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Tracy I George - One of the best experts on this subject based on the ideXlab platform.
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assembly and evaluation of an inventory of guidelines that are available to support clinical Hematology laboratory practice
International Journal of Laboratory Hematology, 2015Co-Authors: Catherine P M Hayward, Tracy I George, Karen A Moffat, Maria ProytchevaAbstract:Summary Introduction Practice guidelines provide helpful support for clinical laboratories. Our goal was to assemble an inventory of publically listed guidelines on Hematology laboratory topics, to create a resource for laboratories and for assessing gaps in practice-focused guidelines. Methods PubMed and website searches were conducted to assemble an inventory of Hematology laboratory-focused guidelines. Exclusions included annual, technical, or collaborative study reports, clinically focused guidelines, position papers, nomenclature, and calibration documents. Results Sixty-eight guidelines were identified on Hematology laboratory practice topics from 12 organizations, some as joint guidelines. The median year of publication was 2010 and 15% were >10 years old. Coagulation topics had the largest numbers of guidelines, whereas some areas of practice had few guidelines. A minority of guidelines showed evidence of periodic updates, as some organizations did not remove or identify outdated guidelines. Conclusions This inventory of current practice guidelines will encourage awareness and uptake of guideline recommendations by the worldwide Hematology laboratory community, with the International Society for Laboratory Hematology facilitating ongoing updates. There is a need to encourage best guideline development practices, to ensure that Hematology laboratory community has current, high-quality, and evidence-based practice guidelines that cover the full scope of Hematology laboratory practice.
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evaluation of the beckman coulter unicel dxh 800 beckman coulter lh 780 and abbott diagnostics cell dyn sapphire Hematology analyzers on adult specimens in a tertiary care hospital
American Journal of Clinical Pathology, 2011Co-Authors: Brent T Tan, Armando J Nava, Tracy I GeorgeAbstract:We evaluated the new Beckman Coulter DxH 800 Hematology analyzer (Beckman Coulter, Miami, FL) vs the Abbott Diagnostics Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) and Beckman Coulter LH 780 Hematology analyzers using 430 adult specimens. The DxH 800 provided a CBC and differential that correlated well with those of the Sapphire and LH 780, with most parameters showing correlation coefficients (r) of more than 0.97. In the instrument vs 400-cell manual differential comparison, all 3 instruments showed similar and acceptable accuracy to the reference method except for nucleated RBC (NRBC) enumeration, in which the DxH 800 and Sapphire outperformed the LH 780. We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency, sensitivity, and specificity of the DxH 800 were 77.0%, 87.1%, and 73.0%, respectively, compared with the Sapphire at 75.8%, 93.5%, and 68.8%, respectively, and LH 780 at 66.1%, 93.5%, and 55.3%, respectively.
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evaluation of the beckman coulter unicel dxh 800 and abbott diagnostics cell dyn sapphire Hematology analyzers on pediatric and neonatal specimens in a tertiary care hospital
American Journal of Clinical Pathology, 2011Co-Authors: Armando J Nava, Tracy I GeorgeAbstract:We evaluated the new UniCel DxH 800 Hematology analyzer (Beckman Coulter, Miami, FL) vs the Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) using 156 pediatric specimens in Microtainer tubes (Becton Dickinson, Franklin Lakes, NJ). The CBC and differential showed good interinstrument correlation, including WBCs ( r = 0.995), RBCs ( r = 0.992), hemoglobin ( r = 0.998), mean corpuscular volume ( r = 0.988), platelets ( r = 0.997), neutrophils ( r = 0.988), lymphocytes ( r = 0.984), monocytes ( r = 0.815), eosinophils ( r = 0.840), basophils ( r = 0.049), and nucleated RBCs (NRBCs; r = 0.906). In the instrument vs 400-cell manual differential comparison, the DxH 800 and Sapphire showed comparable performance for nearly all parameters except for NRBCs, for which the DxH 800 correlated better ( r = 0.989) than the Sapphire ( r = 0.906). We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency of the DxH 800 was 78.0% vs the Sapphire at 68.1%. Both instruments showed identical sensitivity (91.1%), but the specificity for the DxH 800 (71.9%) was higher than that of the Sapphire (57.3%).
Armando J Nava - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the beckman coulter unicel dxh 800 beckman coulter lh 780 and abbott diagnostics cell dyn sapphire Hematology analyzers on adult specimens in a tertiary care hospital
American Journal of Clinical Pathology, 2011Co-Authors: Brent T Tan, Armando J Nava, Tracy I GeorgeAbstract:We evaluated the new Beckman Coulter DxH 800 Hematology analyzer (Beckman Coulter, Miami, FL) vs the Abbott Diagnostics Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) and Beckman Coulter LH 780 Hematology analyzers using 430 adult specimens. The DxH 800 provided a CBC and differential that correlated well with those of the Sapphire and LH 780, with most parameters showing correlation coefficients (r) of more than 0.97. In the instrument vs 400-cell manual differential comparison, all 3 instruments showed similar and acceptable accuracy to the reference method except for nucleated RBC (NRBC) enumeration, in which the DxH 800 and Sapphire outperformed the LH 780. We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency, sensitivity, and specificity of the DxH 800 were 77.0%, 87.1%, and 73.0%, respectively, compared with the Sapphire at 75.8%, 93.5%, and 68.8%, respectively, and LH 780 at 66.1%, 93.5%, and 55.3%, respectively.
