The Experts below are selected from a list of 276 Experts worldwide ranked by ideXlab platform
Pisaln Mairiang - One of the best experts on this subject based on the ideXlab platform.
-
elevated prevalence of helicobacter species and virulence factors in opisthorchiasis and associated Hepatobiliary Disease
Scientific Reports, 2017Co-Authors: Pisaln Mairiang, Raksawan Deenonpoe, Yaovalux Chamgramol, Gabriel Rinaldi, Eimorn Mairiang, Chawalit Pairojkul, Alex Loukas, Paul J BrindleyAbstract:Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and Hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants. H. pylori bacterial load correlated positively with intensity of O. viverrini infection, and participants with opisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of fluke infection. Genotyping of cagA from feces of both infected and uninfected participants revealed that the AB genotype accounted for 78% and Western type 22%. Participants infected with O. viverrini exhibited higher prevalence of typical Western type (EPIYA ABC) and variant AB’C type (EPIYT B) CagA. Multivariate analyses among H. pylori virulence genes and severity of Hepatobiliary Disease revealed positive correlations between biliary periductal fibrosis during opisthorchiasis and CagA and CagA with CagA multimerization (CM) sequence-positive H. pylori. These findings support the hypothesis that H. pylori contributes to the pathogenesis of chronic opisthorchiasis and specifically to opisthorchiasis-associated CCA.
-
immune responsiveness and parasite specific antibody levels in human Hepatobiliary Disease associated with opisthorchis viverrini infection
Clinical and Experimental Immunology, 2008Co-Authors: Melissa Haswellelkins, Eimorn Mairiang, Paiboon Sithithaworn, D B Elkins, Surasakdi Wongratanacheewin, S Kaewkes, Pisaln MairiangAbstract:SUMMARY Opisthorchis viverrini infection is associated with human Hepatobiliary Disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity responses to unrelated antigens, and fluke-specific IgG and IgA levels in serum of this group were also examined. Relationships between immunological parameters, intensity of infection and radiologically measured variables are reported. Immune responsiveness to unrelated antigens did not vary with intensity of parasite infection or Disease status. Of all the variables, IgG levels were most markedly elevated in Disease cases compared with normal subjects and were closely associated with gall bladder size and dysfunction. This is consistent with the hypothesis that an immunopathologic mechanism is involved in opisthorchiasis and suggests that antibody levels may be useful in screening populations for fluke-associated Hepatobiliary Disease.
-
relationship between intensity of opisthorchis viverrini infection and Hepatobiliary Disease detected by ultrasonography
Journal of Gastroenterology and Hepatology, 1992Co-Authors: Eimorn Mairiang, Pisaln Mairiang, Paiboon Sithithaworn, D B Elkins, Jitjaroen Chaiyakum, Nittaya Chamadol, Vallop Loapaiboon, Sumaree Posri, Melissa HaswellelkinsAbstract:: Twenty-four locality-, age- and sex-matched groups of village residents with no light, moderate and heavy Opisthorchis viverrini infection were examined by ultrasonography. Highly significant differences were observed between the groups in the relative size of the left lobe of the liver and the fasting and post-meal size of the gall-bladder. In addition, indistinct gall-bladder wall, the presence of gall-bladder sludge and strongly enhanced portal vein radicle echoes were most frequently observed in the heavily infected group. Two suspected cases of cholangiocarcinoma were identified from the heavy group. The results highlight the importance of intensity of infection on the frequency and severity of fluke-associated Hepatobiliary Disease.
-
a high frequency of Hepatobiliary Disease and suspected cholangiocarcinoma associated with heavy opisthorchis viverrini infection in a small community in north east thailand
Transactions of The Royal Society of Tropical Medicine and Hygiene, 1990Co-Authors: Pisaln Mairiang, Eimorn Mairiang, Melissa Haswellelkins, Paiboon Sithithaworn, D B Elkins, Sasithorn Kaewkes, Vajarabhongsa BhudhisawasdiAbstract:A group of 87 adults from a small village in north-east Thailand was chosen to undergo ultra-sound investigation based on their intensity of infection with the liver fluke, Opisthorchis viverrini, or clinical status (history of jaundice, current hepatomegaly). From this group, 8 cases of suspected early cholangiocarcinoma were found, and the diagnostic features of 6 of the 8 were confirmed by computerized tomography scan and endoscopic retrograde cholangiopancreatography. In addition, several cases of mild gall-bladder Disease, chronic cholecystitis, cholelithiasis and parenchymal liver Disease were detected. A highly significant positive relationship between the intensity of liver fluke worm burden and the severity of biliary tract Disease within individuals is reported. These results indicate that Opisthorchis is associated with moderate to severe Hepatobiliary Disease in a considerable proportion of infected individuals.
