The Experts below are selected from a list of 126 Experts worldwide ranked by ideXlab platform
Håkan Arheden - One of the best experts on this subject based on the ideXlab platform.
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Center of Volume and total Heart Volume variation in healthy subjects and patients before and after coronary bypass surgery.
Clinical physiology and functional imaging, 2005Co-Authors: Marcus Carlsson, Peter A. Cain, Anders H. Rosengren, Martin Ugander, Ulf Ekelund, Håkan ArhedenAbstract:BACKGROUND: Total Heart Volume variation (THVV) and center of Volume variation (COVV) likely affects the efficiency of cardiac pumping, but no study has determined COVV of the Heart throughout the cardiac cycle or the effect of surgery on THVV in adults. Therefore, the purposes of this study were to determine COVV in healthy adults and patients with cardiac failure due to ischemic Heart disease (IHD), identify any difference in THVV between these two groups, and determine how these parameters are affected by coronary bypass surgery. METHODS: Six healthy volunteers and eight patients before and after surgery were investigated with cardiovascular magnetic resonance imaging. The atrioventricular plane movement (AVPM), THVV and time resolved three-dimensional coordinates of the center of the cardiac Volume (COVV) were measured. RESULTS: COVV followed a loop in 3D space that between the end-points was approximately 2 mm with no difference between healthy subjects and patients before surgery (P = 0.093), although AVPM was significantly lower in patients (P = 0.002). However, after surgery the COVV during the cardiac cycle doubled (P = 0.012) and the increase in THVV was significant (P = 0.050), although of very small magnitude, and the AVPM remained unchanged (P = 0.401). CONCLUSION: COVV and THVV were similar in patients and healthy subjects even though AVPM was lower in the patient population. After surgery, however, COVV doubled despite a very small change in THVV and no change in AVPM. Taken together, the results of this study may provide new insights into the energy expenditure and efficiency of cardiac pumping.
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Total Heart Volume variation throughout the cardiac cycle in humans.
American Journal of Physiology-heart and Circulatory Physiology, 2004Co-Authors: Marcus Carlsson, Peter A. Cain, Catarina Holmqvist, Freddy Ståhlberg, Stig Lundback, Håkan ArhedenAbstract:Variations in total Heart Volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors ...
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Total Heart Volume variation throughout the cardiac cycle in humans.
American journal of physiology. Heart and circulatory physiology, 2004Co-Authors: Marcus Carlsson, Catarina Holmqvist, Freddy Ståhlberg, Stig Lundback, Peter Cain, Håkan ArhedenAbstract:Variations in total Heart Volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors of total Heart Volume variation during the cardiac cycle in healthy volunteers with the use of MRI. Eight healthy volunteers were examined by MRI at rest. Changes in total cardiac Volume throughout the cardiac cycle were calculated using the following methods: 1) planimetry derived from gradient-echo cine images and 2) flow-sensitive sequences to quantify flow in all vessels leading to and from the Heart. The maximum total Heart Volume diminished during systole by 8.2 +/- 0.8% (SEM, range 4.8-10.6%) measured by method 1 and 8.8 +/- 1.0% (SEM, range 5.6-11.8%) by method 2 with good agreement between the methods [difference according to Bland-Altman analysis -0.6% +/- 1.0% (SD), intraclass correlation coefficient = 0.999]. This decrease in Volume is predominantly explained by variation at the midcardiac level at the widest diameter of the Heart with a left-sided predominance. In the short axis of the Heart, the change of slice Volume was proportional to the end-diastolic slice Volume. The present study has confirmed the presence of total Heart Volume variation that predominantly occurs in the region of atrioventricular plane movement and on the left side. The total Heart Volume variation may relate to the efficiency of energy use by the Heart to minimize displacement of surrounding tissue while accounting for the energy required to draw blood into the atria during ventricular systole.
Michael Marmot - One of the best experts on this subject based on the ideXlab platform.
