The Experts below are selected from a list of 105 Experts worldwide ranked by ideXlab platform
Sinerik Ayrapetyan - One of the best experts on this subject based on the ideXlab platform.
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age dependent impairment of Heart Muscle Contractility as a primary mechanism for overexpression of na ca 2 exchanger in brain cortex tissues
European Journal of Biophysics, 2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:The cognitive function of brain and Contractility of Heart Muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and Heart Muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and Heart Muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of Heart Muscle Contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced Muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
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Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na + /Ca 2+ Exchanger in Brain Cortex Tissues
2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:The cognitive function of brain and Contractility of Heart Muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and Heart Muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and Heart Muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of Heart Muscle Contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced Muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
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Age-Dependent Comparative Study of 4 Hz and 8 Hz EMF Exposure on Heart Muscle Tissue Hydration of Rats
Open Journal of Biophysics, 2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:Previously we have shown that 4 Hz and 8 Hz EMF exposures have depressing effect on the thermodynamic activity of water, which decreases peroxide formation. It has also been shown that 4 Hz EMF-treated physiological solution modulates the growth and development of microbes and Heart Muscle Contractility, but 8 Hz EMF has pronounced inhibitory effect on bacterial growth and development. Therefore, in order to elucidate the possible mechanism of 4 Hz and 8 Hz EMF effects on Heart Muscle function, in the present work the effects of 4 Hz and 8 Hz EMF exposures on Heart Muscle tissue hydration, the sensitivity of 4 Hz and 8 Hz EMF-induced tissue hydration to 10−4 M ouabain (Na+/K+ pump inhibition) and 10−9 M ouabain (activation of intracellular signaling system) as well as the effects of 4 Hz and 8 Hz EMF exposures on the number of Na+/K+ pump units in the membrane of both young and old rats have been studied. The obtained data allow us to suggest that 8 Hz EMF exposure has more pronounced age-dependent modulation effect on tissue hydration of Heart Muscle than 4 Hz EMF and this effect is sensitive to Na+/K+ pump activity and intracellular signaling system.
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The metabolic pathway of 4 Hz mechanical vibration-induced effect on snail Heart Muscle Contractility
The Environmentalist, 2012Co-Authors: Erna Dadasyan, Gayane Ayrapetyan, Naira Baghdasaryan, Yerazik Mikayelyan, Sinerik AyrapetyanAbstract:It was shown that the 4 Hz 30 dB mechanical vibration (MV) of physiological solution (PS) had modulation effect on snail Heart Contractility. However, the nature of metabolic pathway of MV-treated PS-induced effect is not clear yet. It was suggested that the MV-induced modulation of water molecules dissociation leads to the variation of reactive oxygen species’ level in cell bathing medium, which could serve as a messenger for switching on the metabolic pathway(s) responsible for modulation of Muscle Contractility. The aim of present work was to check this hypothesis and to elucidate the metabolic pathway through which the effect of MV-treated PS on Heart Contractility was realized. For this purpose, the effect of MV on heat fusion periods (HFP) and H_2O_2 content in PS, as well as on Heart Contractility, ^45Ca^2+ efflux, intracellular levels of cGMP and cAMP, Muscle hydration, and ouabain binding were studied. It was shown that MV treatment of PS increased the HFP-(21.33 ± 4%) and decreased the H_2O_2 content-(5 ± 0.9%). The intracardiac perfusion by MV-treated PS increased the amplitudes of Heart Contractility, which was accompanied by the increasing of ^45Ca^2+ efflux (252.4 ± 16%), elevation of cGMP’s level (42.05 ± 7%), decreasing of cAMP’s level (82.67 ± 7%), increasing of the tissue hydration (18.64 ± 3%), and increasing of the number of ouabain binding sides (25 ± 4%). It was suggested that MV-induced increasing of Heart Muscle contraction amplitudes is due to the decreases of H_2O_2 content in the medium, which leads to the elevation of Heart Muscle Contractility in result of activation of cGMP-dependent Na^+/Ca^2+ exchange in forward regime.
