The Experts below are selected from a list of 15894 Experts worldwide ranked by ideXlab platform
Bruno T Roseguini - One of the best experts on this subject based on the ideXlab platform.
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Heat Therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia
Journal of Applied Physiology, 2021Co-Authors: Kyoungrae Kim, Qifan Song, Frederick W Damen, Daniel P Gramling, Trevor D Lehr, Craig J Goergen, Bruno T RoseguiniAbstract:Heat Therapy (HT) has emerged as a potential adjunctive Therapy to alleviate the symptoms of peripheral artery disease (PAD), but the mechanisms underlying the positive effects of this treatment mo...
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Heat Therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia
Journal of Applied Physiology, 2021Co-Authors: Kyoungrae Kim, Qifan Song, Frederick W Damen, Daniel P Gramling, Trevor D Lehr, Craig J Goergen, Bruno T RoseguiniAbstract:The epidemic of obesity-related dyslipidemia and diabetes is a central cause of the increasing burden of peripheral artery disease (PAD), but few accessible therapies exist to mitigate the metaboli...
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acute effects of leg Heat Therapy on walking performance and cardiovascular and inflammatory responses to exercise in patients with peripheral artery disease
Physiological Reports, 2021Co-Authors: Jacob C Monroe, Qifan Song, Raghu L Motaganahalli, Michael S Emery, Daniel M Hirai, Bruno T RoseguiniAbstract:Lower-extremity peripheral artery disease (PAD) is associated with increased risk of cardiovascular events and impaired exercise tolerance. We have previously reported that leg Heat Therapy (HT) applied using liquid-circulating trousers perfused with warm water increases leg blood flow and reduces blood pressure (BP) and the circulating levels of endothelin-1 (ET-1) in patients with symptomatic PAD. In this sham-controlled, randomized, crossover study, sixteen patients with symptomatic PAD (age 65 ± 5.7 years and ankle-brachial index: 0.69 ± 0.1) underwent a single 90-min session of HT or a sham treatment prior to a symptom-limited, graded cardiopulmonary exercise test on the treadmill. The primary outcome was the peak walking time (PWT) during the exercise test. Secondary outcomes included the claudication onset time (COT), resting and exercise BP, calf muscle oxygenation, pulmonary oxygen uptake (VO2 ), and plasma levels of ET-1, interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α). Systolic, but not diastolic BP, was significantly lower (~7 mmHg, p < .05) during HT when compared to the sham treatment. There was also a trend for lower SBP throughout the exercise and the recovery period following HT (p = .057). While COT did not differ between treatments (p = .77), PWT tended to increase following HT (CON: 911 ± 69 s, HT: 954 ± 77 s, p = .059). Post-exercise plasma levels of ET-1 were also lower in the HT session (CON: 2.0 ± 0.1, HT: 1.7 ± 0.1, p = .02). Calf muscle oxygenation, VO2 , COT, IL-6, and TNF-α did not differ between treatments. A single session of leg HT lowers BP and post-exercise circulating levels of ET-1 and may enhance treadmill walking performance in symptomatic PAD patients.
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leg Heat Therapy improves perceived physical function but does not enhance walking capacity or vascular function in patients with peripheral artery disease
Journal of Applied Physiology, 2020Co-Authors: Jacob C Monroe, Chen Lin, Susan M Perkins, Yan Han, Brett J Wong, Raghu L Motaganahalli, Bruno T RoseguiniAbstract:This is the first sham-controlled study to investigate the effects of leg Heat Therapy (HT) on walking performance, vascular function, and quality of life in patients with peripheral artery disease...
