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Dimitrios Hatzichristou - One of the best experts on this subject based on the ideXlab platform.

  • low intensity shockwave therapy improves Hemodynamic Parameters in patients with vasculogenic erectile dysfunction a triplex ultrasonography based sham controlled trial
    The Journal of Sexual Medicine, 2017
    Co-Authors: D Kalyvianakis, Dimitrios Hatzichristou
    Abstract:

    Abstract Background Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile Hemodynamics are lacking. Aim To assess penile Hemodynamics before and 3 months after LI-ESWT in a group of patients with documented vasculogenic ED. Methods This was a double-blinded, randomized, sham-controlled trial. Forty-six patients with ED were randomized; 30 underwent LI-ESWT and 16 had a sham procedure in double-blinded fashion. All patients underwent penile triplex ultrasonography by the same investigator immediately before and 3 months after treatment. Patient demographics, International Index of Erectile Function erectile function domain (IIEF-ED) score, and minimal clinically important difference were assessed at baseline and 1, 3, 6, 9, and 12 months after treatment. Outcomes Changes in peak systolic velocity and resistance index as measured by triplex ultrasonography at baseline and 3 months after treatment were the main outcomes of the study. Secondary outcomes were changes in the IIEF-EF score from baseline to 1, 3, 6, 9, and 12 months after treatment and the percentage of patients reaching a minimal clinically important difference during the same period for the two groups. Results IIEF-EF minimal clinically important differences for the active vs sham group were observed for 56.7% vs 12.5% (P = .005) at 1 month, 56.7% vs 12.5% (P = .003) at 3 months, 63.3% vs 18.8% (P = .006) at 6 months, 66.7% vs 31.3% (P = .022) at 9 months, and 75% vs 25% (P = .008) at 12 months. Mean peak systolic velocity increased by 4.5 and 0.6 cm/s in the LI-ESWT and sham groups, respectively (P Clinical Implications Such results offer objective and subjective documentation of the value of this novel treatment modality for men with vasculogenic ED. Strengths and Limitations Strengths include the prospective, randomized, sham-controlled type of study and the assessment of penile Hemodynamics. Limitations include the small sample and strict inclusion criteria that do not reflect everyday clinical practice. Conclusion The present study confirms the beneficial effect of LI-ESWT on penile Hemodynamics and the beneficial effect of this treatment up to 12 months. Kalyvianakis D, Hatzichristou D. Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients With Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based Sham-Controlled Trial. J Sex Med 2017;14:891–897.

  • low intensity shockwave therapy improves Hemodynamic Parameters in patients with vasculogenic erectile dysfunction a triplex ultrasonography based sham controlled trial
    The Journal of Sexual Medicine, 2017
    Co-Authors: D Kalyvianakis, Dimitrios Hatzichristou
    Abstract:

    Abstract Background Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile Hemodynamics are lacking. Aim To assess penile Hemodynamics before and 3 months after LI-ESWT in a group of patients with documented vasculogenic ED. Methods This was a double-blinded, randomized, sham-controlled trial. Forty-six patients with ED were randomized; 30 underwent LI-ESWT and 16 had a sham procedure in double-blinded fashion. All patients underwent penile triplex ultrasonography by the same investigator immediately before and 3 months after treatment. Patient demographics, International Index of Erectile Function erectile function domain (IIEF-ED) score, and minimal clinically important difference were assessed at baseline and 1, 3, 6, 9, and 12 months after treatment. Outcomes Changes in peak systolic velocity and resistance index as measured by triplex ultrasonography at baseline and 3 months after treatment were the main outcomes of the study. Secondary outcomes were changes in the IIEF-EF score from baseline to 1, 3, 6, 9, and 12 months after treatment and the percentage of patients reaching a minimal clinically important difference during the same period for the two groups. Results IIEF-EF minimal clinically important differences for the active vs sham group were observed for 56.7% vs 12.5% (P = .005) at 1 month, 56.7% vs 12.5% (P = .003) at 3 months, 63.3% vs 18.8% (P = .006) at 6 months, 66.7% vs 31.3% (P = .022) at 9 months, and 75% vs 25% (P = .008) at 12 months. Mean peak systolic velocity increased by 4.5 and 0.6 cm/s in the LI-ESWT and sham groups, respectively (P Clinical Implications Such results offer objective and subjective documentation of the value of this novel treatment modality for men with vasculogenic ED. Strengths and Limitations Strengths include the prospective, randomized, sham-controlled type of study and the assessment of penile Hemodynamics. Limitations include the small sample and strict inclusion criteria that do not reflect everyday clinical practice. Conclusion The present study confirms the beneficial effect of LI-ESWT on penile Hemodynamics and the beneficial effect of this treatment up to 12 months. Kalyvianakis D, Hatzichristou D. Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients With Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based Sham-Controlled Trial. J Sex Med 2017;14:891–897.

