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José M. Morales - One of the best experts on this subject based on the ideXlab platform.

  • Hepatitis C in Renal Disease, Hemodialysis and Transplantation - Hepatitis C in renal disease, hemodialysis and transplantation.
    Contributions to Nephrology, 2012
    Co-Authors: José M. Morales, Beatriz Domínguez-gil, Josep M. Campistol, Michel Jadoul, Lionel Rostaing, David Roth
    Abstract:

    PrefaCe: Morales, J.M. Hepatitis C: Epidemiology, Diagnosis, Natural History and Therapy: Pol, S. Vallet-PiChard, A. Corouge, M. Mallet, V.O. Hepatitis C and Renal Disease: Epidemiology, Diagnosis, Pathogenesis and Therapy: Morales, J.M. Kamar, N. Rostaing, L. Hepatitis C-InduCed Renal Disease in Patients with AIDS: An Emergent Problem: Praga, M. Gutierrez Solis, E. Morales, E. Hepatitis C in Hemodialysis: Epidemiology and Prevention of Hepatitis C Virus Transmission: Jadoul, M. Barril, G. Hepatitis C-Related Liver Disease in Dialysis Patients: Fabrizi, F. Dixit, V. Messa, P. Martin, P. Treatment of Hepatitis C in Dialysis Patients: Esforzado, N. Campistol, J.M. SeleCtion and Management of Hepatitis C Virus-InfeCted Patients for the Kidney Transplant Waiting List: Roth, D. Bloom, R. Kidney Transplantation in the Patient with Hepatitis C Virus InfeCtion: Morales, J.M. Bloom, R. Roth, D. Treatment of Hepatitis C Virus InfeCtion after Kidney Transplantation: Rostaing, L. WeClawiak, H. Izopet, J. Kamar, N. Immunosuppression in Hepatitis C Virus-InfeCted Patients after Kidney Transplantation: Manuel, O. Baid-Agrawal, S. Moradpour, D. PasCual, M. ImpaCt of ExtrahepatiC CompliCations (Diabetes and Glomerulonephritis) AssoCiated with Hepatitis C Virus InfeCtion after Renal Transplantation: Cruzado, J.M. Bestard, O. Grinyo, J.M. Renal Transplantation from Donors with a Positive Serology for Hepatitis C: Dominguez-Gil, B. Esforzado, N. Andres, A. Campistol, J.M. Morales, J.M.

  • Hepatitis C virus and renal transplantation.
    Current opinion in nephrology and hypertension, 1998
    Co-Authors: José M. Morales, Josep M. Campistol, Amado Andrés, Jose L. Rodicio
    Abstract:

    During the past 12 months additional evidenCe has emerged from several studies, indiCating that Hepatitis C virus infeCtion is the most important liver disease after renal transplantation. A new, severe and rare entity Called fibrosing CholestatiC Hepatitis Can lead to early liver failure, although the most important CompliCations appeared in the long-run. EnCouraging results with ribavirin have been desCribed. Although glomerular lesions and more severe infeCtions Can appear in Hepatitis C virus patients, graft and patient survival rates in most series are similar to those in Hepatitis-C-negative patients. Survival is also better among Hepatitis-C-positive patients after renal transplantation than in Hepatitis-C-positive patients on dialysis on the waiting list for transplantation. Finally, the use of kidneys from Hepatitis-C-positive donors is suggested for transplant into Hepatitis C RNA positive patients matChing the Hepatitis C genotype.

Jay H. Hoofnagle - One of the best experts on this subject based on the ideXlab platform.

  • Course and outCome of Hepatitis C: Course and outCome of Hepatitis C
    Hepatology (Baltimore Md.), 2002
    Co-Authors: Jay H. Hoofnagle
    Abstract:

    The Hepatitis C virus (HCV) is a small enveloped RNA virus belonging to the family flaviviridae and genus hepaCivirus. The HCV RNA genome is 9,600 nuCleotides in length and enCodes a single polyprotein that is post-translationally Cleaved into 10 polypeptides inCluding t3 struCtural (C, E1, and E2) and multiple nonstruCtural proteins ([NS] NS2 to NS5). The NS proteins inClude enzymes neCessary for protein proCessing (proteases) and viral repliCation (RNA polymerase). The virus repliCates at a high rate in the liver and has marked sequenCe heterogeneity. There are 6 genotypes and more than 90 subtypes of HCV, the most Common in the United States being 1a and 1b (approximately 75%), 2a and 2b (approximately 15%), and 3 (approximately 7%). ACute Hepatitis C is marked by appearanCe of HCV RNA in serum within 1 to 2 weeks of exposure followed by serum alanine aminotransferase (ALT) elevations, and then symptoms and jaundiCe. Antibody to HCV (anti-HCV) tends to arise late. In aCute resolving Hepatitis, HCV RNA is Cleared and serum ALT levels fall to normal. However, 55% to 85% of patients do not Clear virus, but develop ChroniC Hepatitis C. ChroniC Hepatitis C is often asymptomatiC, but is usually assoCiated with persistent or fluCtuating elevations in ALT levels. The ChroniC sequelae of Hepatitis C inClude progressive hepatiC fibrosis, Cirrhosis, and hepatoCellular CarCinoma. Extra-hepatiC manifestations inClude siCCa syndrome, Cryoglobulinemia, glomerulonephritis, and porphyria Cutanea tarda. Knowledge of the Course and outCome of Hepatitis C is important in developing approaChes to management and therapy.

