The Experts below are selected from a list of 9810 Experts worldwide ranked by ideXlab platform

Robert H Bartlett - One of the best experts on this subject based on the ideXlab platform.

  • development and Hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity
    Journal of Biomaterials Applications, 2014
    Co-Authors: Terry C Major, Hitesh Handa, Gail M Annich, Robert H Bartlett
    Abstract:

    Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for Hemocompatibility include nonthrombogenicity, platelet preservation,...

  • development and Hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity
    Journal of Biomaterials Applications, 2014
    Co-Authors: Terry C Major, Hitesh Handa, Gail M Annich, Robert H Bartlett
    Abstract:

    Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for Hemocompatibility include nonthrombogenicity, platelet preservation, and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective extracorporeal life supporting. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for extracorporeal life supporting longevity. These novel biomaterials may improve extracorporeal circulation Hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit extracorporeal circulation model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial Hemocompatibility testing.

Nan Huang - One of the best experts on this subject based on the ideXlab platform.

  • Hemocompatibility of polyoxymethylene used for bileaflet heart valve
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2014
    Co-Authors: Qiang Song, Tao Liu, Li Liu, Nan Huang
    Abstract:

    The possibility of polyoxymethylene (POM) as heart valve leaflet material was investigated by comparing the Hemocompatibility with that of 316L stainless steel and low-temperature isotropic pyrolytic carbon (LTIC). Surface hydrophobicity was characterized by water contact angle measurement. Platelet adhesion, APTT/PT/TT and hemolysis rate tests were applied for evaluating Hemocompatibility. The results showed that POM was hydrophobic and had a low hemolytic rate, adhesion amount and activation degree of platelets on POM surface were less than 316L stainless steel, and was similar to LTIC. This research pointed out potential application of POM as heart valve leaflets.

  • Optimization of Hemocompatibility of Silicon Oxynitride Films
    Advanced Materials Research, 2009
    Co-Authors: Qi Yi Wang, Ping Yang, Hong Sun, Ju Huang, Jun Liang, Nan Huang
    Abstract:

    Low Hemocompatibility is a major problem of biomaterials that come in contact with blood. Surface modification has become an important way to improve the Hemocompatibility of medical implants and interventional devices. Recently, researchers attempt to investigate the possibility of silicon oxynitride (Si-N-O) films to be applied as novel coating of blood-contacting biomaterials. However, no detailed investigation has been conducted. In this study, our work was focused on the optimization of the Hemocompatibility of Si-N-O films prepared on single-crystal silicon wafers by unbalance magnetron sputtering (UBMS). The structure and chemical composition of films were characterized by X-ray photoelectron spectrometry (XPS), and their physical chemistry property was characterized by contact angle measurements. Platelet adhesion test was performed to investigate the platelet adhesion and activation. Our results suggested that films composed of Si3N4 and SiOx (x

  • Structure and Hemocompatibility of Titanium Oxide Films Synthesized by Continuous or Pulsed DC Magnetron Sputtering
    Key Engineering Materials, 2005
    Co-Authors: Yongxiang Leng, H.f. Zhou, Liu Yang, Nan Huang
    Abstract:

    Titanium oxide films were prepared by reactive magnetron sputtering using continuous or pulsed DC sputtering power. The results of the structure and vitro Hemocompatibility analyses indicated that non-stoichiometric titanium oxide films possess better Hemocompatibility than LTIC and that the Hemocompatibility of the titanium oxide films are evidently improved with the increase of rutile phase. This can result from the lower interface tension between titanium oxide films and biological substances and lower ratio of dispersive and polar component of the surface energy.

  • Hemocompatibility of titanium oxide films.
    Biomaterials, 2003
    Co-Authors: Nan Huang, Ping Yang, Yongxiang Leng, Junying Chen, Hong Sun, Jianxin Wang, Guangjun Wang, Peidao Ding, Yang Leng
    Abstract:

    Hemocompatibility is a key property of biomaterials that come in contact with blood. Surface modification has shown great potential for improving the Hemocompatibility of biomedical materials and devices. In this paper, we describe our work of improving Hemocompatibility with Ti-O thin films prepared by plasma immersion ion implantation and deposition and by sputtering. The structure and surface chemical and physical properties of the films were characterized by X-ray diffraction, Auger electron spectroscopy, atomic force microscopy (AFM), contact angle measurement, and Hall effect measurement. The behavior of fibrinogen adsorption was investigated by 125I radioactive isotope labeling and AFM. Systematic evaluation of Hemocompatibility, including in vitro clotting time, thrombin time, prethrombin time, platelet adhesion, and in vivo implantation into dog's ventral aorta or right auricle from 17 to 90 days, proved that Ti-O films have excellent Hemocompatibility. It is suggested that the significantly lower interface tension between Ti-O films and blood and plasma proteins and the semiconducting nature of Ti-O films give them their improved Hemocompatibility.

