, a flavored milk beverage was formulated using date syrup for flavoring the product and Gum Tragacanth to obtain an acceptable mouth feel. Steady shear and dynamic oscillatory rheological properties of the samples contained 3 concentrations (0, 0.1, 0.2, and 0.3%, wt/wt) of 2 types of Gum Tragacanth ( Astragalus gossypinus and Astragalus rahensis ) which at 3°C, were studied. Particle size distribution and colorimetric assays were determined by laser diffractometry and using reflection spectrometer, respectively. Sensory analysis was performed with 25 semitrained panelists, using a 5-point hedonic scale. The results showed that viscoelastic properties, flow behavior parameters, particle size, and color parameters (L * , a * , and b * , where L * represents lightness, a * represents the redness/greenness quality of the color, and b * represents the yellowness and blueness quality of the colors) were significantly affected by the concentration of the Gum Tragacanth and the severity of this effect was influenced by the type of Gum. The use of appropriate type and concentration of Gum Tragacanth in date milk formulation can improve the texture and mouth feel by affecting on particle size and the flow behavior of this product.

Moslem Tavakol - One of the best experts on this subject based on the ideXlab platform.

  • Physicomechanical, rheological and in vitro cytocompatibility properties of the electron beam irradiated blend hydrogels of tyramine conjugated Gum Tragacanth and poly (vinyl alcohol)
    Materials Science and Engineering: C, 2020
    Co-Authors: Maryam Dehghan-niri, Moslem Tavakol, Ebrahim Vasheghani-farahani, Mohamadreza Baghaban Eslaminejad, Fatemeh Bagheri
    Abstract:

    Abstract In the present study, preparation of blend hydrogels of tyramine conjugated Gum Tragacanth and poly (vinyl alcohol) was carried out by electron beam irradiation, and modification of hydrogel properties with poly (vinyl alcohol) was demonstrated. Gel content, swelling behavior, pore size and mechanical and rheological properties of hydrogels prepared at 14, 28 and 56 kilogray (kGy) with different ratios of polymers were investigated. Gel content increased from 67 ± 2% for pure tyramine conjugated Gum Tragacanth hydrogel to >92% for blend hydrogels. However, the corresponding equilibrium swelling degree decreased from 35.21 ± 1.51 to 9.14 ± 1.66 due to the higher crosslink density of blend hydrogel. The mechanical strength of the hydrogels with interconnected pores increased significantly in the presence of poly (vinyl alcohol) and increasing irradiation dose up to 28 kGy with a twenty-fold enhancement of stress fracture and excellent elastic recovery in cyclic compression analysis. The equilibrium swelling degree of blend hydrogel containing 3% w/v tyramine conjugated Gum Tragacanth and 2% w/v poly (vinyl alcohol) prepared at 28 kGy was 16.59 ± 0.81. The biocompatibility of hydrogels was tested in the presence of rabbit bone marrow mesenchymal stem cells. The viability of cells exposed to hydrogel extract was >92% after 7 days of culture and indicated hydrogel biocompatibility with potential biomedical applications.

  • electron beam irradiation crosslinked hydrogels based on tyramine conjugated Gum Tragacanth
    Carbohydrate Polymers, 2016
    Co-Authors: Moslem Tavakol, Saeedeh Dehshiri, Ebrahim Vasheghanifarahani
    Abstract:

    Abstract In the present study, electron beam irradiation was applied to prepare a chemically crosslinked hydrogel based on tyramine conjugated Gum Tragacanth. Then, the gel content, swelling behavior and cytotoxicity of the hydrogels were evaluated. The gel content of the hydrogels was in the range of 75–85%. Equilibrium swelling degree of the hydrogels decreased from 51 to 14 with increasing polymer concentration and irradiation dose. Moisture retention capability of the hydrogels after 5 h incubation at 37 °C was in the range of 45–52 that is comparable with of commercial hydrogels. The cytotoxicity analysis showed the good biocompatibility of hydrogels. These results indicated that electron beam irradiation is a promising method to prepare chemically crosslinked tyramine conjugated Gum Tragacanth hydrogels for biomedical applications. Also, the versatility of electron beam irradiation for crosslinking of a variety of polymers possessing tyramine groups was demonstrated.