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cardiothoracic ratio and relative Heart Volume as predictors of coronary Heart disease mortality the whitehall study 25 year follow up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of Heart size with mortality from coronary Heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative Heart Volume. A high cardiothoracic ratio and relative Heart Volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (<0·40) was associated with a rate ratio of 1·84 (95% CI 1·14‐2·97) for the eVect on coronary Heart disease mortality. Further adjustment for Heart rate, smoking, cholesterol, angina and ECG ischaemia had little eVect, reducing the rate ratio to 1·65 (95% CI 1·01‐2·70). Similar rate ratios were observed for relative Heart Volume. Conclusions Cardiothoracic ratio within the range considered ‘normal’ in clinical practice predicted coronary Heart disease mortality independent of established coronary Heart disease risk factors. The relative Heart Volume, which uses measurements from the lateral as well as the posteroanterior chest X-ray, did not predict coronary Heart disease any better than the cardiothoracic ratio. The extent to which left ventricular mass and systolic dysfunction— pathophysiological correlates of the cardiothoracic ratio and relative Heart Volume — are independent risk factors for coronary Heart disease should be further investigated. (Eur Heart J 1998; 19: 859‐869)
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Cardiothoracic ratio and relative Heart Volume as predictors of coronary Heart disease mortality The Whitehall study 25 year follow-up
European Heart Journal, 1998Co-Authors: Harry Hemingway, D Christie, Martin J Shipley, Michael MarmotAbstract:Aim To examine the association of radiographic measures of Heart size with mortality from coronary Heart disease. Methods and Results One thousand, one hundred and ninety-one male civil servants aged 40‐69 years were followed-up for mortality over 25 years in relation to cardiothoracic ratio and relative Heart Volume. A high cardiothoracic ratio and relative Heart Volume predicted coronary (n=196 deaths) and all-cause mortality, but not respiratory or malignant mortality. After adjustment for age, systolic and diastolic blood pressure, the highest (§0·47) compared to the lowest quintile of the cardiothoracic ratio (
Marcus Carlsson - One of the best experts on this subject based on the ideXlab platform.
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Center of Volume and total Heart Volume variation in healthy subjects and patients before and after coronary bypass surgery.
Clinical physiology and functional imaging, 2005Co-Authors: Marcus Carlsson, Peter A. Cain, Anders H. Rosengren, Martin Ugander, Ulf Ekelund, Håkan ArhedenAbstract:BACKGROUND: Total Heart Volume variation (THVV) and center of Volume variation (COVV) likely affects the efficiency of cardiac pumping, but no study has determined COVV of the Heart throughout the cardiac cycle or the effect of surgery on THVV in adults. Therefore, the purposes of this study were to determine COVV in healthy adults and patients with cardiac failure due to ischemic Heart disease (IHD), identify any difference in THVV between these two groups, and determine how these parameters are affected by coronary bypass surgery. METHODS: Six healthy volunteers and eight patients before and after surgery were investigated with cardiovascular magnetic resonance imaging. The atrioventricular plane movement (AVPM), THVV and time resolved three-dimensional coordinates of the center of the cardiac Volume (COVV) were measured. RESULTS: COVV followed a loop in 3D space that between the end-points was approximately 2 mm with no difference between healthy subjects and patients before surgery (P = 0.093), although AVPM was significantly lower in patients (P = 0.002). However, after surgery the COVV during the cardiac cycle doubled (P = 0.012) and the increase in THVV was significant (P = 0.050), although of very small magnitude, and the AVPM remained unchanged (P = 0.401). CONCLUSION: COVV and THVV were similar in patients and healthy subjects even though AVPM was lower in the patient population. After surgery, however, COVV doubled despite a very small change in THVV and no change in AVPM. Taken together, the results of this study may provide new insights into the energy expenditure and efficiency of cardiac pumping.