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skeletal muscle adaptations to Heat Therapy
Journal of Applied Physiology, 2020Co-Authors: Kyoungrae Kim, Timothy P Gavin, Jacob C Monroe, Bruno T RoseguiniAbstract:The therapeutic effects of Heat have been harnessed for centuries to treat skeletal muscle disorders and other pathologies. However, the fundamental mechanisms underlying the well-documented clinical benefits associated with Heat Therapy (HT) remain poorly defined. Foundational studies in cultured skeletal muscle and endothelial cells, as well as in rodents, revealed that episodic exposure to Heat stress activates a number of intracellular signaling networks and promotes skeletal muscle remodeling. Renewed interest in the physiology of HT in recent years has provided greater understanding of the signals and molecular players involved in the skeletal muscle adaptations to episodic exposures to HT. It is increasingly clear that Heat stress promotes signaling mechanisms involved in angiogenesis, muscle hypertrophy, mitochondrial biogenesis, and glucose metabolism through not only elevations in tissue temperature but also other perturbations, including increased intramyocellular calcium and enhanced energy turnover. The few available translational studies seem to indicate that the earlier observations in rodents also apply to human skeletal muscle. Indeed, recent findings revealed that both local and whole-body HT may promote capillary growth, enhance mitochondrial content and function, improve insulin sensitivity and attenuate disuse-induced muscle wasting. This accumulating body of work implies that HT may be a practical treatment to combat skeletal abnormalities in individuals with chronic disease who are unwilling or cannot participate in traditional exercise-training regimens.
Christopher T. Minson - One of the best experts on this subject based on the ideXlab platform.
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Heat Therapy mechanistic underpinnings and applications to cardiovascular health
Journal of Applied Physiology, 2021Co-Authors: Vienna E. Brunt, Christopher T. MinsonAbstract:Cardiovascular diseases (CVD) are the leading cause of death worldwide, and novel therapies are drastically needed to prevent or delay the onset of CVD to reduce the societal and healthcare burdens associated with these chronic diseases. One such Therapy is "Heat Therapy," or chronic, repeated use of hot baths or saunas. Although using Heat exposure to improve health is not a new concept, it has received renewed attention in recent years as a growing number of studies have demonstrated robust and widespread beneficial effects of Heat Therapy on cardiovascular health. Here, we review the existing literature, with particular focus on the molecular mechanisms that underscore the cardiovascular benefits of this practice.
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Heat Therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2019Co-Authors: Vienna E. Brunt, Lindan N. Comrada, Michael A. Francisco, Brett R Ely, John R Halliwill, Samantha D Bryan, Emily A Larson, Christopher T. MinsonAbstract:Polycystic ovary syndrome (PCOS) affects up to 15% of women and is associated with increased risk of obesity and cardiovascular disease. Repeated passive Heat exposure [termed “Heat Therapy” (HT)] ...
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Heat Therapy improves glucose tolerance and adipose tissue insulin signaling in polycystic ovary syndrome
American Journal of Physiology-endocrinology and Metabolism, 2019Co-Authors: Brett R Ely, Lindan N. Comrada, Zachary S Clayton, Carrie E Mccurdy, Joshua Pfeiffer, Karen Wiedenfeld Needham, Christopher T. MinsonAbstract:Polycystic ovary syndrome (PCOS) is associated with high rates of obesity and metabolic dysfunction. Repeated passive Heat exposure (termed Heat Therapy) is a novel lifestyle intervention for impro...
