The Experts below are selected from a list of 204 Experts worldwide ranked by ideXlab platform

Peter M Clifton - One of the best experts on this subject based on the ideXlab platform.

  • Psychological benefits of a High-Protein, Low-Carbohydrate Diet in obese women with polycystic ovary syndrome--a pilot study.
    Appetite, 2007
    Co-Authors: Cherrie Galletly, Manny Noakes, Peter M Clifton, Lisa J. Moran, Lisa Tomlinson, Robert J. Norman
    Abstract:

    This study compared the psychological effects of a low-protein high-carbohydrate (LPHC) Diet and a High-Protein Low-Carbohydrate (HPLC) Diet in women with polycystic ovary syndrome (PCOS). Twenty-five overweight women with PCOS were matched for age, weight, and whether they were trying to conceive. They were randomly allocated to the LPHC or HPLC Diet for 16 weeks. All participants attended a weekly exercise, group support and educational program. The Hospital Anxiety and Depression Scale and the Rosenberg Self Esteem Scale were administered at the beginning and end of the study. The HPLC Diet was associated with significant reduction in depression and improvement in self-esteem. There was no change in any psychological measures for the LPHC group. There was no difference in weight loss between the groups. Due to enhanced feelings of well-being, it is possible that HPLC Diets may be associated with better compliance and hence be more successful in the long term treatment of obesity.

  • long term effects of a high protein low carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects

  • Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    OBJECTIVE: To compare the long-term compliance and effects of two low-fat Diets differing in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular disease risk in obese subjects with hyperinsulinemia. DESIGN: Outpatient, parallel, clinical intervention study of two groups of subjects randomly assigned to either a standard protein (SP; 15% protein, 55% carbohydrate) or High-Protein (HP; 30% protein, 40% carbohydrate) Diet, during 12 weeks of energy restriction (∼6.5 MJ/day) and 4 weeks of energy balance (∼8.3 MJ/day). Subsequently, subjects were asked to maintain the same Dietary pattern for the succeeding 52 weeks with minimal professional support. SUBJECTS: A total of 58 obese, nonDietetic subjects with hyperinsulinemia (13 males/45 females, mean age 50.2 y, mean body mass index (BMI) 34.0 kg/m^2, mean fasting insulin 17.8 mU/l) participated in the study. MEASUREMENTS: Body composition, blood pressure, blood lipids, fasting glucose, insulin, CRP and sICAM-1 were measured at baseline and at weeks 16 and 68. Urinary urea/creatinine ratio was measured at baseline, week 16 and at 3 monthly intervals thereafter. RESULTS: In total, 43 subjects completed the study with similar dropouts in each group ( P =0.76). At week 68, there was net weight loss (SP −2.9±3.6%, HP −4.1±5.8%; P

Grant D Brinkworth - One of the best experts on this subject based on the ideXlab platform.

  • long term effects of a high protein low carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects

  • Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    OBJECTIVE: To compare the long-term compliance and effects of two low-fat Diets differing in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular disease risk in obese subjects with hyperinsulinemia. DESIGN: Outpatient, parallel, clinical intervention study of two groups of subjects randomly assigned to either a standard protein (SP; 15% protein, 55% carbohydrate) or High-Protein (HP; 30% protein, 40% carbohydrate) Diet, during 12 weeks of energy restriction (∼6.5 MJ/day) and 4 weeks of energy balance (∼8.3 MJ/day). Subsequently, subjects were asked to maintain the same Dietary pattern for the succeeding 52 weeks with minimal professional support. SUBJECTS: A total of 58 obese, nonDietetic subjects with hyperinsulinemia (13 males/45 females, mean age 50.2 y, mean body mass index (BMI) 34.0 kg/m^2, mean fasting insulin 17.8 mU/l) participated in the study. MEASUREMENTS: Body composition, blood pressure, blood lipids, fasting glucose, insulin, CRP and sICAM-1 were measured at baseline and at weeks 16 and 68. Urinary urea/creatinine ratio was measured at baseline, week 16 and at 3 monthly intervals thereafter. RESULTS: In total, 43 subjects completed the study with similar dropouts in each group ( P =0.76). At week 68, there was net weight loss (SP −2.9±3.6%, HP −4.1±5.8%; P

Frank Q. Nuttall - One of the best experts on this subject based on the ideXlab platform.