D Kalyvianakis - One of the best experts on this subject based on the ideXlab platform.

  • low intensity shockwave therapy improves Hemodynamic Parameters in patients with vasculogenic erectile dysfunction a triplex ultrasonography based sham controlled trial
    The Journal of Sexual Medicine, 2017
    Co-Authors: D Kalyvianakis, Dimitrios Hatzichristou
    Abstract:

    Abstract Background Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile Hemodynamics are lacking. Aim To assess penile Hemodynamics before and 3 months after LI-ESWT in a group of patients with documented vasculogenic ED. Methods This was a double-blinded, randomized, sham-controlled trial. Forty-six patients with ED were randomized; 30 underwent LI-ESWT and 16 had a sham procedure in double-blinded fashion. All patients underwent penile triplex ultrasonography by the same investigator immediately before and 3 months after treatment. Patient demographics, International Index of Erectile Function erectile function domain (IIEF-ED) score, and minimal clinically important difference were assessed at baseline and 1, 3, 6, 9, and 12 months after treatment. Outcomes Changes in peak systolic velocity and resistance index as measured by triplex ultrasonography at baseline and 3 months after treatment were the main outcomes of the study. Secondary outcomes were changes in the IIEF-EF score from baseline to 1, 3, 6, 9, and 12 months after treatment and the percentage of patients reaching a minimal clinically important difference during the same period for the two groups. Results IIEF-EF minimal clinically important differences for the active vs sham group were observed for 56.7% vs 12.5% (P = .005) at 1 month, 56.7% vs 12.5% (P = .003) at 3 months, 63.3% vs 18.8% (P = .006) at 6 months, 66.7% vs 31.3% (P = .022) at 9 months, and 75% vs 25% (P = .008) at 12 months. Mean peak systolic velocity increased by 4.5 and 0.6 cm/s in the LI-ESWT and sham groups, respectively (P Clinical Implications Such results offer objective and subjective documentation of the value of this novel treatment modality for men with vasculogenic ED. Strengths and Limitations Strengths include the prospective, randomized, sham-controlled type of study and the assessment of penile Hemodynamics. Limitations include the small sample and strict inclusion criteria that do not reflect everyday clinical practice. Conclusion The present study confirms the beneficial effect of LI-ESWT on penile Hemodynamics and the beneficial effect of this treatment up to 12 months. Kalyvianakis D, Hatzichristou D. Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients With Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based Sham-Controlled Trial. J Sex Med 2017;14:891–897.

  • low intensity shockwave therapy improves Hemodynamic Parameters in patients with vasculogenic erectile dysfunction a triplex ultrasonography based sham controlled trial
    The Journal of Sexual Medicine, 2017
    Co-Authors: D Kalyvianakis, Dimitrios Hatzichristou
    Abstract:

    Abstract Background Although several reports have documented the subjective improvement of erectile function after low-intensity extracorporeal shockwave therapy (LI-ESWT) in patients with vasculogenic erectile dysfunction (ED), objective assessment data of penile Hemodynamics are lacking. Aim To assess penile Hemodynamics before and 3 months after LI-ESWT in a group of patients with documented vasculogenic ED. Methods This was a double-blinded, randomized, sham-controlled trial. Forty-six patients with ED were randomized; 30 underwent LI-ESWT and 16 had a sham procedure in double-blinded fashion. All patients underwent penile triplex ultrasonography by the same investigator immediately before and 3 months after treatment. Patient demographics, International Index of Erectile Function erectile function domain (IIEF-ED) score, and minimal clinically important difference were assessed at baseline and 1, 3, 6, 9, and 12 months after treatment. Outcomes Changes in peak systolic velocity and resistance index as measured by triplex ultrasonography at baseline and 3 months after treatment were the main outcomes of the study. Secondary outcomes were changes in the IIEF-EF score from baseline to 1, 3, 6, 9, and 12 months after treatment and the percentage of patients reaching a minimal clinically important difference during the same period for the two groups. Results IIEF-EF minimal clinically important differences for the active vs sham group were observed for 56.7% vs 12.5% (P = .005) at 1 month, 56.7% vs 12.5% (P = .003) at 3 months, 63.3% vs 18.8% (P = .006) at 6 months, 66.7% vs 31.3% (P = .022) at 9 months, and 75% vs 25% (P = .008) at 12 months. Mean peak systolic velocity increased by 4.5 and 0.6 cm/s in the LI-ESWT and sham groups, respectively (P Clinical Implications Such results offer objective and subjective documentation of the value of this novel treatment modality for men with vasculogenic ED. Strengths and Limitations Strengths include the prospective, randomized, sham-controlled type of study and the assessment of penile Hemodynamics. Limitations include the small sample and strict inclusion criteria that do not reflect everyday clinical practice. Conclusion The present study confirms the beneficial effect of LI-ESWT on penile Hemodynamics and the beneficial effect of this treatment up to 12 months. Kalyvianakis D, Hatzichristou D. Low-Intensity Shockwave Therapy Improves Hemodynamic Parameters in Patients With Vasculogenic Erectile Dysfunction: A Triplex Ultrasonography-Based Sham-Controlled Trial. J Sex Med 2017;14:891–897.

