The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Donghyun Kang - One of the best experts on this subject based on the ideXlab platform.
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alicyclobacillus spp in the fruit juice industry history characteristics and current isolation detection procedures
Critical Reviews in Microbiology, 2004Co-Authors: Susen Chang, Donghyun KangAbstract:The first Alicyclobacillus spp. was isolated in 1982, and was originally thought to be strictly limited to thermophilic and acidic environments. Two years later, another Alicyclobacillus sp., A. acidoterrestris, was identified as the causative agent in spoilage of commercially pasteurized apple juice. Subsequent studies soon found that Alicyclobacillus spp. are soilborne bacteria, and do not strictly require thermophilic and acidic environments. Alicyclobacillus spp. posess several distinct characteristics; the major one is their ability to survive commercial pasteurization processes and produce off-flavors in fruit juices. The fruit juice industry has acknowledged Alicyclobacillus spp. as a major quality control target microorganism.Guaiacol and Halophenols were identified as the offensive smelling agent in many Alicyclobacillus spp. related spoilage. Though the exact formation pathway of these off-flavors by Alicyclobacillus spp. are not yet identified, studies report that the presence of Alicyclobacill...
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alicyclobacillus spp in the fruit juice industry history characteristics and current isolation detection procedures
Critical Reviews in Microbiology, 2004Co-Authors: Susen Chang, Donghyun KangAbstract:The first Alicyclobacillus spp. was isolated in 1982, and was originally thought to be strictly limited to thermophilic and acidic environments. Two years later, another Alicyclobacillus sp., A. acidoterrestris, was identified as the causative agent in spoilage of commercially pasteurized apple juice. Subsequent studies soon found that Alicyclobacillus spp. are soilborne bacteria, and do not strictly require thermophilic and acidic environments. Alicyclobacillus spp. posess several distinct characteristics; the major one is their ability to survive commercial pasteurization processes and produce off-flavors in fruit juices. The fruit juice industry has acknowledged Alicyclobacillus spp. as a major quality control target microorganism. Guaiacol and Halophenols were identified as the offensive smelling agent in many Alicyclobacillus spp. related spoilage. Though the exact formation pathway of these off-flavors by Alicyclobacillus spp. are not yet identified, studies report that the presence of Alicyclobacillus spp. in the medium may be a major contributor to the formation of these off-flavors. Many identification methods and isolation media were developed in the last two decades. However, most of these methods were developed specifically for A. acidoterrestris, which was the first identified off-flavor producing Alicyclobacillus. However, recent studies indicate that other species of Alicyclobacillus may also produce guaiacol or the Halophenols. In this respect, all Alicyclobacillus spp. should be monitored as potential spoilage bacteria in fruit juices. This article includes an overall review of the history of Alicyclobacillus spp., characteristics, suggested off-flavor production pathways, and commonly used identification methods for the currently identified Alicyclobacillus spp.
Florenz Sasse - One of the best experts on this subject based on the ideXlab platform.
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cytotoxic and antivascular 1 methyl 4 3 fluoro 4 methoxyphenyl 5 halophenyl imidazoles
ChemInform, 2012Co-Authors: Bernhard Biersack, Rainer Schobert, Yazh Muthukumar, Florenz SasseAbstract:New N-methylimidazole bridged analogues (VI) (8 examples) of combretastatin A-4 are synthesized and evaluated for their cytotoxicity and antiangiogenic activity.
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cytotoxic and antivascular 1 methyl 4 3 fluoro 4 methoxyphenyl 5 halophenyl imidazoles
Bioorganic & Medicinal Chemistry Letters, 2011Co-Authors: Bernhard Biersack, Rainer Schobert, Yazh Muthukumar, Florenz SasseAbstract:A series of 1-methyl-4,5-diphenylimidazoles 6 with various patterns of m-halogen substitution at the 5-phenyl ring were tested for cytotoxicity in cancer and nonmalignant cell lines and for their capacity to prevent tube formation in HUVEC cultures. Unlike the monofluoro and difluoro derivatives 6a and 6e, the monobromo and diiodo analogs 6c and 6h were strongly cytotoxic and inhibited the polymerization of tubulin and the tube formation by HUVEC. The dibromo derivative 6g displayed a unique selectivity for KB-3-1 cervix and PC-3 prostate cancer cells. It also inhibited the tube formation by HUVEC and the polymerization of tubulin which is indicative of its potential antiangiogenic activity in solid tumors.
Susen Chang - One of the best experts on this subject based on the ideXlab platform.
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alicyclobacillus spp in the fruit juice industry history characteristics and current isolation detection procedures
Critical Reviews in Microbiology, 2004Co-Authors: Susen Chang, Donghyun KangAbstract:The first Alicyclobacillus spp. was isolated in 1982, and was originally thought to be strictly limited to thermophilic and acidic environments. Two years later, another Alicyclobacillus sp., A. acidoterrestris, was identified as the causative agent in spoilage of commercially pasteurized apple juice. Subsequent studies soon found that Alicyclobacillus spp. are soilborne bacteria, and do not strictly require thermophilic and acidic environments. Alicyclobacillus spp. posess several distinct characteristics; the major one is their ability to survive commercial pasteurization processes and produce off-flavors in fruit juices. The fruit juice industry has acknowledged Alicyclobacillus spp. as a major quality control target microorganism.Guaiacol and Halophenols were identified as the offensive smelling agent in many Alicyclobacillus spp. related spoilage. Though the exact formation pathway of these off-flavors by Alicyclobacillus spp. are not yet identified, studies report that the presence of Alicyclobacill...
