The Experts below are selected from a list of 147 Experts worldwide ranked by ideXlab platform
M I Voevoda - One of the best experts on this subject based on the ideXlab platform.
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association of ptpn22 haplotypes with Hashimotos Thyroiditis in population of novosibirsk
Clinical and experimental thyroidology, 2009Co-Authors: Yu Nikitin, O D Rymar, V N Maksimov, G I Simonova, M Zankina, S V Mustafina, L Sherbakova, N Chernova, M I VoevodaAbstract:The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos Thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.
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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk
VIDAR-M LLC, 2008Co-Authors: Yu Nikitin, O D Rymar, M Zankina, S V Mustafina, N Chernova, V Maksimov, G Simonova, L Sherbacova, M I VoevodaAbstract:Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. The aim of the study was to investigate the association between the exon 1 CTLA-4 gene polymorphism A(49)G and susceptibility to graves’ disease (GD) and Hashimotos Thyroiditis (HT). Materials and methods. We analyzed the A(49)G exon 1 CTLA-4 gene polymorphism in 105 unrelated Novosibirsk patients with GD, in 101 patients with HT and 150 matched healthy subjects. Results. The distribution of genotype frequencies differed significantly between patients with GD and controls (p = 0.039). The allele G and the genotype GG were associated with the increased risk for GD (odds ratio OR = 1,55, 95% CI, 1,09—2,21, OR = 2,43, 95% CI, 1,17—5,01 respectively). In contrast, no differences in genotype frequencies were observed between HT patients and controls for the A(49)G exon 1 CTLA-4 gene polymorphism. Conclusion: This suggests that the CTLA-4 gene might play a role in the development of DTS in the Novosibirsk population
Yu Nikitin - One of the best experts on this subject based on the ideXlab platform.
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association of ptpn22 haplotypes with Hashimotos Thyroiditis in population of novosibirsk
Clinical and experimental thyroidology, 2009Co-Authors: Yu Nikitin, O D Rymar, V N Maksimov, G I Simonova, M Zankina, S V Mustafina, L Sherbakova, N Chernova, M I VoevodaAbstract:The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos Thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.
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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk
VIDAR-M LLC, 2008Co-Authors: Yu Nikitin, O D Rymar, M Zankina, S V Mustafina, N Chernova, V Maksimov, G Simonova, L Sherbacova, M I VoevodaAbstract:Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. The aim of the study was to investigate the association between the exon 1 CTLA-4 gene polymorphism A(49)G and susceptibility to graves’ disease (GD) and Hashimotos Thyroiditis (HT). Materials and methods. We analyzed the A(49)G exon 1 CTLA-4 gene polymorphism in 105 unrelated Novosibirsk patients with GD, in 101 patients with HT and 150 matched healthy subjects. Results. The distribution of genotype frequencies differed significantly between patients with GD and controls (p = 0.039). The allele G and the genotype GG were associated with the increased risk for GD (odds ratio OR = 1,55, 95% CI, 1,09—2,21, OR = 2,43, 95% CI, 1,17—5,01 respectively). In contrast, no differences in genotype frequencies were observed between HT patients and controls for the A(49)G exon 1 CTLA-4 gene polymorphism. Conclusion: This suggests that the CTLA-4 gene might play a role in the development of DTS in the Novosibirsk population
N Chernova - One of the best experts on this subject based on the ideXlab platform.
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association of ptpn22 haplotypes with Hashimotos Thyroiditis in population of novosibirsk
Clinical and experimental thyroidology, 2009Co-Authors: Yu Nikitin, O D Rymar, V N Maksimov, G I Simonova, M Zankina, S V Mustafina, L Sherbakova, N Chernova, M I VoevodaAbstract:The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos Thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.
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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk
VIDAR-M LLC, 2008Co-Authors: Yu Nikitin, O D Rymar, M Zankina, S V Mustafina, N Chernova, V Maksimov, G Simonova, L Sherbacova, M I VoevodaAbstract:Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. The aim of the study was to investigate the association between the exon 1 CTLA-4 gene polymorphism A(49)G and susceptibility to graves’ disease (GD) and Hashimotos Thyroiditis (HT). Materials and methods. We analyzed the A(49)G exon 1 CTLA-4 gene polymorphism in 105 unrelated Novosibirsk patients with GD, in 101 patients with HT and 150 matched healthy subjects. Results. The distribution of genotype frequencies differed significantly between patients with GD and controls (p = 0.039). The allele G and the genotype GG were associated with the increased risk for GD (odds ratio OR = 1,55, 95% CI, 1,09—2,21, OR = 2,43, 95% CI, 1,17—5,01 respectively). In contrast, no differences in genotype frequencies were observed between HT patients and controls for the A(49)G exon 1 CTLA-4 gene polymorphism. Conclusion: This suggests that the CTLA-4 gene might play a role in the development of DTS in the Novosibirsk population
S V Mustafina - One of the best experts on this subject based on the ideXlab platform.