Kyung Woon Jeung - One of the best experts on this subject based on the ideXlab platform.

  • relationship between Hemodynamic Parameters and severity of ischemia induced left ventricular wall thickening during cardiopulmonary resuscitation of consistent quality
    PLOS ONE, 2018
    Co-Authors: Sehyeok Park, Yong Deok Lim, Yong Hun Jung, Kyung Woon Jeung
    Abstract:

    Ischemia-induced left ventricular (LV) wall thickening compromises the Hemodynamic effectiveness of cardiopulmonary resuscitation (CPR). However, accurate assessment of the severity of ischemia-induced LV wall thickening during CPR is challenging. We investigated, in a swine model, whether Hemodynamic Parameters, including end-tidal carbon dioxide (ETCO2) level, are linearly associated with the severity of ischemia-induced LV wall thickening during CPR of consistent quality. We retrospectively analyzed 96 datasets for ETCO2 level, arterial pressure, LV wall thickness, and the percent of measured end-diastolic volume (%EDV) relative to EDV at the onset of ventricular fibrillation from eight pigs. Animals underwent advanced cardiovascular life support based on resuscitation guidelines. During CPR, LV wall thickness progressively increased while %EDV progressively decreased. Systolic and diastolic arterial pressure and ETCO2 level were significantly correlated with LV wall thickness and %EDV. Linear mixed effect models revealed that, after adjustment for significant covariates, systolic and diastolic arterial pressure were not associated with LV wall thickness or %EDV. ETCO2 level had a significant linear relationship with %EDV (P = 0.004). However, it could explain only 28.2% of the total variance of %EDV in our model. In conclusion, none of the Hemodynamic Parameters examined in this study appeared to provide sufficient information on the severity of ischemia-induced LV wall thickening.

  • Relationship between Hemodynamic Parameters and severity of ischemia-induced left ventricular wall thickening during cardiopulmonary resuscitation of consistent quality
    2018
    Co-Authors: Sehyeok Park, Yong Deok Lim, Yong Hun Jung, Kyung Woon Jeung
    Abstract:

    Ischemia-induced left ventricular (LV) wall thickening compromises the Hemodynamic effectiveness of cardiopulmonary resuscitation (CPR). However, accurate assessment of the severity of ischemia-induced LV wall thickening during CPR is challenging. We investigated, in a swine model, whether Hemodynamic Parameters, including end-tidal carbon dioxide (ETCO2) level, are linearly associated with the severity of ischemia-induced LV wall thickening during CPR of consistent quality. We retrospectively analyzed 96 datasets for ETCO2 level, arterial pressure, LV wall thickness, and the percent of measured end-diastolic volume (íV) relative to EDV at the onset of ventricular fibrillation from eight pigs. Animals underwent advanced cardiovascular life support based on resuscitation guidelines. During CPR, LV wall thickness progressively increased while íV progressively decreased. Systolic and diastolic arterial pressure and ETCO2 level were significantly correlated with LV wall thickness and íV. Linear mixed effect models revealed that, after adjustment for significant covariates, systolic and diastolic arterial pressure were not associated with LV wall thickness or íV. ETCO2 level had a significant linear relationship with íV (P = 0.004). However, it could explain only 28.2% of the total variance of íV in our model. In conclusion, none of the Hemodynamic Parameters examined in this study appeared to provide sufficient information on the severity of ischemia-induced LV wall thickening.

Sehyeok Park - One of the best experts on this subject based on the ideXlab platform.

  • relationship between Hemodynamic Parameters and severity of ischemia induced left ventricular wall thickening during cardiopulmonary resuscitation of consistent quality
    PLOS ONE, 2018
    Co-Authors: Sehyeok Park, Yong Deok Lim, Yong Hun Jung, Kyung Woon Jeung
    Abstract:

