The Experts below are selected from a list of 83646 Experts worldwide ranked by ideXlab platform
Stephanie E Chiuve - One of the best experts on this subject based on the ideXlab platform.
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Healthy Lifestyle in the primordial prevention of cardiovascular disease among young women
Journal of the American College of Cardiology, 2015Co-Authors: Andrea K Chomistek, Walter C Willett, Kenneth J Mukamal, Stephanie E Chiuve, Heather A Eliassen, Eric B RimmAbstract:Abstract Background Overall mortality rates from coronary heart disease (CHD) in the United States have declined in recent decades, but the rate has plateaued among younger women. The potential for further reductions in mortality rates among young women through changes in Lifestyle is unknown. Objectives The aim of this study was to estimate the proportion of CHD cases and clinical cardiovascular disease (CVD) risk factors among young women that might be attributable to poor adherence to a Healthy Lifestyle. Methods A prospective analysis was conducted among 88,940 women ages 27 to 44 years at baseline in the Nurses’ Health Study II who were followed from 1991 to 2011. Lifestyle factors were updated repeatedly by questionnaire. A Healthy Lifestyle was defined as not smoking, a normal body mass index, physical activity ≥ 2.5 h/week, television viewing ≤ 7 h/week, diet in the top 40% of the Alternative Healthy Eating Index–2010, and 0.1 to 14.9 g/day of alcohol. To estimate the proportion of CHD and clinical CVD risk factors (diabetes, hypertension, and hypercholesterolemia) that could be attributed to poor adherence to a Healthy Lifestyle, we calculated the population-attributable risk percent. Results During 20 years of follow-up, we documented 456 incident CHD cases. In multivariable-adjusted models, nonsmoking, a Healthy body mass index, exercise, and a Healthy diet were independently and significantly associated with lower CHD risk. Compared with women with no Healthy Lifestyle factors, the hazard ratio for CHD for women with 6 Lifestyle factors was 0.08 (95% confidence interval: 0.03 to 0.22). Approximately 73% (95% confidence interval: 39% to 89%) of CHD cases were attributable to poor adherence to a Healthy Lifestyle. Similarly, 46% (95% confidence interval: 43% to 49%) of clinical CVD risk factor cases were attributable to a poor Lifestyle. Conclusions Primordial prevention through maintenance of a Healthy Lifestyle among young women may substantially lower the burden of CVD.
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Healthy Lifestyle and leukocyte telomere length in u s women
PLOS ONE, 2012Co-Authors: Stephanie E Chiuve, Jennifer Prescott, Frank B Hu, Immaculata De Vivo, Meir J StampferAbstract:Context: Whether a Healthy Lifestyle may be associated with longer telomere length is largely unknown. Objectives: To examine Healthy Lifestyle practices, which are primary prevention measures against major age-related chronic diseases, in relation to leukocyte telomere length. Design and Setting: Cross-sectional analysis in the Nurses' Health Study (NHS). Participants: The population consisted of 5,862 women who participated in multiple prospective case-control studies within the NHS cohort. Z scores of leukocyte telomere length were derived within each case-control study. Based on prior work, we defined low-risk or Healthy categories for five major modifiable factors assessed in 1988 or 1990: non-current smoking, maintaining a Healthy body weight (body mass index in 18.5-24.9 kg/m(2)), engaging in regular moderate or vigorous physical activities (>= 150 minutes/week), drinking alcohol in moderation (1 drink/week to,2 drinks/day), and eating a Healthy diet (Alternate Healthy Eating Index score in top 50%). We calculated difference (%) of the z scores contrasting low-risk groups with reference groups to evaluate the association of interest. Results: Although none of the individual low-risk factors was significantly associated with larger leukocyte telomere length z scores, we observed a significant, positive relationship between the number of low-risk factors and the z scores. In comparison with women who had zero low-risk factors (1.9% of the total population) and were, therefore, considered the least Healthy group, the leukocyte telomere length z scores were 16.4%, 22.1%, 28.7%, 22.6%, and 31.2% (P for trend = 0.015) higher for women who had 1 to 5 low-risk factors, respectively. Conclusions: Adherence to a Healthy Lifestyle, defined by major modifiable risk factors, was associated with longer telomere length in leukocytes.
Eric B Rimm - One of the best experts on this subject based on the ideXlab platform.
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Healthy Lifestyle in the primordial prevention of cardiovascular disease among young women
Journal of the American College of Cardiology, 2015Co-Authors: Andrea K Chomistek, Walter C Willett, Kenneth J Mukamal, Stephanie E Chiuve, Heather A Eliassen, Eric B RimmAbstract:Abstract Background Overall mortality rates from coronary heart disease (CHD) in the United States have declined in recent decades, but the rate has plateaued among younger women. The potential for further reductions in mortality rates among young women through changes in Lifestyle is unknown. Objectives The aim of this study was to estimate the proportion of CHD cases and clinical cardiovascular disease (CVD) risk factors among young women that might be attributable to poor adherence to a Healthy Lifestyle. Methods A prospective analysis was conducted among 88,940 women ages 27 to 44 years at baseline in the Nurses’ Health Study II who were followed from 1991 to 2011. Lifestyle factors were updated repeatedly by questionnaire. A Healthy Lifestyle was defined as not smoking, a normal body mass index, physical activity ≥ 2.5 h/week, television viewing ≤ 7 h/week, diet in the top 40% of the Alternative Healthy Eating Index–2010, and 0.1 to 14.9 g/day of alcohol. To estimate the proportion of CHD and clinical CVD risk factors (diabetes, hypertension, and hypercholesterolemia) that could be attributed to poor adherence to a Healthy Lifestyle, we calculated the population-attributable risk percent. Results During 20 years of follow-up, we documented 456 incident CHD cases. In multivariable-adjusted models, nonsmoking, a Healthy body mass index, exercise, and a Healthy diet were independently and significantly associated with lower CHD risk. Compared with women with no Healthy Lifestyle factors, the hazard ratio for CHD for women with 6 Lifestyle factors was 0.08 (95% confidence interval: 0.03 to 0.22). Approximately 73% (95% confidence interval: 39% to 89%) of CHD cases were attributable to poor adherence to a Healthy Lifestyle. Similarly, 46% (95% confidence interval: 43% to 49%) of clinical CVD risk factor cases were attributable to a poor Lifestyle. Conclusions Primordial prevention through maintenance of a Healthy Lifestyle among young women may substantially lower the burden of CVD.
