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Jane T Seto - One of the best experts on this subject based on the ideXlab platform.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α -Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence in metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle, however the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateurs male endurance runners participated in the study. Blood samples and urine were collected before, immediately after, one, three and fifteen days after the marathon race. Urine, Hematological Parameters, iron metabolism and ACTN3 genotyping analyses were performed. The marathon race induced a decrease on erythrocytes, Hb and Ht, an increase on hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or one day after the marathon race follows a reduction three or fifteen days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes-induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin and bilirubin unbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results are based on a small sample they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore these findings should be further replicated.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, Hematological Parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.

Giscard Lima - One of the best experts on this subject based on the ideXlab platform.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α -Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence in metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle, however the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateurs male endurance runners participated in the study. Blood samples and urine were collected before, immediately after, one, three and fifteen days after the marathon race. Urine, Hematological Parameters, iron metabolism and ACTN3 genotyping analyses were performed. The marathon race induced a decrease on erythrocytes, Hb and Ht, an increase on hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or one day after the marathon race follows a reduction three or fifteen days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes-induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin and bilirubin unbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results are based on a small sample they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore these findings should be further replicated.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, Hematological Parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.

Ana Paula Renno Sierra - One of the best experts on this subject based on the ideXlab platform.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α -Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence in metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle, however the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateurs male endurance runners participated in the study. Blood samples and urine were collected before, immediately after, one, three and fifteen days after the marathon race. Urine, Hematological Parameters, iron metabolism and ACTN3 genotyping analyses were performed. The marathon race induced a decrease on erythrocytes, Hb and Ht, an increase on hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or one day after the marathon race follows a reduction three or fifteen days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes-induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin and bilirubin unbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results are based on a small sample they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore these findings should be further replicated.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, Hematological Parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.

Abderraouf Ben Abderrahman - One of the best experts on this subject based on the ideXlab platform.

  • effects of a six week period of congested match play on plasma volume variations Hematological Parameters training workload and physical fitness in elite soccer players
    PLOS ONE, 2019
    Co-Authors: Karim Saidi, Hassane Zouhal, Fatma Rhibi, Jed M Tijani, Daniel A Boullosa, Amel Chebbi, Anthony C Hackney, Urs Granacher, Benoit Bideau, Abderraouf Ben Abderrahman
    Abstract:

    OBJECTIVES The aims of this study were to investigate the effects of a six-week in-season period of soccer training and games (congested period) on plasma volume variations (PV), Hematological Parameters, and physical fitness in elite players. In addition, we analyzed relationships between training load, Hematological Parameters and players' physical fitness. METHODS Eighteen elite players were evaluated before (T1) and after (T2) a six-week in-season period interspersed with 10 soccer matches. At T1 and T2, players performed the Yo-Yo intermittent recovery test level 1 (YYIR1), the repeated shuttle sprint ability test (RSSA), the countermovement jump test (CMJ), and the squat jump test (SJ). In addition, PV and Hematological Parameters (erythrocytes [M/mm3], hematocrit [%], hemoglobin [g/dl], mean corpuscular volume [fl], mean corpuscular hemoglobin content [pg], and mean hemoglobin concentration [%]) were assessed. Daily ratings of perceived exertion (RPE) were monitored in order to quantify the internal training load. RESULTS From T1 to T2, significant performance declines were found for the YYIR1 (p<0.001, effect size [ES] = 0.5), RSSA (p<0.01, ES = 0.6) and SJ tests (p< 0.046, ES = 0.7). However, no significant changes were found for the CMJ (p = 0.86, ES = 0.1). Post-exercise, RSSA blood lactate (p<0.012, ES = 0.2) and PV (p<0.01, ES = 0.7) increased significantly from T1 to T2. A significant decrease was found from T1 to T2 for the erythrocyte value (p<0.002, ES = 0.5) and the hemoglobin concentration (p<0.018, ES = 0.8). The hematocrit percentage rate was also significantly lower (p<0.001, ES = 0.6) at T2. The mean corpuscular volume, mean corpuscular hemoglobin content and the mean hemoglobin content values were not statistically different from T1 to T2. No significant relationships were detected between training load Parameters and percentage changes of Hematological Parameters. However, a significant relationship was observed between training load and changes in RSSA performance (r = -0.60; p<0.003). CONCLUSIONS An intensive period of "congested match play" over 6 weeks significantly compromised players' physical fitness. These changes were not related to Hematological Parameters, even though significant alterations were detected for selected measures.

Carlos Anibal Sierra - One of the best experts on this subject based on the ideXlab platform.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α -Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence in metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle, however the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateurs male endurance runners participated in the study. Blood samples and urine were collected before, immediately after, one, three and fifteen days after the marathon race. Urine, Hematological Parameters, iron metabolism and ACTN3 genotyping analyses were performed. The marathon race induced a decrease on erythrocytes, Hb and Ht, an increase on hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or one day after the marathon race follows a reduction three or fifteen days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes-induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin and bilirubin unbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results are based on a small sample they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore these findings should be further replicated.

  • association between Hematological Parameters and iron metabolism response after marathon race and actn3 genotype
    Frontiers in Physiology, 2019
    Co-Authors: Ana Paula Renno Sierra, Rodrigo Assuncao Oliveira, Elton Dias Da Silva, Giscard Lima, Marino Benetti, Maria Augusta Pedanti Kiss, Carlos Anibal Sierra, Nabil Ghorayeb, Jane T Seto
    Abstract:

    α-Actinin-3 (ACTN3 R577X, rs.1815739) polymorphism is a genetic variation that shows the most consistent influence on metabolic pathway and muscle phenotype. XX genotype is associated with higher metabolic efficiency of skeletal muscle; however, the role of ACTN3 polymorphism in oxygen transport and utilization system has not yet been investigated. Therefore, the aim of this study was to determine the influence of ACTN3 polymorphisms on Hematological and iron metabolism response induced by marathon race. Eighty-one Brazilian amateur male endurance runners participated in the study. Blood samples and urine were collected before; immediately after; and 1, 3, and 15 days after the marathon race. Urine, Hematological Parameters, iron metabolism, and ACTN3 genotyping analyses were performed. The marathon race induced a decrease in erythrocytes, Hb, and Ht, and an increase in hematuria, creatinine, myoglobin, red cell distribution width, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, direct and indirect bilirubin and erythropoietin. Moreover, an elevation immediately or 1 day after the marathon race follows a reduction 3 or 15 days after the marathon race were observed on transferrin saturation and iron and transferrin levels. Hematological Parameters and iron metabolism changes induced by marathon race were not observed in XX genotypes. Hematuria and decreased erythrocytes, Hb, Ht, and iron and transferrin levels were observed only in RR and/or RX genotypes but not in XX genotypes. The percentage of runners with hematuria, leukocyturia, iron deficiency, creatinine, myoglobin, and bilirubin imbalance was higher in RR compared to XX genotypes. ACTN3 polymorphism is associated with iron metabolism and Hematological responses after endurance exercise. Despite these results being based on a small sample, they highlight a protective role of the XX genotype on Hematological and renal changes induced by long-distance exercise. Therefore, these findings should be further replicated.