The Experts below are selected from a list of 1665 Experts worldwide ranked by ideXlab platform

Ann M. Gronowski - One of the best experts on this subject based on the ideXlab platform.

  • Heterophile Antibody interference in qualitative urine serum hcg devices case report
    Clinical Biochemistry, 2016
    Co-Authors: Khushbu Patel, Ann M. Gronowski
    Abstract:

    Abstract Objectives This case report investigates the origin of a false positive result on a serum qualitative human chorionic gonadotropin (hCG) device. Patient and methods A 46-year-old woman diagnosed with chronic myeloid leukemia presented with nausea and vomiting. A qualitative serum hCG test was interpreted as positive; however, a quantitative serum hCG test was negative ( Results The qualitative test result was negative after pretreatment with heterophilic blocking reagent. Other devices composed of antibodies from different animal sources also demonstrated mixed results with the patient's sample. Blocking reagent obtained from the automated quantitative assay inhibited the Heterophile Antibody interference in the patient's sample. Conclusion This case demonstrates that positive serum point-of-care hCG results should be interpreted with caution and confirmed with a quantitative serum hCG immunoassay when clinical suspicion is raised.

  • Heterophile Antibody interference in qualitative urine/serum hCG devices: Case report
    Clinical biochemistry, 2016
    Co-Authors: Khushbu Patel, Ann M. Gronowski
    Abstract:

    Abstract Objectives This case report investigates the origin of a false positive result on a serum qualitative human chorionic gonadotropin (hCG) device. Patient and methods A 46-year-old woman diagnosed with chronic myeloid leukemia presented with nausea and vomiting. A qualitative serum hCG test was interpreted as positive; however, a quantitative serum hCG test was negative ( Results The qualitative test result was negative after pretreatment with heterophilic blocking reagent. Other devices composed of antibodies from different animal sources also demonstrated mixed results with the patient's sample. Blocking reagent obtained from the automated quantitative assay inhibited the Heterophile Antibody interference in the patient's sample. Conclusion This case demonstrates that positive serum point-of-care hCG results should be interpreted with caution and confirmed with a quantitative serum hCG immunoassay when clinical suspicion is raised.

  • diagnostic performance of a new automated Heterophile Antibody test in adults and children
    Diagnostic Microbiology and Infectious Disease, 2008
    Co-Authors: Stacey J Klutts, Andrew Smith, Belinda Yenlieberman, Ann M. Gronowski
    Abstract:

    Epstein-Barr virus serologic profiles were obtained from 618 patients using an automated platform, including the new BioPlex Heterophile assay. When compared with 2 IgM viral capsid antigen (VCA) assays and a predicate Heterophile assay, the BioPlex Heterophile assay was more likely to be associated with serologic patterns of acute infection.

Khushbu Patel - One of the best experts on this subject based on the ideXlab platform.

  • Heterophile Antibody interference in qualitative urine serum hcg devices case report
    Clinical Biochemistry, 2016
    Co-Authors: Khushbu Patel, Ann M. Gronowski
    Abstract:

    Abstract Objectives This case report investigates the origin of a false positive result on a serum qualitative human chorionic gonadotropin (hCG) device. Patient and methods A 46-year-old woman diagnosed with chronic myeloid leukemia presented with nausea and vomiting. A qualitative serum hCG test was interpreted as positive; however, a quantitative serum hCG test was negative ( Results The qualitative test result was negative after pretreatment with heterophilic blocking reagent. Other devices composed of antibodies from different animal sources also demonstrated mixed results with the patient's sample. Blocking reagent obtained from the automated quantitative assay inhibited the Heterophile Antibody interference in the patient's sample. Conclusion This case demonstrates that positive serum point-of-care hCG results should be interpreted with caution and confirmed with a quantitative serum hCG immunoassay when clinical suspicion is raised.

  • Heterophile Antibody interference in qualitative urine/serum hCG devices: Case report
    Clinical biochemistry, 2016
    Co-Authors: Khushbu Patel, Ann M. Gronowski
    Abstract:

    Abstract Objectives This case report investigates the origin of a false positive result on a serum qualitative human chorionic gonadotropin (hCG) device. Patient and methods A 46-year-old woman diagnosed with chronic myeloid leukemia presented with nausea and vomiting. A qualitative serum hCG test was interpreted as positive; however, a quantitative serum hCG test was negative ( Results The qualitative test result was negative after pretreatment with heterophilic blocking reagent. Other devices composed of antibodies from different animal sources also demonstrated mixed results with the patient's sample. Blocking reagent obtained from the automated quantitative assay inhibited the Heterophile Antibody interference in the patient's sample. Conclusion This case demonstrates that positive serum point-of-care hCG results should be interpreted with caution and confirmed with a quantitative serum hCG immunoassay when clinical suspicion is raised.

Jeffrey M Goldberg - One of the best experts on this subject based on the ideXlab platform.

