The Experts below are selected from a list of 57 Experts worldwide ranked by ideXlab platform
Edmund Koch - One of the best experts on this subject based on the ideXlab platform.
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Heart Valve Stenosis in laser spotlights: Insights into a complex disease
Clinical hemorheology and microcirculation, 2014Co-Authors: Petra Büttner, Roberta Galli, Anett Jannasch, Christian Schnabel, Thomas Waldow, Edmund KochAbstract:Degenerative Heart Valve disease is a life-threatening disease affecting about 3% of the population over 65 years. Up to date, cardiac surgery with Heart Valve replacement is the only available therapy. The disease is characterized by degenerative disorganization of the Heart Valve structure and alterations in the residing cell populations. Causes and mechanisms of disease genesis are still not fully understood and until now pharmacological therapies are not available. Thus there is enormous interest in new technologies that enable a better characterization of structure and composition of diseased Valves. Currently most research techniques demand for extensive processing of extracted Valve material. We present a novel approach combining coherent anti-Stokes Raman scattering, endogenous two-photon excited fluorescence and second harmonic generation. Cusp constituents can be examined simultaneously, three-dimensionally and without extensive manipulation of the sample enabling impressive insights into a complex disease.
Gerard Pasterkamp - One of the best experts on this subject based on the ideXlab platform.
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In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact.
Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 2015Co-Authors: Amir Basir, Philip De Groot, Paul F. Gründeman, Claudia Tersteeg, Coen Maas, Arjan D. Barendrecht, Joost A. Van Herwaarden, Jolanda Kluin, Frans L. Moll, Gerard PasterkampAbstract:OBJECTIVE Heart Valve and vascular prosthesis implantation is a common procedure for patients with Heart Valve Stenosis or regurgitation and dilated or obstructive vascular disease. Drawbacks of conventional Valve prostheses are the requirement for anticoagulant drugs, moderate durability, and suboptimal resistance to fatigue and tear. Dyneema Purity fibers are made from ultra-high-molecular-weight polyethylene filaments and are very thin, flexible, and fatigue and abrasion resistant and have high strength. Therefore, prostheses made from Dyneema Purity fibers might be attractive for use in the minimally invasive treatment of valvular- and vascular diseases. The aim of this study was to test the hemocompatibility of Dyneema Purity fibers in contact with blood. METHODS Real-time platelet adhesion in human blood of 3 volunteers was quantified after 5 minutes of perfusion on single filaments (O 15 μm) of Dyneema Purity and polyester fibers. Plasma thrombin generation was measured by fluoroscopy for patches of Dyneema Purity fibers and for 5 commonly used polyester and expanded polytetrafluoroethylene cardiovascular prostheses. RESULTS Platelet adhesion per 1 mm was 6 ± 1.4 on Dyneema Purity filaments and 15 ± 3.4 on polyester filaments (P = 0.02). Total formed thrombin and the time to peak of its maximum were noninferior for patches of Dyneema Purity fibers compared with the reference materials. CONCLUSIONS Dyneema Purity fibers are noninferior in adhesion and coagulation activation compared with commonly used cardiovascular prostheses.
Pasterkamp Gerard - One of the best experts on this subject based on the ideXlab platform.
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In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact
Sage Publications Inc, 2015Co-Authors: Basir Amir, Moll Frans, De Groot Philip, Gründeman, Paul F, Tersteeg Claudia, Maas Coen, Barendrecht Arjan, Van Herwaarden Joost, Kluin Jolanda, Pasterkamp GerardAbstract:Heart Valve and vascular prosthesis implantation is a common procedure for patients with Heart Valve Stenosis or regurgitation and dilated or obstructive vascular disease. Drawbacks of conventional Valve prostheses are the requirement for anticoagulant drugs, moderate durability, and suboptimal resistance to fatigue and tear. Dyneema Purity fibers are made from ultra-high-molecular-weight polyethylene filaments and are very thin, flexible, and fatigue and abrasion resistant and have high strength. Therefore, prostheses made from Dyneema Purity fibers might be attractive for use in the minimally invasive treatment of valvular- and vascular diseases. The aim of this study was to test the hemocompatibility of Dyneema Purity fibers in contact with blood.status: publishe
Petra Büttner - One of the best experts on this subject based on the ideXlab platform.
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Heart Valve Stenosis in laser spotlights: Insights into a complex disease
Clinical hemorheology and microcirculation, 2014Co-Authors: Petra Büttner, Roberta Galli, Anett Jannasch, Christian Schnabel, Thomas Waldow, Edmund KochAbstract:Degenerative Heart Valve disease is a life-threatening disease affecting about 3% of the population over 65 years. Up to date, cardiac surgery with Heart Valve replacement is the only available therapy. The disease is characterized by degenerative disorganization of the Heart Valve structure and alterations in the residing cell populations. Causes and mechanisms of disease genesis are still not fully understood and until now pharmacological therapies are not available. Thus there is enormous interest in new technologies that enable a better characterization of structure and composition of diseased Valves. Currently most research techniques demand for extensive processing of extracted Valve material. We present a novel approach combining coherent anti-Stokes Raman scattering, endogenous two-photon excited fluorescence and second harmonic generation. Cusp constituents can be examined simultaneously, three-dimensionally and without extensive manipulation of the sample enabling impressive insights into a complex disease.
Amir Basir - One of the best experts on this subject based on the ideXlab platform.
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In Vitro Hemocompatibility Testing of Dyneema Purity Fibers in Blood Contact.
Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 2015Co-Authors: Amir Basir, Philip De Groot, Paul F. Gründeman, Claudia Tersteeg, Coen Maas, Arjan D. Barendrecht, Joost A. Van Herwaarden, Jolanda Kluin, Frans L. Moll, Gerard PasterkampAbstract:OBJECTIVE Heart Valve and vascular prosthesis implantation is a common procedure for patients with Heart Valve Stenosis or regurgitation and dilated or obstructive vascular disease. Drawbacks of conventional Valve prostheses are the requirement for anticoagulant drugs, moderate durability, and suboptimal resistance to fatigue and tear. Dyneema Purity fibers are made from ultra-high-molecular-weight polyethylene filaments and are very thin, flexible, and fatigue and abrasion resistant and have high strength. Therefore, prostheses made from Dyneema Purity fibers might be attractive for use in the minimally invasive treatment of valvular- and vascular diseases. The aim of this study was to test the hemocompatibility of Dyneema Purity fibers in contact with blood. METHODS Real-time platelet adhesion in human blood of 3 volunteers was quantified after 5 minutes of perfusion on single filaments (O 15 μm) of Dyneema Purity and polyester fibers. Plasma thrombin generation was measured by fluoroscopy for patches of Dyneema Purity fibers and for 5 commonly used polyester and expanded polytetrafluoroethylene cardiovascular prostheses. RESULTS Platelet adhesion per 1 mm was 6 ± 1.4 on Dyneema Purity filaments and 15 ± 3.4 on polyester filaments (P = 0.02). Total formed thrombin and the time to peak of its maximum were noninferior for patches of Dyneema Purity fibers compared with the reference materials. CONCLUSIONS Dyneema Purity fibers are noninferior in adhesion and coagulation activation compared with commonly used cardiovascular prostheses.
