The Experts below are selected from a list of 9255 Experts worldwide ranked by ideXlab platform
Hope Hospital Salford - One of the best experts on this subject based on the ideXlab platform.
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GENITAL TRACT
2016Co-Authors: R. J. Farrand, Hope Hospital SalfordAbstract:are most commonly due to capsulate type-b strains in young children, and no Infections of the genital tract were recorded by Turk and May (1967) in their review of the pathogenicity of this species. More recently, Skirrow and Prakash (1970) described a case of tubo-ovarian abscess caused by H. influenzae, and Hurley (1970) reported a case of endometritis associated with Haemophilus Infection of an intra-uterine contraceptive loop. Non-capsulate strains of H. influenzae were responsible in both. Four cases of puerperal Infection caused by H. influenzae have also been reported. In two, the organism was isolated from the blood of the newborn infants, the Infection origin-ating from maternal amnionitis in each case (Ingman, 1970); one strain was type b, but typing of the other was not performed. In two cases described by Ellner and Shahidi (1969), maternal blood cultures taken soon after delivery yielded H. influenzae; a type-f strain was obtained from a patient with suspected endometritis, and a non-capsulate strain from a patient with amnionitis and placentitis. The present paper reports two genital tract Infections caused by non-capsulate strains of H. influenzae
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SHORT ARTICLES Haemophilus INFLUENZAE InfectionS OF T H E GENITAL TRACT
2015Co-Authors: R. J. Farrand, Hope Hospital SalfordAbstract:are most commonly due to capsulate type-b strains in young children, and no Infections of the genital tract were recorded by Turk and May (1967) in their review of the pathogenicity of this species. More recently, Skirrow and Prakash (1970) described a case of tubo-ovarian abscess caused by H. influenzae, and Hurley (1970) reported a case of endometritis associated with Haemophilus Infection of an intra-uterine contraceptive loop. Non-capsulate strains of H. influenzae were responsible in both. Four cases of puerperal Infection caused by H. influenzae have also been reported. In two, the organism was isolated from the blood of the newborn infants, the Infection origin-ating from maternal amnionitis in each case (Ingman, 1970); one strain was type b, but typing of the other was not performed. In two cases described by Ellner and Shahidi (1969), maternal blood cultures taken soon after delivery yielded H. influenzae; a type-f strain was obtained from a patient with suspected endometritis, and a non-capsulate strain from a patient with amnionitis and placentitis. The present paper reports two genital tract Infections caused by non-capsulate strains of H. influenzae
Linda Yrlid - One of the best experts on this subject based on the ideXlab platform.
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multi omics links il 6 trans signalling with neutrophil extracellular trap formation and Haemophilus Infection in copd
European Respiratory Journal, 2021Co-Authors: Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca E Riise, Suado M Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda YrlidAbstract:Background IL-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases, however the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6TS pathway activation remain poorly understood. Objective Our aim was to identify and characterize COPD patients with increased airway IL-6TS and to elucidate the biological drivers of IL-6TS pathway activation. Methods We used an IL-6TS-specific sputum biomarker profile (sIL-6R, IL-6, IL-1β, IL-8, MIP-1β) to stratify sputum data from patients with COPD (n=74; BEAT-COPD) by hierarchical clustering. The IL-6TS signature was related to clinical characteristics and sputum microbiome profiles. The induction of neutrophil extracellular trap formation (NETosis) and IL-6TS by Haemophilus influenzae were studied in human neutrophils. Results Hierarchical clustering revealed an IL-6TS-high subset (n=24) of COPD patients, which shared phenotypic traits with an IL-6TS-high subset previously identified in asthma. The subset was characterized by increased sputum cell counts (p=0.0001), persistent sputum neutrophilia (p=0.0004), reduced quality of life (CRQ total score; p=0.008), and increased levels of pro-inflammatory mediators and MMPs in sputum. IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased soluble IL-6 receptor (sIL-6R) levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients. Conclusion IL-6TS pathway activation due to chronic colonization with Haemophilus may be an important disease driver in a subset of COPD patients.