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Total Heart Volume variation throughout the cardiac cycle in humans.
American Journal of Physiology-heart and Circulatory Physiology, 2004Co-Authors: Marcus Carlsson, Peter A. Cain, Catarina Holmqvist, Freddy Ståhlberg, Stig Lundback, Håkan ArhedenAbstract:Variations in total Heart Volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors ...
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Total Heart Volume variation throughout the cardiac cycle in humans.
American journal of physiology. Heart and circulatory physiology, 2004Co-Authors: Marcus Carlsson, Catarina Holmqvist, Freddy Ståhlberg, Stig Lundback, Peter Cain, Håkan ArhedenAbstract:Variations in total Heart Volume (atria plus ventricles) during a cardiac cycle affect efficiency of cardiac pumping. The goals of this study were to confirm the presence, extent, and contributors of total Heart Volume variation during the cardiac cycle in healthy volunteers with the use of MRI. Eight healthy volunteers were examined by MRI at rest. Changes in total cardiac Volume throughout the cardiac cycle were calculated using the following methods: 1) planimetry derived from gradient-echo cine images and 2) flow-sensitive sequences to quantify flow in all vessels leading to and from the Heart. The maximum total Heart Volume diminished during systole by 8.2 +/- 0.8% (SEM, range 4.8-10.6%) measured by method 1 and 8.8 +/- 1.0% (SEM, range 5.6-11.8%) by method 2 with good agreement between the methods [difference according to Bland-Altman analysis -0.6% +/- 1.0% (SD), intraclass correlation coefficient = 0.999]. This decrease in Volume is predominantly explained by variation at the midcardiac level at the widest diameter of the Heart with a left-sided predominance. In the short axis of the Heart, the change of slice Volume was proportional to the end-diastolic slice Volume. The present study has confirmed the presence of total Heart Volume variation that predominantly occurs in the region of atrioventricular plane movement and on the left side. The total Heart Volume variation may relate to the efficiency of energy use by the Heart to minimize displacement of surrounding tissue while accounting for the energy required to draw blood into the atria during ventricular systole.
Hamed Emami - One of the best experts on this subject based on the ideXlab platform.
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Small whole Heart Volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial
European Radiology, 2021Co-Authors: Borek Foldyna, Roman Zeleznik, Parastou Eslami, Thomas Mayrhofer, Jan-erik Scholtz, Maros Ferencik, Daniel O. Bittner, Nandini M. Meyersohn, Stefan B. Puchner, Hamed EmamiAbstract:Objectives The size of the Heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole Heart Volume (WHV) derived from non-contrast cardiac computed tomography (CT). Methods Among participants randomized to the CT arm of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE), we used deep learning to extract WHV, defined as the Volume of the pericardial sac. We compared the WHV across categories of cardiovascular risk factors and coronary artery disease (CAD) characteristics and determined the association of WHV with MACE (all-cause death, myocardial infarction, unstable angina; median follow-up: 26 months). Results In the 3798 included patients (60.5 ± 8.2 years; 51.5% women), the WHV was 351.9 ± 57.6 cm^3/m^2. We found smaller WHV in no- or non-obstructive CAD, women, people with diabetes, sedentary lifestyle, and metabolic syndrome. Larger WHV was found in obstructive CAD, men, and increased atherosclerosis cardiovascular disease (ASCVD) risk score ( p < 0.05). In a time-to-event analysis, small WHV was associated with over 4.4-fold risk of MACE (HR (per one standard deviation) = 0.221; 95% CI: 0.068–0.721; p = 0.012) independent of ASCVD risk score and CT-derived CAD characteristics. In patients with non-obstructive CAD, but not in those with no- or obstructive CAD, WHV increased the discriminatory capacity of ASCVD and CT-derived CAD characteristics significantly. Conclusions Small WHV may represent a novel imaging marker of MACE in stable chest pain. In particular, WHV may improve risk stratification in patients with non-obstructive CAD, a cohort with an unmet need for better risk stratification. Key Points • Heart Volume is easily assessable from non-contrast cardiac computed tomography. • Small Heart Volume may be an imaging marker of major adverse cardiac events independent and incremental to traditional cardiovascular risk factors and established CT measures of CAD. • Heart Volume may improve cardiovascular risk stratification in patients with non-obstructive CAD.
