The Experts below are selected from a list of 54 Experts worldwide ranked by ideXlab platform
Jingping Zhao - One of the best experts on this subject based on the ideXlab platform.
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Dysfunction in Serotonergic and Noradrenergic Systems and Somatic Symptoms in Psychiatric Disorders
Frontiers in Psychiatry, 2019Co-Authors: Jingping ZhaoAbstract:Somatic symptoms include a range of physical experiences, such as pain, muscle tension, body shaking, difficulty in breathing, Heart Palpitation, blushing, fatigue, and sweating. Somatic symptoms are common in major depressive disorder (MDD), anxiety disorders, and some other psychiatric disorders. However, the etiology of somatic symptoms remains unclear. Somatic symptoms could be a response to emotional distress in patients with those psychiatric conditions. Increasing evidence supports the role of aberrant serotoninergic and noradrenergic neurotransmission in somatic symptoms. The physiological alterations underlying diminished serotonin (5-HT) and norepinephrine (NE) signaling may contribute to impaired signal transduction, reduced 5-HT, or NE release from terminals of presynaptic neurons, and result in alternations in function and/or number of receptors and changes in intracellular signal processing. Multiple resources of data support each of these mechanisms. Animal models have shown physiological responses, similar as somatic symptoms seen in psychiatric patients, after manipulations of 5-HT and NE neurotransmission. Human genetic studies have identified many single-nucleotide polymorphisms risk loci associated with somatic symptoms. Several neuroimaging findings support that somatic symptoms are possibly associated with a state of reduced receptor binding. This narrative literature review was to discuss the involvement of serotonergic and noradrenergic systems in the pathophysiology of somatic symptoms. Future research combining neuroimaging techniques and genetic analysis to further elucidate the biological mechanisms of somatic symptoms and to develop novel treatment strategies is needed.
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dysfunction in serotonergic and noradrenergic systems and somatic symptoms in psychiatric disorders
Frontiers in Psychiatry, 2019Co-Authors: Jingping ZhaoAbstract:Somatic symptoms include a range of physical experiences, such as pain, muscle tension, body shaking, difficulty in breathing, Heart Palpitation, blushing, fatigue, and sweating. Somatic symptoms are common in major depressive disorder (MDD), anxiety disorders, and some other psychiatric disorders. However, the etiology of somatic symptoms remains unclear. Somatic symptoms could be a response to emotional distress in patients with those psychiatric conditions. Increasing evidence supports the role of aberrant serotoninergic and noradrenergic neurotransmission in somatic symptoms. The physiological alterations underlying diminished serotonin (5-HT) and norepinephrine (NE) signaling may contribute to impaired signal transduction, reduced 5-HT, or NE release from terminals of presynaptic neurons, and result in alternations in function and/or number of receptors and changes in intracellular signal processing. Multiple resources of data support each of these mechanisms. Animal models have shown physiological responses, similar to somatic symptoms seen in psychiatric patients, after manipulations of 5-HT and NE neurotransmission. Human genetic studies have identified many single-nucleotide polymorphisms risk loci associated with somatic symptoms. Several neuroimaging findings support that somatic symptoms are possibly associated with a state of reduced receptor binding. This narrative literature review aimed to discuss the involvement of serotonergic and noradrenergic systems in the pathophysiology of somatic symptoms. Future research combining neuroimaging techniques and genetic analysis to further elucidate the biological mechanisms of somatic symptoms and to develop novel treatment strategies is needed.
Sima Sadrai - One of the best experts on this subject based on the ideXlab platform.
