Healing Environment

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Sue Weidemann - One of the best experts on this subject based on the ideXlab platform.

Erhan Demir - One of the best experts on this subject based on the ideXlab platform.

  • a prospective clinical trial comparing biobrane1 dressilk1 and polymem1 dressings on partial thickness skin graft donor sites
    Burns, 2016
    Co-Authors: Alexandra Schulz, Christian Deppner, Rolf Lefering, Julian Kricheldorff, Sonja Kastner, Paul Christian Fuchs, Erhan Demir
    Abstract:

    Abstract Introduction In a single-center, prospective, randomized clinical trial three different configured wound dressings Biobrane ® , Dressilk ® and PolyMem ® were compared with each other regarding objective and subjective Healing parameters and cost efficiency. Methods 28 burn patients received surgical treatment with split-thickness skin grafting, while utilizing Biobrane ® , Dressilk ® and PolyMem ® as a single bound donor site wound dressing in all patients. Following a standardized case report form, we monitored several parameters such as pain, transparency of the dressing, active bleeding, exudation and inflammation by using the Verbal Rating Scale 1–10 through out. Results With regard to re-epithelialization, pain and acute bleeding all three dressings were equivalent. Dressilk ® and Biobrane ® presented clearly superior to PolyMem ® in both wound assessment and in the reduction of mild inflammation and exudation. High subjective satisfaction rates were reported with Dressilk ® and Biobrane ® dressings in regard to comfort and mobility. During the continuous monitoring period Biobrane ® outperformed Dressilk ® by providing higher wound transparency rates and offering a better level of wound control during the entire study period. Regarding their cost efficiency, PolyMem ® and Dressilk ® are clearly superior to Biobrane ® . Conclusion The "ideal" wound dressing maximizes patients' comfort while reducing pain and the risk of pulling off migrating epidermal cells from the wound surface. In addition reliable wound status evaluation (minimizing complications), an increase of treatment cost value efficacy, and reduced hospitalization rates should be provided. Dressilk ® and Biobrane ® were favored by patients and surgeons for providing an effective and safe Healing Environment, with overall low complication rates with respect to infection and exudation. Regarding cost-effectiveness PolyMem ® and Dressilk ® presented superior to Biobrane ® .

Nicholas Watkins - One of the best experts on this subject based on the ideXlab platform.

Alexandra Schulz - One of the best experts on this subject based on the ideXlab platform.

  • a prospective clinical trial comparing biobrane1 dressilk1 and polymem1 dressings on partial thickness skin graft donor sites
    Burns, 2016
    Co-Authors: Alexandra Schulz, Christian Deppner, Rolf Lefering, Julian Kricheldorff, Sonja Kastner, Paul Christian Fuchs, Erhan Demir
    Abstract:

    Abstract Introduction In a single-center, prospective, randomized clinical trial three different configured wound dressings Biobrane ® , Dressilk ® and PolyMem ® were compared with each other regarding objective and subjective Healing parameters and cost efficiency. Methods 28 burn patients received surgical treatment with split-thickness skin grafting, while utilizing Biobrane ® , Dressilk ® and PolyMem ® as a single bound donor site wound dressing in all patients. Following a standardized case report form, we monitored several parameters such as pain, transparency of the dressing, active bleeding, exudation and inflammation by using the Verbal Rating Scale 1–10 through out. Results With regard to re-epithelialization, pain and acute bleeding all three dressings were equivalent. Dressilk ® and Biobrane ® presented clearly superior to PolyMem ® in both wound assessment and in the reduction of mild inflammation and exudation. High subjective satisfaction rates were reported with Dressilk ® and Biobrane ® dressings in regard to comfort and mobility. During the continuous monitoring period Biobrane ® outperformed Dressilk ® by providing higher wound transparency rates and offering a better level of wound control during the entire study period. Regarding their cost efficiency, PolyMem ® and Dressilk ® are clearly superior to Biobrane ® . Conclusion The "ideal" wound dressing maximizes patients' comfort while reducing pain and the risk of pulling off migrating epidermal cells from the wound surface. In addition reliable wound status evaluation (minimizing complications), an increase of treatment cost value efficacy, and reduced hospitalization rates should be provided. Dressilk ® and Biobrane ® were favored by patients and surgeons for providing an effective and safe Healing Environment, with overall low complication rates with respect to infection and exudation. Regarding cost-effectiveness PolyMem ® and Dressilk ® presented superior to Biobrane ® .

Tomoharu Kiyosawa - One of the best experts on this subject based on the ideXlab platform.