Melissa Haswellelkins - One of the best experts on this subject based on the ideXlab platform.
-
immune responsiveness and parasite specific antibody levels in human Hepatobiliary Disease associated with opisthorchis viverrini infection
Clinical and Experimental Immunology, 2008Co-Authors: Melissa Haswellelkins, Eimorn Mairiang, Paiboon Sithithaworn, D B Elkins, Surasakdi Wongratanacheewin, S Kaewkes, Pisaln MairiangAbstract:SUMMARY Opisthorchis viverrini infection is associated with human Hepatobiliary Disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity responses to unrelated antigens, and fluke-specific IgG and IgA levels in serum of this group were also examined. Relationships between immunological parameters, intensity of infection and radiologically measured variables are reported. Immune responsiveness to unrelated antigens did not vary with intensity of parasite infection or Disease status. Of all the variables, IgG levels were most markedly elevated in Disease cases compared with normal subjects and were closely associated with gall bladder size and dysfunction. This is consistent with the hypothesis that an immunopathologic mechanism is involved in opisthorchiasis and suggests that antibody levels may be useful in screening populations for fluke-associated Hepatobiliary Disease.
-
relationship between intensity of opisthorchis viverrini infection and Hepatobiliary Disease detected by ultrasonography
Journal of Gastroenterology and Hepatology, 1992Co-Authors: Eimorn Mairiang, Pisaln Mairiang, Paiboon Sithithaworn, D B Elkins, Jitjaroen Chaiyakum, Nittaya Chamadol, Vallop Loapaiboon, Sumaree Posri, Melissa HaswellelkinsAbstract:: Twenty-four locality-, age- and sex-matched groups of village residents with no light, moderate and heavy Opisthorchis viverrini infection were examined by ultrasonography. Highly significant differences were observed between the groups in the relative size of the left lobe of the liver and the fasting and post-meal size of the gall-bladder. In addition, indistinct gall-bladder wall, the presence of gall-bladder sludge and strongly enhanced portal vein radicle echoes were most frequently observed in the heavily infected group. Two suspected cases of cholangiocarcinoma were identified from the heavy group. The results highlight the importance of intensity of infection on the frequency and severity of fluke-associated Hepatobiliary Disease.
-
a high frequency of Hepatobiliary Disease and suspected cholangiocarcinoma associated with heavy opisthorchis viverrini infection in a small community in north east thailand
Transactions of The Royal Society of Tropical Medicine and Hygiene, 1990Co-Authors: Pisaln Mairiang, Eimorn Mairiang, Melissa Haswellelkins, Paiboon Sithithaworn, D B Elkins, Sasithorn Kaewkes, Vajarabhongsa BhudhisawasdiAbstract:A group of 87 adults from a small village in north-east Thailand was chosen to undergo ultra-sound investigation based on their intensity of infection with the liver fluke, Opisthorchis viverrini, or clinical status (history of jaundice, current hepatomegaly). From this group, 8 cases of suspected early cholangiocarcinoma were found, and the diagnostic features of 6 of the 8 were confirmed by computerized tomography scan and endoscopic retrograde cholangiopancreatography. In addition, several cases of mild gall-bladder Disease, chronic cholecystitis, cholelithiasis and parenchymal liver Disease were detected. A highly significant positive relationship between the intensity of liver fluke worm burden and the severity of biliary tract Disease within individuals is reported. These results indicate that Opisthorchis is associated with moderate to severe Hepatobiliary Disease in a considerable proportion of infected individuals.
Eimorn Mairiang - One of the best experts on this subject based on the ideXlab platform.
