The Experts below are selected from a list of 360 Experts worldwide ranked by ideXlab platform
Yong-xing Song - One of the best experts on this subject based on the ideXlab platform.
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asymmetric construction of bispiro oxindole pyrrolidine rhodanine s via squaramide catalyzed domino michael mannich 3 2 cycloaddition of rhodanine derivatives with n 2 2 2 trifluoroethyl isatin ketimines
Journal of Organic Chemistry, 2018Co-Authors: Yong-xing SongAbstract:Squaramide-catalyzed asymmetric domino Michael/Mannich [3 + 2] cycloaddition reaction between rhodanine derivatives and N-(2,2,2-trifluoroethyl)isatin ketimines has been developed to synthesize various bispiro[oxindole-pyrrolidine-rhodanine]s with good to excellent yields (up to 99%) and excellent stereoselectivities (up to >99% ee and >99:1 dr). The biologically active rhodanine, oxindole, and pyrrolidine moieties were embedded in these novel bispirocyclic products, which will provide some support for the enrichment of chiral Heterocyclic Compound databases with potential medical value.
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Asymmetric Construction of Bispiro[oxindole-pyrrolidine-rhodanine]s via Squaramide-Catalyzed Domino Michael/Mannich [3 + 2] Cycloaddition of Rhodanine Derivatives with N‑(2,2,2-Trifluoroethyl)isatin Ketimines
2018Co-Authors: Yong-xing SongAbstract:Squaramide-catalyzed asymmetric domino Michael/Mannich [3 + 2] cycloaddition reaction between rhodanine derivatives and N-(2,2,2-trifluoroethyl)isatin ketimines has been developed to synthesize various bispiro[oxindole-pyrrolidine-rhodanine]s with good to excellent yields (up to 99%) and excellent stereoselectivities (up to >99% ee and >99:1 dr). The biologically active rhodanine, oxindole, and pyrrolidine moieties were embedded in these novel bispirocyclic products, which will provide some support for the enrichment of chiral Heterocyclic Compound databases with potential medical value
Frances J. Harding - One of the best experts on this subject based on the ideXlab platform.
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Biochemical and pharmacological characterization of isatin and its derivatives: from structure to activity
Pharmacological Reports, 2013Co-Authors: Parvaneh Pakravan, Soheila Kashanian, Mohammad M. Khodaei, Frances J. HardingAbstract:Isatin, k1H-indole-2,3-dione, kis a Heterocyclic Compound of significant importance in medicinal chemistry. It is a synthetically versatile molecule, ka precursor for a large number of pharmacologically active Compounds. Isatin and its derivatives have aroused great attention in recent years due to their wide variety of biological activities, krelevant to application as insecticides and fungicides and in a broad range of drug therapies, kincluding anticancer drugs, kantibiotics and antidepressants. The purpose of this review is to provide an overview of the pharmacological activities of isatin and its synthetic and natural derivatives. Molecular modifications to tailor the properties of isatin and its derivatives are also discussed.
S R Niranjana - One of the best experts on this subject based on the ideXlab platform.
