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Peng Jiang - One of the best experts on this subject based on the ideXlab platform.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    Nutrients, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early-life environment have been identified, protective factors remain elusive. Here, we conducted a longitudinal study with 671 Nile rats whereby we examined the interplay between early-life environment (maternal Diet) and later-life environment (offspring Diet) using opposing Diets that induce or prevent Diet-induced diabetes. Specifically, we modulated the early-life environment throughout oogenesis, pregnancy, and nursing by feeding Nile rat dams a lifelong High-Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We found that exposure to a High-Fiber maternal Diet prior to weaning significantly lowered the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High-Fiber Diet after weaning did not develop Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of a High-Fiber Diet can be transmitted to the offspring through the maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early life environment have been identified, protective factors remain elusive. Here, we modulate the early life environment using a maternal High Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We examined the interplay between early life environment (maternal Diet) and later life environment (offspring Diet) using a longitudinal study with 671 Nile rats. We found that exposure to a High Fiber maternal Diet prior to weaning significantly lowers the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High Fiber Diet after weaning do not get Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of High Fiber can be transmitted to the offspring through a maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring on diabetogenic Diet in the nile rat
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Type 2 diabetes is strongly associated with both parental history and eating habits. The Nile rat is a model of type 2 diabetes that is Highly sensitive to nutritional imbalances. Our aim is to understand the effect of early nutrition derived from maternal Diet on the long-term risk of Diet-induced diabetes in the offspring. Using a two-by-two factorial design, 671 Nile rat dams and offspring were randomly fed a High Fiber Diet or a diabetogenic Diet, divided into two developmental stages prior or after weaning. Random blood glucose (RBG) levels were measured every four weeks from 4 to 40 weeks old. To confirm that the observed differences in the progression of RBG is statistically robust, we built a simple Bayesian network using three nodes – maternal Diet, offspring Diet, and sex. Among the offspring weaned onto a diabetogenic Diet, the influence of maternal Diet is remarkable. In these offspring, when the early nutrition is derived from a High Fiber maternal Diet, the onset of diabetes is delayed by about 16 weeks. Based on our Bayesian modeling, the largest benefit was observed at 36 weeks old with a 48.90% reduced probability of diabetes from 81.77% to 32.87%. This maternal High Fiber Diet protection effect is more obvious in male than in female offspring. Interestingly, in offspring weaned onto a High Fiber Diet, maternal Diet is irrelevant, and these offspring do not develop type 2 diabetes. Our study provides evidence that the protective effect of High Fiber against type 2 diabetes can be transmitted to the offspring through maternal feeding. Hence, improving maternal nutrition is an effective strategy for the prevention of type 2 diabetes.

James A Thomson - One of the best experts on this subject based on the ideXlab platform.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    Nutrients, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early-life environment have been identified, protective factors remain elusive. Here, we conducted a longitudinal study with 671 Nile rats whereby we examined the interplay between early-life environment (maternal Diet) and later-life environment (offspring Diet) using opposing Diets that induce or prevent Diet-induced diabetes. Specifically, we modulated the early-life environment throughout oogenesis, pregnancy, and nursing by feeding Nile rat dams a lifelong High-Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We found that exposure to a High-Fiber maternal Diet prior to weaning significantly lowered the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High-Fiber Diet after weaning did not develop Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of a High-Fiber Diet can be transmitted to the offspring through the maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early life environment have been identified, protective factors remain elusive. Here, we modulate the early life environment using a maternal High Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We examined the interplay between early life environment (maternal Diet) and later life environment (offspring Diet) using a longitudinal study with 671 Nile rats. We found that exposure to a High Fiber maternal Diet prior to weaning significantly lowers the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High Fiber Diet after weaning do not get Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of High Fiber can be transmitted to the offspring through a maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring on diabetogenic Diet in the nile rat
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Type 2 diabetes is strongly associated with both parental history and eating habits. The Nile rat is a model of type 2 diabetes that is Highly sensitive to nutritional imbalances. Our aim is to understand the effect of early nutrition derived from maternal Diet on the long-term risk of Diet-induced diabetes in the offspring. Using a two-by-two factorial design, 671 Nile rat dams and offspring were randomly fed a High Fiber Diet or a diabetogenic Diet, divided into two developmental stages prior or after weaning. Random blood glucose (RBG) levels were measured every four weeks from 4 to 40 weeks old. To confirm that the observed differences in the progression of RBG is statistically robust, we built a simple Bayesian network using three nodes – maternal Diet, offspring Diet, and sex. Among the offspring weaned onto a diabetogenic Diet, the influence of maternal Diet is remarkable. In these offspring, when the early nutrition is derived from a High Fiber maternal Diet, the onset of diabetes is delayed by about 16 weeks. Based on our Bayesian modeling, the largest benefit was observed at 36 weeks old with a 48.90% reduced probability of diabetes from 81.77% to 32.87%. This maternal High Fiber Diet protection effect is more obvious in male than in female offspring. Interestingly, in offspring weaned onto a High Fiber Diet, maternal Diet is irrelevant, and these offspring do not develop type 2 diabetes. Our study provides evidence that the protective effect of High Fiber against type 2 diabetes can be transmitted to the offspring through maternal feeding. Hence, improving maternal nutrition is an effective strategy for the prevention of type 2 diabetes.

