The Experts below are selected from a list of 6 Experts worldwide ranked by ideXlab platform
Balwant Kowe - One of the best experts on this subject based on the ideXlab platform.
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Ectopic Thymic Cyst Presenting as Lateral Neck Mass in a Young Boy: A Case Report
'JCDR Research and Publications', 2021Co-Authors: Vaishali A Walke, Sonali Datar, Sonal Meshram, Roshni Jacob, Balwant KoweAbstract:The thymus is derived from ectoderm and endoderm of third pharyngeal pouches. It descends down along the cervical region to anterior mediastinum and involutes by increasing age. The ectopic thymic tissue in neck is a rarity and few mentioned in literature are described as sporadic case reports. Ectopic thymic cyst accounts for less than 1% of all cystic neck masses in children and even more rare in adults. Worldwide literature states that there are about 150 cases of congenital ectopic thymic tissue. It can occur anywhere along the path of its descent, from mandible to mediastinum. This entity being unusual is infrequently considered in the differential diagnosis of cervical cystic masses. Histopathology forms the mainstay in confirmation of diagnosis. Here, we report a case of 12-year-old boy who presented with right-sided neck mass. The excised specimen revealed presence of lymphoid tissue with Hassalls Corpuscles in the wall of cyst. This hallmarking feature is the pointer to arrive at a correct diagnosis of thymic cyst and to exclude its closest differential at this anatomical location including branchial cyst, cystic hygroma, lymphadenopathy and epidermoid cyst. The literature is reviewed and differentials of ectopic thymic cyst in cervical region are being discussed
Vaishali A Walke - One of the best experts on this subject based on the ideXlab platform.
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Ectopic Thymic Cyst Presenting as Lateral Neck Mass in a Young Boy: A Case Report
'JCDR Research and Publications', 2021Co-Authors: Vaishali A Walke, Sonali Datar, Sonal Meshram, Roshni Jacob, Balwant KoweAbstract:The thymus is derived from ectoderm and endoderm of third pharyngeal pouches. It descends down along the cervical region to anterior mediastinum and involutes by increasing age. The ectopic thymic tissue in neck is a rarity and few mentioned in literature are described as sporadic case reports. Ectopic thymic cyst accounts for less than 1% of all cystic neck masses in children and even more rare in adults. Worldwide literature states that there are about 150 cases of congenital ectopic thymic tissue. It can occur anywhere along the path of its descent, from mandible to mediastinum. This entity being unusual is infrequently considered in the differential diagnosis of cervical cystic masses. Histopathology forms the mainstay in confirmation of diagnosis. Here, we report a case of 12-year-old boy who presented with right-sided neck mass. The excised specimen revealed presence of lymphoid tissue with Hassalls Corpuscles in the wall of cyst. This hallmarking feature is the pointer to arrive at a correct diagnosis of thymic cyst and to exclude its closest differential at this anatomical location including branchial cyst, cystic hygroma, lymphadenopathy and epidermoid cyst. The literature is reviewed and differentials of ectopic thymic cyst in cervical region are being discussed
Bm Foxwell - One of the best experts on this subject based on the ideXlab platform.
