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Hangping Yao - One of the best experts on this subject based on the ideXlab platform.

Ding-shinn Chen - One of the best experts on this subject based on the ideXlab platform.

  • <B>HepatitisB> B Virus infection
    Nature Reviews Disease Primers, 2018
    Co-Authors: Man-fung Yuen, Ding-shinn Chen, Geoffrey Dusheiko, Harry L A Janssen, Daryl T Y Lau, Stephen Locarnini, Marion G Peters, Chinglung Lai
    Abstract:

    <B>HepatitisB> B Virus (HBV) is a hepatotropic Virus that can estaBlish a persistent and chronic infection in humans through immune anergy. Currently, 3.5% of the gloBal population is chronically infected with HBV, although the incidence of HBV infections is decreasing owing to vaccination and, to a lesser extent, the use of antiviral therapy to reduce the viral load of chronically infected individuals. The course of chronic HBV infection typically comprises different clinical phases, each of which potentially lasts for decades. Well-defined and verified serum and liver Biopsy diagnostic markers enaBle the assessment of disease severity, viral replication status, patient risk stratification and treatment decisions. Current therapy includes antiviral agents that directly act on viral replication and immunomodulators, such as interferon therapy. Antiviral agents for HBV include reverse transcriptase inhiBitors, which are nucleoside or nucleotide analogues that can profoundly suppress HBV replication But require long-term maintenance therapy. Novel compounds are Being actively investigated to achieve the goal of HBV surface antigen seroclearance (functional cure), a serological state that is associated with a higher remission rate (thus, no viral reBound) after treatment cessation and a lower rate of cirrhosis and hepatocellular carcinoma. This Primer addresses several aspects of HBV infection, including epidemiology, immune pathophysiology, diagnosis, prevention and management. <B>HepatitisB> B Virus is a human hepatotropic DNA Virus that can cause a lifelong chronic infection and progressive liver disease. This Primer discusses the epidemiology, mechanisms, diagnosis, prevention and management of chronic <B>HepatitisB> B Virus infection.

  • <B>HepatitisB> B Virus integration in <B>HepatitisB> B Virus-related hepatocellular carcinoma in childhood.
    Hepatology (Baltimore Md.), 1991
    Co-Authors: Mei-hwei Chang, Pei-jer Chen, Jen-yang Chen, Ming-yang Lai, Hey-chi Hsu, Der‐cheng Lian, Yueh-giao Liu, Ding-shinn Chen
    Abstract:

    In Taiwan, hepatocellular carcinoma is one of the major malignancies in children Between 5 and 14 yr of age. We studied the status of <B>HepatitisB> B Virus DNA in the hepatocellular carcinoma and nontumorous liver tissues of eight children with positive serum HBsAg and maternal HBsAg. The hepatocellular carcinoma tissues from five of the eight children showed integration of <B>HepatitisB> B Virus DNA into host cellular DNA sequences. A pattern of single-site integration in four children and a multiple-site integration pattern in one child were demonstrated. In the remaining three children, <B>HepatitisB> B Virus DNA could not Be demonstrated in the tumor tissues. Using suBgenomic fragments of the <B>HepatitisB> B Virus genome as proBes, we found that the X gene fragment and the surface antigen gene fragment were the most conserved sequences. The single-site integration of <B>HepatitisB> B Virus DNA in childhood hepatocellular carcinoma may have hit the critical region, resulting in insertional mutagenesis and early development of hepatocellular carcinoma. With a short incuBation period and less exposure to environmental carcinogens during early life, childhood hepatocellular carcinoma may provide a good model to study the carcinogenic potential of <B>HepatitisB> B Virus. (HEPATOLOGY 1991;13:316–320).

Bo Hong - One of the best experts on this subject based on the ideXlab platform.

George N. Dalekos - One of the best experts on this subject based on the ideXlab platform.

Qi Wang - One of the best experts on this subject based on the ideXlab platform.