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passive Heat Therapy protects against endothelial cell hypoxia reoxygenation via effects of elevations in temperature and circulating factors
The Journal of Physiology, 2018Co-Authors: Vienna E. Brunt, Lindan N. Comrada, Karen Wiedenfeldneedham, Christopher T. MinsonAbstract:Key points Accumulating evidence indicates that passive Heat Therapy (chronic use of hot tubs or saunas) has widespread physiological benefits, including enhanced resistance against novel stressors ('stress resistance'). Using a cell culture model to isolate the key stimuli that are likely to underlie physiological adaptation with Heat Therapy, we showed that both mild elevations in temperature (to 39°C) and exposure to serum from human subjects who have undergone 8 weeks of Heat Therapy (i.e. altered circulating factors) independently prevented oxidative and inflammatory stress associated with hypoxia-reoxygenation in cultured endothelial cells. Our results elucidate some of the mechanisms (i.e. direct effects of temperature vs. circulating factors) by which Heat Therapy seems to improve resistance against oxidative and inflammatory stress. Heat Therapy may be a promising intervention for reducing cellular damage following ischaemic events, which has broad implications for patients with cardiovascular diseases and conditions characterized by 'chronic' ischaemia (e.g. peripheral artery disease, metabolic diseases, obesity). Abstract Repeated exposure to passive Heat stress ('Heat Therapy') has widespread physiological benefits, including cellular protection against novel stressors. Increased Heat shock protein (HSP) expression and upregulation of circulating factors may impart this protection. We tested the isolated abilities of mild Heat pretreatment and serum from human subjects (n = 10) who had undergone 8 weeks of Heat Therapy to protect against cellular stress following hypoxia-reoxygenation (H/R), a model of ischaemic cardiovascular events. Cultured human umbilical vein endothelial cells were incubated for 24 h at 37°C (control), 39°C (Heat pretreatment) or 37°C with 10% serum collected before and after 8 weeks of passive Heat Therapy (four to five times per week to increase rectal temperature to ≥ 38.5°C for 60 min). Cells were then collected before and after incubation at 1% O2 for 16 h (hypoxia; 37°C), followed by 20% O2 for 4 h (reoxygenation; 37°C) and assessed for markers of cell stress. In control cells, H/R increased nuclear NF-κB p65 protein (i.e. activation) by 106 ± 38%, increased IL-6 release by 37 ± 8% and increased superoxide production by 272 ± 45%. Both Heat pretreatment and exposure to Heat Therapy serum prevented H/R-induced NF-κB activation and attenuated superoxide production; by contrast, only exposure to serum attenuated IL-6 release. H/R also decreased cytoplasmic haemeoxygenase-1 (HO-1) protein (known to suppress NF-κB), in control cells (-25 ± 8%), whereas HO-1 protein increased following H/R in cells pretreated with Heat or serum-exposed, providing a possible mechanism of protection against H/R. These data indicate Heat Therapy is capable of imparting resistance against inflammatory and oxidative stress via direct Heat and humoral factors.
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Heat Therapy decreases adipose tissue inflammation and improves insulin signaling in polycystic ovary syndrome
The FASEB Journal, 2018Co-Authors: Brett R Ely, Zachary S Clayton, Carrie E Mccurdy, Joshua Pfeiffer, Karen Wiedenfeld Needham, Christopher T. MinsonAbstract:Passive hot water immersion promotes improvements in glucose control in humans, potentially by enhancing insulin sensitivity. In animal models, this improvement is mediated by increased Heat shock ...
Vienna E. Brunt - One of the best experts on this subject based on the ideXlab platform.
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Heat Therapy mechanistic underpinnings and applications to cardiovascular health
Journal of Applied Physiology, 2021Co-Authors: Vienna E. Brunt, Christopher T. MinsonAbstract:Cardiovascular diseases (CVD) are the leading cause of death worldwide, and novel therapies are drastically needed to prevent or delay the onset of CVD to reduce the societal and healthcare burdens associated with these chronic diseases. One such Therapy is "Heat Therapy," or chronic, repeated use of hot baths or saunas. Although using Heat exposure to improve health is not a new concept, it has received renewed attention in recent years as a growing number of studies have demonstrated robust and widespread beneficial effects of Heat Therapy on cardiovascular health. Here, we review the existing literature, with particular focus on the molecular mechanisms that underscore the cardiovascular benefits of this practice.
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Heat Therapy reduces sympathetic activity and improves cardiovascular risk profile in women who are obese with polycystic ovary syndrome
American Journal of Physiology-regulatory Integrative and Comparative Physiology, 2019Co-Authors: Vienna E. Brunt, Lindan N. Comrada, Michael A. Francisco, Brett R Ely, John R Halliwill, Samantha D Bryan, Emily A Larson, Christopher T. MinsonAbstract:Polycystic ovary syndrome (PCOS) affects up to 15% of women and is associated with increased risk of obesity and cardiovascular disease. Repeated passive Heat exposure [termed “Heat Therapy” (HT)] ...