Frank A J L Scheer - One of the best experts on this subject based on the ideXlab platform.
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a Healthy Lifestyle reducing t2dm risk in shift workers
Nature Reviews Endocrinology, 2019Co-Authors: Celine Vetter, Frank A J L ScheerAbstract:A recent study shows that a history of rotating night-shift work and an unHealthy Lifestyle are associated with increased risk of type 2 diabetes mellitus (T2DM), both independently and synergistically. This is the first large-scale, prospective study to quantify how a Healthy Lifestyle might partially offset T2DM risk in shift workers.
Andrea K Chomistek - One of the best experts on this subject based on the ideXlab platform.
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Healthy Lifestyle in the primordial prevention of cardiovascular disease among young women
Journal of the American College of Cardiology, 2015Co-Authors: Andrea K Chomistek, Walter C Willett, Kenneth J Mukamal, Stephanie E Chiuve, Heather A Eliassen, Eric B RimmAbstract:Abstract Background Overall mortality rates from coronary heart disease (CHD) in the United States have declined in recent decades, but the rate has plateaued among younger women. The potential for further reductions in mortality rates among young women through changes in Lifestyle is unknown. Objectives The aim of this study was to estimate the proportion of CHD cases and clinical cardiovascular disease (CVD) risk factors among young women that might be attributable to poor adherence to a Healthy Lifestyle. Methods A prospective analysis was conducted among 88,940 women ages 27 to 44 years at baseline in the Nurses’ Health Study II who were followed from 1991 to 2011. Lifestyle factors were updated repeatedly by questionnaire. A Healthy Lifestyle was defined as not smoking, a normal body mass index, physical activity ≥ 2.5 h/week, television viewing ≤ 7 h/week, diet in the top 40% of the Alternative Healthy Eating Index–2010, and 0.1 to 14.9 g/day of alcohol. To estimate the proportion of CHD and clinical CVD risk factors (diabetes, hypertension, and hypercholesterolemia) that could be attributed to poor adherence to a Healthy Lifestyle, we calculated the population-attributable risk percent. Results During 20 years of follow-up, we documented 456 incident CHD cases. In multivariable-adjusted models, nonsmoking, a Healthy body mass index, exercise, and a Healthy diet were independently and significantly associated with lower CHD risk. Compared with women with no Healthy Lifestyle factors, the hazard ratio for CHD for women with 6 Lifestyle factors was 0.08 (95% confidence interval: 0.03 to 0.22). Approximately 73% (95% confidence interval: 39% to 89%) of CHD cases were attributable to poor adherence to a Healthy Lifestyle. Similarly, 46% (95% confidence interval: 43% to 49%) of clinical CVD risk factor cases were attributable to a poor Lifestyle. Conclusions Primordial prevention through maintenance of a Healthy Lifestyle among young women may substantially lower the burden of CVD.
Liz Ruizestigarribia - One of the best experts on this subject based on the ideXlab platform.
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Healthy Lifestyle and incidence of metabolic syndrome in the sun cohort
Nutrients, 2018Co-Authors: Maria Garraldadelvillar, Silvia Carloschilleron, Jesus Diazgutierrez, Miguel Ruizcanela, Alfredo Gea, Miguel A Martinezgonzalez, Maira Besrastrollo, Liz RuizestigarribiaAbstract:We assessed the relationship between a Healthy Lifestyle and the subsequent risk of developing metabolic syndrome. The “Seguimiento Universidad de Navarra” (SUN) Project is a prospective cohort study, focused on nutrition, Lifestyle, and chronic diseases. Participants (n = 10,807, mean age 37 years, 67% women) initially free of metabolic syndrome were followed prospectively for a minimum of 6 years. To evaluate Healthy Lifestyle, nine habits were used to derive a Healthy Lifestyle Score (HLS): Never smoking, moderate to high physical activity (>20 MET-h/week), Mediterranean diet (≥4/8 adherence points), moderate alcohol consumption (women, 0.1–5.0 g/day; men, 0.1–10.0 g/day), low television exposure ( 1 h/day, and working at least 40 h/week. Metabolic syndrome was defined according to the harmonizing definition. The association between the baseline HLS and metabolic syndrome at follow-up was assessed with multivariable-adjusted logistic regressions. During follow-up, we observed 458 (4.24%) new cases of metabolic syndrome. Participants in the highest category of HLS adherence (7–9 points) enjoyed a significantly reduced risk of developing metabolic syndrome compared to those in the lowest category (0–3 points) (adjusted odds ratio (OR) = 0.66, 95% confidence interval (CI) = 0.47–0.93). Higher adherence to the Healthy Lifestyle Score was associated with a lower risk of developing metabolic syndrome. The HLS may be a simple metabolic health promotion tool.
