The Experts below are selected from a list of 222 Experts worldwide ranked by ideXlab platform
Birgit Skoldenberg - One of the best experts on this subject based on the ideXlab platform.
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Herpes Simplex Encephalitis lack of clinical benefit of long term valacyclovir therapy
Clinical Infectious Diseases, 2015Co-Authors: John W Gnann, Daniel F Hanley, Fred Y Aoki, E Aurelius, Birgit Skoldenberg, John Hart, Silvia Schliamser, Marie Studahl, Britt Marie Eriksson, Alan JacksonAbstract:Background: Despite the proven efficacy of acyclovir (ACV) therapy, Herpes Simplex Encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with AC ...
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rapid diagnosis of Herpes Simplex Encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid
The Lancet, 1991Co-Authors: E Aurelius, B Johansson, A Staland, Marianne Forsgren, Birgit SkoldenbergAbstract:Abstract With the aim of improving early diagnosis of Herpes Simplex Encephalitis a polymerase chain reaction (PCR) assay with two "nested" primer pairs was developed for the amplification of Herpes Simplex virus DNA in cerebrospinal fluid (CSF). Southern blotting was used to confirm the specificity of the amplification. The assay was applied to 151 CSF samples from 43 consecutive patients with Herpes Simplex Encephalitis verified by the finding of Herpes Simplex virus/viral antigen in a brain biopsy sample or at necropsy (13) and/or intrathecal production of IgG antibody to the virus (40). As controls, 87 CSF samples from 60 patients with acute febrile focal encephalopathy (initially suspected to be Herpes Simplex Encephalitis but excluded by the absence of intrathecal antibody synthesis) were tested. PCR detected Herpes Simplex virus DNA in 42 of the 43 patients with proven Herpes Simplex Encephalitis; all but 1 were positive in the first CSF sample taken. The 1 PCR-negative patient had been treated with acyclovir from 20 h after the onset of symptoms. All the control subjects were PCR negative, as were 270 internal contamination controls. The PCR result remained positive in samples drawn up to 27 days after the onset of neurological symptoms. This method is a rapid and non-invasive means to diagnose Herpes Simplex Encephalitis; it is highly sensitive and specific.
E Aurelius - One of the best experts on this subject based on the ideXlab platform.
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Herpes Simplex Encephalitis lack of clinical benefit of long term valacyclovir therapy
Clinical Infectious Diseases, 2015Co-Authors: John W Gnann, Daniel F Hanley, Fred Y Aoki, E Aurelius, Birgit Skoldenberg, John Hart, Silvia Schliamser, Marie Studahl, Britt Marie Eriksson, Alan JacksonAbstract:Background: Despite the proven efficacy of acyclovir (ACV) therapy, Herpes Simplex Encephalitis (HSE) continues to cause substantial morbidity and mortality. Among patients with HSE treated with AC ...
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rapid diagnosis of Herpes Simplex Encephalitis by nested polymerase chain reaction assay of cerebrospinal fluid
The Lancet, 1991Co-Authors: E Aurelius, B Johansson, A Staland, Marianne Forsgren, Birgit SkoldenbergAbstract:Abstract With the aim of improving early diagnosis of Herpes Simplex Encephalitis a polymerase chain reaction (PCR) assay with two "nested" primer pairs was developed for the amplification of Herpes Simplex virus DNA in cerebrospinal fluid (CSF). Southern blotting was used to confirm the specificity of the amplification. The assay was applied to 151 CSF samples from 43 consecutive patients with Herpes Simplex Encephalitis verified by the finding of Herpes Simplex virus/viral antigen in a brain biopsy sample or at necropsy (13) and/or intrathecal production of IgG antibody to the virus (40). As controls, 87 CSF samples from 60 patients with acute febrile focal encephalopathy (initially suspected to be Herpes Simplex Encephalitis but excluded by the absence of intrathecal antibody synthesis) were tested. PCR detected Herpes Simplex virus DNA in 42 of the 43 patients with proven Herpes Simplex Encephalitis; all but 1 were positive in the first CSF sample taken. The 1 PCR-negative patient had been treated with acyclovir from 20 h after the onset of symptoms. All the control subjects were PCR negative, as were 270 internal contamination controls. The PCR result remained positive in samples drawn up to 27 days after the onset of neurological symptoms. This method is a rapid and non-invasive means to diagnose Herpes Simplex Encephalitis; it is highly sensitive and specific.