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cell bathing medium as a target for non thermal efiect of mmw on Heart Muscle Contractility
2009Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, E R Mikayelyan, Sedrak Barseghyan, Sinerik AyrapetyanAbstract:The comparative study of the efiects of weak intensity speciflc absorption rate (SAR = 1:8mW/g) of 4Hz modulated 160GHz millimeter wave (MMW) and near Infrared (IR) irradiation on thermodynamic properties, speciflc electrical conductivity (SEC) of physiological solution (PS) and hydrogen peroxide (H2O2) formation in it as well as the efiect of MMW- treated PS on Heart Muscle Contractility, 45 Ca uptake was performed. The heat fusion capacity of MMW-pretreated PS after freezing by liquid nitrogen (N2) is signiflcantly less than the heat fusion capacity of sham and IR-treated PS. MMW unlike IR, has time-dependent elevation efiect on water SEC and SAR, which is accompanied by the increase of H2O2 formation in it. The direct MMW radiation, MMW-pretreated PS and H2O2-containing PS have increasing efiect on Heart Muscle Contractility. The MMW-pretreated PS and the H2O2{containing PS have activation efiect on 45 Ca uptake and dehydration efiect on Heart Muscle Contractility. Thus, the obtained data allow us to consider water dissociation as a main target through which the non-thermal efiect of MMW on physicochemical properties of water is realized, while the MMW-induced formation of H2O2 in cell bathing medium serves as a messenger through which the modulation of intracellular metabolism takes place.
Gayane Ayrapetyan - One of the best experts on this subject based on the ideXlab platform.
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The metabolic pathway of 4 Hz mechanical vibration-induced effect on snail Heart Muscle Contractility
The Environmentalist, 2012Co-Authors: Erna Dadasyan, Gayane Ayrapetyan, Naira Baghdasaryan, Yerazik Mikayelyan, Sinerik AyrapetyanAbstract:It was shown that the 4 Hz 30 dB mechanical vibration (MV) of physiological solution (PS) had modulation effect on snail Heart Contractility. However, the nature of metabolic pathway of MV-treated PS-induced effect is not clear yet. It was suggested that the MV-induced modulation of water molecules dissociation leads to the variation of reactive oxygen species’ level in cell bathing medium, which could serve as a messenger for switching on the metabolic pathway(s) responsible for modulation of Muscle Contractility. The aim of present work was to check this hypothesis and to elucidate the metabolic pathway through which the effect of MV-treated PS on Heart Contractility was realized. For this purpose, the effect of MV on heat fusion periods (HFP) and H_2O_2 content in PS, as well as on Heart Contractility, ^45Ca^2+ efflux, intracellular levels of cGMP and cAMP, Muscle hydration, and ouabain binding were studied. It was shown that MV treatment of PS increased the HFP-(21.33 ± 4%) and decreased the H_2O_2 content-(5 ± 0.9%). The intracardiac perfusion by MV-treated PS increased the amplitudes of Heart Contractility, which was accompanied by the increasing of ^45Ca^2+ efflux (252.4 ± 16%), elevation of cGMP’s level (42.05 ± 7%), decreasing of cAMP’s level (82.67 ± 7%), increasing of the tissue hydration (18.64 ± 3%), and increasing of the number of ouabain binding sides (25 ± 4%). It was suggested that MV-induced increasing of Heart Muscle contraction amplitudes is due to the decreases of H_2O_2 content in the medium, which leads to the elevation of Heart Muscle Contractility in result of activation of cGMP-dependent Na^+/Ca^2+ exchange in forward regime.