Nobuo Nakabayashi - One of the best experts on this subject based on the ideXlab platform.

  • Hemocompatible cellulose dialysis membranes modified with phospholipid polymers.
    Artificial organs, 1995
    Co-Authors: Kazuhiko Ishihara, Nobuo Nakabayashi
    Abstract:

    : Hemocompatibility is one of the most important properties for hemodialysis membranes. For improvement of the Hemocompatibility on a cellulose dialysis membrane, modifications with new blood-compatible phospholipid polymers were carried out. These methods included a direct grafting of the phospholipid monomer on the membrane surface, coaling the membrane surface with a water-soluble graft copolymer composed of a cellulose backbone and phospholipid polymer as a branch, and covalent bonding with a reactive phospholipid polymer on the membrane surface. These modified membranes could reduce protein adsorption as well as complement activation and platelet adhesion on the surface without any adverse effects on the membrane performance.

  • improvement of Hemocompatibility on a cellulose dialysis membrane with a novel biomedical polymer having a phospholipid polar group
    Artificial Organs, 1994
    Co-Authors: Kazuhiko Ishihara, Kikuko Fukumoto, Hideki Miyazaki, Nobuo Nakabayashi
    Abstract:

    : To improve surface Hemocompatibility on cellulose hollow fibers for hemodialysis, newly designed hemocompatible polymers with a phospholipid polar group, 2–methacryloyloxyethyl phosphory[choline (MPC) polymers, were introduced on the surface through two different methods: direct grafting of MPC on the surface, or coating of a water–soluble cellulose grafted with MPC. The MPC was polymerized using cerium ion as an initiator in the cellulose hollow fibers, and the poly(MPC) chains were grafted directly on the surface. Another modification of the cellulose hollow fibers was attempted by coating them with a water–soluble graft copolymer composed of a poly(MPC) side chain and a cellulose backbone. The coating process from an aqueous solution of the graft copolymer was very convenient, and the graft copolymer on the surface was not detached even after water circulated into the hollow fibers. These cellulose hollow fibers modified with MPC polymers displayed excellent Hemocompatibility such as prevention of blood cell adhesion and aggregation after contact with blood without an anticoagulant. The permeability of the hollow fibers did not decrease as a result of these modifications. From these results, it is clearly suggested that introduction of the MPC units was effective for improving the Hemocompatibility of the hollow fibers for hemodialysis.

Terry C Major - One of the best experts on this subject based on the ideXlab platform.

  • development and Hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity
    Journal of Biomaterials Applications, 2014
    Co-Authors: Terry C Major, Hitesh Handa, Gail M Annich, Robert H Bartlett
    Abstract:

    Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for Hemocompatibility include nonthrombogenicity, platelet preservation,...

  • development and Hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity
    Journal of Biomaterials Applications, 2014
    Co-Authors: Terry C Major, Hitesh Handa, Gail M Annich, Robert H Bartlett
    Abstract:

    Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for Hemocompatibility include nonthrombogenicity, platelet preservation, and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective extracorporeal life supporting. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for extracorporeal life supporting longevity. These novel biomaterials may improve extracorporeal circulation Hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit extracorporeal circulation model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial Hemocompatibility testing.

Giorgio Soldani - One of the best experts on this subject based on the ideXlab platform.

  • PDMS content affects in vitro Hemocompatibility of synthetic vascular grafts.
    Journal of materials science. Materials in medicine, 2007
    Co-Authors: Dario Spiller, Paola Losi, Enrica Briganti, Silverio Sbrana, Silvia Kull, Ilaria Martinelli, Giorgio Soldani
    Abstract:

    An unsolved problem when employing small-diameter vascular grafts for aorto-coronary by-pass and peripheral reconstruction is the early thrombotic occlusion. The PEtU-PDMS is a new elastomeric material, composed of poly(ether)urethane and polydimethylsiloxane, synthesized to realize grafts with improved Hemocompatibility characteristics. In order to investigate the effect of PDMS content on Hemocompatibility, three different percentages of PDMS containing grafts (10, 25 and 40) were evaluated. Grafts realized with Estane 5714-F1® and silicone medical grade tubes were used as references. The Hemocompatibility was investigated by an in vitro circuit in which human anticoagulated blood was circulated into grafts by a peristaltic pump modified to obtain a passive flow. For each experiment, 40 cm length graft was closed into a circular loop and put in rotation for 2 h at 37°C. At the end of the experiments different parameters regarding platelet adhesion and activation were evaluated: circulating platelets count, β-thromboglobulin release, platelet CD62P expression and amount of monocyte-platelet conjugates. PEtU-PDMS grafts with 25 and 40% of PDMS induced the lowest platelet adhesion, plasma level of β-TG and amount of monocyte-platelet conjugates. No significative variations were observed in CD62P expression. In conclusion, PDMS content significatively affects blood-graft surface interaction, in fact higher PDMS percentage containing grafts showed the best in vitro Hemocompatibility.