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Supriyadi Supriyadi - One of the best experts on this subject based on the ideXlab platform.

  • Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats
    International Journal of Public Health Science (IJPHS), 2016
    Co-Authors: Yunita Satya Pratiwi, Bambang Wirjatmadi, Mangestuti Agil, Merryana Adriyani, Supriyadi Supriyadi
    Abstract:

    The aim of this study was to determine the Hepatoprotective Effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective Effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α

  • Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats
    International Journal of Public Health Science (IJPHS), 2016
    Co-Authors: Yunita Satya Pratiwi, Bambang Wirjatmadi, Mangestuti Agil, Merryana Adriyani, Supriyadi Supriyadi
    Abstract:

    <p>The aim of this study was to determine the Hepatoprotective Effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective Effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α &lt;0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide Hepatoprotective Effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.</p>

Wang Jinhui - One of the best experts on this subject based on the ideXlab platform.

Matthias F Melzig - One of the best experts on this subject based on the ideXlab platform.

  • Hepatoprotective Effect of isoquercitrin against acetaminophen induced liver injury
    Life Sciences, 2016
    Co-Authors: Meng Wang, Matthias F Melzig, Xiaoying Zhang, Chen Chen
    Abstract:

    Abstract Aims Acetaminophen (APAP) overdose leads to severe hepatotoxicity. Isoquercitrin exhibited potential Hepatoprotective Effect in our previous study. The present investigation aimed to evaluate the Effect of isoquercitrin against APAP induced liver injury and to explore its possible mechanism. Main methods Mice were treated intragastrically with isoquercitrin (10, 20, or 50 mg/kg) for 3 days before APAP (300 mg/kg) injection. After 24 h from APAP treatment, the levels of serum aminotransferase, hepatic oxidative stress and nitrosative stress biomarkers were determined by commercial kits or western bolt. Activities of UDP-glucuronosyltransferases (UGTs), sulfotransferases (SULTs) and cytochrome 2E1 (CYP2E1) were evaluated using ELISA methods and standard biochemical procedures. Subsequently, the protein and mRNA levels of inflammatory factors including TNF-α, IL-1β, IL-6 and iNOS were determined using ELISA methods, western blot or real-time PCR. The Effect of isoquercitrin on APAP activated NFκB/MAPK pathway was assessed by western bolt. Key findings Isoquercitrin pretreatments markedly attenuated APAP induced hepatic oxidative stress, nitrosative stress and centrilobular necrosis. In addition to potent antioxidant activity, isoquercitrin was able to regulate the activities of SULTs and CYP2E1, therefore promoted APAP hepatic detoxification. The anti-inflammatory activity of isoquercitrin which involved in the amelioration of iNOS, TNF-α, IL-1β and IL-6 production via the blockade of NF-κB and MAPK pathways also responsible for its Hepatoprotective Effect. Significance Our data evidenced that isoquercitrin protected liver from APAP induced injury though inhibition of oxidative stress, nitrosative stress and inflammation, as well as regulation of APAP metabolism, suggesting that isoquercitrin could be a potential Hepatoprotective agent.

Yunita Satya Pratiwi - One of the best experts on this subject based on the ideXlab platform.

  • Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats
    International Journal of Public Health Science (IJPHS), 2016
    Co-Authors: Yunita Satya Pratiwi, Bambang Wirjatmadi, Mangestuti Agil, Merryana Adriyani, Supriyadi Supriyadi
    Abstract:

    The aim of this study was to determine the Hepatoprotective Effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective Effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α

  • Hepatoprotective Effect of Mangosteen Peel Extract on Borax-Induced Male Rats
    International Journal of Public Health Science (IJPHS), 2016
    Co-Authors: Yunita Satya Pratiwi, Bambang Wirjatmadi, Mangestuti Agil, Merryana Adriyani, Supriyadi Supriyadi
    Abstract:

    <p>The aim of this study was to determine the Hepatoprotective Effect of mangosteen peel extract (MPE) on borax-induced male rats. Hepatoprotective Effect is represented by the variables of liver weight, SGOT (Serum Glutamic oxaloacetic transaminase) and SGPT (Serum Glutamic Pyruvate Transaminase). The true experimental study used randomized separated pretest-posttest control group design. MPE was made with 50% ethanol and 0.5% carboxymethyl cellulose-sodium (CMC-Na) stabilizer solutions. Studied groups included three control groups (positive, negative pretest and posttest) and three experimental groups (MPE dose of 200 mg/kg, 400 mg/kg and 600 mg/kg rats body weight (BW)). Samples consisted 36 male rats. The length of intervention was 16 days by providing borax, and then MPE was started on day 3 (in 3 experimental groups). Results showed that up to 16th day the SGOT tended to decrease (α &lt;0.05), while the SGPT levels was stable, and so was the liver weight. Thus, up to day 16 the MPE was generally able to provide Hepatoprotective Effects mainly based on the variable SGOT in doses of 200 and 400 mg/kg. It has been proved that liver function of the rats was still relatively normal. This is in relations to the antioxidant potential of the MPE polyphenols.</p>

Li Guoyu - One of the best experts on this subject based on the ideXlab platform.