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association of ptpn22 haplotypes with Hashimotos Thyroiditis in population of novosibirsk
Clinical and experimental thyroidology, 2009Co-Authors: Yu Nikitin, O D Rymar, V N Maksimov, G I Simonova, M Zankina, S V Mustafina, L Sherbakova, N Chernova, M I VoevodaAbstract:The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos Thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.
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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk
VIDAR-M LLC, 2008Co-Authors: Yu Nikitin, O D Rymar, M Zankina, S V Mustafina, N Chernova, V Maksimov, G Simonova, L Sherbacova, M I VoevodaAbstract:Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. The aim of the study was to investigate the association between the exon 1 CTLA-4 gene polymorphism A(49)G and susceptibility to graves’ disease (GD) and Hashimotos Thyroiditis (HT). Materials and methods. We analyzed the A(49)G exon 1 CTLA-4 gene polymorphism in 105 unrelated Novosibirsk patients with GD, in 101 patients with HT and 150 matched healthy subjects. Results. The distribution of genotype frequencies differed significantly between patients with GD and controls (p = 0.039). The allele G and the genotype GG were associated with the increased risk for GD (odds ratio OR = 1,55, 95% CI, 1,09—2,21, OR = 2,43, 95% CI, 1,17—5,01 respectively). In contrast, no differences in genotype frequencies were observed between HT patients and controls for the A(49)G exon 1 CTLA-4 gene polymorphism. Conclusion: This suggests that the CTLA-4 gene might play a role in the development of DTS in the Novosibirsk population
M Zankina - One of the best experts on this subject based on the ideXlab platform.
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association of ptpn22 haplotypes with Hashimotos Thyroiditis in population of novosibirsk
Clinical and experimental thyroidology, 2009Co-Authors: Yu Nikitin, O D Rymar, V N Maksimov, G I Simonova, M Zankina, S V Mustafina, L Sherbakova, N Chernova, M I VoevodaAbstract:The single nucleotide polymorphism (SNP) C1858T within the PTPN22 gene was recently associated with autoimmune thyroid disease (AITD). The purpose of this study was to examine the joint association of this polymorphism with the AITD. Materials and methods: In this association study 358 subjects were genotyped for the C1858T polymorphism PTPN22 gene. The study population included 215 patients with both autoimmune thyroid diseases (AITD): 108 Novosibirsk patients with Graves' disease (GD) and 107 Hashimotos Thyroiditis (HT), and 143 healthy controls. Results. No differences in genotype frequencies were observed between GD and controls for the C1858T polymorphism PTPN22 gene in population of Novosibirsk. The PTPN22 1858 T-allele frequency was strongly increased in patients with HT 24,3% versus controls 12.9%; χ2 = 10.8, (р = 0.001, OR = 2.16, 95% CI 1.36–3.44). The T-allele frequency was 24.7% in women with HT and 12,1% in the control group; χ2 = 7.62, р = 0.006. The T-allele were associated with the increased risk for HT in women (odds ratio OR = 2.39 95% CI 1.27-4.89). Conclusion: The PTPN22 gene is a joint susceptibility locus for HT.
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Association of the T-cell Regulatory Ggene CTLA-4 with Suscep-tibility to Autoimmune Thyroid Disease in Population of Novosibirsk
VIDAR-M LLC, 2008Co-Authors: Yu Nikitin, O D Rymar, M Zankina, S V Mustafina, N Chernova, V Maksimov, G Simonova, L Sherbacova, M I VoevodaAbstract:Autoimmune thyroid disease (AITD) is caused by an immune response to self-thyroid antigen. The cytotoxic T-lymphocyte antigen-4 (CTLA4) gene, encoding a negative regulator of the T-lymphocyte immune response, had been reported to be associated and/or linked to AITD. The aim of the study was to investigate the association between the exon 1 CTLA-4 gene polymorphism A(49)G and susceptibility to graves’ disease (GD) and Hashimotos Thyroiditis (HT). Materials and methods. We analyzed the A(49)G exon 1 CTLA-4 gene polymorphism in 105 unrelated Novosibirsk patients with GD, in 101 patients with HT and 150 matched healthy subjects. Results. The distribution of genotype frequencies differed significantly between patients with GD and controls (p = 0.039). The allele G and the genotype GG were associated with the increased risk for GD (odds ratio OR = 1,55, 95% CI, 1,09—2,21, OR = 2,43, 95% CI, 1,17—5,01 respectively). In contrast, no differences in genotype frequencies were observed between HT patients and controls for the A(49)G exon 1 CTLA-4 gene polymorphism. Conclusion: This suggests that the CTLA-4 gene might play a role in the development of DTS in the Novosibirsk population