    Ischemia-induced left ventricular (LV) wall thickening compromises the Hemodynamic effectiveness of cardiopulmonary resuscitation (CPR). However, accurate assessment of the severity of ischemia-induced LV wall thickening during CPR is challenging. We investigated, in a swine model, whether Hemodynamic Parameters, including end-tidal carbon dioxide (ETCO2) level, are linearly associated with the severity of ischemia-induced LV wall thickening during CPR of consistent quality. We retrospectively analyzed 96 datasets for ETCO2 level, arterial pressure, LV wall thickness, and the percent of measured end-diastolic volume (%EDV) relative to EDV at the onset of ventricular fibrillation from eight pigs. Animals underwent advanced cardiovascular life support based on resuscitation guidelines. During CPR, LV wall thickness progressively increased while %EDV progressively decreased. Systolic and diastolic arterial pressure and ETCO2 level were significantly correlated with LV wall thickness and %EDV. Linear mixed effect models revealed that, after adjustment for significant covariates, systolic and diastolic arterial pressure were not associated with LV wall thickness or %EDV. ETCO2 level had a significant linear relationship with %EDV (P = 0.004). However, it could explain only 28.2% of the total variance of %EDV in our model. In conclusion, none of the Hemodynamic Parameters examined in this study appeared to provide sufficient information on the severity of ischemia-induced LV wall thickening.

  • Relationship between Hemodynamic Parameters and severity of ischemia-induced left ventricular wall thickening during cardiopulmonary resuscitation of consistent quality
    2018
    Co-Authors: Sehyeok Park, Yong Deok Lim, Yong Hun Jung, Kyung Woon Jeung
    Abstract:

    Ischemia-induced left ventricular (LV) wall thickening compromises the Hemodynamic effectiveness of cardiopulmonary resuscitation (CPR). However, accurate assessment of the severity of ischemia-induced LV wall thickening during CPR is challenging. We investigated, in a swine model, whether Hemodynamic Parameters, including end-tidal carbon dioxide (ETCO2) level, are linearly associated with the severity of ischemia-induced LV wall thickening during CPR of consistent quality. We retrospectively analyzed 96 datasets for ETCO2 level, arterial pressure, LV wall thickness, and the percent of measured end-diastolic volume (íV) relative to EDV at the onset of ventricular fibrillation from eight pigs. Animals underwent advanced cardiovascular life support based on resuscitation guidelines. During CPR, LV wall thickness progressively increased while íV progressively decreased. Systolic and diastolic arterial pressure and ETCO2 level were significantly correlated with LV wall thickness and íV. Linear mixed effect models revealed that, after adjustment for significant covariates, systolic and diastolic arterial pressure were not associated with LV wall thickness or íV. ETCO2 level had a significant linear relationship with íV (P = 0.004). However, it could explain only 28.2% of the total variance of íV in our model. In conclusion, none of the Hemodynamic Parameters examined in this study appeared to provide sufficient information on the severity of ischemia-induced LV wall thickening.

Yaşam Kemal Akpak - One of the best experts on this subject based on the ideXlab platform.

  • Effects of postoperative intravenous infusion of tramadol and addition of dexmedetomidine to tramadol on analgesia and Hemodynamic Parameters in gynecologic surgery: A prospective (double blind) randomised controlled trial
    Archives of Clinical and Experimental Medicine, 2018
    Co-Authors: Hakan Emirkadı, Hüseyin Şen, Güner Dağlı, Bulat Aytek Şık, Yaşam Kemal Akpak
    Abstract:

    Aim: We designed this double-blind study to test and compare the effects of intravenous tramadol and intravenous tramadol plus dexmedetomidine on analgesia and Hemodynamic Parameters for treatment of postoperative pain in gynecologic surgeries with Pfannenstiel incision. Methods: Sixty patients undergoing total abdominal hysterectomy with Pfannenstiel incision under general anesthesia were randomly allocated into two groups. Group C (Tramadol) and Group D (Tramadol + Dexmedetomidin). The anesthetic technique was standardized. Postoperatively, the patients in both groups received patient controlled analgesia during 24 hours after surgery (tramadol 20 mg bolus for Group C, tramadol 20 mg+dexmedetomidine 10 mg first four hours, then tramadol 20 mg for Group D with a lock-out time of 15 minutes). Postoperative assessment included verbal pain score, sedation score, nausea and vomiting score, consumption of tramadol, Hemodynamic Parameters and patient’s satisfaction. Results: Postoperative pain scores were significantly lower in Group D compared with Group C and patient-controlled analgesia tramadol use was significantly reduced in Group D. Total PCA tramadol use was decreased by 27% in Group D compared with Group C (p=0.001). Patient satisfaction with pain treatment was significantly improved in Group D compared with Group C (p=0.001). A significant increase in sedation scores at the 1st, 2nd and 4th hours were observed in Group D. Heart rate was lower in Group D at the 1st, 2nd and 4th hours postoperatively (p=0.001, p=0.001 and p=0.01, respectively). Nausea and vomiting score was lower in Group D (p<0.05 for all). Conclusion: The addition of dexmedetomidine to tramadol by patient controlled analgesia method significantly reduces tramadol consumption and increases analgesia level and patient satisfaction in gynecological operations