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G Chales - One of the best experts on this subject based on the ideXlab platform.
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high energy extracorporeal Shock Wave therapy for calcifying tendinitis of the rotator cuff a randomised trial
Journal of Bone and Joint Surgery-british Volume, 2007Co-Authors: Jeandavid Albert, J Meadeb, Pascal Guggenbuhl, F Marin, T Benkalfate, H Thomazeau, G ChalesAbstract:In a prospective randomised trial of calcifying tendinitis of the rotator cuff, we compared the efficacy of dual treatment sessions delivering 2500 extracorporeal Shock Waves at either high- or low-energy, via an electromagnetic generator under fluoroscopic guidance. Patients were eligible for the study if they had more than a three-month history of calcifying tendinitis of the rotator cuff, with calcification measuring 10 mm or more in maximum dimension. The primary outcome measure was the change in the Constant and Murley Score. A total of 80 patients were enrolled (40 in each group), and were re-evaluated at a mean of 110 (41 to 255) days after treatment when the increase in Constant and Murley score was significantly greater (t-test, p = 0.026) in the High-Energy treatment group than in the low-energy group. The improvement from the baseline level was significant in the High-Energy group, with a mean gain of 12.5 (-20.7 to 47.5) points (p < 0.0001). The improvement was not significant in the low-energy group. Total or subtotal resorption of the calcification occurred in six patients (15%) in the High-Energy group and in two patients (5%) in the low-energy group. High-Energy Shock-Wave therapy significantly improves symptoms in refractory calcifying tendinitis of the shoulder after three months of follow-up, but the calcific deposit remains unchanged in size in the majority of patients.
Jeandavid Albert - One of the best experts on this subject based on the ideXlab platform.
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high energy extracorporeal Shock Wave therapy for calcifying tendinitis of the rotator cuff a randomised trial
Journal of Bone and Joint Surgery-british Volume, 2007Co-Authors: Jeandavid Albert, J Meadeb, Pascal Guggenbuhl, F Marin, T Benkalfate, H Thomazeau, G ChalesAbstract:In a prospective randomised trial of calcifying tendinitis of the rotator cuff, we compared the efficacy of dual treatment sessions delivering 2500 extracorporeal Shock Waves at either high- or low-energy, via an electromagnetic generator under fluoroscopic guidance. Patients were eligible for the study if they had more than a three-month history of calcifying tendinitis of the rotator cuff, with calcification measuring 10 mm or more in maximum dimension. The primary outcome measure was the change in the Constant and Murley Score. A total of 80 patients were enrolled (40 in each group), and were re-evaluated at a mean of 110 (41 to 255) days after treatment when the increase in Constant and Murley score was significantly greater (t-test, p = 0.026) in the High-Energy treatment group than in the low-energy group. The improvement from the baseline level was significant in the High-Energy group, with a mean gain of 12.5 (-20.7 to 47.5) points (p < 0.0001). The improvement was not significant in the low-energy group. Total or subtotal resorption of the calcification occurred in six patients (15%) in the High-Energy group and in two patients (5%) in the low-energy group. High-Energy Shock-Wave therapy significantly improves symptoms in refractory calcifying tendinitis of the shoulder after three months of follow-up, but the calcific deposit remains unchanged in size in the majority of patients.
Mark Thomsen - One of the best experts on this subject based on the ideXlab platform.
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treatment of calcifying tendinitis of rotator cuff by extracorporeal Shock Waves a preliminary report
Journal of Shoulder and Elbow Surgery, 1995Co-Authors: Markus Loew, Wigand Jurgowski, Mark ThomsenAbstract:This study examined the effects of High-Energy Shock Wave treatment on the course of calcifying tendinitis of the shoulder. Twenty patients were included in the protocol. Shock Waves were applied to the calcifications with a lithotripter in two sessions of 2000 pulses each. The energy that produced the Shock Wave was 18 to 22 kV. Six and 12 weeks after treatment the subjective and functional state was assessed with the Constant score. All patients underwent radiographs and magnetic resonance imaging. At the 12-week follow-up evaluation 15 patients had a marked reduction of symptoms with an average of 30% improvement in the Constant score. Radiographs showed a complete elimination of the calcifications in seven patients, and in five cases a partial disintegration was seen. The overall morbidity was low; 14 patients had a transient subcutaneous hematoma. Magnetic resonance imaging did not show any lasting damage to bone or soft tissue.
Chen Xing - One of the best experts on this subject based on the ideXlab platform.