  • novel hydrocolloid sheet as wound dressing to stimulate Healing impaired wound Healing in diabetic db db mice
    Bio-medical Materials and Engineering, 2012
    Co-Authors: Satoshi Yanagibayashi, Kaoru Murakami, Hiroshi Aoki, Megumi Takikawa, Satoko Kishimoto, Masayuki Ishihara, Masanori Fujita, Mitsuru Sekido, Tomoharu Kiyosawa
    Abstract:

    To create a moist Environment for wound Healing, a hydrocolloid-sheet composed of alginate, chitin/chitosan and fucoidan (ACF-HS) has been developed as a functional wound dressing. ACF-HS gradually adsorbed medium without any maceration and the medium adsorption in vitro reached constant after 18 h. ACF-HS could effectively interact with and protect a Healing-impaired wound in diabetic db/db mice, providing a good moist Healing Environment with exudate. Furthermore, the wound dressing could have other properties like ease of application and removal, and proper adherence. The aim of this study was to evaluate an accelerating effect of ACF-HS on wound Healing for Healing-impaired wounds in diabetic db/db mice. Round full-thickness skin defects (12 mm in diameter) were made on the back of db/db mice to prepare Healing-impaired wounds. After applying ACF-HS to the wounds, the mice were later killed and histological sections of the wound were prepared. Histological examinations showed significantly advanced granulation tissue and capillary formations in the wounds treated with ACF-HS on days 4, 9 and 14 compared with those in commercially available hydrocolloid wound dressing and non-treatment (control). Thus, ACF-HS may serve as a new wound dressing for diabetic Healing-impaired wounds.

  • hydrogel blends of chitin chitosan fucoidan and alginate as Healing impaired wound dressings
    Biomaterials, 2010
    Co-Authors: Kaoru Murakami, Hiroshi Aoki, Shingo Nakamura, Shinichiro Nakamura, Megumi Takikawa, Motoaki Hanzawa, Satoko Kishimoto, Hidemi Hattori, Yoshihiro Tanaka, Tomoharu Kiyosawa
    Abstract:

    Abstract In order to create a moist Environment for rapid wound Healing, a hydrogel sheet composed of a blended powder of alginate, chitin/chitosan and fucoidan (ACF-HS; 60:20:2:4 w/w) has been developed as a functional wound dressing. ACF-HS gradually absorbed DMEM without any maceration, and fluid absorption became constant within 18 h. On application, ACF-HS was expected to effectively interact with and protect the wound in rats, providing a good moist Healing Environment with exudates. In addition, the wound dressing has properties such as ease of application and removal and good adherence. Full-thickness skin defects were made on the backs of rats and mitomycin C solution (1 mg/ml in saline) was applied onto the wound for 10 min in order to prepare Healing-impaired wounds. After thoroughly washing out the mitomycin C, ACF-HS was applied to the Healing-impaired wounds. Although normal rat wound repair was not stimulated by the application of ACF-HS, Healing-impaired wound repair was significantly stimulated. Histological examination demonstrated significantly advanced granulation tissue and capillary formation in the Healing-impaired wounds treated with ACF-HS on day 7, as compared to those treated with calcium alginate fiber (Kaltostat ® ; Convatec Ltd., Tokyo, Japan) and those left untreated.

  • hydrogel blends of chitin chitosan fucoidan and alginate as Healing impaired wound dressings
    Biomaterials, 2010
    Co-Authors: Kaoru Murakami, Hiroshi Aoki, Shingo Nakamura, Shinichiro Nakamura, Megumi Takikawa, Motoaki Hanzawa, Satoko Kishimoto, Hidemi Hattori, Yoshihiro Tanaka, Tomoharu Kiyosawa
    Abstract:

    Abstract In order to create a moist Environment for rapid wound Healing, a hydrogel sheet composed of a blended powder of alginate, chitin/chitosan and fucoidan (ACF-HS; 60:20:2:4 w/w) has been developed as a functional wound dressing. ACF-HS gradually absorbed DMEM without any maceration, and fluid absorption became constant within 18 h. On application, ACF-HS was expected to effectively interact with and protect the wound in rats, providing a good moist Healing Environment with exudates. In addition, the wound dressing has properties such as ease of application and removal and good adherence. Full-thickness skin defects were made on the backs of rats and mitomycin C solution (1 mg/ml in saline) was applied onto the wound for 10 min in order to prepare Healing-impaired wounds. After thoroughly washing out the mitomycin C, ACF-HS was applied to the Healing-impaired wounds. Although normal rat wound repair was not stimulated by the application of ACF-HS, Healing-impaired wound repair was significantly stimulated. Histological examination demonstrated significantly advanced granulation tissue and capillary formation in the Healing-impaired wounds treated with ACF-HS on day 7, as compared to those treated with calcium alginate fiber (Kaltostat ® ; Convatec Ltd., Tokyo, Japan) and those left untreated.