R. J. Farrand - One of the best experts on this subject based on the ideXlab platform.
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GENITAL TRACT
2016Co-Authors: R. J. Farrand, Hope Hospital SalfordAbstract:are most commonly due to capsulate type-b strains in young children, and no Infections of the genital tract were recorded by Turk and May (1967) in their review of the pathogenicity of this species. More recently, Skirrow and Prakash (1970) described a case of tubo-ovarian abscess caused by H. influenzae, and Hurley (1970) reported a case of endometritis associated with Haemophilus Infection of an intra-uterine contraceptive loop. Non-capsulate strains of H. influenzae were responsible in both. Four cases of puerperal Infection caused by H. influenzae have also been reported. In two, the organism was isolated from the blood of the newborn infants, the Infection origin-ating from maternal amnionitis in each case (Ingman, 1970); one strain was type b, but typing of the other was not performed. In two cases described by Ellner and Shahidi (1969), maternal blood cultures taken soon after delivery yielded H. influenzae; a type-f strain was obtained from a patient with suspected endometritis, and a non-capsulate strain from a patient with amnionitis and placentitis. The present paper reports two genital tract Infections caused by non-capsulate strains of H. influenzae
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SHORT ARTICLES Haemophilus INFLUENZAE InfectionS OF T H E GENITAL TRACT
2015Co-Authors: R. J. Farrand, Hope Hospital SalfordAbstract:are most commonly due to capsulate type-b strains in young children, and no Infections of the genital tract were recorded by Turk and May (1967) in their review of the pathogenicity of this species. More recently, Skirrow and Prakash (1970) described a case of tubo-ovarian abscess caused by H. influenzae, and Hurley (1970) reported a case of endometritis associated with Haemophilus Infection of an intra-uterine contraceptive loop. Non-capsulate strains of H. influenzae were responsible in both. Four cases of puerperal Infection caused by H. influenzae have also been reported. In two, the organism was isolated from the blood of the newborn infants, the Infection origin-ating from maternal amnionitis in each case (Ingman, 1970); one strain was type b, but typing of the other was not performed. In two cases described by Ellner and Shahidi (1969), maternal blood cultures taken soon after delivery yielded H. influenzae; a type-f strain was obtained from a patient with suspected endometritis, and a non-capsulate strain from a patient with amnionitis and placentitis. The present paper reports two genital tract Infections caused by non-capsulate strains of H. influenzae
Sofia Winslow - One of the best experts on this subject based on the ideXlab platform.
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multi omics links il 6 trans signalling with neutrophil extracellular trap formation and Haemophilus Infection in copd
European Respiratory Journal, 2021Co-Authors: Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca E Riise, Suado M Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda YrlidAbstract:Background IL-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases, however the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6TS pathway activation remain poorly understood. Objective Our aim was to identify and characterize COPD patients with increased airway IL-6TS and to elucidate the biological drivers of IL-6TS pathway activation. Methods We used an IL-6TS-specific sputum biomarker profile (sIL-6R, IL-6, IL-1β, IL-8, MIP-1β) to stratify sputum data from patients with COPD (n=74; BEAT-COPD) by hierarchical clustering. The IL-6TS signature was related to clinical characteristics and sputum microbiome profiles. The induction of neutrophil extracellular trap formation (NETosis) and IL-6TS by Haemophilus influenzae were studied in human neutrophils. Results Hierarchical clustering revealed an IL-6TS-high subset (n=24) of COPD patients, which shared phenotypic traits with an IL-6TS-high subset previously identified in asthma. The subset was characterized by increased sputum cell counts (p=0.0001), persistent sputum neutrophilia (p=0.0004), reduced quality of life (CRQ total score; p=0.008), and increased levels of pro-inflammatory mediators and MMPs in sputum. IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased soluble IL-6 receptor (sIL-6R) levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients. Conclusion IL-6TS pathway activation due to chronic colonization with Haemophilus may be an important disease driver in a subset of COPD patients.
Sarah Diver - One of the best experts on this subject based on the ideXlab platform.
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multi omics links il 6 trans signalling with neutrophil extracellular trap formation and Haemophilus Infection in copd
European Respiratory Journal, 2021Co-Authors: Sofia Winslow, Lina Odqvist, Sarah Diver, Rebecca E Riise, Suado M Abdillahi, Cecilia Wingren, Helena Lindmark, Annika Wellner, Sofia Lundin, Linda YrlidAbstract:Background IL-6 trans-signalling (IL-6TS) is emerging as a pathogenic mechanism in chronic respiratory diseases, however the drivers of IL-6TS in the airways and the phenotypic characteristic of patients with increased IL-6TS pathway activation remain poorly understood. Objective Our aim was to identify and characterize COPD patients with increased airway IL-6TS and to elucidate the biological drivers of IL-6TS pathway activation. Methods We used an IL-6TS-specific sputum biomarker profile (sIL-6R, IL-6, IL-1β, IL-8, MIP-1β) to stratify sputum data from patients with COPD (n=74; BEAT-COPD) by hierarchical clustering. The IL-6TS signature was related to clinical characteristics and sputum microbiome profiles. The induction of neutrophil extracellular trap formation (NETosis) and IL-6TS by Haemophilus influenzae were studied in human neutrophils. Results Hierarchical clustering revealed an IL-6TS-high subset (n=24) of COPD patients, which shared phenotypic traits with an IL-6TS-high subset previously identified in asthma. The subset was characterized by increased sputum cell counts (p=0.0001), persistent sputum neutrophilia (p=0.0004), reduced quality of life (CRQ total score; p=0.008), and increased levels of pro-inflammatory mediators and MMPs in sputum. IL-6TS-high COPD patients showed an increase in Proteobacteria, with Haemophilus as the dominating genus. NETosis induced by H. influenzae was identified as a potential mechanism for increased soluble IL-6 receptor (sIL-6R) levels. This was supported by a significant positive correlation between sIL-6R and NETosis markers in bronchoalveolar lavage fluid from COPD patients. Conclusion IL-6TS pathway activation due to chronic colonization with Haemophilus may be an important disease driver in a subset of COPD patients.