  • Heterophile Antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay.
    Obstetrics and gynecology, 2003
    Co-Authors: Navid Esfandiari, Jeffrey M Goldberg
    Abstract:

    Persistently false positive human chorionic gonadotropin (hCG) test results in the absence of an intrauterine pregnancy may lead to a diagnosis of ectopic pregnancy or gestational trophoblastic neoplasia and unnecessary testing and therapy. A 38-year-old woman on oral contraceptives and a 53-year-old perimenopausal woman presented with persistently elevated serum beta-hCG levels from 30 to 225 mIU/mL. Both women had a history of working with mice. Urine hCG testing was negative. Serum beta-hCG levels for both patients were negative after pretreatment of their serum with a Heterophile Antibody blocking agent. These cases illustrate that serum Heterophile antibodies can interfere with the hCG enzyme immunoassay and result in false positive values. The addition of Heterophile blocking agent to the serum can exclude false positives, thereby preventing unnecessary evaluation and treatment.

  • Heterophile Antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay.
    Obstetrics & Gynecology, 2003
    Co-Authors: Navid Esfandiari, Jeffrey M Goldberg
    Abstract:

    Abstract background Persistently false positive human chorionic gonadotropin (hCG) test results in the absence of an intrauterine pregnancy may lead to a diagnosis of ectopic pregnancy or gestational trophoblastic neoplasia and unnecessary testing and therapy. Cases A 38-year-old woman on oral contraceptives and a 53-year-old perimenopausal woman presented with persistently elevated serum β-hCG levels from 30 to 225 mIU/mL. Both women had a history of working with mice. Urine hCG testing was negative. Serum β-hCG levels for both patients were negative after pretreatment of their serum with a Heterophile Antibody blocking agent. Conclusion These cases illustrate that serum Heterophile antibodies can interfere with the hCG enzyme immunoassay and result in false positive values. The addition of Heterophile blocking agent to the serum can exclude false positives, thereby preventing unnecessary evaluation and treatment.

Navid Esfandiari - One of the best experts on this subject based on the ideXlab platform.

  • Heterophile Antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay.
    Obstetrics and gynecology, 2003
    Co-Authors: Navid Esfandiari, Jeffrey M Goldberg
    Abstract:

    Persistently false positive human chorionic gonadotropin (hCG) test results in the absence of an intrauterine pregnancy may lead to a diagnosis of ectopic pregnancy or gestational trophoblastic neoplasia and unnecessary testing and therapy. A 38-year-old woman on oral contraceptives and a 53-year-old perimenopausal woman presented with persistently elevated serum beta-hCG levels from 30 to 225 mIU/mL. Both women had a history of working with mice. Urine hCG testing was negative. Serum beta-hCG levels for both patients were negative after pretreatment of their serum with a Heterophile Antibody blocking agent. These cases illustrate that serum Heterophile antibodies can interfere with the hCG enzyme immunoassay and result in false positive values. The addition of Heterophile blocking agent to the serum can exclude false positives, thereby preventing unnecessary evaluation and treatment.

  • Heterophile Antibody blocking agent to confirm false positive serum human chorionic gonadotropin assay.
    Obstetrics & Gynecology, 2003
    Co-Authors: Navid Esfandiari, Jeffrey M Goldberg
    Abstract:

    Abstract background Persistently false positive human chorionic gonadotropin (hCG) test results in the absence of an intrauterine pregnancy may lead to a diagnosis of ectopic pregnancy or gestational trophoblastic neoplasia and unnecessary testing and therapy. Cases A 38-year-old woman on oral contraceptives and a 53-year-old perimenopausal woman presented with persistently elevated serum β-hCG levels from 30 to 225 mIU/mL. Both women had a history of working with mice. Urine hCG testing was negative. Serum β-hCG levels for both patients were negative after pretreatment of their serum with a Heterophile Antibody blocking agent. Conclusion These cases illustrate that serum Heterophile antibodies can interfere with the hCG enzyme immunoassay and result in false positive values. The addition of Heterophile blocking agent to the serum can exclude false positives, thereby preventing unnecessary evaluation and treatment.

John D. Jacobson - One of the best experts on this subject based on the ideXlab platform.

  • Falsely elevated testosterone due to Heterophile antibodies.
    Obstetrics & Gynecology, 2012
    Co-Authors: Irene Cheng, John M. Norian, John D. Jacobson
    Abstract:

    BACKGROUND: Falsely elevated testosterone is a rare phenomenon that may result from Heterophile antibodies. Similar to patients with Heterophile antibodies for β-hCG, incorrect management may result in unnecessary testing or therapy. CASE: A previously healthy postmenopausal woman presented with a falsely elevated total testosterone level due to interference consistent with Heterophile antibodies, with subsequent normal levels detected by liquid chromatography-mass spectrometry. CONCLUSION: Asymptomatic patients may present with an elevated hormone level due to Heterophile Antibody interference. Molecular studies for hormone levels can assist greatly when falsely elevated levels are suspected, but these tests are costly and time-intensive.

  • Falsely elevated testosterone due to Heterophile antibodies.
    Obstetrics and gynecology, 2012
    Co-Authors: Irene Cheng, John M. Norian, John D. Jacobson
    Abstract:

    Falsely elevated testosterone is a rare phenomenon that may result from Heterophile antibodies. Similar to patients with Heterophile antibodies for β-hCG, incorrect management may result in unnecessary testing or therapy. A previously healthy postmenopausal woman presented with a falsely elevated total testosterone level due to interference consistent with Heterophile antibodies, with subsequent normal levels detected by liquid chromatography-mass spectrometry. Asymptomatic patients may present with an elevated hormone level due to Heterophile Antibody interference. Molecular studies for hormone levels can assist greatly when falsely elevated levels are suspected, but these tests are costly and time-intensive.