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passive Heat Therapy protects against endothelial cell hypoxia reoxygenation via effects of elevations in temperature and circulating factors
The Journal of Physiology, 2018Co-Authors: Vienna E. Brunt, Lindan N. Comrada, Karen Wiedenfeldneedham, Christopher T. MinsonAbstract:Key points Accumulating evidence indicates that passive Heat Therapy (chronic use of hot tubs or saunas) has widespread physiological benefits, including enhanced resistance against novel stressors ('stress resistance'). Using a cell culture model to isolate the key stimuli that are likely to underlie physiological adaptation with Heat Therapy, we showed that both mild elevations in temperature (to 39°C) and exposure to serum from human subjects who have undergone 8 weeks of Heat Therapy (i.e. altered circulating factors) independently prevented oxidative and inflammatory stress associated with hypoxia-reoxygenation in cultured endothelial cells. Our results elucidate some of the mechanisms (i.e. direct effects of temperature vs. circulating factors) by which Heat Therapy seems to improve resistance against oxidative and inflammatory stress. Heat Therapy may be a promising intervention for reducing cellular damage following ischaemic events, which has broad implications for patients with cardiovascular diseases and conditions characterized by 'chronic' ischaemia (e.g. peripheral artery disease, metabolic diseases, obesity). Abstract Repeated exposure to passive Heat stress ('Heat Therapy') has widespread physiological benefits, including cellular protection against novel stressors. Increased Heat shock protein (HSP) expression and upregulation of circulating factors may impart this protection. We tested the isolated abilities of mild Heat pretreatment and serum from human subjects (n = 10) who had undergone 8 weeks of Heat Therapy to protect against cellular stress following hypoxia-reoxygenation (H/R), a model of ischaemic cardiovascular events. Cultured human umbilical vein endothelial cells were incubated for 24 h at 37°C (control), 39°C (Heat pretreatment) or 37°C with 10% serum collected before and after 8 weeks of passive Heat Therapy (four to five times per week to increase rectal temperature to ≥ 38.5°C for 60 min). Cells were then collected before and after incubation at 1% O2 for 16 h (hypoxia; 37°C), followed by 20% O2 for 4 h (reoxygenation; 37°C) and assessed for markers of cell stress. In control cells, H/R increased nuclear NF-κB p65 protein (i.e. activation) by 106 ± 38%, increased IL-6 release by 37 ± 8% and increased superoxide production by 272 ± 45%. Both Heat pretreatment and exposure to Heat Therapy serum prevented H/R-induced NF-κB activation and attenuated superoxide production; by contrast, only exposure to serum attenuated IL-6 release. H/R also decreased cytoplasmic haemeoxygenase-1 (HO-1) protein (known to suppress NF-κB), in control cells (-25 ± 8%), whereas HO-1 protein increased following H/R in cells pretreated with Heat or serum-exposed, providing a possible mechanism of protection against H/R. These data indicate Heat Therapy is capable of imparting resistance against inflammatory and oxidative stress via direct Heat and humoral factors.
