The Experts below are selected from a list of 8532 Experts worldwide ranked by ideXlab platform
Xiqing Bian - One of the best experts on this subject based on the ideXlab platform.
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paenibacillin a a new 2 1h pyrazinone ring containing natural product from the endophytic bacterium paenibacillus sp xy 2
Natural Product Research, 2016Co-Authors: Xiqing Bian, Shengdong Huang, Kaibo Wang, Meili Shao, Xin WuAbstract:A new 2(1H)-pyrazinone ring-containing natural product, paenibacillin A (1), together with five known diketopiperazine derivatives 2–6 and two known isoflavones 7–8, was isolated from the culture of an endophytic bacterium Paenibacillus sp. Xy-2. The structure of compound 1 was elucidated by extensive spectral methods, including UV, IR, HR-ESI-MS, 1D and 2D NMR and ECD experiments. Compound 1 exhibited moderate cytotoxicity against HL-60 Cell Line with IC50 value of 50.48 μM.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.
Yue-hu Pei - One of the best experts on this subject based on the ideXlab platform.
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a novel 3 4 dihydronaphthalen 1 2h one with spiro butyrolactone and a new isocoumarin isolated from the endophytic fungus phoma sp yn02 p 3
Journal of Asian Natural Products Research, 2017Co-Authors: Xianan Sang, Gang Chen, Shaofei Chen, Haifeng Wang, Yue-hu PeiAbstract:AbstractA novel 3,4-dihydronaphthalen-1(2H)-one with spiro-butyrolactone phomol (1) and a new isocoumarin phomasatin (2), together with two known compounds (3–4) were isolated from the solid culture of the endophytic fungus Phoma sp. YN02-P-3. Their structures including the absolute configurations were characterized on the basis of extensive 1D, 2D NMR (HSQC, HMBC, NOESY), MS, and CD spectral data. Compound 1 showed selective cytotoxic activity against HL-60 Cell Line with the IC50 value of 29.05 μM.
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butenolide derivatives from the plant endophytic fungus aspergillus terreus
Fitoterapia, 2016Co-Authors: Feng Guo, Hui-ming Hua, Yue-hu Pei, Kaibo Wang, Meili Shao, Haifeng Wang, Feng Zhao, Jiao BaiAbstract:Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), asperteretal B (2), and asperteretal C (3), together with seven known butenolides (4-10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var. assamica. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra. Compounds 1, 3, 5 and 6-8 showed potent inhibitory effects on NO production in RAW 264.7 lipopolysaccharide-induced macrophages, and compounds 5 and 8 also exhibited moderate cytotoxicity against HL-60 Cell Line.
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lecanicillones a c three dimeric isomers of spiciferone a with a cyclobutane ring from an entomopathogenic fungus lecanicillium sp pr m 3
RSC Advances, 2016Co-Authors: Zaiying Wang, Hui-ming Hua, Yue-hu Pei, Chunmei Xue, Xianan Sang, Ke Sun, Shengdong Huang, Shengshuang Chen, Lanfeng Ban, Jiao BaiAbstract:Lecanicillones A–C (1–3), three unusual dimeric spiciferones with acyclobutane ring via a [2 + 2] cycloaddition, were isolated from an entomopathogenic fungus Lecanicillium sp. PR-M-3. The structures of 1–3 were elucidated on the basis of spectral data, single-crystal X-ray diffraction, and ECD analysis. Compounds 1 and 3 showed moderate cytotoxicity against the HL-60 Cell Line.
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two pairs of enantiomeric alkaloid dimers from macleaya cordata
ChemInform, 2016Co-Authors: Chunmei Sai, Jiao Bai, Yue-hu Pei, Chunmei Xue, Kaibo Wang, Yongkui Jing, Hui-ming HuaAbstract:Two pairs of enantiomeric alkaloid dimers, (±)-macleayins A (1) and B (2), representing a novel dimerization pattern of two different types of alkaloids via a C-C σ-bond, were isolated from the aerial parts of Macleaya cordata. The enantiomeric separation was achieved by chiral chromatography. Their structures and stereochemistry were determined by the analysis of extensive spectroscopic data, electronic circular dichroism calculation, and single-crystal X-ray diffraction data. (-)-Macleayin A exhibits modest cytotoxic activity against HL-60 Cell Line with the IC50 value of 3.51 μM.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.