  • 4 ACute Hepatitis C
    Hepatitis C, 2000
    Co-Authors: Jay H. Hoofnagle
    Abstract:

    Publisher Summary This Chapter disCusses the development, diagnosis, and therapy of aCute Hepatitis C. ACute Hepatitis C aCCounts for 15 to 16 % of aCute viral Hepatitis in the United States and appears to be deCreasing in inCidenCe with the introduCtion of sCreening of blood for anti-Hepatitis C virus (HCV), widespread reCommendations for prevention of the spread of Hepatitis C, and a reCent deCrease in injeCtion drug use. The aCute disease has an inCubation period of 7 weeks, and jaundiCe and symptoms oCCur in approximately one-third of patients. Hepatitis C virus RNA appears in the serum during the inCubation period, often within 1 to 2 weeks of exposure. Viral RNA levels inCrease and peak at or around the time of onset of symptoms and disappear with ConvalesCenCe. The antibody to HCV as deteCted by enzyme immunoassay and reCombinant immunoblot assay appears during the Course of illness, but may not be deteCtable at the onset of symptoms. Some patients do not produCe deteCtable anti-HCV, whereas in other patients this antibody is short-lived, whiCh makes serologiCal testing for the prevalenCe of HCV infeCtion somewhat inaCCurate. The major CompliCation of aCute Hepatitis C is a progression to ChroniC infeCtion, whiCh oCCurs in 75 % of patients, more Commonly in adults than Children and in men than women. The role and benefit of antiviral therapy for aCute Hepatitis C have not been defined. At present it is prudent to delay therapy until the patient has Clearly developed ChroniC infeCtion and to treat the infeCtion as is reCommended for ChroniC Hepatitis C.

  • AbsenCe of Hepatitis C viral RNA from saliva and semen of patients with ChroniC Hepatitis C.
    Gastroenterology, 1992
    Co-Authors: M W Fried, Jay H. Hoofnagle, M Shindo, T L Fong, P C Fox, Adrian M. Di Bisceglie
    Abstract:

    Body fluids from 14 patients with ChroniC Hepatitis C were analyzed for the presenCe of Hepatitis C viral RNA using the polymerase Chain reaCtion. NuCleiC aCids were extraCted from serum, saliva, and semen in guanidinium thioCyanate, subjeCted to reverse transCription, and then amplified by a double polymerase Chain reaCtion teChnique using "nested" primers from the highly Conserved 5' non-Coding region of the Hepatitis C virus genome. Hepatitis C viral RNA was found in the serum of all patients in titers ranging between 10(-1) and 10(-3). The Hepatitis C viral genome was not deteCted in any saliva or semen sample. These findings suggest that body fluids of patients with ChroniC Hepatitis C are rarely, if ever, Contaminated with the Hepatitis C virus. This may help to explain the infrequent transmission of this disease by sexual or Close physiCal ContaCt.

  • deCrease in serum Hepatitis C viral rna during alpha interferon therapy for ChroniC Hepatitis C
    Annals of Internal Medicine, 1991
    Co-Authors: Michiko Shindo, Adrian M. Di Bisceglie, Ling Cheung, Waikuo J Shih, Karen Cristiano, Stephen M Feinstone, Jay H. Hoofnagle
    Abstract:

    AbstraCt ▪ObjeCtive:To assess the effeCt of alpha-interferon therapy on Hepatitis C viral RNA in serum of patients with ChroniC Hepatitis C. ▪Design:RetrospeCtive testing for Hepatitis C viral (HCV...

Jose L. Rodicio - One of the best experts on this subject based on the ideXlab platform.

  • Hepatitis C virus and renal transplantation.
    Current opinion in nephrology and hypertension, 1998
    Co-Authors: José M. Morales, Josep M. Campistol, Amado Andrés, Jose L. Rodicio
    Abstract:

    During the past 12 months additional evidenCe has emerged from several studies, indiCating that Hepatitis C virus infeCtion is the most important liver disease after renal transplantation. A new, severe and rare entity Called fibrosing CholestatiC Hepatitis Can lead to early liver failure, although the most important CompliCations appeared in the long-run. EnCouraging results with ribavirin have been desCribed. Although glomerular lesions and more severe infeCtions Can appear in Hepatitis C virus patients, graft and patient survival rates in most series are similar to those in Hepatitis-C-negative patients. Survival is also better among Hepatitis-C-positive patients after renal transplantation than in Hepatitis-C-positive patients on dialysis on the waiting list for transplantation. Finally, the use of kidneys from Hepatitis-C-positive donors is suggested for transplant into Hepatitis C RNA positive patients matChing the Hepatitis C genotype.

Adrian M. Di Bisceglie - One of the best experts on this subject based on the ideXlab platform.