Tran Thi Hong Chau - One of the best experts on this subject based on the ideXlab platform.
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valacyclovir for Herpes Simplex Encephalitis
Antimicrobial Agents and Chemotherapy, 2011Co-Authors: Thomas Pouplin, Julie Nguyen Pouplin, Niklas Lindegardh, Rogier H Van Doorn, Tran Tinh Hien, Jeremy Farrar, Estee M Torok, Tran Thi Hong ChauAbstract:The recommended treatment for Herpes Simplex Encephalitis (HSE) remains intravenous acyclovir. In resource-poor countries, however, intravenous formulations are usually unavailable or unaffordable. We report the penetration of acyclovir into the cerebrospinal fluid (CSF) in patients with HSE, treated with the oral prodrug valacyclovir at 1,000 mg three times daily. The oral therapy achieved adequate acyclovir concentrations in the CSF and may be an acceptable early treatment for suspected HSE in resource-limited settings.
A L Baert - One of the best experts on this subject based on the ideXlab platform.
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mri of Herpes Simplex Encephalitis
Neuroradiology, 1992Co-Authors: Ph Demaerel, Guy Wilms, Wim Robberecht, K Johannik, P Van Hecke, Herwig Carton, A L BaertAbstract:The magnetic resonance imaging (MRI) findings in eight patients with Herpes Simplex meningoEncephalitis were reviewed: 14 examinations were analysed. The most striking finding was high signal intensity in the temporal lobe(s) with the typical configuration known from CT. Meningeal enhancement after Gd-DTPA administration was clearly seen in four patients. Haemorrhagic changes are much better seen on MRI than on CT. When adequate motion control can be achieved, MRI becomes the examination of choice in the diagnosis and follow-up of Herpes Simplex Encephalitis. Localized1H MR spectroscopy also proved promising in the study of neuronal loss.
J Gordon Millichap - One of the best experts on this subject based on the ideXlab platform.
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Diagnosis and Outcome of Herpes Simplex Encephalitis
Pediatric Neurology Briefs, 2007Co-Authors: J Gordon MillichapAbstract:Children with Herpes Simplex Encephalitis (HSE) admitted to the Hospital for Sick Children, Toronto, Canada, between Jan 1994 and Dec 2005, were studied prospectively.
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Herpes Simplex Encephalitis Relapse
Pediatric Neurology Briefs, 2003Co-Authors: J Gordon MillichapAbstract:The clinical, biological, and radiological features of 8 episodes of Herpes Simplex Encephalitis (HSE) relapse are reviewed from the Hopital Saint Vincent de Paul, Paris.
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Early Diagnosis of Herpes Simplex Encephalitis
Pediatric Neurology Briefs, 2003Co-Authors: J Gordon MillichapAbstract:Records of 38 patients, 23 boys and 15 girls (ages 3 months to 16 years [42% ages 3-12 months]), seen between 1990 and 1997 with proven Herpes Simplex Encephalitis (HSE), were reviewed retrospectively to determine the diagnostic reliability of polymerase chain reaction (PCR) results, in a study at the Neuropediatric Service, Hopital Saint Vincent de Paul, Paris, France.
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Relapsing Herpes Simplex Encephalitis with Chorea
Pediatric Neurology Briefs, 1991Co-Authors: J Gordon MillichapAbstract:Herpes Simplex Encephalitis (HSE) followed a biphasic course with relapse in 3 children aged 11 years, 9 months, and 11 months reported from the Hospital for Sick Children, London and South Hampton General Hospital, England.