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Maimuna Mendy - One of the best experts on this subject based on the ideXlab platform.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Steve Kaye, David Jeffries, Andrew J. Hall, Marianne Ab Sande Van Der, Sarah Crozier, Hilton C Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE. MEthods ThE study was conductEd on 190 HBV chronic carriErs, agEd 1–19 yEars who wErE followEd for 19 yEars. 160, 99 and 123 wErE tracEd at 5, 9 and 19 yEars latEr. All availablE samplEs wErE tEstEd for HBsAg and HBEAg, whilst 170, 61, 63 and 81 wErE tEstEd for HBV DNA at thE basElinE, and at 5, 9 and 19 yEars following rEcruitmEnt. REsults In gEnEral HBEAg which corrElatEd with high lEvEls of HBV DNA was lost at a much fastEr ratE than HBsAg. 86% of thE carriErs who wErE rEcruitEd at thE agE of 1–4 yrs lost HBEAg by thE agE of 19 yEars comparEd to 30% who lost HBsAg. HBEAg nEgativE carriErs had sErum HBV DNA lEvEls of < 10^5 copiEs pEr mL, HBV DNA positivity dEclinEd from 100% in 1–4 yrs old carriErs at rEcruitmEnt to 62.5%,60% and 88% at 5, 9 and 19 yEars rEspEctivEly following rEcruitmEnt. Conclusion AftEr 19 yEars of follow up, thE majority of HBV surfacE antigEn carriErs had lost HBEAg positivity and had low lEvEls of viral rEplication. HowEvEr small proportions (10–20%) rEtainEd HBEAg and continuE to havE high lEvEls of viral rEplication.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Marianne A B Sande Van Der, Sarah R. Crozier, Steve Kaye, David Jeffries, Andrew J. Hall, Hilton Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE.

Hilton C Whittle - One of the best experts on this subject based on the ideXlab platform.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Steve Kaye, David Jeffries, Andrew J. Hall, Marianne Ab Sande Van Der, Sarah Crozier, Hilton C Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE. MEthods ThE study was conductEd on 190 HBV chronic carriErs, agEd 1–19 yEars who wErE followEd for 19 yEars. 160, 99 and 123 wErE tracEd at 5, 9 and 19 yEars latEr. All availablE samplEs wErE tEstEd for HBsAg and HBEAg, whilst 170, 61, 63 and 81 wErE tEstEd for HBV DNA at thE basElinE, and at 5, 9 and 19 yEars following rEcruitmEnt. REsults In gEnEral HBEAg which corrElatEd with high lEvEls of HBV DNA was lost at a much fastEr ratE than HBsAg. 86% of thE carriErs who wErE rEcruitEd at thE agE of 1–4 yrs lost HBEAg by thE agE of 19 yEars comparEd to 30% who lost HBsAg. HBEAg nEgativE carriErs had sErum HBV DNA lEvEls of < 10^5 copiEs pEr mL, HBV DNA positivity dEclinEd from 100% in 1–4 yrs old carriErs at rEcruitmEnt to 62.5%,60% and 88% at 5, 9 and 19 yEars rEspEctivEly following rEcruitmEnt. Conclusion AftEr 19 yEars of follow up, thE majority of HBV surfacE antigEn carriErs had lost HBEAg positivity and had low lEvEls of viral rEplication. HowEvEr small proportions (10–20%) rEtainEd HBEAg and continuE to havE high lEvEls of viral rEplication.

Samuel J. Mcconkey - One of the best experts on this subject based on the ideXlab platform.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Steve Kaye, David Jeffries, Andrew J. Hall, Marianne Ab Sande Van Der, Sarah Crozier, Hilton C Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE. MEthods ThE study was conductEd on 190 HBV chronic carriErs, agEd 1–19 yEars who wErE followEd for 19 yEars. 160, 99 and 123 wErE tracEd at 5, 9 and 19 yEars latEr. All availablE samplEs wErE tEstEd for HBsAg and HBEAg, whilst 170, 61, 63 and 81 wErE tEstEd for HBV DNA at thE basElinE, and at 5, 9 and 19 yEars following rEcruitmEnt. REsults In gEnEral HBEAg which corrElatEd with high lEvEls of HBV DNA was lost at a much fastEr ratE than HBsAg. 86% of thE carriErs who wErE rEcruitEd at thE agE of 1–4 yrs lost HBEAg by thE agE of 19 yEars comparEd to 30% who lost HBsAg. HBEAg nEgativE carriErs had sErum HBV DNA lEvEls of < 10^5 copiEs pEr mL, HBV DNA positivity dEclinEd from 100% in 1–4 yrs old carriErs at rEcruitmEnt to 62.5%,60% and 88% at 5, 9 and 19 yEars rEspEctivEly following rEcruitmEnt. Conclusion AftEr 19 yEars of follow up, thE majority of HBV surfacE antigEn carriErs had lost HBEAg positivity and had low lEvEls of viral rEplication. HowEvEr small proportions (10–20%) rEtainEd HBEAg and continuE to havE high lEvEls of viral rEplication.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Marianne A B Sande Van Der, Sarah R. Crozier, Steve Kaye, David Jeffries, Andrew J. Hall, Hilton Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE.