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Small whole Heart Volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial.
European radiology, 2021Co-Authors: Borek Foldyna, Roman Zeleznik, Parastou Eslami, Thomas Mayrhofer, Jan-erik Scholtz, Maros Ferencik, Daniel O. Bittner, Nandini M. Meyersohn, Stefan B. Puchner, Hamed EmamiAbstract:The size of the Heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole Heart Volume (WHV) derived from non-contrast cardiac computed tomography (CT). Among participants randomized to the CT arm of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE), we used deep learning to extract WHV, defined as the Volume of the pericardial sac. We compared the WHV across categories of cardiovascular risk factors and coronary artery disease (CAD) characteristics and determined the association of WHV with MACE (all-cause death, myocardial infarction, unstable angina; median follow-up: 26 months). In the 3798 included patients (60.5 ± 8.2 years; 51.5% women), the WHV was 351.9 ± 57.6 cm3/m2. We found smaller WHV in no- or non-obstructive CAD, women, people with diabetes, sedentary lifestyle, and metabolic syndrome. Larger WHV was found in obstructive CAD, men, and increased atherosclerosis cardiovascular disease (ASCVD) risk score (p < 0.05). In a time-to-event analysis, small WHV was associated with over 4.4-fold risk of MACE (HR (per one standard deviation) = 0.221; 95% CI: 0.068–0.721; p = 0.012) independent of ASCVD risk score and CT-derived CAD characteristics. In patients with non-obstructive CAD, but not in those with no- or obstructive CAD, WHV increased the discriminatory capacity of ASCVD and CT-derived CAD characteristics significantly. Small WHV may represent a novel imaging marker of MACE in stable chest pain. In particular, WHV may improve risk stratification in patients with non-obstructive CAD, a cohort with an unmet need for better risk stratification. • Heart Volume is easily assessable from non-contrast cardiac computed tomography. • Small Heart Volume may be an imaging marker of major adverse cardiac events independent and incremental to traditional cardiovascular risk factors and established CT measures of CAD. • Heart Volume may improve cardiovascular risk stratification in patients with non-obstructive CAD.
Borek Foldyna - One of the best experts on this subject based on the ideXlab platform.
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Small whole Heart Volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial
European Radiology, 2021Co-Authors: Borek Foldyna, Roman Zeleznik, Parastou Eslami, Thomas Mayrhofer, Jan-erik Scholtz, Maros Ferencik, Daniel O. Bittner, Nandini M. Meyersohn, Stefan B. Puchner, Hamed EmamiAbstract:Objectives The size of the Heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole Heart Volume (WHV) derived from non-contrast cardiac computed tomography (CT). Methods Among participants randomized to the CT arm of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE), we used deep learning to extract WHV, defined as the Volume of the pericardial sac. We compared the WHV across categories of cardiovascular risk factors and coronary artery disease (CAD) characteristics and determined the association of WHV with MACE (all-cause death, myocardial infarction, unstable angina; median follow-up: 26 months). Results In the 3798 included patients (60.5 ± 8.2 years; 51.5% women), the WHV was 351.9 ± 57.6 cm^3/m^2. We found smaller WHV in no- or non-obstructive CAD, women, people with diabetes, sedentary lifestyle, and metabolic syndrome. Larger WHV was found in obstructive CAD, men, and increased atherosclerosis cardiovascular disease (ASCVD) risk score ( p < 0.05). In a time-to-event analysis, small WHV was associated with over 4.4-fold risk of MACE (HR (per one standard deviation) = 0.221; 95% CI: 0.068–0.721; p = 0.012) independent of ASCVD risk score and CT-derived CAD characteristics. In patients with non-obstructive CAD, but not in those with no- or obstructive CAD, WHV increased the discriminatory capacity of ASCVD and CT-derived CAD characteristics significantly. Conclusions Small WHV may represent a novel imaging marker of MACE in stable chest pain. In particular, WHV may improve risk stratification in patients with non-obstructive CAD, a cohort with an unmet need for better risk stratification. Key Points • Heart Volume is easily assessable from non-contrast cardiac computed tomography. • Small Heart Volume may be an imaging marker of major adverse cardiac events independent and incremental to traditional cardiovascular risk factors and established CT measures of CAD. • Heart Volume may improve cardiovascular risk stratification in patients with non-obstructive CAD.