-
elevated prevalence of helicobacter species and virulence factors in opisthorchiasis and associated Hepatobiliary Disease
Scientific Reports, 2017Co-Authors: Pisaln Mairiang, Raksawan Deenonpoe, Yaovalux Chamgramol, Gabriel Rinaldi, Eimorn Mairiang, Chawalit Pairojkul, Alex Loukas, Paul J BrindleyAbstract:Recent reports suggest that Opisthorchis viverrini serves as a reservoir of Helicobacter and implicate Helicobacter in pathogenesis of opisthorchiasis-associated cholangiocarcinoma (CCA). Here, 553 age-sex matched cases and controls, 293 and 260 positive and negative for liver fluke O. viverrini eggs, of residents in Northeastern Thailand were investigated for associations among infection with liver fluke, Helicobacter and Hepatobiliary fibrosis. The prevalence of H. pylori infection was higher in O. viverrini-infected than uninfected participants. H. pylori bacterial load correlated positively with intensity of O. viverrini infection, and participants with opisthorchiasis exhibited higher frequency of virulent cagA-positive H. pylori than those free of fluke infection. Genotyping of cagA from feces of both infected and uninfected participants revealed that the AB genotype accounted for 78% and Western type 22%. Participants infected with O. viverrini exhibited higher prevalence of typical Western type (EPIYA ABC) and variant AB’C type (EPIYT B) CagA. Multivariate analyses among H. pylori virulence genes and severity of Hepatobiliary Disease revealed positive correlations between biliary periductal fibrosis during opisthorchiasis and CagA and CagA with CagA multimerization (CM) sequence-positive H. pylori. These findings support the hypothesis that H. pylori contributes to the pathogenesis of chronic opisthorchiasis and specifically to opisthorchiasis-associated CCA.
-
immune responsiveness and parasite specific antibody levels in human Hepatobiliary Disease associated with opisthorchis viverrini infection
Clinical and Experimental Immunology, 2008Co-Authors: Melissa Haswellelkins, Eimorn Mairiang, Paiboon Sithithaworn, D B Elkins, Surasakdi Wongratanacheewin, S Kaewkes, Pisaln MairiangAbstract:SUMMARY Opisthorchis viverrini infection is associated with human Hepatobiliary Disease and cholangiocarcinoma, but the role of the immune response in the pathogenesis of infection is unclear. Here ultrasonography was used to examine the biliary tracts of residents from an endemic community. Delayed-type hypersensitivity responses to unrelated antigens, and fluke-specific IgG and IgA levels in serum of this group were also examined. Relationships between immunological parameters, intensity of infection and radiologically measured variables are reported. Immune responsiveness to unrelated antigens did not vary with intensity of parasite infection or Disease status. Of all the variables, IgG levels were most markedly elevated in Disease cases compared with normal subjects and were closely associated with gall bladder size and dysfunction. This is consistent with the hypothesis that an immunopathologic mechanism is involved in opisthorchiasis and suggests that antibody levels may be useful in screening populations for fluke-associated Hepatobiliary Disease.
-
relationship between intensity of opisthorchis viverrini infection and Hepatobiliary Disease detected by ultrasonography
Journal of Gastroenterology and Hepatology, 1992Co-Authors: Eimorn Mairiang, Pisaln Mairiang, Paiboon Sithithaworn, D B Elkins, Jitjaroen Chaiyakum, Nittaya Chamadol, Vallop Loapaiboon, Sumaree Posri, Melissa HaswellelkinsAbstract:: Twenty-four locality-, age- and sex-matched groups of village residents with no light, moderate and heavy Opisthorchis viverrini infection were examined by ultrasonography. Highly significant differences were observed between the groups in the relative size of the left lobe of the liver and the fasting and post-meal size of the gall-bladder. In addition, indistinct gall-bladder wall, the presence of gall-bladder sludge and strongly enhanced portal vein radicle echoes were most frequently observed in the heavily infected group. Two suspected cases of cholangiocarcinoma were identified from the heavy group. The results highlight the importance of intensity of infection on the frequency and severity of fluke-associated Hepatobiliary Disease.
-
a high frequency of Hepatobiliary Disease and suspected cholangiocarcinoma associated with heavy opisthorchis viverrini infection in a small community in north east thailand
Transactions of The Royal Society of Tropical Medicine and Hygiene, 1990Co-Authors: Pisaln Mairiang, Eimorn Mairiang, Melissa Haswellelkins, Paiboon Sithithaworn, D B Elkins, Sasithorn Kaewkes, Vajarabhongsa BhudhisawasdiAbstract:A group of 87 adults from a small village in north-east Thailand was chosen to undergo ultra-sound investigation based on their intensity of infection with the liver fluke, Opisthorchis viverrini, or clinical status (history of jaundice, current hepatomegaly). From this group, 8 cases of suspected early cholangiocarcinoma were found, and the diagnostic features of 6 of the 8 were confirmed by computerized tomography scan and endoscopic retrograde cholangiopancreatography. In addition, several cases of mild gall-bladder Disease, chronic cholecystitis, cholelithiasis and parenchymal liver Disease were detected. A highly significant positive relationship between the intensity of liver fluke worm burden and the severity of biliary tract Disease within individuals is reported. These results indicate that Opisthorchis is associated with moderate to severe Hepatobiliary Disease in a considerable proportion of infected individuals.