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passive Heat Therapy improves endothelial function arterial stiffness and blood pressure in sedentary humans
The Journal of Physiology, 2016Co-Authors: Vienna E. Brunt, Michael A. Francisco, Matthew Howard, Brett R Ely, Christopher T. MinsonAbstract:Key points A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular-related and all-cause mortality; however, the specific cardiovascular adaptations that cause this chronic protection are currently unknown. We investigated the effects of 8 weeks of repeated hot water immersion (‘Heat Therapy’) on various biomarkers of cardiovascular health in young, sedentary humans. We showed that, relative to a sham group which participated in thermoneutral water immersion, Heat Therapy increased flow-mediated dilatation, reduced arterial stiffness, reduced mean arterial and diastolic blood pressure, and reduced carotid intima media thickness, with changes all on par or greater than what is typically observed in sedentary subjects with exercise training. Our results show for the first time that Heat Therapy has widespread and robust effects on vascular function, and as such, could be a viable treatment option for improving cardiovascular health in a variety of patient populations, particularly those with limited exercise tolerance and/or capabilities. Abstract The majority of cardiovascular diseases are characterized by disorders of the arteries, predominantly caused by endothelial dysfunction and arterial stiffening. Intermittent hot water immersion (‘Heat Therapy’) results in elevations in core temperature and changes in cardiovascular haemodynamics, such as cardiac output and vascular shear stress, that are similar to exercise, and thus may provide an alternative means of improving health which could be utilized by patients with low exercise tolerance and/or capabilities. We sought to comprehensively assess the effects of 8 weeks of Heat Therapy on biomarkers of vascular function in young, sedentary subjects. Twenty young, sedentary subjects were assigned to participate in 8 weeks (4–5 times per week) of Heat Therapy (n = 10; immersion in a 40.5°C bath sufficient to maintain rectal temperature ≥ 38.5°C for 60 min per session) or thermoneutral water immersion (n = 10; sham). Eight weeks of Heat Therapy increased flow-mediated dilatation from 5.6 ± 0.3 to 10.9 ± 1.0% (P < 0.01) and superficial femoral dynamic arterial compliance from 0.06 ± 0.01 to 0.09 ±0.01 mm2 mmHg−1 (P = 0.03), and reduced (i.e. improved) aortic pulse wave velocity from 7.1 ± 0.3 to 6.1 ± 0.3 m s−1 (P = 0.03), carotid intima media thickness from 0.43 ± 0.01 to 0.37 ± 0.01 mm (P < 0.001), and mean arterial blood pressure from 83 ± 1 to 78 ± 2 mmHg (P = 0.02). No changes were observed in the sham group or for carotid arterial compliance, superficial femoral intima media thickness or endothelium-independent dilatation. Heat Therapy improved endothelium-dependent dilatation, arterial stiffness, intima media thickness and blood pressure, indicating improved cardiovascular health. These data suggest Heat Therapy may provide a simple and effective tool for improving cardiovascular health in various populations.
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passive Heat Therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide dependent dilation
Journal of Applied Physiology, 2016Co-Authors: Vienna E. Brunt, Michael A. Francisco, Taylor M Eymann, Matthew Howard, Christopher T. MinsonAbstract:We showed for the first time that passive Heat Therapy improves cutaneous microvascular function in humans via improved nitric oxide (NO)-dependent dilation. This is the first study to investigate ...
Kyoungrae Kim - One of the best experts on this subject based on the ideXlab platform.
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Heat Therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia
Journal of Applied Physiology, 2021Co-Authors: Kyoungrae Kim, Qifan Song, Frederick W Damen, Daniel P Gramling, Trevor D Lehr, Craig J Goergen, Bruno T RoseguiniAbstract:The epidemic of obesity-related dyslipidemia and diabetes is a central cause of the increasing burden of peripheral artery disease (PAD), but few accessible therapies exist to mitigate the metaboli...
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Heat Therapy improves body composition and muscle function but does not affect capillary or collateral growth in a model of obesity and hindlimb ischemia
Journal of Applied Physiology, 2021Co-Authors: Kyoungrae Kim, Qifan Song, Frederick W Damen, Daniel P Gramling, Trevor D Lehr, Craig J Goergen, Bruno T RoseguiniAbstract:Heat Therapy (HT) has emerged as a potential adjunctive Therapy to alleviate the symptoms of peripheral artery disease (PAD), but the mechanisms underlying the positive effects of this treatment mo...