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alicyclobacillus spp in the fruit juice industry history characteristics and current isolation detection procedures
Critical Reviews in Microbiology, 2004Co-Authors: Susen Chang, Donghyun KangAbstract:The first Alicyclobacillus spp. was isolated in 1982, and was originally thought to be strictly limited to thermophilic and acidic environments. Two years later, another Alicyclobacillus sp., A. acidoterrestris, was identified as the causative agent in spoilage of commercially pasteurized apple juice. Subsequent studies soon found that Alicyclobacillus spp. are soilborne bacteria, and do not strictly require thermophilic and acidic environments. Alicyclobacillus spp. posess several distinct characteristics; the major one is their ability to survive commercial pasteurization processes and produce off-flavors in fruit juices. The fruit juice industry has acknowledged Alicyclobacillus spp. as a major quality control target microorganism. Guaiacol and Halophenols were identified as the offensive smelling agent in many Alicyclobacillus spp. related spoilage. Though the exact formation pathway of these off-flavors by Alicyclobacillus spp. are not yet identified, studies report that the presence of Alicyclobacillus spp. in the medium may be a major contributor to the formation of these off-flavors. Many identification methods and isolation media were developed in the last two decades. However, most of these methods were developed specifically for A. acidoterrestris, which was the first identified off-flavor producing Alicyclobacillus. However, recent studies indicate that other species of Alicyclobacillus may also produce guaiacol or the Halophenols. In this respect, all Alicyclobacillus spp. should be monitored as potential spoilage bacteria in fruit juices. This article includes an overall review of the history of Alicyclobacillus spp., characteristics, suggested off-flavor production pathways, and commonly used identification methods for the currently identified Alicyclobacillus spp.
Bernhard Biersack - One of the best experts on this subject based on the ideXlab platform.
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cytotoxic and antivascular 1 methyl 4 3 fluoro 4 methoxyphenyl 5 halophenyl imidazoles
ChemInform, 2012Co-Authors: Bernhard Biersack, Rainer Schobert, Yazh Muthukumar, Florenz SasseAbstract:New N-methylimidazole bridged analogues (VI) (8 examples) of combretastatin A-4 are synthesized and evaluated for their cytotoxicity and antiangiogenic activity.
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cytotoxic and antivascular 1 methyl 4 3 fluoro 4 methoxyphenyl 5 halophenyl imidazoles
Bioorganic & Medicinal Chemistry Letters, 2011Co-Authors: Bernhard Biersack, Rainer Schobert, Yazh Muthukumar, Florenz SasseAbstract:A series of 1-methyl-4,5-diphenylimidazoles 6 with various patterns of m-halogen substitution at the 5-phenyl ring were tested for cytotoxicity in cancer and nonmalignant cell lines and for their capacity to prevent tube formation in HUVEC cultures. Unlike the monofluoro and difluoro derivatives 6a and 6e, the monobromo and diiodo analogs 6c and 6h were strongly cytotoxic and inhibited the polymerization of tubulin and the tube formation by HUVEC. The dibromo derivative 6g displayed a unique selectivity for KB-3-1 cervix and PC-3 prostate cancer cells. It also inhibited the tube formation by HUVEC and the polymerization of tubulin which is indicative of its potential antiangiogenic activity in solid tumors.
Dimitri Komiotis - One of the best experts on this subject based on the ideXlab platform.
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a novel and easy two step microwave assisted method for the synthesis of halophenyl pyrrolo 2 3 b quinoxalines via their pyrrolo precursors evaluation of their bioactivity
ChemInform, 2014Co-Authors: Stella Manta, Dimitraniki Gkaragkouni, Eleni Kaffesaki, Petros Gkizis, Dimitra Hadjipavloulitina, Eleni Pontiki, Jan Balzarini, Wim Dehaen, Dimitri KomiotisAbstract:In a one-pot three-component reaction, 4-halobenzaldehydes are condensed with MeNH2 and sodium diethyloxalacetate to 2,3-dioxo-5-halophenylpyrrolo derivatives (III) which are then reacted with o-phenylenediamine to form either non-aromatized or aromatized halophenyl-pyrrolo[2,3-b]quinoxalines [(VI) or (VII), resp.].
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a novel and easy two step microwave assisted method for the synthesis of halophenyl pyrrolo 2 3 b quinoxalines via their pyrrolo precursors evaluation of their bioactivity
Tetrahedron Letters, 2014Co-Authors: Stella Manta, Dimitraniki Gkaragkouni, Eleni Kaffesaki, Petros Gkizis, Dimitra Hadjipavloulitina, Eleni Pontiki, Jan Balzarini, Wim Dehaen, Dimitri KomiotisAbstract:Abstract A novel, two-step, facile route for the synthesis of pyrrolo[2,3- b ]quinoxalines via 2,3-dioxopyrroles, enhanced by microwave irradiation, is presented. The newly synthesized 2,3-dioxo-5-halophenyl pyrrolo precursors 4a – c as well as the non-aromatized ethyl 2-(4-halophenyl)-1-methyl-2,4-dihydro-1 H -pyrrolo[2,3- b ]quinoxaline-3-carboxylates 6a – c and the aromatized ethyl 2-(4-halophenyl)-1-methyl-1 H -pyrrolo[2,3- b ]quinoxaline-3-carboxylates 7a – c were evaluated for their antioxidant, cytostatic, and antiviral properties. Most of them proved to be potent hydroxyl radical scavengers and inhibited in vitro lipid peroxidation. The compounds showed moderate antiproliferative activity, while 6a inhibited vaccinia virus at an EC 50 value of 2 μM, and 4c and 6c inhibited Sindbis virus at EC 50 values of 4 μM.