  • AbsenCe of Hepatitis C viral RNA from saliva and semen of patients with ChroniC Hepatitis C.
    Gastroenterology, 1992
    Co-Authors: M W Fried, Jay H. Hoofnagle, M Shindo, T L Fong, P C Fox, Adrian M. Di Bisceglie
    Abstract:

    Body fluids from 14 patients with ChroniC Hepatitis C were analyzed for the presenCe of Hepatitis C viral RNA using the polymerase Chain reaCtion. NuCleiC aCids were extraCted from serum, saliva, and semen in guanidinium thioCyanate, subjeCted to reverse transCription, and then amplified by a double polymerase Chain reaCtion teChnique using "nested" primers from the highly Conserved 5' non-Coding region of the Hepatitis C virus genome. Hepatitis C viral RNA was found in the serum of all patients in titers ranging between 10(-1) and 10(-3). The Hepatitis C viral genome was not deteCted in any saliva or semen sample. These findings suggest that body fluids of patients with ChroniC Hepatitis C are rarely, if ever, Contaminated with the Hepatitis C virus. This may help to explain the infrequent transmission of this disease by sexual or Close physiCal ContaCt.

  • deCrease in serum Hepatitis C viral rna during alpha interferon therapy for ChroniC Hepatitis C
    Annals of Internal Medicine, 1991
    Co-Authors: Michiko Shindo, Adrian M. Di Bisceglie, Ling Cheung, Waikuo J Shih, Karen Cristiano, Stephen M Feinstone, Jay H. Hoofnagle
    Abstract:

    AbstraCt ▪ObjeCtive:To assess the effeCt of alpha-interferon therapy on Hepatitis C viral RNA in serum of patients with ChroniC Hepatitis C. ▪Design:RetrospeCtive testing for Hepatitis C viral (HCV...

Josep M. Campistol - One of the best experts on this subject based on the ideXlab platform.

  • Hepatitis C in Renal Disease, Hemodialysis and Transplantation - Hepatitis C in renal disease, hemodialysis and transplantation.
    Contributions to Nephrology, 2012
    Co-Authors: José M. Morales, Beatriz Domínguez-gil, Josep M. Campistol, Michel Jadoul, Lionel Rostaing, David Roth
    Abstract:

    PrefaCe: Morales, J.M. Hepatitis C: Epidemiology, Diagnosis, Natural History and Therapy: Pol, S. Vallet-PiChard, A. Corouge, M. Mallet, V.O. Hepatitis C and Renal Disease: Epidemiology, Diagnosis, Pathogenesis and Therapy: Morales, J.M. Kamar, N. Rostaing, L. Hepatitis C-InduCed Renal Disease in Patients with AIDS: An Emergent Problem: Praga, M. Gutierrez Solis, E. Morales, E. Hepatitis C in Hemodialysis: Epidemiology and Prevention of Hepatitis C Virus Transmission: Jadoul, M. Barril, G. Hepatitis C-Related Liver Disease in Dialysis Patients: Fabrizi, F. Dixit, V. Messa, P. Martin, P. Treatment of Hepatitis C in Dialysis Patients: Esforzado, N. Campistol, J.M. SeleCtion and Management of Hepatitis C Virus-InfeCted Patients for the Kidney Transplant Waiting List: Roth, D. Bloom, R. Kidney Transplantation in the Patient with Hepatitis C Virus InfeCtion: Morales, J.M. Bloom, R. Roth, D. Treatment of Hepatitis C Virus InfeCtion after Kidney Transplantation: Rostaing, L. WeClawiak, H. Izopet, J. Kamar, N. Immunosuppression in Hepatitis C Virus-InfeCted Patients after Kidney Transplantation: Manuel, O. Baid-Agrawal, S. Moradpour, D. PasCual, M. ImpaCt of ExtrahepatiC CompliCations (Diabetes and Glomerulonephritis) AssoCiated with Hepatitis C Virus InfeCtion after Renal Transplantation: Cruzado, J.M. Bestard, O. Grinyo, J.M. Renal Transplantation from Donors with a Positive Serology for Hepatitis C: Dominguez-Gil, B. Esforzado, N. Andres, A. Campistol, J.M. Morales, J.M.

  • Hepatitis C virus and renal transplantation.
    Current opinion in nephrology and hypertension, 1998
    Co-Authors: José M. Morales, Josep M. Campistol, Amado Andrés, Jose L. Rodicio
    Abstract:

    During the past 12 months additional evidenCe has emerged from several studies, indiCating that Hepatitis C virus infeCtion is the most important liver disease after renal transplantation. A new, severe and rare entity Called fibrosing CholestatiC Hepatitis Can lead to early liver failure, although the most important CompliCations appeared in the long-run. EnCouraging results with ribavirin have been desCribed. Although glomerular lesions and more severe infeCtions Can appear in Hepatitis C virus patients, graft and patient survival rates in most series are similar to those in Hepatitis-C-negative patients. Survival is also better among Hepatitis-C-positive patients after renal transplantation than in Hepatitis-C-positive patients on dialysis on the waiting list for transplantation. Finally, the use of kidneys from Hepatitis-C-positive donors is suggested for transplant into Hepatitis C RNA positive patients matChing the Hepatitis C genotype.