The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Bruce J Paster - One of the best experts on this subject based on the ideXlab platform.
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a practical guide to the oral microbiome and its relation to Health and Disease
Oral Diseases, 2017Co-Authors: K Krishnan, T Chen, Bruce J PasterAbstract:The oral microbiome is incredibly complex with the average adult harboring about 50-100 billion bacteria in the oral cavity, which represent about 200 predominant bacterial species. Collectively, there are approximately 700 predominant taxa of which less than one-third still have not yet been grown in vitro. Compared to other body sites, the oral microbiome is unique and readily accessible. There is extensive literature available describing the oral microbiome and discussing the roles that bacteria may play in oral Health and Disease. However, the purpose of this review is not to rehash these detailed studies but rather to educate the reader with understanding the essence of the oral microbiome, namely that there are abundant bacteria in numbers and types, that there are molecular methods to rapidly determine bacterial associations, that there is site specificity for colonization of the host, that there are specific associations with oral Health and Disease, that oral bacteria may serve as biomarkers for non-oral Diseases, and that oral microbial profiles may have potential use to assess Disease risk.
Jorge Friaslopez - One of the best experts on this subject based on the ideXlab platform.
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beyond microbial community composition functional activities of the oral microbiome in Health and Disease
Microbes and Infection, 2015Co-Authors: Ana E Duranpinedo, Jorge FriaslopezAbstract:The oral microbiome plays a relevant role in the Health status of the host and is a key element in a variety of oral and non-oral Diseases. Despite advances in our knowledge of changes in microbial composition associated with different Health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in Health and Disease and how novel technologies are expanding our knowledge on this subject.
Ann B. Moser - One of the best experts on this subject based on the ideXlab platform.
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functions of plasmalogen lipids in Health and Disease
Biochimica et Biophysica Acta, 2012Co-Authors: Nancy Braverman, Ann B. MoserAbstract:Abstract Plasmalogens are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn -1 position, and enriched in polyunsaturated fatty acids at the sn -2 position of the glycerol backbone. These two features provide novel properties to these compounds. Although plasmalogens represent up to 20% of the total phospholipid mass in humans their physiological roles have been challenging to identify, and are likely to be particular to different tissues, metabolic processes and developmental stages. Their biosynthesis starts in peroxisomes, and defects at these steps cause the malformation syndrome, Rhizomelic Chondrodysplasia Punctata (RCDP). The RCDP phenotype predicts developmental roles for plasmalogens in bone, brain, lens, lung, kidney and heart. Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in Health and Disease. This article is part of a Special Issue entitled: Metabolic Functions and Biogenesis of peroxisomes in Health and Disease.
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functions of plasmalogen lipids in Health and Disease
Biochimica et Biophysica Acta, 2012Co-Authors: Nancy Braverman, Ann B. MoserAbstract:Plasmalogens are a unique class of membrane glycerophospholipids containing a fatty alcohol with a vinyl-ether bond at the sn-1 position, and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone. These two features provide novel properties to these compounds. Although plasmalogens represent up to 20% of the total phospholipid mass in humans their physiological roles have been challenging to identify, and are likely to be particular to different tissues, metabolic processes and developmental stages. Their biosynthesis starts in peroxisomes, and defects at these steps cause the malformation syndrome, Rhizomelic Chondrodysplasia Punctata (RCDP). The RCDP phenotype predicts developmental roles for plasmalogens in bone, brain, lens, lung, kidney and heart. Recent studies have revealed secondary plasmalogen deficiencies associated with more common disorders and allow us to tease out additional pathways dependent on plasmalogen functions. In this review, we present current knowledge of plasmalogen biology in Health and Disease.
K Krishnan - One of the best experts on this subject based on the ideXlab platform.
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a practical guide to the oral microbiome and its relation to Health and Disease
Oral Diseases, 2017Co-Authors: K Krishnan, T Chen, Bruce J PasterAbstract:The oral microbiome is incredibly complex with the average adult harboring about 50-100 billion bacteria in the oral cavity, which represent about 200 predominant bacterial species. Collectively, there are approximately 700 predominant taxa of which less than one-third still have not yet been grown in vitro. Compared to other body sites, the oral microbiome is unique and readily accessible. There is extensive literature available describing the oral microbiome and discussing the roles that bacteria may play in oral Health and Disease. However, the purpose of this review is not to rehash these detailed studies but rather to educate the reader with understanding the essence of the oral microbiome, namely that there are abundant bacteria in numbers and types, that there are molecular methods to rapidly determine bacterial associations, that there is site specificity for colonization of the host, that there are specific associations with oral Health and Disease, that oral bacteria may serve as biomarkers for non-oral Diseases, and that oral microbial profiles may have potential use to assess Disease risk.
Daniel L Hamilos - One of the best experts on this subject based on the ideXlab platform.
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the nasal and sinus microbiome in Health and Disease
Current Allergy and Asthma Reports, 2014Co-Authors: Michael T Wilson, Daniel L HamilosAbstract:There has been great interest in unraveling the complex inter-relationships between microbes and humans as they relate to human Health and Disease. This review will focus on recent advances in the appreciation and understanding of these relationships in terms of the upper respiratory tract, specifically the nose and paranasal sinuses.