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Small whole Heart Volume predicts cardiovascular events in patients with stable chest pain: insights from the PROMISE trial.
European radiology, 2021Co-Authors: Borek Foldyna, Roman Zeleznik, Parastou Eslami, Thomas Mayrhofer, Jan-erik Scholtz, Maros Ferencik, Daniel O. Bittner, Nandini M. Meyersohn, Stefan B. Puchner, Hamed EmamiAbstract:The size of the Heart may predict major cardiovascular events (MACE) in patients with stable chest pain. We aimed to evaluate the prognostic value of 3D whole Heart Volume (WHV) derived from non-contrast cardiac computed tomography (CT). Among participants randomized to the CT arm of the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE), we used deep learning to extract WHV, defined as the Volume of the pericardial sac. We compared the WHV across categories of cardiovascular risk factors and coronary artery disease (CAD) characteristics and determined the association of WHV with MACE (all-cause death, myocardial infarction, unstable angina; median follow-up: 26 months). In the 3798 included patients (60.5 ± 8.2 years; 51.5% women), the WHV was 351.9 ± 57.6 cm3/m2. We found smaller WHV in no- or non-obstructive CAD, women, people with diabetes, sedentary lifestyle, and metabolic syndrome. Larger WHV was found in obstructive CAD, men, and increased atherosclerosis cardiovascular disease (ASCVD) risk score (p < 0.05). In a time-to-event analysis, small WHV was associated with over 4.4-fold risk of MACE (HR (per one standard deviation) = 0.221; 95% CI: 0.068–0.721; p = 0.012) independent of ASCVD risk score and CT-derived CAD characteristics. In patients with non-obstructive CAD, but not in those with no- or obstructive CAD, WHV increased the discriminatory capacity of ASCVD and CT-derived CAD characteristics significantly. Small WHV may represent a novel imaging marker of MACE in stable chest pain. In particular, WHV may improve risk stratification in patients with non-obstructive CAD, a cohort with an unmet need for better risk stratification. • Heart Volume is easily assessable from non-contrast cardiac computed tomography. • Small Heart Volume may be an imaging marker of major adverse cardiac events independent and incremental to traditional cardiovascular risk factors and established CT measures of CAD. • Heart Volume may improve cardiovascular risk stratification in patients with non-obstructive CAD.
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small Heart Volume predicts adverse cardiac events in patients with nonobstructive coronary artery disease insights from the prospective multicenter imaging study for evaluation of chest pain promise trial
Journal of the American College of Cardiology, 2019Co-Authors: Borek Foldyna, Parastou Eslami, Thomas Mayrhofer, Jan-erik Scholtz, Maros Ferencik, Daniel O. Bittner, Nandini M. Meyersohn, Balint Szilveszter, Julia Karady, Stefan B. PuchnerAbstract:In the era of advanced cross-sectional imaging, the focus has been on the association of individual Heart chamber sizes and major adverse cardiovascular events (MACE). We explore the potential prognostic value of 3D whole Heart Volume (WHV) with traditional morphometric measures of cardiovascular