Wendy A Davis - One of the best experts on this subject based on the ideXlab platform.
-
1499 p Hepatobiliary Disease in type 2 diabetes is it increasing and is fatty liver important
Diabetes, 2020Co-Authors: Timothy M E Davis, Wendy A DavisAbstract:Objective: To determine whether the incidence/adverse outcomes of Hepatobiliary Disease (HPD) has increased over recent decades in community-based Australians. Methods: Longitudinal data from the Fremantle Diabetes Study Phase I (FDS1; recruitment 1993-1996) and Phase II (FDS2; 2008-2011) were analyzed. Participants with type 2 diabetes from both Phases were age-, sex- and zip code-matched 1:4 to people without diabetes. Incident HPD and associated mortality were ascertained from hospitalization, cancer registration and/or death certification for an ICD-coded diagnosis (principal/secondary) of liver Disease, viral hepatitis, primary malignancy, and gallbladder/biliary tract Disease. Incidence rates (IRs) and IR ratios (IRRs) for those with versus without diabetes in FDS1 and FDS2 were calculated. Results: Data relating to IRs for HPD and associated mortality are shown in the Table. HPD IRs for people without diabetes did not change between Phases but the IRR increased, reflecting an IRR (95% CI) for people with diabetes in FDS2 versus FDS1 of 1.30 (1.01-1.68). Nonalcoholic fatty liver Disease/steatohepatitis (NAFLD/NASH) accounted for Conclusions: HPD is more frequent in people with versus without type 2 diabetes. This discrepancy has increased in the 15 years between FDS Phases. Hospitalizations/deaths due to NAFLD/NASH remain uncommon. Disclosure T. Davis: Advisory Panel; Self; Lilly Diabetes, Merck Sharp & Dohme Corp., Novo Nordisk A/S. Speaker’s Bureau; Spouse/Partner; Boehringer Ingelheim International GmbH. Speaker’s Bureau; Self; Lilly Diabetes, Merck Sharp & Dohme Corp., Mylan, Novo Nordisk A/S, Sanofi-Aventis. Other Relationship; Self; Protemics International. Other Relationship; Spouse/Partner; Protemics International. W.A. Davis: Advisory Panel; Spouse/Partner; Lilly Diabetes, Merck Sharp & Dohme Corp., Novo Nordisk A/S. Speaker’s Bureau; Self; Boehringer Ingelheim International GmbH. Speaker’s Bureau; Spouse/Partner; Lilly Diabetes, Merck Sharp & Dohme Corp., Mylan, Novo Nordisk A/S, Sanofi-Aventis. Other Relationship; Self; Proteomics International. Other Relationship; Spouse/Partner; Proteomics International. Funding Raine Foundation; University of Washington; National Health and Medical Research Council (513781, 1042231); Medical Research Future Fund Practitioner Fellowship
-
prevalence incidence and prognosis of Hepatobiliary Disease in community based patients with type 2 diabetes the fremantle diabetes study
The Journal of Clinical Endocrinology and Metabolism, 2012Co-Authors: Timothy M E Davis, Kirsten Peters, David G Bruce, Wendy A DavisAbstract:CONTEXT: Few studies have examined morbidity and mortality associated with Hepatobiliary Disease in diabetes. Most have used administrative databases and/or have had limited/incomplete data including recognized risk factors for Hepatobiliary Disease. OBJECTIVE: The objective of the study was to explore the relationship between type 2 diabetes and Hepatobiliary Disease in well-characterized patients with detailed risk factor data including viral hepatitis status and hemochromatosis genotype. DESIGN: This was a community-based longitudinal observational study. SETTING: The study was conducted in an urban Australian community. PATIENTS: The study included 1294 patients of mean ± SD aged 64.1 ± 11.3 yr and 5156 age-, gender-, and ZIP code-matched nondiabetic controls. MAIN OUTCOME MEASURES: Prevalent and incident Hepatobiliary Disease and Hepatobiliary Disease-related death were measured. Competing risks proportional hazard models provided independent associates of these end points. RESULTS: During 13,705 patient-years (mean 11.5 yr), 144 patients had an initial Hepatobiliary Disease-related hospitalization/cancer registration vs. 403 controls during 63,937 person-years of follow-up, an incidence rate ratio of 1.66 (95% confidence interval 1.37-2.02). Incident Hepatobiliary Disease was associated with a lower glycosylated hemoglobin and higher urinary albumin to creatinine ratio. Nearly half of the patients (49.9%) died during follow-up [crude mortality ratio vs. nondiabetic controls 1.97 (1.16-3.32)], and 21 (3.3%) from Hepatobiliary Disease including two cases of cirrhosis attributable to nonalcoholic steatohepatitis. Hepatobiliary Disease-related death was independently predicted by prior Hepatobiliary Disease, hepatitis C seropositivity, retinopathy, and peripheral neuropathy; higher educational level and higher fasting serum glucose were protective. CONCLUSIONS: Hepatobiliary Disease and associated mortality are increased in type 2 diabetes. Multiple factors including fatty infiltration, microangiopathy, and direct glucotoxicity are likely to contribute, but hospitalization and death due to cirrhosis from nonalcoholic steatohepatitis appear uncommon.