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skeletal muscle adaptations to Heat Therapy
Journal of Applied Physiology, 2020Co-Authors: Kyoungrae Kim, Timothy P Gavin, Jacob C Monroe, Bruno T RoseguiniAbstract:The therapeutic effects of Heat have been harnessed for centuries to treat skeletal muscle disorders and other pathologies. However, the fundamental mechanisms underlying the well-documented clinical benefits associated with Heat Therapy (HT) remain poorly defined. Foundational studies in cultured skeletal muscle and endothelial cells, as well as in rodents, revealed that episodic exposure to Heat stress activates a number of intracellular signaling networks and promotes skeletal muscle remodeling. Renewed interest in the physiology of HT in recent years has provided greater understanding of the signals and molecular players involved in the skeletal muscle adaptations to episodic exposures to HT. It is increasingly clear that Heat stress promotes signaling mechanisms involved in angiogenesis, muscle hypertrophy, mitochondrial biogenesis, and glucose metabolism through not only elevations in tissue temperature but also other perturbations, including increased intramyocellular calcium and enhanced energy turnover. The few available translational studies seem to indicate that the earlier observations in rodents also apply to human skeletal muscle. Indeed, recent findings revealed that both local and whole-body HT may promote capillary growth, enhance mitochondrial content and function, improve insulin sensitivity and attenuate disuse-induced muscle wasting. This accumulating body of work implies that HT may be a practical treatment to combat skeletal abnormalities in individuals with chronic disease who are unwilling or cannot participate in traditional exercise-training regimens.
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effects of repeated local Heat Therapy on skeletal muscle structure and function in humans
Journal of Applied Physiology, 2020Co-Authors: Kyoungrae Kim, Blake A Reid, Caitlin A Casey, Brooke E Bender, Qifan Song, Adam J Trewin, Aaron C Petersen, Shihuan Kuang, Timothy P Gavin, Bruno T RoseguiniAbstract:We demonstrate that repeated application of Heat Therapy to the thigh with a garment perfused with warm water enhances the strength of knee extensors and influences muscle capillarization in parall...
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Heat Therapy improves soleus muscle force in a model of ischemia induced muscle damage
Journal of Applied Physiology, 2019Co-Authors: Kyoungrae Kim, Blake A Reid, Caitlin A Casey, Qifan Song, Shihuan Kuang, Bruno T RoseguiniAbstract:This is the first study to comprehensively examine the impact of temperature and muscle fiber type composition on the adaptations to repeated Heat stress in a model of ischemia-induced muscle damag...
Mark E Polhemus - One of the best experts on this subject based on the ideXlab platform.
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A Randomized Controlled Trial of Local Heat Therapy Versus Intravenous Sodium Stibogluconate for the Treatment of Cutaneous Leishmania major Infection
2016Co-Authors: Naomi E Aronson, William R Byrne, Robin S Howard, Mark E Polhemus, Mary A. Marovich, Glenn W. Wortmann, Wendy B, In-kyu Yoon, Kelly A. Hummer, Robert AAbstract:Background: Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive. Methodology/Principal Findings: Participants with parasitologically confirmed L. major infection were randomized to receive intravenous sodium stibogluconate (SSG) 20mg/kg/day for ten doses or localized ThermoMed (TM) device Heat treatment (applied at 50uC for 30 seconds) in one session. Those with facial lesions, infection with other species of Leishmania, or more than 20 lesions were excluded. Primary outcome was complete re-epithelialization or visual healing at two months without relapse over 12 months. Fifty-four/56 enrolled participants received intervention, 27 SSG and 27 TM. In an intent to treat analysis the per subject efficacy at two months with 12 months follow-up was 54 % SSG and 48 % TM (p = 0.78), and the per lesion efficacy was 59 % SSG and 73 % TM (p = 0.053). Reversible abdominal pain/pancreatitis, arthralgias, myalgias, headache, fatigue, mild cytopenias, and elevated transaminases were more commonly present in the SSG treated participants, whereas blistering, oozing, and erythema were more common in the TM arm. Conclusions/Significance: Skin lesions due to L. major treated with Heat delivered by the ThermoMed device healed at
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a randomized controlled trial of local Heat Therapy versus intravenous sodium stibogluconate for the treatment of cutaneous leishmania major infection
PLOS Neglected Tropical Diseases, 2010Co-Authors: Naomi E Aronson, Glenn Wortmann, William R Byrne, Robin S Howard, Wendy B Bernstein, Mary Marovich, Mark E PolhemusAbstract:Background Cutaneous Leishmania major has affected many travelers including military personnel in Iraq and Afghanistan. Optimal treatment for this localized infection has not been defined, but interestingly the parasite is thermosensitive.