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Protective effects of salvia miltiorrhiza and verapamil on high energy Shock Wave induced renal damage in rabbits
Journal of the Fourth Military Medical University, 2004Co-Authors: Chen XingAbstract:AIM: To study the protective effects of salvia miltiorrhiza on high energy Shock Wave induced renal damage in rabbits. METHODS: A total of 45 rabbits was randomly assigned to 3 groups. Control received physiological saline and the others received salvia miltiorrhiza and verapamil for 3 days before extracorporeal Shock Wave lithotripy (ESWL), respectively. Plasma ET 1, SOD and serum MDA were measured. RESULTS: After ESWL, there was a significant increase in plasma ET 1 ( P =0.015) and serum MDA levels ( P =0.01) and the activity of SOD in plasma decreased significantly ( P =0.003) compared with that before ESWL in control. In salvia miltiorrhiza and verapamil groups, however, plasma ET 1 and serum MDA after ESWL were not significantly different compared with the values before ESWL and were significantly lower than those of the controlled groups. Although the levels of the plasma SOD after ESWL decreased compared with the pre ESWL levels, the activity of SOD in plasma was significantly higher than that of the controlled ones (salvia miltiorrhiza: P =0.001, verapamil: P =0.022). All parameters were not significantly different between salvia miltiorrhiza and verapamil groups. CONCLUSION: Salvia miltiorrhiza and verapamil both have protective effects on ShockWave induced renal injury in rabbits.
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Effects of Astragalus membranaceus on histopathology of renal tissue induced by High-Energy Shock Wave
Journal of the Fourth Military Medical University, 2004Co-Authors: Chen XingAbstract:AIM: To study the protective effects of astragalus membranaceus on renal damage induced by high energy Shock Wave (HESW). METHODS: Forty five healthy male New Zealand white rabbits were divided into three groups at random control group ( n =15), shams ( n =15), and astragulus membranaceus treated animals ( n =15) and respectively were given intravenously verapamil (0.4 mg/kg), physiological saline (20 mL), and astragulus membranaceus (2.4 g/kg). HESW (1500 Shocks, 18 kV, MZ V made in China) was applied to the right kidneys of the anesthetized male rabbits in the three groups and the renal histopathological changes were observed. RESULTS: Light microscopy revealed injury of interstitial congestion and segmental renal tubular necrosis in the shams after Shocking. There was cell wall injury in part of epithelial cells due to cellular necrosis or changes of adhesiveness. Electron microscopy revealed changes as follows: a sharp decrease in glomerular capillary, vascular deformity, loss of normal foot process pattern over capillary, and thickening and fragmentation of glomerular basement membranes. The tubular cells were desquamated,which contained a deformed nucleus and destroyed organelles. We observed a decrease in mitochondria in epithelial cells of proximal convoluted tubules, edema of cell nucleus, and massive chromosomal aggregation. The damaged cell lost its brush border and had a sharp decrease in microvilli. Histopathology showed that renal damage in the animals given astragulus membranaceus and verapamil was slighter than that in sham group, especially in the astragulus membranaceus group. CONCLUSION: Astragulus membranaceus has protective effects on histopathological damage in rabbit kidney induced by HESW.
B Nafe - One of the best experts on this subject based on the ideXlab platform.
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Shock Wave therapy versus conventional surgery in the treatment of calcifying tendinitis of the shoulder
Clinical Orthopaedics and Related Research, 2001Co-Authors: J D Rompe, Jan Zoellner, B NafeAbstract:A prospective quasirandomized study was performed to compare the effects of surgical extirpation (Group I, 29 patients) with the outcome after High-Energy extracorporeal Shock Wave therapy (Group II, 50 patients; 3000 impulses of an energy flux density of 0.6 mJ/mm 2 ) in patients with a chronic calcifying tendinitis in the supraspinatus tendon. Symptoms and demographic data of the two groups were comparable. According to the University of California Los Angeles Rating System, the mean score in Group I was 30 points with 75% good or excellent results after 12 months, and 32 points with 90% good or excellent results after 24 months. Radiologically, there was no calcific deposit in 85% of the patients after 1 year. In Group II, the mean score was 28 points with 60% good or excellent results after 12 months, and 29 points with 64% good or excellent results after 2 years. Radiologically, complete elimination of the deposit was observed in 47% of the patients after 1 year. Clinically, according to the University of California Los Angeles score, there was no significant difference between both groups at 1 year. At 2 years, there was a significantly better result in Group II. Both groups then were subdivided into patients who had a homogenous deposit as seen on radiographs and patients who had an inhomogenous deposit before treatment. Surgery was superior compared with High-Energy Shock Wave therapy for patients with homogenous deposits. For patients with inhomogenous deposits, High-Energy extracorporeal Shock Wave therapy was equivalent to surgery and should be given priority because of its noninvasiveness.