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evaluation of the beckman coulter unicel dxh 800 and abbott diagnostics cell dyn sapphire Hematology analyzers on pediatric and neonatal specimens in a tertiary care hospital
American Journal of Clinical Pathology, 2011Co-Authors: Armando J Nava, Tracy I GeorgeAbstract:We evaluated the new UniCel DxH 800 Hematology analyzer (Beckman Coulter, Miami, FL) vs the Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) using 156 pediatric specimens in Microtainer tubes (Becton Dickinson, Franklin Lakes, NJ). The CBC and differential showed good interinstrument correlation, including WBCs ( r = 0.995), RBCs ( r = 0.992), hemoglobin ( r = 0.998), mean corpuscular volume ( r = 0.988), platelets ( r = 0.997), neutrophils ( r = 0.988), lymphocytes ( r = 0.984), monocytes ( r = 0.815), eosinophils ( r = 0.840), basophils ( r = 0.049), and nucleated RBCs (NRBCs; r = 0.906). In the instrument vs 400-cell manual differential comparison, the DxH 800 and Sapphire showed comparable performance for nearly all parameters except for NRBCs, for which the DxH 800 correlated better ( r = 0.989) than the Sapphire ( r = 0.906). We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency of the DxH 800 was 78.0% vs the Sapphire at 68.1%. Both instruments showed identical sensitivity (91.1%), but the specificity for the DxH 800 (71.9%) was higher than that of the Sapphire (57.3%).
François Mullier - One of the best experts on this subject based on the ideXlab platform.
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Usefulness of thresholds for smear review of neutropenic samples analyzed with a Sysmex XN-10 analyzer
Scandinavian Journal of Clinical and Laboratory Investigation, 2017Co-Authors: Emily Ronez, Carole Geara, Sylvie Coito, Hugues Jacqmin, Edouard Cornet, Xavier Troussard, Bernard Chatelain, François MullierAbstract:Neutropenia is one of the main criteria for a blood smear review. The objective of this study was to compare the thresholds proposed by the international consensus group for Hematology review (1.0 10/L) and the French speaking Group for Cellular Haematology (1.5 10/L) in terms of the number of useless smears. We collected 112,097 analyzed samples from four laboratories equipped with XN instruments (Sysmex, Kobe, Japan) during early 2016. The only exclusion criterion was a leucocyte count below 0.5 10/L. In the absence of abnormal cells and/or morphology suggesting haematological disease, samples were classified as 'negative for morphology' and the differential from the XN-10 was reported. These smear procedures were considered as uninformative. Some 2202 samples met the criterion for neutropenia (
T. Green - One of the best experts on this subject based on the ideXlab platform.
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The European Hematology Association Roadmap for European Hematology Research: a consensus document
Haematologica, 2016Co-Authors: A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T.d. Wit, S. Eichinger, W. Fibbe, T. GreenAbstract:The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European Hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on Hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at euro23 billion per year, a level of cost that is not matched in current European Hematology research funding. In recent decades, Hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap.The EHA Roadmap identifies nine 'sections' in Hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in Hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders.The EHA Roadmap identifies priorities and needs across the field of Hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients
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The European Hematology Association Roadmap for European Hematology Research: a consensus document
Haematologica, 2016Co-Authors: A. Engert, C. Balduini, A. Brand, B. Coiffier, C. Cordonnier, H. Dohner, T.d. Wit, S. Eichinger, W. Fibbe, T. GreenAbstract:The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clin ...
Brent T Tan - One of the best experts on this subject based on the ideXlab platform.
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evaluation of the beckman coulter unicel dxh 800 beckman coulter lh 780 and abbott diagnostics cell dyn sapphire Hematology analyzers on adult specimens in a tertiary care hospital
American Journal of Clinical Pathology, 2011Co-Authors: Brent T Tan, Armando J Nava, Tracy I GeorgeAbstract:We evaluated the new Beckman Coulter DxH 800 Hematology analyzer (Beckman Coulter, Miami, FL) vs the Abbott Diagnostics Cell-Dyn Sapphire (Abbott Diagnostics, Santa Clara, CA) and Beckman Coulter LH 780 Hematology analyzers using 430 adult specimens. The DxH 800 provided a CBC and differential that correlated well with those of the Sapphire and LH 780, with most parameters showing correlation coefficients (r) of more than 0.97. In the instrument vs 400-cell manual differential comparison, all 3 instruments showed similar and acceptable accuracy to the reference method except for nucleated RBC (NRBC) enumeration, in which the DxH 800 and Sapphire outperformed the LH 780. We also compared clinical efficiency by determining whether flagged specimens showed abnormalities on a peripheral blood smear as defined by International Council for Standardization in Haematology criteria. The efficiency, sensitivity, and specificity of the DxH 800 were 77.0%, 87.1%, and 73.0%, respectively, compared with the Sapphire at 75.8%, 93.5%, and 68.8%, respectively, and LH 780 at 66.1%, 93.5%, and 55.3%, respectively.