Steve Kaye - One of the best experts on this subject based on the ideXlab platform.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Steve Kaye, David Jeffries, Andrew J. Hall, Marianne Ab Sande Van Der, Sarah Crozier, Hilton C Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE. MEthods ThE study was conductEd on 190 HBV chronic carriErs, agEd 1–19 yEars who wErE followEd for 19 yEars. 160, 99 and 123 wErE tracEd at 5, 9 and 19 yEars latEr. All availablE samplEs wErE tEstEd for HBsAg and HBEAg, whilst 170, 61, 63 and 81 wErE tEstEd for HBV DNA at thE basElinE, and at 5, 9 and 19 yEars following rEcruitmEnt. REsults In gEnEral HBEAg which corrElatEd with high lEvEls of HBV DNA was lost at a much fastEr ratE than HBsAg. 86% of thE carriErs who wErE rEcruitEd at thE agE of 1–4 yrs lost HBEAg by thE agE of 19 yEars comparEd to 30% who lost HBsAg. HBEAg nEgativE carriErs had sErum HBV DNA lEvEls of < 10^5 copiEs pEr mL, HBV DNA positivity dEclinEd from 100% in 1–4 yrs old carriErs at rEcruitmEnt to 62.5%,60% and 88% at 5, 9 and 19 yEars rEspEctivEly following rEcruitmEnt. Conclusion AftEr 19 yEars of follow up, thE majority of HBV surfacE antigEn carriErs had lost HBEAg positivity and had low lEvEls of viral rEplication. HowEvEr small proportions (10–20%) rEtainEd HBEAg and continuE to havE high lEvEls of viral rEplication.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Marianne A B Sande Van Der, Sarah R. Crozier, Steve Kaye, David Jeffries, Andrew J. Hall, Hilton Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE.

David Jeffries - One of the best experts on this subject based on the ideXlab platform.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Steve Kaye, David Jeffries, Andrew J. Hall, Marianne Ab Sande Van Der, Sarah Crozier, Hilton C Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE. MEthods ThE study was conductEd on 190 HBV chronic carriErs, agEd 1–19 yEars who wErE followEd for 19 yEars. 160, 99 and 123 wErE tracEd at 5, 9 and 19 yEars latEr. All availablE samplEs wErE tEstEd for HBsAg and HBEAg, whilst 170, 61, 63 and 81 wErE tEstEd for HBV DNA at thE basElinE, and at 5, 9 and 19 yEars following rEcruitmEnt. REsults In gEnEral HBEAg which corrElatEd with high lEvEls of HBV DNA was lost at a much fastEr ratE than HBsAg. 86% of thE carriErs who wErE rEcruitEd at thE agE of 1–4 yrs lost HBEAg by thE agE of 19 yEars comparEd to 30% who lost HBsAg. HBEAg nEgativE carriErs had sErum HBV DNA lEvEls of < 10^5 copiEs pEr mL, HBV DNA positivity dEclinEd from 100% in 1–4 yrs old carriErs at rEcruitmEnt to 62.5%,60% and 88% at 5, 9 and 19 yEars rEspEctivEly following rEcruitmEnt. Conclusion AftEr 19 yEars of follow up, thE majority of HBV surfacE antigEn carriErs had lost HBEAg positivity and had low lEvEls of viral rEplication. HowEvEr small proportions (10–20%) rEtainEd HBEAg and continuE to havE high lEvEls of viral rEplication.

  • ChangEs in viral load and HBsAg and HBEAg status with agE in HBV chronic carriErs in ThE Gambia
    Virology Journal, 2008
    Co-Authors: Maimuna Mendy, Samuel J. Mcconkey, Marianne A B Sande Van Der, Sarah R. Crozier, Steve Kaye, David Jeffries, Andrew J. Hall, Hilton Whittle
    Abstract:

    Background LittlE is known about changEs in HEpatitis B viral load (HBV DNA) in rElation to agE in Africa. ThE aim of this study is to dEtErminE thE natural coursE of HBV chronic infEction, particularly in rElation to sEquEntial changEs in sErum HBV DNA lEvEls and HEpatitis B surfacE (HBsAg) antigEn/HEpatitis E antigEn (HBEAg) status by agE.