R W Chapman - One of the best experts on this subject based on the ideXlab platform.
-
igg4 related Hepatobiliary Disease an overview
Nature Reviews Gastroenterology & Hepatology, 2016Co-Authors: Emma L Culver, R W ChapmanAbstract:IgG4-related Hepatobiliary Diseases are part of a multiorgan fibroinflammatory condition termed IgG4-related Disease. In this Review, Chapman and Culver provide an overview on the natural history, manifestations and aetiopathogenesis of IgG4-related Hepatobiliary Disease with an emphasis on IgG4-sclerosing cholangitis.
-
IgG4-related Hepatobiliary Disease: an overview
Nature Reviews Gastroenterology & Hepatology, 2016Co-Authors: Emma L Culver, R W ChapmanAbstract:IgG4-related Hepatobiliary Diseases are part of a multiorgan fibroinflammatory condition termed IgG4-related Disease, and include IgG4-related sclerosing cholangitis (IgG4-SC) and IgG4-related hepatopathy. These Diseases can present with biliary strictures and/or mass lesions, making them difficult to differentiate from primary sclerosing cholangitis (PSC) or other Hepatobiliary malignancies. Diagnosis is based on a combination of clinical, biochemical, radiological and histological findings. However, a gold standard diagnostic test is lacking, warranting the identification of more specific Disease markers. Novel assays — such as the serum IgG4:IgG1 ratio and IgG4:IgG RNA ratio (which distinguish IgG4-SC from PSC with high serum IgG4 levels), and plasmablast expansion to recognize IgG4-SC with normal serum IgG4 levels — require further validation. Steroids and other immunosuppressive therapies can lead to clinical and radiological improvement when given in the inflammatory phase of the Disease, but evidence for the efficacy of treatment regimens is limited. Progressive fibrosclerotic Disease, liver cirrhosis and an increased risk of malignancy are now recognized outcomes. Insights into the genetic and immunological features of the Disease have increased over the past decade, with an emphasis on HLAs, T cells, circulating memory B cells and plasmablasts, chemokine-mediated trafficking, as well as the role of the innate immune system. IgG4-related Hepatobiliary Diseases (IgG4-HBD) are part of a systemic fibroinflammatory condition, termed IgG4-related Disease. IgG4-HBD includes IgG4-related sclerosing cholangitis (IgG4-SC) and IgG4-related hepatopathy IgG4-HBD can present with abnormal liver biochemistry, biliary strictures and/or masses, impeding the differentiation from other benign and malignant Hepatobiliary disorders Diagnosis is based on a combination of clinical, biochemical, radiological and histological findings. A gold standard diagnostic test is lacking, although novel markers might help to differentiate IgG4-HBD from other conditions Treatment regimens have been reached by international consensus but are not supported by randomized controlled trials. First-line therapy is corticosteroids, often in combination with biliary stenting for patients with IgG4-SC The long-term outcome in IgG4-HBD is not well established. Disease-related inflammatory and fibrotic complications and an increased risk of all-cause malignancy have been reported in prospective studies Insights into the genetic and immunological aspects of Disease pathogenesis have increased over the past decade. Defining the initiating and driving factors for fibrotic Disease remains an important challenge IgG4-related Hepatobiliary Diseases are part of a multiorgan fibroinflammatory condition termed IgG4-related Disease. In this Review, Chapman and Culver provide an overview on the natural history, manifestations and aetiopathogenesis of IgG4-related Hepatobiliary Disease with an emphasis on IgG4-sclerosing cholangitis.