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K21-antigen: a molecule shared by the microenvironments of the human thymus and germinal centers
'Hindawi Limited', 1998Co-Authors: Imami N, Hm Ladyman, Vincents B, Al-tubuly A, Freysdóttir J, Ml Sedibane, Da Taylor-fishwick, Bm FoxwellAbstract:The mouse IgG1 monoclonal antibody (mAb) K21 recognizes a 230-kD molecule (K21-Ag) on Hassalls Corpuscles in the human thymus. This mAb also stains cultured thymic epithelial cells as well as other epithelial cell lines, revealing a predominant intracellular localization. Further analysis with mAb K21 on other lymphoid tissues showed that it also stains cells within the germinal centers of human tonsils, both lymphoid (B) cells and some with the appearance of follicular dendritic cells. Double immunostaining of tonsil sections shows that K21-Ag is not expressed by T cells, whereas staining with anti-CD22 and -CD23 mAb revealed some double-positive cells. A subpopulation of the lymphoid cells express the K21-Ag much more strongly. This K21++/CD23++ subpopulation of cells is localized in the apical light zone of germinal centers, suggesting that K21-Ag may be an important marker for the selected centrocytes within germinal centers and may play a role in B-cell selection and/or development of B-cell memory. Flow cytometric analysis showed that K21-Ag is expressed on the surface of a very low percentage of thymocytes, tonsillar lymphocytes, and peripheral blood mononuclear cells. Analysis of purified/separated tonsillar T and B lymphocytes showed that T cells do not express the K21-Ag; in contrast, B cells express low levels of the K21-Ag, and this together with CD23 is upregulated after mitogenic stimulation. Our data therefore raise the possibility that the K21-Ag may play a role in B-lymphocyte activation/selection
Sonali Datar - One of the best experts on this subject based on the ideXlab platform.
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Ectopic Thymic Cyst Presenting as Lateral Neck Mass in a Young Boy: A Case Report
'JCDR Research and Publications', 2021Co-Authors: Vaishali A Walke, Sonali Datar, Sonal Meshram, Roshni Jacob, Balwant KoweAbstract:The thymus is derived from ectoderm and endoderm of third pharyngeal pouches. It descends down along the cervical region to anterior mediastinum and involutes by increasing age. The ectopic thymic tissue in neck is a rarity and few mentioned in literature are described as sporadic case reports. Ectopic thymic cyst accounts for less than 1% of all cystic neck masses in children and even more rare in adults. Worldwide literature states that there are about 150 cases of congenital ectopic thymic tissue. It can occur anywhere along the path of its descent, from mandible to mediastinum. This entity being unusual is infrequently considered in the differential diagnosis of cervical cystic masses. Histopathology forms the mainstay in confirmation of diagnosis. Here, we report a case of 12-year-old boy who presented with right-sided neck mass. The excised specimen revealed presence of lymphoid tissue with Hassalls Corpuscles in the wall of cyst. This hallmarking feature is the pointer to arrive at a correct diagnosis of thymic cyst and to exclude its closest differential at this anatomical location including branchial cyst, cystic hygroma, lymphadenopathy and epidermoid cyst. The literature is reviewed and differentials of ectopic thymic cyst in cervical region are being discussed
Sonal Meshram - One of the best experts on this subject based on the ideXlab platform.
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Ectopic Thymic Cyst Presenting as Lateral Neck Mass in a Young Boy: A Case Report
'JCDR Research and Publications', 2021Co-Authors: Vaishali A Walke, Sonali Datar, Sonal Meshram, Roshni Jacob, Balwant KoweAbstract:The thymus is derived from ectoderm and endoderm of third pharyngeal pouches. It descends down along the cervical region to anterior mediastinum and involutes by increasing age. The ectopic thymic tissue in neck is a rarity and few mentioned in literature are described as sporadic case reports. Ectopic thymic cyst accounts for less than 1% of all cystic neck masses in children and even more rare in adults. Worldwide literature states that there are about 150 cases of congenital ectopic thymic tissue. It can occur anywhere along the path of its descent, from mandible to mediastinum. This entity being unusual is infrequently considered in the differential diagnosis of cervical cystic masses. Histopathology forms the mainstay in confirmation of diagnosis. Here, we report a case of 12-year-old boy who presented with right-sided neck mass. The excised specimen revealed presence of lymphoid tissue with Hassalls Corpuscles in the wall of cyst. This hallmarking feature is the pointer to arrive at a correct diagnosis of thymic cyst and to exclude its closest differential at this anatomical location including branchial cyst, cystic hygroma, lymphadenopathy and epidermoid cyst. The literature is reviewed and differentials of ectopic thymic cyst in cervical region are being discussed