  • The metabolic response to a High-Protein, Low-Carbohydrate Diet in men with type 2 diabetes mellitus
    Metabolism-clinical and Experimental, 2006
    Co-Authors: Frank Q. Nuttall, Mary C. Gannon
    Abstract:

    Abstract We recently reported that in subjects with untreated type 2 diabetes mellitus, a 5-week Diet of 20:30:50 carbohydrate-protein-fat ratio resulted in a dramatic decrease in 24-hour integrated glucose and total glycohemoglobin compared with a control Diet of 55:15:30. Body weight, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and serum ketones were unchanged; insulin and nonesterified fatty acids were decreased. We now present data on other hormones and metabolites considered to be affected by Dietary macronutrient changes. The test Diet resulted in an elevated fasting plasma total insulin-like growth factor 1, but not growth hormone. Urinary aldosterone was unchanged; free cortisol was increased, although not statistically. Urinary pH and calcium were unchanged. Blood pressure, creatinine clearance, serum vitamin B 12 , folate, homocysteine, thyroid hormones, and uric acid were unchanged. Serum creatinine was modestly increased. Plasma α -amino nitrogen and urea nitrogen were increased. Urea production rate was increased such that a new steady state was present. The calculated urea production rate accounted for 87% of protein ingested on the control Diet, but only 67% on the test Diet, suggesting net nitrogen retention on the latter. The lack of negative effects, improved glucose control, and a positive nitrogen balance suggest beneficial effects for subjects with type 2 diabetes mellitus at risk for loss of lean body mass.

  • effect of a high protein low carbohydrate Diet on blood glucose control in people with type 2 diabetes
    Diabetes, 2004
    Co-Authors: Mary C. Gannon, Frank Q. Nuttall
    Abstract:

    There has been interest in the effect of various types and amounts of Dietary carbohydrates and proteins on blood glucose. On the basis of our previous data, we designed a High-Protein/Low-Carbohydrate, weight-maintaining, nonketogenic Diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. We refer to this as a low-biologically-available-glucose (LoBAG) Diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control Diet was 55:15:30. The test Diet ratio was 20:30:50. Plasma and urinary β-hydroxybutyrate were similar on both Diets. The mean 24-h integrated serum glucose at the end of the control and LoBAG Diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 ± 0.5 and 7.6 ± 0.3, respectively. It was still decreasing at the end of the LoBAG Diet. Thus, the final calculated glycohemoglobin was estimated to be ∼6.3–5.4%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged. Thus, a LoBAG Diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a Diet remain to be determined.

Mary C. Gannon - One of the best experts on this subject based on the ideXlab platform.

  • The metabolic response to a High-Protein, Low-Carbohydrate Diet in men with type 2 diabetes mellitus
    Metabolism-clinical and Experimental, 2006
    Co-Authors: Frank Q. Nuttall, Mary C. Gannon
    Abstract:

    Abstract We recently reported that in subjects with untreated type 2 diabetes mellitus, a 5-week Diet of 20:30:50 carbohydrate-protein-fat ratio resulted in a dramatic decrease in 24-hour integrated glucose and total glycohemoglobin compared with a control Diet of 55:15:30. Body weight, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and serum ketones were unchanged; insulin and nonesterified fatty acids were decreased. We now present data on other hormones and metabolites considered to be affected by Dietary macronutrient changes. The test Diet resulted in an elevated fasting plasma total insulin-like growth factor 1, but not growth hormone. Urinary aldosterone was unchanged; free cortisol was increased, although not statistically. Urinary pH and calcium were unchanged. Blood pressure, creatinine clearance, serum vitamin B 12 , folate, homocysteine, thyroid hormones, and uric acid were unchanged. Serum creatinine was modestly increased. Plasma α -amino nitrogen and urea nitrogen were increased. Urea production rate was increased such that a new steady state was present. The calculated urea production rate accounted for 87% of protein ingested on the control Diet, but only 67% on the test Diet, suggesting net nitrogen retention on the latter. The lack of negative effects, improved glucose control, and a positive nitrogen balance suggest beneficial effects for subjects with type 2 diabetes mellitus at risk for loss of lean body mass.