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cell bathing medium as a target for non thermal efiect of mmw on Heart Muscle Contractility
2009Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, E R Mikayelyan, Sedrak Barseghyan, Sinerik AyrapetyanAbstract:The comparative study of the efiects of weak intensity speciflc absorption rate (SAR = 1:8mW/g) of 4Hz modulated 160GHz millimeter wave (MMW) and near Infrared (IR) irradiation on thermodynamic properties, speciflc electrical conductivity (SEC) of physiological solution (PS) and hydrogen peroxide (H2O2) formation in it as well as the efiect of MMW- treated PS on Heart Muscle Contractility, 45 Ca uptake was performed. The heat fusion capacity of MMW-pretreated PS after freezing by liquid nitrogen (N2) is signiflcantly less than the heat fusion capacity of sham and IR-treated PS. MMW unlike IR, has time-dependent elevation efiect on water SEC and SAR, which is accompanied by the increase of H2O2 formation in it. The direct MMW radiation, MMW-pretreated PS and H2O2-containing PS have increasing efiect on Heart Muscle Contractility. The MMW-pretreated PS and the H2O2{containing PS have activation efiect on 45 Ca uptake and dehydration efiect on Heart Muscle Contractility. Thus, the obtained data allow us to consider water dissociation as a main target through which the non-thermal efiect of MMW on physicochemical properties of water is realized, while the MMW-induced formation of H2O2 in cell bathing medium serves as a messenger through which the modulation of intracellular metabolism takes place.
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Exogenous hydrogen peroxide as a possible messenger for the stimulation effect of magnetized physiological solution on Heart Contractility.
Bioelectromagnetics, 2008Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, Hovik Hayrapetyan, Sinerik AyrapetyanAbstract:The dual effect of magnetized physiological solution (MPS) on snail Heart Muscle Contractility (Muscle relaxation and stimulation of Heartbeat) was shown previously. The MPS-induced relaxation of the Heart Muscle has been explained by activation of cGMP-dependent Ca2+ effluxes from the Muscle; however, the mechanism of the stimulating effect of MPS on Heartbeat remains unclear. As in the presence of paramagnetic oxygen molecules, magnetic fields could generate the exogenous reactive oxygen species such as hydrogen peroxide (H2O2), we hypothesize that H2O2 may play a role as the possible messengers through which the activation effect of MPS on Heartbeat is realized. To test this hypothesis, the dose-dependent effects of exogenous H2O2 on Heart Muscle Contractility and 45Ca uptake were studied. Here we compared the obtained data with the previous results of the effects of MPS on Heart Muscle Contractility and 45Ca uptake. We found that exogenous H2O2 and MPS have similar effects on Na+–K+ pump-induced transient inhibition of Muscle Contractility and 45Ca uptake. The Na+–K+ pump-induced depression of H2O2-sensitivity of Muscle Contractility is determined by activation of Ca2+ efflux from the cell. On the basis of these data we suggest the exogenous H2O2 as a possible messenger through which the stimulation effect of MPS on Heart Muscle is realized. Bioelectromagnetics 29:549–558, 2008. © 2008 Wiley-Liss, Inc.
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The comparative study of the effects of 4 Hz Electromagnetic Fields-, Infrasound-treated and hydrogen peroxide containing physiological solutions on Na pump-induced inhibition of Heart Muscle Contractility
The Environmentalist, 2007Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, Anahit Grigoryan, Sinerik AyrapetyanAbstract:The effects of 4 Hz extremely low frequency Electromagnetic Fields (ELF EMF), Infrasound (IS) and hydrogen peroxide (H_2O_2) on Na^+–K^+ pump-induced transient inhibition of Heart Muscle Contractility was studied. It was documented that EMF-treated and H_2O_2-containing physiological solution had synergic depressing effect on Na^+–K^+ pump-induced inhibition of Muscle Contractility, while the IS had elevation effect on it. On the basis of the obtained data the H_2O_2 could be suggested as the messenger through which the stimulation effect of EMF on Heart Muscle is realised, while the relaxing effect of IS on Heart Contractility is due to the decrease of CO_2 solubility of Muscle bathing aqueous medium.