  • synthesis and characterization of an in situ forming hydrogel using tyramine conjugated high methoxyl Gum Tragacanth
    Journal of Biomaterials Applications, 2016
    Co-Authors: Moslem Tavakol, Mohammad Amin Mohammadifar, Ebrahim Vasheghanifarahani, Masoud Soleimani, Sameereh Hasheminajafabadi
    Abstract:

    In this study, an enzyme catalyzed in situ forming hydrogel based on tyramine conjugated high methoxyl content Gum Tragacanth (TA-HMGT) was prepared and characterized. TA-HMGT was synthesized via heterogeneous ammonolysis of methyl ester groups of HMGT. Then, the hydrogel was prepared via horseradish peroxidase catalyzed coupling reaction in the presence of hydrogen peroxide. Hydrogel properties, such as gelation time, swelling/degradation behavior and rheological properties could be adjusted by tuning the gelation parameters and extent of tyramine conjugation. This system was a soft elastic hydrogel with appropriate biocompatibility. The fast gelation of the hydrogel is desirable for clinical applications. Also, in vitro bovine serum albumin release from the synthesized hydrogel showed good release profile with limited burst release.

  • drug release from enzyme mediated in situ forming hydrogel based on Gum Tragacanth tyramine conjugate
    Journal of Biomaterials Applications, 2015
    Co-Authors: Maryam Dehghanniri, Moslem Tavakol, Ebrahim Vasheghanifarahani, Fariba Ganji
    Abstract:

    In the present study, injectable hydrogels based on Gum Tragacanth–tyramine conjugate were prepared by enzymatic oxidation of tyramine radicals in the presence of hydrogen peroxide. Then, in vitro ...

  • Drug release from enzyme-mediated in situ-forming hydrogel based on Gum Tragacanth-tyramine conjugate.
    Journal of Biomaterials Applications, 2015
    Co-Authors: Maryam Dehghan-niri, Moslem Tavakol, Ebrahim Vasheghani-farahani, Fariba Ganji
    Abstract:

    In the present study, injectable hydrogels based on Gum Tragacanth–tyramine conjugate were prepared by enzymatic oxidation of tyramine radicals in the presence of hydrogen peroxide. Then, in vitro release of bovine serum albumin and insulin as model protein drugs from this polymeric network was investigated. Also, to improve the properties of this hydrogel, a blended hydrogel composed of tyramine-conjugated gelatin and tyramine-conjugated Tragacanth was prepared. Experimental results showed that the gelation time ranged from 3 to 28 s depending on the polymer and enzyme concentrations. Results of morphological investigation of hydrogels indicated that the average pore size of hydrogels varied from 120 to 160 µm. Swelling degree of hydrogels and the rate of drug release decreased by increasing of hydrogen peroxide and polymer concentrations. The release profile of drug from hydrogels followed Higuchi and Fickian diffusion mechanism. Finally, it was shown that the swelling characteristics and drug release b...

Rassoul Kadkhodaee - One of the best experts on this subject based on the ideXlab platform.

  • Gum Tragacanth-polyvinyl alcohol aerogel for oral delivery of silymarin.
    International Journal of Biological Macromolecules, 2020
    Co-Authors: Nushin Niknia, Rassoul Kadkhodaee, M. N. Eshtiaghi
    Abstract:

    Abstract This study reports for the first time the fabrication of highly porous aerogels of mixed Gum Tragacanth-polyvinyl alcohol (GT-PVA) for loading and oral delivery of silymarin (SM). Various analytical techniques were used to investigate changes in the physical, textural, mechanical and microstructural properties of aerogels as affected by blending ratio and vacuum impregnation (VI) of SM. Results showed that the mixing ratio of 1:1 led to aerogels of larger surface area (1029.20 m2·g−1) and superior physicochemical properties. However, at mixing ratio of 3:1 (GT:PVA) higher loading capacity (45.57% ± 2.3%) was obtained. SM loading, on the other hand, had an adverse effect on the porosity, microstructure and physical attributes of aerogels transforming them from meso-porous to macro-porous structures. The release rate of SM in simulated gastrointestinal media was found to follow Korsmeyere-Peppas model.