Guangyue Su - One of the best experts on this subject based on the ideXlab platform.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.
Xiaolan Hu - One of the best experts on this subject based on the ideXlab platform.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Xiaolan Hu, Xin Wu, Guangyue SuAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.
Hui-ming Hua - One of the best experts on this subject based on the ideXlab platform.
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New benzyl-aporphine alkaloids from Thalictrum cultratum
2018Co-Authors: Wen-jia Kang, Shengshuang Chen, Hui-ming Hua, Jiao BaiAbstract:Two new rare benzyl-aporphine alkaloids, thalicuLine (1) and 6a,7-dehydrothalicuLine (2), were isolated from the roots of Thalictrum cultratum Wall. Their structures were determined based on spectroscopic analysis including 1D, 2D NMR, and HR-ESI-MS. The stereochemistry of 1 was assigned by ECD spectroscopy. Compound 1 exhibited weak cytotoxicity against HL-60 Cell Line with IC50 value of 31.40 μM.
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butenolide derivatives from the plant endophytic fungus aspergillus terreus
Fitoterapia, 2016Co-Authors: Feng Guo, Hui-ming Hua, Yue-hu Pei, Kaibo Wang, Meili Shao, Haifeng Wang, Feng Zhao, Jiao BaiAbstract:Three new butenolides containing 5-hydroxyfuran-2(5H)-one core, asperteretal A (1), asperteretal B (2), and asperteretal C (3), together with seven known butenolides (4-10), were obtained from an endophytic fungus Aspergillus terreus PR-P-2 isolated from the plant Camellia sinensis var. assamica. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis including UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra. Compounds 1, 3, 5 and 6-8 showed potent inhibitory effects on NO production in RAW 264.7 lipopolysaccharide-induced macrophages, and compounds 5 and 8 also exhibited moderate cytotoxicity against HL-60 Cell Line.
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lecanicillones a c three dimeric isomers of spiciferone a with a cyclobutane ring from an entomopathogenic fungus lecanicillium sp pr m 3
RSC Advances, 2016Co-Authors: Zaiying Wang, Hui-ming Hua, Yue-hu Pei, Chunmei Xue, Xianan Sang, Ke Sun, Shengdong Huang, Shengshuang Chen, Lanfeng Ban, Jiao BaiAbstract:Lecanicillones A–C (1–3), three unusual dimeric spiciferones with acyclobutane ring via a [2 + 2] cycloaddition, were isolated from an entomopathogenic fungus Lecanicillium sp. PR-M-3. The structures of 1–3 were elucidated on the basis of spectral data, single-crystal X-ray diffraction, and ECD analysis. Compounds 1 and 3 showed moderate cytotoxicity against the HL-60 Cell Line.
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two pairs of enantiomeric alkaloid dimers from macleaya cordata
ChemInform, 2016Co-Authors: Chunmei Sai, Jiao Bai, Yue-hu Pei, Chunmei Xue, Kaibo Wang, Yongkui Jing, Hui-ming HuaAbstract:Two pairs of enantiomeric alkaloid dimers, (±)-macleayins A (1) and B (2), representing a novel dimerization pattern of two different types of alkaloids via a C-C σ-bond, were isolated from the aerial parts of Macleaya cordata. The enantiomeric separation was achieved by chiral chromatography. Their structures and stereochemistry were determined by the analysis of extensive spectroscopic data, electronic circular dichroism calculation, and single-crystal X-ray diffraction data. (-)-Macleayin A exhibits modest cytotoxic activity against HL-60 Cell Line with the IC50 value of 3.51 μM.
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penioxalicin a novel 3 nor 2 3 seco labdane type diterpene from the fungus penicillium oxalicum tw01 1
Tetrahedron Letters, 2015Co-Authors: Xiqing Bian, Jiao Bai, Hui-ming Hua, Aihong Han, Chunmei Xue, Yue-hu PeiAbstract:Penioxalicin (1), the first 3-nor-2,3-seco-labdane type diterpene featuring the fission between C-2 and C-3 in the ring A and the decarboxylation at C-3, was isolated from the fungus Penicillium oxalicum TW01-1. Its planar structure and absolute configuration were elucidated mainly by analysis of 1D and 2D-NMR, ECD spectroscopic data, and single-crystal X-ray diffraction. Compound 1 showed moderate cytotoxicity against HL-60 Cell Line. The possible biosynthetic pathway of 1 was also proposed.