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Metabolic pathway of magnetized fluid-induced relaxation effects on Heart Muscle
Bioelectromagnetics, 2005Co-Authors: Gayane Ayrapetyan, Hovik Hayrapetyan, Alexander Papanyan, Sinerik AyrapetyanAbstract:The effect of magnetized physiological solution (MPS) on isolated, perfused snail Heart Muscle Contractility, 45Ca uptake and intracellular level of cAMP, and cGMP was studied. The existence of the relaxing effect of MPS on Heart Muscle at room temperature (22 °C) and its absence in cold medium (4 °C) was shown. The MPS had a depressing effect on 45Ca uptake by Muscles and intracellular cAMP content and an elevating effect on intracellular cGMP level. It is suggested that the relaxing effect of MPS on Heart Muscle is due to the decrease of intracellular Ca ions as the result of activation of cGMP-dependent Ca efflux. The MPS induced decrease of intracellular cAMP content can be considered as a consequence of intracellular Ca loss, leading to the Na + K-ATPase reactivation, and causing the decrease of the intracellular level of ATP, serving as a substrate and positive modulator of cyclase activity. Bioelectromagnetics © 2005 Wiley-Liss, Inc.
Erna Dadasyan - One of the best experts on this subject based on the ideXlab platform.
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The metabolic pathway of 4 Hz mechanical vibration-induced effect on snail Heart Muscle Contractility
The Environmentalist, 2012Co-Authors: Erna Dadasyan, Gayane Ayrapetyan, Naira Baghdasaryan, Yerazik Mikayelyan, Sinerik AyrapetyanAbstract:It was shown that the 4 Hz 30 dB mechanical vibration (MV) of physiological solution (PS) had modulation effect on snail Heart Contractility. However, the nature of metabolic pathway of MV-treated PS-induced effect is not clear yet. It was suggested that the MV-induced modulation of water molecules dissociation leads to the variation of reactive oxygen species’ level in cell bathing medium, which could serve as a messenger for switching on the metabolic pathway(s) responsible for modulation of Muscle Contractility. The aim of present work was to check this hypothesis and to elucidate the metabolic pathway through which the effect of MV-treated PS on Heart Contractility was realized. For this purpose, the effect of MV on heat fusion periods (HFP) and H_2O_2 content in PS, as well as on Heart Contractility, ^45Ca^2+ efflux, intracellular levels of cGMP and cAMP, Muscle hydration, and ouabain binding were studied. It was shown that MV treatment of PS increased the HFP-(21.33 ± 4%) and decreased the H_2O_2 content-(5 ± 0.9%). The intracardiac perfusion by MV-treated PS increased the amplitudes of Heart Contractility, which was accompanied by the increasing of ^45Ca^2+ efflux (252.4 ± 16%), elevation of cGMP’s level (42.05 ± 7%), decreasing of cAMP’s level (82.67 ± 7%), increasing of the tissue hydration (18.64 ± 3%), and increasing of the number of ouabain binding sides (25 ± 4%). It was suggested that MV-induced increasing of Heart Muscle contraction amplitudes is due to the decreases of H_2O_2 content in the medium, which leads to the elevation of Heart Muscle Contractility in result of activation of cGMP-dependent Na^+/Ca^2+ exchange in forward regime.