  • Gum Tragacanth polyvinyl alcohol cryogel and xerogel blends for oral delivery of silymarin structural characterization and mucoadhesive property
    Carbohydrate Polymers, 2017
    Co-Authors: Nushin Niknia, Rassoul Kadkhodaee
    Abstract:

    Abstract In this study silymarin (SM) loaded cryo- and xerogels of Gum Tragacanth-polyvinyl alcohol (GT-PVA) were prepared and their physico-mechanical, microstructural and release properties were investigated. The results showed that unlike cryogels, which were highly porous, xerogels exhibited a densely packed agglomerated microstructure with a continuous network of cracks. The bulk density, mechanical strength and SM retention of xerogels were also much higher than those of cryogels. Furthermore, it was revealed that increasing the ratio of GT adversely influenced both physico-mechanical and structural features of the dried gels, but improved the release profile of SM. Incorporation of SM into the gels led to a distinct enhancement in their porosity, microstructure and physical properties. Rheological measurements indicated that rising the ratio of GT and inclusion of SM increased the viscosity of mucin-polymers blend and improved mucoadhesive property of the gels.

  • factors affecting microstructure physicochemical and textural properties of a novel Gum Tragacanth pva blend cryogel
    Carbohydrate Polymers, 2017
    Co-Authors: Nushin Niknia, Rassoul Kadkhodaee
    Abstract:

    Abstract Gum Tragacanth (GT) gels are usually formed by using chemical crosslinkers which cause safety concerns owing to their toxicity. This study introduces a novel and safe method for gelation of GT in the presence of small amounts of polyvinyl alcohol (PVA) followed by successive freeze-thaw (F-T) cycles. Gel formation was performed at two GT: PVA mixing ratios (1:1 and 3:1), four F-T consecutive cycles and two different thawing temperatures (25 and 5 °C). Gel fraction, syneresis as well as mechanical properties and microstructural characteristics of the resultant gels were then studied. Gel fraction and mechanical properties improved by increasing F-T cycles and decreasing thawing temperature. Gel fraction increased by increasing the number of F-T cycles and decreasing the thawing temperature. Syneresis increased by increasing F-T cycles at GT: PVA mixing ratio of 1:1; whilst it was diminished at GT: PVA mixing ratio of 3:1. Microstructural observations by SEM confirmed mechanical properties.

  • characterisation of whey protein isolate Gum Tragacanth electrostatic interactions in aqueous solutions
    International Journal of Food Science and Technology, 2016
    Co-Authors: Nassim Raoufi, Rassoul Kadkhodaee, Glyn O Phillips, Yapeng Fang, Masoud Najaf Najafi
    Abstract:

    Summary The main objectives of this study were to measure molecular parameters of Gum Tragacanth by GPC-MALLS system and investigate the complexation behaviour of whey protein isolate/Gum Tragacanth mixed dispersions (0.5 wt% total biopolymer concentration) as a function of pH (7.00–2.00) and the biopolymer mixing ratio (r = 0.1–10) using spectrophotometric, zeta potential and precipitate yield determination methods. GPC-MALLS revealed that Gum Tragacanth contains relatively heterogeneous particles with high weight-average and number-average (Mw = 7.74 × 105 g mol−1 and Mn = 3.87 × 105 g mol−1) molecular mass and high dispersity index (~2.04 ± 0.3). Results of complexation displayed that as the biopolymer mixing ratio increases, the net neutrality shifts to the higher pHs. The critical values associated with the complex structure formation were found at r = 2 in which the charge density of the mixture was near zero at a wide range of pH (3.0–4.0). However, the highest precipitate yield achieved in pH 3.4.