  • effect of a high protein low carbohydrate Diet on blood glucose control in people with type 2 diabetes
    Diabetes, 2004
    Co-Authors: Mary C. Gannon, Frank Q. Nuttall
    Abstract:

    There has been interest in the effect of various types and amounts of Dietary carbohydrates and proteins on blood glucose. On the basis of our previous data, we designed a High-Protein/Low-Carbohydrate, weight-maintaining, nonketogenic Diet. Its effect on glucose control in people with untreated type 2 diabetes was determined. We refer to this as a low-biologically-available-glucose (LoBAG) Diet. Eight men were studied using a randomized 5-week crossover design with a 5-week washout period. The carbohydrate:protein:fat ratio of the control Diet was 55:15:30. The test Diet ratio was 20:30:50. Plasma and urinary β-hydroxybutyrate were similar on both Diets. The mean 24-h integrated serum glucose at the end of the control and LoBAG Diets was 198 and 126 mg/dl, respectively. The percentage of glycohemoglobin was 9.8 ± 0.5 and 7.6 ± 0.3, respectively. It was still decreasing at the end of the LoBAG Diet. Thus, the final calculated glycohemoglobin was estimated to be ∼6.3–5.4%. Serum insulin was decreased, and plasma glucagon was increased. Serum cholesterol was unchanged. Thus, a LoBAG Diet ingested for 5 weeks dramatically reduced the circulating glucose concentration in people with untreated type 2 diabetes. Potentially, this could be a patient-empowering way to ameliorate hyperglycemia without pharmacological intervention. The long-term effects of such a Diet remain to be determined.

Manny Noakes - One of the best experts on this subject based on the ideXlab platform.

  • Psychological benefits of a High-Protein, Low-Carbohydrate Diet in obese women with polycystic ovary syndrome--a pilot study.
    Appetite, 2007
    Co-Authors: Cherrie Galletly, Manny Noakes, Peter M Clifton, Lisa J. Moran, Lisa Tomlinson, Robert J. Norman
    Abstract:

    This study compared the psychological effects of a low-protein high-carbohydrate (LPHC) Diet and a High-Protein Low-Carbohydrate (HPLC) Diet in women with polycystic ovary syndrome (PCOS). Twenty-five overweight women with PCOS were matched for age, weight, and whether they were trying to conceive. They were randomly allocated to the LPHC or HPLC Diet for 16 weeks. All participants attended a weekly exercise, group support and educational program. The Hospital Anxiety and Depression Scale and the Rosenberg Self Esteem Scale were administered at the beginning and end of the study. The HPLC Diet was associated with significant reduction in depression and improvement in self-esteem. There was no change in any psychological measures for the LPHC group. There was no difference in weight loss between the groups. Due to enhanced feelings of well-being, it is possible that HPLC Diets may be associated with better compliance and hence be more successful in the long term treatment of obesity.

  • long term effects of a high protein low carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects

  • Long-term effects of a High-Protein, Low-Carbohydrate Diet on weight control and cardiovascular risk markers in obese hyperinsulinemic subjects
    International Journal of Obesity, 2004
    Co-Authors: Grant D Brinkworth, Manny Noakes, N D Luscombe, Gary A. Wittert, Jennifer B Keogh, Peter M Clifton
    Abstract:

    OBJECTIVE: To compare the long-term compliance and effects of two low-fat Diets differing in carbohydrate to protein ratio on body composition and biomarkers of cardiovascular disease risk in obese subjects with hyperinsulinemia. DESIGN: Outpatient, parallel, clinical intervention study of two groups of subjects randomly assigned to either a standard protein (SP; 15% protein, 55% carbohydrate) or High-Protein (HP; 30% protein, 40% carbohydrate) Diet, during 12 weeks of energy restriction (∼6.5 MJ/day) and 4 weeks of energy balance (∼8.3 MJ/day). Subsequently, subjects were asked to maintain the same Dietary pattern for the succeeding 52 weeks with minimal professional support. SUBJECTS: A total of 58 obese, nonDietetic subjects with hyperinsulinemia (13 males/45 females, mean age 50.2 y, mean body mass index (BMI) 34.0 kg/m^2, mean fasting insulin 17.8 mU/l) participated in the study. MEASUREMENTS: Body composition, blood pressure, blood lipids, fasting glucose, insulin, CRP and sICAM-1 were measured at baseline and at weeks 16 and 68. Urinary urea/creatinine ratio was measured at baseline, week 16 and at 3 monthly intervals thereafter. RESULTS: In total, 43 subjects completed the study with similar dropouts in each group ( P =0.76). At week 68, there was net weight loss (SP −2.9±3.6%, HP −4.1±5.8%; P