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Svetlana Vojvodic - One of the best experts on this subject based on the ideXlab platform.

  • Investigating class II HLA Antigens' association with insulin-dependent diabetes mellitus in population of Vojvodina
    Medical review, 2003
    Co-Authors: Svetlana Vojvodic
    Abstract:

    INTRODUCTION Class II HLA Antigens were investigated in a group of 28 patients with insulin-dependent diabetes mellitus (IDDM) and 218 healthy unrelated persons (control group) from Vojvodina. MATERIAL AND METHODS We used a modified two-colour immunofluorescence method (serologic technique) to determine the phenotype of DR and DQ locus HLA Antigens. Phenotype frequencies of class II HLA Antigens were determined in both investigated groups and were used for calculating relative risk (RR). If RR was higher than 1, we calculated the population attributable risk (EF), and if RR was lower than 1, we calculated the preventive fraction (PF). Investigation of statistically significant differences in frequencies of class II HLA Antigens in patients and control group was performed by using chi 2 test. RESULTS Results of investigation showed that values of RR were higher than 1 for HLA DR4 (2,808), DR10 (1,116) and DQ3 (1,386), while we noticed a statistically significant difference in frequencies of HLA DR4 (chi 2 test: 4,805) in patients regarding control group. HLA DQ1 Antigen has a preventive role in development of IDDM due to highest value of PF (0,314). CONCLUSION Results of our investigation confirm that there is an association of HLA DR4 with IDDM in population of Vojvodina. High values of relative risk of IDDM, noticed in persons with HLA-DR4 Antigen, point to the degree of risk of IDDM, which is a disease with great socioeconomic importance in Vojvodina.

Anthony L. Komaroff - One of the best experts on this subject based on the ideXlab platform.

  • The Frequency of HLA Class II Antigens in Chronic Fatigue Syndrome
    Journal of Chronic Fatigue Syndrome, 2003
    Co-Authors: Richard S. Schacterle, Edgar L. Milford, Anthony L. Komaroff
    Abstract:

    AbstractChronic fatigue syndrome is a condition characterized by unexplained, persistent fatigue in conjunction with other generalized symptoms. However, the patients as a group are more likely to have objective abnormalities of the immune system than control subjects. We measured the frequency of certain HLA Antigens in a representative group of 35 patients. We restricted our analysis to class II molecules as these appear to be more specific predictors of susceptibility to immunologically-based disorders.The frequency of the HLA-DQ1 Antigen was increased in patients compared to general population Caucasian controls. This association between chronic fatigue syndrome and the HLA-DQ1 Antigen translates into a relative risk of 3.2. This association has not been reported previously in chronic fatigue syndrome. Differences in the ethnic sub-grouping of patients in this study and in previous studies also could have contributed to the difference between our findings and those of previous investigators. Conversel...

Richard S. Schacterle - One of the best experts on this subject based on the ideXlab platform.

  • The Frequency of HLA Class II Antigens in Chronic Fatigue Syndrome
    Journal of Chronic Fatigue Syndrome, 2003
    Co-Authors: Richard S. Schacterle, Edgar L. Milford, Anthony L. Komaroff
    Abstract:

    AbstractChronic fatigue syndrome is a condition characterized by unexplained, persistent fatigue in conjunction with other generalized symptoms. However, the patients as a group are more likely to have objective abnormalities of the immune system than control subjects. We measured the frequency of certain HLA Antigens in a representative group of 35 patients. We restricted our analysis to class II molecules as these appear to be more specific predictors of susceptibility to immunologically-based disorders.The frequency of the HLA-DQ1 Antigen was increased in patients compared to general population Caucasian controls. This association between chronic fatigue syndrome and the HLA-DQ1 Antigen translates into a relative risk of 3.2. This association has not been reported previously in chronic fatigue syndrome. Differences in the ethnic sub-grouping of patients in this study and in previous studies also could have contributed to the difference between our findings and those of previous investigators. Conversel...

Edgar L. Milford - One of the best experts on this subject based on the ideXlab platform.

  • The Frequency of HLA Class II Antigens in Chronic Fatigue Syndrome
    Journal of Chronic Fatigue Syndrome, 2003
    Co-Authors: Richard S. Schacterle, Edgar L. Milford, Anthony L. Komaroff
    Abstract:

    AbstractChronic fatigue syndrome is a condition characterized by unexplained, persistent fatigue in conjunction with other generalized symptoms. However, the patients as a group are more likely to have objective abnormalities of the immune system than control subjects. We measured the frequency of certain HLA Antigens in a representative group of 35 patients. We restricted our analysis to class II molecules as these appear to be more specific predictors of susceptibility to immunologically-based disorders.The frequency of the HLA-DQ1 Antigen was increased in patients compared to general population Caucasian controls. This association between chronic fatigue syndrome and the HLA-DQ1 Antigen translates into a relative risk of 3.2. This association has not been reported previously in chronic fatigue syndrome. Differences in the ethnic sub-grouping of patients in this study and in previous studies also could have contributed to the difference between our findings and those of previous investigators. Conversel...