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cell bathing medium as a target for non thermal efiect of mmw on Heart Muscle Contractility
2009Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, E R Mikayelyan, Sedrak Barseghyan, Sinerik AyrapetyanAbstract:The comparative study of the efiects of weak intensity speciflc absorption rate (SAR = 1:8mW/g) of 4Hz modulated 160GHz millimeter wave (MMW) and near Infrared (IR) irradiation on thermodynamic properties, speciflc electrical conductivity (SEC) of physiological solution (PS) and hydrogen peroxide (H2O2) formation in it as well as the efiect of MMW- treated PS on Heart Muscle Contractility, 45 Ca uptake was performed. The heat fusion capacity of MMW-pretreated PS after freezing by liquid nitrogen (N2) is signiflcantly less than the heat fusion capacity of sham and IR-treated PS. MMW unlike IR, has time-dependent elevation efiect on water SEC and SAR, which is accompanied by the increase of H2O2 formation in it. The direct MMW radiation, MMW-pretreated PS and H2O2-containing PS have increasing efiect on Heart Muscle Contractility. The MMW-pretreated PS and the H2O2{containing PS have activation efiect on 45 Ca uptake and dehydration efiect on Heart Muscle Contractility. Thus, the obtained data allow us to consider water dissociation as a main target through which the non-thermal efiect of MMW on physicochemical properties of water is realized, while the MMW-induced formation of H2O2 in cell bathing medium serves as a messenger through which the modulation of intracellular metabolism takes place.
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Exogenous hydrogen peroxide as a possible messenger for the stimulation effect of magnetized physiological solution on Heart Contractility.
Bioelectromagnetics, 2008Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, Hovik Hayrapetyan, Sinerik AyrapetyanAbstract:The dual effect of magnetized physiological solution (MPS) on snail Heart Muscle Contractility (Muscle relaxation and stimulation of Heartbeat) was shown previously. The MPS-induced relaxation of the Heart Muscle has been explained by activation of cGMP-dependent Ca2+ effluxes from the Muscle; however, the mechanism of the stimulating effect of MPS on Heartbeat remains unclear. As in the presence of paramagnetic oxygen molecules, magnetic fields could generate the exogenous reactive oxygen species such as hydrogen peroxide (H2O2), we hypothesize that H2O2 may play a role as the possible messengers through which the activation effect of MPS on Heartbeat is realized. To test this hypothesis, the dose-dependent effects of exogenous H2O2 on Heart Muscle Contractility and 45Ca uptake were studied. Here we compared the obtained data with the previous results of the effects of MPS on Heart Muscle Contractility and 45Ca uptake. We found that exogenous H2O2 and MPS have similar effects on Na+–K+ pump-induced transient inhibition of Muscle Contractility and 45Ca uptake. The Na+–K+ pump-induced depression of H2O2-sensitivity of Muscle Contractility is determined by activation of Ca2+ efflux from the cell. On the basis of these data we suggest the exogenous H2O2 as a possible messenger through which the stimulation effect of MPS on Heart Muscle is realized. Bioelectromagnetics 29:549–558, 2008. © 2008 Wiley-Liss, Inc.
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The comparative study of the effects of 4 Hz Electromagnetic Fields-, Infrasound-treated and hydrogen peroxide containing physiological solutions on Na pump-induced inhibition of Heart Muscle Contractility
The Environmentalist, 2007Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, Anahit Grigoryan, Sinerik AyrapetyanAbstract:The effects of 4 Hz extremely low frequency Electromagnetic Fields (ELF EMF), Infrasound (IS) and hydrogen peroxide (H_2O_2) on Na^+–K^+ pump-induced transient inhibition of Heart Muscle Contractility was studied. It was documented that EMF-treated and H_2O_2-containing physiological solution had synergic depressing effect on Na^+–K^+ pump-induced inhibition of Muscle Contractility, while the IS had elevation effect on it. On the basis of the obtained data the H_2O_2 could be suggested as the messenger through which the stimulation effect of EMF on Heart Muscle is realised, while the relaxing effect of IS on Heart Contractility is due to the decrease of CO_2 solubility of Muscle bathing aqueous medium.
Lilia Narinyan - One of the best experts on this subject based on the ideXlab platform.