  • Characterisation of whey protein isolate–Gum Tragacanth electrostatic interactions in aqueous solutions
    International Journal of Food Science and Technology, 2016
    Co-Authors: Nassim Raoufi, Rassoul Kadkhodaee, Glyn O Phillips, Yapeng Fang, Masoud Najaf Najafi
    Abstract:

    Summary The main objectives of this study were to measure molecular parameters of Gum Tragacanth by GPC-MALLS system and investigate the complexation behaviour of whey protein isolate/Gum Tragacanth mixed dispersions (0.5 wt% total biopolymer concentration) as a function of pH (7.00–2.00) and the biopolymer mixing ratio (r = 0.1–10) using spectrophotometric, zeta potential and precipitate yield determination methods. GPC-MALLS revealed that Gum Tragacanth contains relatively heterogeneous particles with high weight-average and number-average (Mw = 7.74 × 105 g mol−1 and Mn = 3.87 × 105 g mol−1) molecular mass and high dispersity index (~2.04 ± 0.3). Results of complexation displayed that as the biopolymer mixing ratio increases, the net neutrality shifts to the higher pHs. The critical values associated with the complex structure formation were found at r = 2 in which the charge density of the mixture was near zero at a wide range of pH (3.0–4.0). However, the highest precipitate yield achieved in pH 3.4.

Marziyeh Ranjbarmohammadi - One of the best experts on this subject based on the ideXlab platform.

  • low cost hydrogels based on Gum Tragacanth and tio2 nanoparticles characterization and rbfnn modelling of methylene blue dye removal
    International Journal of Biological Macromolecules, 2019
    Co-Authors: Marziyeh Ranjbarmohammadi, Mehdi Rahimdokht, Elmira Pajootan
    Abstract:

    Abstract In this study, low-cost and high adsorption capacity hydrogels based on Gum Tragacanth biopolymer (GT or TG) and TiO2 nanoparticles were produced by using glutaraldehyde as the crosslinking agent. These hydrogels were applied in photocatalytic process to remove methylene blue from simulated colored solution. TiO2-Gum Tragacanth hydrogels (TGTH) were characterized by FESEM and FTIR to investigate the surface morphology and functional group of the synthesized hydrogel. Contact angle measurements showed that, the hydrophilicity nature of crosslinked TGTH decreased compared to GT films. The effect of particle size, initial dye concentration, pH of the solution and adsorbent/photocatalyst dosage on the removal efficiency was assessed. The obtained results demonstrated that lower dosage of the prepared TGTH (0.15g/L) outperformed GT (0.2 g/L) reaching 87% of dye removal, while GT resulted in 69% of removal. In order to model the cationic dye removal process, a Radial Basis Function Neural Network (RBFNN) was investigated. This network was applied to predict dye removal based on the time duration, initial dye concentration, pH of the solution and TiO2dosage in Gum Tragacanth hydrogel structure ([TiO2/Gum Tragacanth hydrogel]0 (g/L)). The performance of the proposed model was validated by several training data. The RBFNN model mostly overlapped with the experimental data due to selecting proper structure and training algorithm.