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Heart Palpitation relief with melissa officinalis leaf extract double blind randomized placebo controlled trial of efficacy and safety
Journal of Ethnopharmacology, 2015Co-Authors: Fatemeh Alijaniha, Mohsen Naseri, Suleiman Afsharypuor, Faramarz Fallahi, Ahmad Ali Noorbala, Mahmood Mosaddegh, Soghrat Faghihzadeh, Sima SadraiAbstract:Abstract Ethnopharmacological relevance In Traditional Iranian Medicine (TIM), Melissa officinalis L. is commonly regarded as an effective therapy for Heart Palpitations. Objective Heart Palpitation is a common complaint that is often benign and associated with a marked distress that makes the condition difficult to treat. Herbal medicines provide an alternative to conventional drugs for treating various kinds of diseases. This study was done as a double blind randomized placebo-controlled clinical trial to evaluate the efficacy and safety of the dried extract of M. officinalis on adults suffering from benign Palpitations. Materials and methods Eligible volunteers were randomly assigned as outpatients to a 14 day treatment with 500 mg twice a day of lyophilized aqueous extract of M. officinalis leaves (or placebo). Participants in the tests, physicians and researchers were blind to group assignments. Both primary and secondary outcomes were patient-reported. Primary outcomes were obtained from two measures: mean frequency of Palpitation episodes per week, derived from patients׳ diaries, and mean intensity of Palpitation estimated through Visual Analogue Scale (VAS) in a self-report questionnaire. Psychiatric symptoms (somatization, anxiety and insomnia, social dysfunction and severe depression) were evaluated as secondary outcomes by General Health Questionnaire-28 (GHQ-28), before and after intervention. Results Fifty-five volunteers out of 71 recruited study subjects completed the trial. Results showed that 14-day of treatment with lyophilized aqueous extract of M. officinalis leaves reduced frequency of Palpitation episodes and significantly reduced the number of anxious patients in comparison to the placebo ( P =0.0001, P =0.004 resp.). Also, M. officinalis extract showed no indication of any serious side effects. Conclusion Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign Palpitations.
Fatemeh Alijaniha - One of the best experts on this subject based on the ideXlab platform.
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Heart Palpitation relief with melissa officinalis leaf extract double blind randomized placebo controlled trial of efficacy and safety
Journal of Ethnopharmacology, 2015Co-Authors: Fatemeh Alijaniha, Mohsen Naseri, Suleiman Afsharypuor, Faramarz Fallahi, Ahmad Ali Noorbala, Mahmood Mosaddegh, Soghrat Faghihzadeh, Sima SadraiAbstract:Abstract Ethnopharmacological relevance In Traditional Iranian Medicine (TIM), Melissa officinalis L. is commonly regarded as an effective therapy for Heart Palpitations. Objective Heart Palpitation is a common complaint that is often benign and associated with a marked distress that makes the condition difficult to treat. Herbal medicines provide an alternative to conventional drugs for treating various kinds of diseases. This study was done as a double blind randomized placebo-controlled clinical trial to evaluate the efficacy and safety of the dried extract of M. officinalis on adults suffering from benign Palpitations. Materials and methods Eligible volunteers were randomly assigned as outpatients to a 14 day treatment with 500 mg twice a day of lyophilized aqueous extract of M. officinalis leaves (or placebo). Participants in the tests, physicians and researchers were blind to group assignments. Both primary and secondary outcomes were patient-reported. Primary outcomes were obtained from two measures: mean frequency of Palpitation episodes per week, derived from patients׳ diaries, and mean intensity of Palpitation estimated through Visual Analogue Scale (VAS) in a self-report questionnaire. Psychiatric symptoms (somatization, anxiety and insomnia, social dysfunction and severe depression) were evaluated as secondary outcomes by General Health Questionnaire-28 (GHQ-28), before and after intervention. Results Fifty-five volunteers out of 71 recruited study subjects completed the trial. Results showed that 14-day of treatment with lyophilized aqueous extract of M. officinalis leaves reduced frequency of Palpitation episodes and significantly reduced the number of anxious patients in comparison to the placebo ( P =0.0001, P =0.004 resp.). Also, M. officinalis extract showed no indication of any serious side effects. Conclusion Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign Palpitations.
Soghrat Faghihzadeh - One of the best experts on this subject based on the ideXlab platform.
