Haemophilus Influenzae Vaccine

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Lorna Medd - One of the best experts on this subject based on the ideXlab platform.

  • safety and immunogenicity of Haemophilus Influenzae Vaccine tetanus toxoid conjugate administered concurrently or combined with diphtheria and tetanus toxoids pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two four and
    Pediatric Infectious Disease Journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

  • Safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two, four
    The Pediatric infectious disease journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P < 0.001), 27% vs. 24% and 15% vs. 13%, respectively. Systemic reactions occurred at similar rates in both groups. The combined Vaccine induced tetanus and diphtheria antitoxin titers > or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

Ronald Gold - One of the best experts on this subject based on the ideXlab platform.

  • safety and immunogenicity of Haemophilus Influenzae Vaccine tetanus toxoid conjugate administered concurrently or combined with diphtheria and tetanus toxoids pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two four and
    Pediatric Infectious Disease Journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

  • Safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two, four
    The Pediatric infectious disease journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P < 0.001), 27% vs. 24% and 15% vs. 13%, respectively. Systemic reactions occurred at similar rates in both groups. The combined Vaccine induced tetanus and diphtheria antitoxin titers > or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

Roland Guasparini - One of the best experts on this subject based on the ideXlab platform.

  • safety and immunogenicity of Haemophilus Influenzae Vaccine tetanus toxoid conjugate administered concurrently or combined with diphtheria and tetanus toxoids pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two four and
    Pediatric Infectious Disease Journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

  • Safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two, four
    The Pediatric infectious disease journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P < 0.001), 27% vs. 24% and 15% vs. 13%, respectively. Systemic reactions occurred at similar rates in both groups. The combined Vaccine induced tetanus and diphtheria antitoxin titers > or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

William Meekison - One of the best experts on this subject based on the ideXlab platform.

  • safety and immunogenicity of Haemophilus Influenzae Vaccine tetanus toxoid conjugate administered concurrently or combined with diphtheria and tetanus toxoids pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two four and
    Pediatric Infectious Disease Journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

  • Safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two, four
    The Pediatric infectious disease journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P < 0.001), 27% vs. 24% and 15% vs. 13%, respectively. Systemic reactions occurred at similar rates in both groups. The combined Vaccine induced tetanus and diphtheria antitoxin titers > or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

Gordean Bjornson - One of the best experts on this subject based on the ideXlab platform.

  • safety and immunogenicity of Haemophilus Influenzae Vaccine tetanus toxoid conjugate administered concurrently or combined with diphtheria and tetanus toxoids pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two four and
    Pediatric Infectious Disease Journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.

  • Safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate) administered concurrently or combined with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine to healthy infants at two, four
    The Pediatric infectious disease journal, 1994
    Co-Authors: Ronald Gold, David W Scheifele, Luis Barreto, Sharon Wiltsey, Gordean Bjornson, William Meekison, Roland Guasparini, Lorna Medd
    Abstract:

    The safety and immunogenicity of Haemophilus Influenzae Vaccine (tetanus toxoid conjugate (PRP-T) administered concurrently in separate sites or mixed in the same syringe with diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine were assessed in 439 infants at 2, 4 and 6 months of age. The proportions with local redness, tenderness and swelling in the separate and combined groups were 18% vs. 11% (P < 0.001), 27% vs. 24% and 15% vs. 13%, respectively. Systemic reactions occurred at similar rates in both groups. The combined Vaccine induced tetanus and diphtheria antitoxin titers > or = 0.01 IU/ml in 99.5 and 99.1% of infants, pertussis agglutinin titers > or = 64 in 92.4%, anti-polyribosylribitol phosphate titers > or = 0.15 microgram/ml in 93.8% and > or = 1.0 microgram/ml in 75% and polio-neutralizing titers > or = 8 in > 98% of infants. However, antibody concentrations to PRP-T, some pertussis antigens and tetanus toxoid were significantly lower after combined than after separate injections of DPT/diphtheria and tetanus toxoids, pertussis Vaccine and inactivated poliomyelitis Vaccine and PRP-T. The clinical significance of these differences is not known, but the interactions observed among the components of the pentavalent Vaccine may be of concern because they might influence antibody persistence until the fourth dose is administered.