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age dependent impairment of Heart Muscle Contractility as a primary mechanism for overexpression of na ca 2 exchanger in brain cortex tissues
European Journal of Biophysics, 2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:The cognitive function of brain and Contractility of Heart Muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and Heart Muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and Heart Muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of Heart Muscle Contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced Muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
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Age-Dependent Impairment of Heart Muscle Contractility as a Primary Mechanism for Overexpression of Na + /Ca 2+ Exchanger in Brain Cortex Tissues
2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:The cognitive function of brain and Contractility of Heart Muscle are accompanied with age-dependent dehydration of tissues of these two organs. The aim of the present study is to reveal which of the abovementioned two organs primarily fail as a result of dysfunction of age-sensitive metabolic mechanism. For this purpose, the age-dependent sensitivity of cell hydration in brain cortex and Heart Muscle tissues are studied through depressing metabolic activity by cooling and its activation by supplying animals with distilled water, by inactivation of Na+/K+ pump and activation of Na+/Ca2+ exchange in the reverse mode. The obtained data bring us to the conclusion that the metabolic regulation of brain cortex and Heart Muscle tissues has different nature. The age-dependent dysfunction of Na+/K+ pump–induced activation of RNa+/Ca2+ exchange leads to dysfunction of Heart Muscle Contractility because of activation of Ca-calmoduline-NO-cGMP production, which brings to FNa+/Ca2+ exchange induced Muscle relaxation and it could serve as a primary mechanism for dysfunction of brain tissues’ metabolic control of cell hydration, which leads to overexpression of Na+/Ca2+ exchanger in the membrane.
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Age-Dependent Comparative Study of 4 Hz and 8 Hz EMF Exposure on Heart Muscle Tissue Hydration of Rats
Open Journal of Biophysics, 2019Co-Authors: Lilia Narinyan, Sinerik AyrapetyanAbstract:Previously we have shown that 4 Hz and 8 Hz EMF exposures have depressing effect on the thermodynamic activity of water, which decreases peroxide formation. It has also been shown that 4 Hz EMF-treated physiological solution modulates the growth and development of microbes and Heart Muscle Contractility, but 8 Hz EMF has pronounced inhibitory effect on bacterial growth and development. Therefore, in order to elucidate the possible mechanism of 4 Hz and 8 Hz EMF effects on Heart Muscle function, in the present work the effects of 4 Hz and 8 Hz EMF exposures on Heart Muscle tissue hydration, the sensitivity of 4 Hz and 8 Hz EMF-induced tissue hydration to 10−4 M ouabain (Na+/K+ pump inhibition) and 10−9 M ouabain (activation of intracellular signaling system) as well as the effects of 4 Hz and 8 Hz EMF exposures on the number of Na+/K+ pump units in the membrane of both young and old rats have been studied. The obtained data allow us to suggest that 8 Hz EMF exposure has more pronounced age-dependent modulation effect on tissue hydration of Heart Muscle than 4 Hz EMF and this effect is sensitive to Na+/K+ pump activity and intracellular signaling system.
Anahit Grigoryan - One of the best experts on this subject based on the ideXlab platform.
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The comparative study of the effects of 4 Hz Electromagnetic Fields-, Infrasound-treated and hydrogen peroxide containing physiological solutions on Na pump-induced inhibition of Heart Muscle Contractility
The Environmentalist, 2007Co-Authors: Gayane Ayrapetyan, Erna Dadasyan, Anahit Grigoryan, Sinerik AyrapetyanAbstract:The effects of 4 Hz extremely low frequency Electromagnetic Fields (ELF EMF), Infrasound (IS) and hydrogen peroxide (H_2O_2) on Na^+–K^+ pump-induced transient inhibition of Heart Muscle Contractility was studied. It was documented that EMF-treated and H_2O_2-containing physiological solution had synergic depressing effect on Na^+–K^+ pump-induced inhibition of Muscle Contractility, while the IS had elevation effect on it. On the basis of the obtained data the H_2O_2 could be suggested as the messenger through which the stimulation effect of EMF on Heart Muscle is realised, while the relaxing effect of IS on Heart Contractility is due to the decrease of CO_2 solubility of Muscle bathing aqueous medium.