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Heart Palpitation relief with melissa officinalis leaf extract double blind randomized placebo controlled trial of efficacy and safety
Journal of Ethnopharmacology, 2015Co-Authors: Fatemeh Alijaniha, Mohsen Naseri, Suleiman Afsharypuor, Faramarz Fallahi, Ahmad Ali Noorbala, Mahmood Mosaddegh, Soghrat Faghihzadeh, Sima SadraiAbstract:Abstract Ethnopharmacological relevance In Traditional Iranian Medicine (TIM), Melissa officinalis L. is commonly regarded as an effective therapy for Heart Palpitations. Objective Heart Palpitation is a common complaint that is often benign and associated with a marked distress that makes the condition difficult to treat. Herbal medicines provide an alternative to conventional drugs for treating various kinds of diseases. This study was done as a double blind randomized placebo-controlled clinical trial to evaluate the efficacy and safety of the dried extract of M. officinalis on adults suffering from benign Palpitations. Materials and methods Eligible volunteers were randomly assigned as outpatients to a 14 day treatment with 500 mg twice a day of lyophilized aqueous extract of M. officinalis leaves (or placebo). Participants in the tests, physicians and researchers were blind to group assignments. Both primary and secondary outcomes were patient-reported. Primary outcomes were obtained from two measures: mean frequency of Palpitation episodes per week, derived from patients׳ diaries, and mean intensity of Palpitation estimated through Visual Analogue Scale (VAS) in a self-report questionnaire. Psychiatric symptoms (somatization, anxiety and insomnia, social dysfunction and severe depression) were evaluated as secondary outcomes by General Health Questionnaire-28 (GHQ-28), before and after intervention. Results Fifty-five volunteers out of 71 recruited study subjects completed the trial. Results showed that 14-day of treatment with lyophilized aqueous extract of M. officinalis leaves reduced frequency of Palpitation episodes and significantly reduced the number of anxious patients in comparison to the placebo ( P =0.0001, P =0.004 resp.). Also, M. officinalis extract showed no indication of any serious side effects. Conclusion Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign Palpitations.
Mohsen Naseri - One of the best experts on this subject based on the ideXlab platform.
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Heart Palpitation relief with melissa officinalis leaf extract double blind randomized placebo controlled trial of efficacy and safety
Journal of Ethnopharmacology, 2015Co-Authors: Fatemeh Alijaniha, Mohsen Naseri, Suleiman Afsharypuor, Faramarz Fallahi, Ahmad Ali Noorbala, Mahmood Mosaddegh, Soghrat Faghihzadeh, Sima SadraiAbstract:Abstract Ethnopharmacological relevance In Traditional Iranian Medicine (TIM), Melissa officinalis L. is commonly regarded as an effective therapy for Heart Palpitations. Objective Heart Palpitation is a common complaint that is often benign and associated with a marked distress that makes the condition difficult to treat. Herbal medicines provide an alternative to conventional drugs for treating various kinds of diseases. This study was done as a double blind randomized placebo-controlled clinical trial to evaluate the efficacy and safety of the dried extract of M. officinalis on adults suffering from benign Palpitations. Materials and methods Eligible volunteers were randomly assigned as outpatients to a 14 day treatment with 500 mg twice a day of lyophilized aqueous extract of M. officinalis leaves (or placebo). Participants in the tests, physicians and researchers were blind to group assignments. Both primary and secondary outcomes were patient-reported. Primary outcomes were obtained from two measures: mean frequency of Palpitation episodes per week, derived from patients׳ diaries, and mean intensity of Palpitation estimated through Visual Analogue Scale (VAS) in a self-report questionnaire. Psychiatric symptoms (somatization, anxiety and insomnia, social dysfunction and severe depression) were evaluated as secondary outcomes by General Health Questionnaire-28 (GHQ-28), before and after intervention. Results Fifty-five volunteers out of 71 recruited study subjects completed the trial. Results showed that 14-day of treatment with lyophilized aqueous extract of M. officinalis leaves reduced frequency of Palpitation episodes and significantly reduced the number of anxious patients in comparison to the placebo ( P =0.0001, P =0.004 resp.). Also, M. officinalis extract showed no indication of any serious side effects. Conclusion Lyophilized aqueous extract of M. officinalis leaves may be a proper and safe herbal drug for the treatment of benign Palpitations.