  • production of cotton fabrics with durable antibacterial property by using Gum Tragacanth and silver
    International Journal of Biological Macromolecules, 2018
    Co-Authors: Marziyeh Ranjbarmohammadi
    Abstract:

    Abstract A simple and inexpensive procedure has been devised to prepare antibacterial cotton fabric using silver nanoparticles (AgNPs) and bio degradable Gum Tragacanth (GT). For this, different concentrations of GT (2, 4 and 6 g/L) along with a constant amount of Ag (5%; according to weight of dry GT used in the solutions) were applied to investigate the efficacy of antibacterial potency against Escherichia coli and Staphylococcus aureus and their effect on physical, mechanical and biological characteristics of cotton fabric. Our study exhibited the presence of small amount of AgNPs in the composite structure was enough to increase the antibacterial activity of fabrics compared to fabric that were treated by only GT. Moreover, the treated cotton with GT-4%/Ag indicated proper tensile strength and stiffness compared to treated fabric with GT-6%/Ag composite. The biocompatibility of the GT and GT/Ag treated fabrics was verified through MTT assay on fibroblast cells.

  • fabrication of curcumin loaded Gum Tragacanth poly vinyl alcohol nanofibers with optimized electrospinning parameters
    Journal of Industrial Textiles, 2017
    Co-Authors: Marziyeh Ranjbarmohammadi, Saeid Kargozar, Hajir S Bahrami, M T Joghataei
    Abstract:

    This paper focuses on using response surface methodology (RSM) and artificial neural network (ANN) to optimize the diameter of Gum Tragacanth (GT)/poly(vinyl alcohol) (PVA) nanofibers. However, pro...

  • Gum Tragacanth poly l lactic acid nanofibrous scaffolds for application in regeneration of peripheral nerve damage
    Carbohydrate Polymers, 2016
    Co-Authors: Marziyeh Ranjbarmohammadi, Hajir S Bahrami, Molamma P Prabhakaran, Seeram Ramakrishna
    Abstract:

    Abstract Nanofibrous nerve guides have gained huge interest in supporting the peripheral nerve regeneration due to their abilities to simulate the topography, mechanical, biological and extracellular matrix morphology of native tissue. Gum Tragacanth (GT) is a biocompatible mixture of polysaccharides that has been used in biomedical applications. During this study, we fabricated aligned and random nanofibers from poly( l -lactic acid) and Gum Tragacanth (PLLA/GT) in various ratios (100:0, 75:25, and 50:50) by electrospinning. Scanning electron microscope demonstrated smooth and uniform nanofibers with diameters in the range of 733 ± 65 nm and 226 ± 73 nm for align PLLA and random PLLA/GT 50:50 nanofibers, respectively. FTIR analysis, contact angle, in vitro biodegradation and tensile measurements were carried out to evaluate the chemical and mechanical properties of the different scaffolds. PLLA/GT 75:25 exhibited the most balanced properties compared to other scaffolds and was used for in vitro culture of nerve cells (PC12) to assess the potential of using these scaffolds as a substrate for nerve regeneration. The cells were found to attach and proliferate on aligned PLLA/GT 75:25 scaffolds, expressing bi-polar neurite extensions and the orientation of nerve cells was along the direction of the fiber alignment. Results of 8 days of in vitro culture of PC12 cells on aligned PLLA/GT 75:25 nanofibers, showed 20% increase in cell proliferation compared to PLLA/GT 75:25 random nanofibers. PLLA/GT 75:25 aligned nanofibers acted as a favorable cue to support neurite outgrowth and nerve cell elongation compared with PLLA nanofibers. Our results showed that aligned PLLA/GT 75:25 nanofibers are promising substrates for application as bioengineered grafts for nerve tissue regeneration.

  • electrospun curcumin loaded poly e caprolactone Gum Tragacanth nanofibers for biomedical application
    International Journal of Biological Macromolecules, 2016
    Co-Authors: Marziyeh Ranjbarmohammadi, Hajir S Bahrami
    Abstract:

    In this work curcumin (Cur)-loaded poly(e-caprolactone) (PCL)/Gum Tragacanth (GT) scaffold membranes which provided the controlled release of curcumin for over 20 days were fabricated by electrospinning. Field Emission Scanning Electron Microscopy (FESEM) analysis, Fourier Transform Infrared Spectroscopy (FTIR) and differential scanning calorimetry (DSC) were applied to characterize the produced nanofibers. These nanofibers were evaluated for water absorption capacity, in vitro drug release, biodegradation test, cell culture and MTT analysis. The water contact angle measurements indicated that addition of GT and curcumin in composition resulted in increase in the hydrophilicity of the nanofibers. Biodegradation test for the fabricated nanofibers exhibited that PCL/GT, PCL/Cur-3% and PCL/GT/Cur-3% nanofibers preserved their structure after 15 days. The in vitro release profile of curcumin showed 6.86, 14 and 30.09% burst release for PCL/GT/Cur-1%, PCL/GT/Cur-3% and PCL/Cur-3% nanofibers respectively. The effect of curcumin concentration in the nanofibers composition on the cell viability was assessed by the MTS assay. The cytotoxic effect of released curcumin on the fibroblast cells was examined. The PCL/GT/Cur-3% with suitable mechanical properties, excellent biological characteristics, and maintaining their original structure in degradation media may have potential application as a wound dressing patch for healing slow rate wounds.

Ebrahim Vasheghanifarahani - One of the best experts on this subject based on the ideXlab platform.

  • electron beam irradiation crosslinked hydrogels based on tyramine conjugated Gum Tragacanth
    Carbohydrate Polymers, 2016
    Co-Authors: Moslem Tavakol, Saeedeh Dehshiri, Ebrahim Vasheghanifarahani
    Abstract:

    Abstract In the present study, electron beam irradiation was applied to prepare a chemically crosslinked hydrogel based on tyramine conjugated Gum Tragacanth. Then, the gel content, swelling behavior and cytotoxicity of the hydrogels were evaluated. The gel content of the hydrogels was in the range of 75–85%. Equilibrium swelling degree of the hydrogels decreased from 51 to 14 with increasing polymer concentration and irradiation dose. Moisture retention capability of the hydrogels after 5 h incubation at 37 °C was in the range of 45–52 that is comparable with of commercial hydrogels. The cytotoxicity analysis showed the good biocompatibility of hydrogels. These results indicated that electron beam irradiation is a promising method to prepare chemically crosslinked tyramine conjugated Gum Tragacanth hydrogels for biomedical applications. Also, the versatility of electron beam irradiation for crosslinking of a variety of polymers possessing tyramine groups was demonstrated.

  • synthesis and characterization of an in situ forming hydrogel using tyramine conjugated high methoxyl Gum Tragacanth
    Journal of Biomaterials Applications, 2016
    Co-Authors: Moslem Tavakol, Mohammad Amin Mohammadifar, Ebrahim Vasheghanifarahani, Masoud Soleimani, Sameereh Hasheminajafabadi
    Abstract:

    In this study, an enzyme catalyzed in situ forming hydrogel based on tyramine conjugated high methoxyl content Gum Tragacanth (TA-HMGT) was prepared and characterized. TA-HMGT was synthesized via heterogeneous ammonolysis of methyl ester groups of HMGT. Then, the hydrogel was prepared via horseradish peroxidase catalyzed coupling reaction in the presence of hydrogen peroxide. Hydrogel properties, such as gelation time, swelling/degradation behavior and rheological properties could be adjusted by tuning the gelation parameters and extent of tyramine conjugation. This system was a soft elastic hydrogel with appropriate biocompatibility. The fast gelation of the hydrogel is desirable for clinical applications. Also, in vitro bovine serum albumin release from the synthesized hydrogel showed good release profile with limited burst release.

  • drug release from enzyme mediated in situ forming hydrogel based on Gum Tragacanth tyramine conjugate
    Journal of Biomaterials Applications, 2015
    Co-Authors: Maryam Dehghanniri, Moslem Tavakol, Ebrahim Vasheghanifarahani, Fariba Ganji
    Abstract:

    In the present study, injectable hydrogels based on Gum Tragacanth–tyramine conjugate were prepared by enzymatic oxidation of tyramine radicals in the presence of hydrogen peroxide. Then, in vitro ...