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delftia tsuruhatensis wgr uom bt1 a novel rhizobacterium with pgpr properties from rauwolfia serpentina l benth ex kurz also suppresses fungal phytopathogens by producing a new antibiotic amtm
Letters in Applied Microbiology, 2015Co-Authors: S P Prasannakumar, H G Gowtham, P Hariprasad, K Shivaprasad, S R NiranjanaAbstract:UNLABELLED The bacterial strain designated as WGR-UOM-BT1 isolated from rhizosphere of Rauwolfia serpentina exhibited broad-spectrum antifungal activity and also improved early plant growth. Based on morphological, biochemical and 16S rRNA gene sequence analyses, the strain BT1 was identified as Delftia tsuruhatensis (KF727978). Under in vitro conditions, the strain BT1 suppressed the growth of wide range of fungal phytopathogens. Purified antimicrobial metabolite from the strain BT1 was identified as nitrogen-containing Heterocyclic Compound, 'amino(5-(4-methoxyphenyl)-2-methyl-2-(thiophen-2-yl)-2,3-dihydrofuran-3-yl)methanol' (AMTM), with molecular mass of 340•40 and molecular formula of C17 H19 NO3 S. The strain BT1 was positive for rhizosphere colonization (tomato), IAA production, 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity and phosphate solubilization. Under laboratory and greenhouse conditions, the strain BT1 promoted plant growth and suppressed foliar and root fungal pathogens of tomato. Therefore, antimicrobial and disease protection properties of strain BT1 could serve as an effective biological control candidate against devastating fungal pathogens of vegetable plants. Besides, the production of IAA, P solubilization and ACC deaminase activity enhance its potential as a biofertilizer and may stabilize the plant performance under fluctuating environmental conditions. SIGNIFICANCE AND IMPACT OF THE STUDY In this study, we reported that Delftia tsuruhatensis WGR-UOM-BT1 strain has the plant growth promotion activities such as rhizosphere colonization (tomato), IAA production, 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity and phosphate solubilization. This bacterial strain was found producing an antimicrobial nitrogen-containing Heterocyclic Compound identified as 'amino(5-(4-methoxyphenyl)-2-methyl-2-(thiophen-2-yl)-2,3-dihydrofuran-3-yl)methanol' [C17 H19 NO3 S] (AMTM), which is new to the bacterial world.
Niranjana S. R. - One of the best experts on this subject based on the ideXlab platform.
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Delftia tsuruhatensis WGR-UOM-BT1, a novel rhizobacterium with PGPR properties from Rauwolfia serpentina (L.) Benth. ex Kurz also suppresses fungal phytopathogens by producing a new antibiotic-AMTM
'Wiley', 2015Co-Authors: Prasannakumar S. P., Gowtham H. G., Hariprasad P., Shivaprasad K., Niranjana S. R.Abstract:The bacterial strain designated as WGR-UOM-BT1 isolated from rhizosphere of Rauwolfia serpentina exhibited broad-spectrum antifungal activity and also improved early plant growth. Based on morphological, biochemical and 16S rRNA gene sequence analyses, the strain BT1 was identified as Delftia tsuruhatensis (KF727978). Under in vitro conditions, the strain BT1 suppressed the growth of wide range of fungal phytopathogens. Purified antimicrobial metabolite from the strain BT1 was identified as nitrogen-containing Heterocyclic Compound, `amino(5-(4-methoxyphenyl)-2-methyl-2-(thiophen-2-yl)-2,3-dihydrofuran-3 -yl) methanol' (AMTM), with molecular mass of 340.40 and molecular formula of C17H19NO3S. The strain BT1 was positive for rhizosphere colonization (tomato), IAA production, 1-aminocyclopropane-1-carboxylate (ACC) deaminase activity and phosphate solubilization. Under laboratory and greenhouse conditions, the strain BT1 promoted plant growth and suppressed foliar and root fungal pathogens of tomato. Therefore, antimicrobial and disease protection properties of strain BT1 could serve as an effective biological control candidate against devastating fungal pathogens of vegetable plants. Besides, the production of IAA, P solubilization and ACC deaminase activity enhance its potential as a biofertilizer and may stabilize the plant performance under fluctuating environmental conditions
Ramachandra S Hosmane - One of the best experts on this subject based on the ideXlab platform.
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a novel broad spectrum anticancer Compound containing the imidazo 4 5 e 1 3 diazepine ring system
Bioorganic & Medicinal Chemistry Letters, 2010Co-Authors: Min Xie, Ravi K Ujjinamatada, Mariola Sadowska, Rena G Lapidus, Martin J Edelman, Ramachandra S HosmaneAbstract:Abstract Synthesis and broad-spectrum anticancer activity of a novel Heterocyclic Compound 1 containing the title imidazo[4,5- e ][1,3]diazepine ring system have been reported. The Compound shows potent in vitro antitumor activity with low micromolar IC 50 ’s against prostate, lung, breast, and ovarian cancer cell lines tested. The long alkyl chain attached to the six-position of the Heterocyclic ring of 1 appears to be necessary for the observed biological activity.