Huishi Toh - One of the best experts on this subject based on the ideXlab platform.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    Nutrients, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early-life environment have been identified, protective factors remain elusive. Here, we conducted a longitudinal study with 671 Nile rats whereby we examined the interplay between early-life environment (maternal Diet) and later-life environment (offspring Diet) using opposing Diets that induce or prevent Diet-induced diabetes. Specifically, we modulated the early-life environment throughout oogenesis, pregnancy, and nursing by feeding Nile rat dams a lifelong High-Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We found that exposure to a High-Fiber maternal Diet prior to weaning significantly lowered the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High-Fiber Diet after weaning did not develop Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of a High-Fiber Diet can be transmitted to the offspring through the maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring against type 2 diabetes
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Previous studies have reported that maternal malnutrition is linked to increased risk of developing type 2 diabetes in adulthood. Although several diabetic risk factors associated with early life environment have been identified, protective factors remain elusive. Here, we modulate the early life environment using a maternal High Fiber Diet to investigate whether the offspring are protected from type 2 diabetes. We examined the interplay between early life environment (maternal Diet) and later life environment (offspring Diet) using a longitudinal study with 671 Nile rats. We found that exposure to a High Fiber maternal Diet prior to weaning significantly lowers the risk of Diet-induced diabetes in the offspring. Interestingly, offspring consuming a High Fiber Diet after weaning do not get Diet-induced diabetes, even when exposed to a diabetogenic maternal Diet. Here, we provide the first evidence that the protective effect of High Fiber can be transmitted to the offspring through a maternal Diet, which has important implications in diabetes prevention.

  • maternal High Fiber Diet protects offspring on diabetogenic Diet in the nile rat
    bioRxiv, 2020
    Co-Authors: Huishi Toh, James A Thomson, Peng Jiang
    Abstract:

    Abstract Type 2 diabetes is strongly associated with both parental history and eating habits. The Nile rat is a model of type 2 diabetes that is Highly sensitive to nutritional imbalances. Our aim is to understand the effect of early nutrition derived from maternal Diet on the long-term risk of Diet-induced diabetes in the offspring. Using a two-by-two factorial design, 671 Nile rat dams and offspring were randomly fed a High Fiber Diet or a diabetogenic Diet, divided into two developmental stages prior or after weaning. Random blood glucose (RBG) levels were measured every four weeks from 4 to 40 weeks old. To confirm that the observed differences in the progression of RBG is statistically robust, we built a simple Bayesian network using three nodes – maternal Diet, offspring Diet, and sex. Among the offspring weaned onto a diabetogenic Diet, the influence of maternal Diet is remarkable. In these offspring, when the early nutrition is derived from a High Fiber maternal Diet, the onset of diabetes is delayed by about 16 weeks. Based on our Bayesian modeling, the largest benefit was observed at 36 weeks old with a 48.90% reduced probability of diabetes from 81.77% to 32.87%. This maternal High Fiber Diet protection effect is more obvious in male than in female offspring. Interestingly, in offspring weaned onto a High Fiber Diet, maternal Diet is irrelevant, and these offspring do not develop type 2 diabetes. Our study provides evidence that the protective effect of High Fiber against type 2 diabetes can be transmitted to the offspring through maternal feeding. Hence, improving maternal nutrition is an effective strategy for the prevention of type 2 diabetes.

L. E. Strong - One of the best experts on this subject based on the ideXlab platform.

  • High-Fiber Diet reduces serum estrogen concentrations in premenopausal women
    American Journal of Clinical Nutrition, 1991
    Co-Authors: D P Rose, J. M. Connolly, M. Goldman, L. E. Strong
    Abstract:

    The effect of Dietary Fiber on serum estrogen concentrations was studied in 62 premenopausal women. Their estimated daily Dietary Fiber intake was increased from an average of approximately 15 g to 30 g/d by supplementation with wheat, oat, or corn bran. This was done without any significant decrease in Dietary fat consumption. After 2 mo on the High-Fiber Diets, the wheat-bran-supplemented group showed significant reductions in serum estrone (P less than 0.002) and estradiol (P less than 0.02) but no change in serum progesterone or sex-hormone-binding globulin concentrations. The serum estrogens were unaffected by Dietary-Fiber supplementation with oat or corn brans.

George L Arnold - One of the best experts on this subject based on the ideXlab platform.