The Experts below are selected from a list of 15 Experts worldwide ranked by ideXlab platform
Demireva M - One of the best experts on this subject based on the ideXlab platform.
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Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy
Problemi na khigienata, 1997Co-Authors: Baltadzhieva D, Bocheva S, Altŭnkova I, Demireva MAbstract:Tylosin-specific lymphocyte proliferation in vitro and its restriction of HLA class II Antigens have been investigated in 21 allergic workers exposed to tylosin. Nine workers from tylosin industry without allergic symptoms and five nonexposed nonallergic subjects served as controls. The results showed a significantly higher lymphocyte proliferative response to tylosin in allergic workers compared to control groups. Lymphocyte proliferation was observed in five workers with allergic complaints but negative skin tests. The tylosin concentration leading to maximal proliferative response varied from 10 to 1000 micrograms/ml among individuals. Six from seven workers with maximal response to the lowest concentration of tylosin carried HLA-DQ2 Antigen. Lymphocyte from most control subjects did not respond in vitro to tylosin. Weak proliferative response to tylosin was observed in two workers without clinical symptoms of allergy. No association was found between lymphocyte reactivity to PHA and tylosin in the three studied groups. In conclusion, tylosin leads to a specific activation of T lymphocytes in occupationally sensitized workers. Possibly, the T cell recognition of the hapten/protein complex is restricted by HLA-DQ2 Antigen in tylosin occupational allergy. Lymphocyte stimulation test can be used for the diagnosis of tylosin occupational allergy, as well as for the detection of latently sensitized workers.
Baltadzhieva D - One of the best experts on this subject based on the ideXlab platform.
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Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy
Problemi na khigienata, 1997Co-Authors: Baltadzhieva D, Bocheva S, Altŭnkova I, Demireva MAbstract:Tylosin-specific lymphocyte proliferation in vitro and its restriction of HLA class II Antigens have been investigated in 21 allergic workers exposed to tylosin. Nine workers from tylosin industry without allergic symptoms and five nonexposed nonallergic subjects served as controls. The results showed a significantly higher lymphocyte proliferative response to tylosin in allergic workers compared to control groups. Lymphocyte proliferation was observed in five workers with allergic complaints but negative skin tests. The tylosin concentration leading to maximal proliferative response varied from 10 to 1000 micrograms/ml among individuals. Six from seven workers with maximal response to the lowest concentration of tylosin carried HLA-DQ2 Antigen. Lymphocyte from most control subjects did not respond in vitro to tylosin. Weak proliferative response to tylosin was observed in two workers without clinical symptoms of allergy. No association was found between lymphocyte reactivity to PHA and tylosin in the three studied groups. In conclusion, tylosin leads to a specific activation of T lymphocytes in occupationally sensitized workers. Possibly, the T cell recognition of the hapten/protein complex is restricted by HLA-DQ2 Antigen in tylosin occupational allergy. Lymphocyte stimulation test can be used for the diagnosis of tylosin occupational allergy, as well as for the detection of latently sensitized workers.
Altŭnkova I - One of the best experts on this subject based on the ideXlab platform.
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Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy
Problemi na khigienata, 1997Co-Authors: Baltadzhieva D, Bocheva S, Altŭnkova I, Demireva MAbstract:Tylosin-specific lymphocyte proliferation in vitro and its restriction of HLA class II Antigens have been investigated in 21 allergic workers exposed to tylosin. Nine workers from tylosin industry without allergic symptoms and five nonexposed nonallergic subjects served as controls. The results showed a significantly higher lymphocyte proliferative response to tylosin in allergic workers compared to control groups. Lymphocyte proliferation was observed in five workers with allergic complaints but negative skin tests. The tylosin concentration leading to maximal proliferative response varied from 10 to 1000 micrograms/ml among individuals. Six from seven workers with maximal response to the lowest concentration of tylosin carried HLA-DQ2 Antigen. Lymphocyte from most control subjects did not respond in vitro to tylosin. Weak proliferative response to tylosin was observed in two workers without clinical symptoms of allergy. No association was found between lymphocyte reactivity to PHA and tylosin in the three studied groups. In conclusion, tylosin leads to a specific activation of T lymphocytes in occupationally sensitized workers. Possibly, the T cell recognition of the hapten/protein complex is restricted by HLA-DQ2 Antigen in tylosin occupational allergy. Lymphocyte stimulation test can be used for the diagnosis of tylosin occupational allergy, as well as for the detection of latently sensitized workers.
Bocheva S - One of the best experts on this subject based on the ideXlab platform.
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Tylosin-specific proliferation in vitro of the peripheral blood mononuclear cells in occupational tylosin allergy
Problemi na khigienata, 1997Co-Authors: Baltadzhieva D, Bocheva S, Altŭnkova I, Demireva MAbstract:Tylosin-specific lymphocyte proliferation in vitro and its restriction of HLA class II Antigens have been investigated in 21 allergic workers exposed to tylosin. Nine workers from tylosin industry without allergic symptoms and five nonexposed nonallergic subjects served as controls. The results showed a significantly higher lymphocyte proliferative response to tylosin in allergic workers compared to control groups. Lymphocyte proliferation was observed in five workers with allergic complaints but negative skin tests. The tylosin concentration leading to maximal proliferative response varied from 10 to 1000 micrograms/ml among individuals. Six from seven workers with maximal response to the lowest concentration of tylosin carried HLA-DQ2 Antigen. Lymphocyte from most control subjects did not respond in vitro to tylosin. Weak proliferative response to tylosin was observed in two workers without clinical symptoms of allergy. No association was found between lymphocyte reactivity to PHA and tylosin in the three studied groups. In conclusion, tylosin leads to a specific activation of T lymphocytes in occupationally sensitized workers. Possibly, the T cell recognition of the hapten/protein complex is restricted by HLA-DQ2 Antigen in tylosin occupational allergy. Lymphocyte stimulation test can be used for the diagnosis of tylosin occupational allergy, as well as for the detection of latently sensitized workers.
Ferenc Szalay - One of the best experts on this subject based on the ideXlab platform.
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Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: A case report
World journal of gastroenterology, 2006Co-Authors: Timea Csak, Anikó Folhoffer, Andrea Horváth, Judit Halász, Csaba Diczházi, Zsuzsa Schaff, Ferenc SzalayAbstract:A 35-year-old female patient presented with the following symptoms of Holmes-Adie syndrome: photophobia, enlargement of the left pupil unresponsive to light, Achilles areflexia. The pilocarpine test was positive. No tumor or other neurological abnormality was found. She had a 19-year history of autoimmune hepatitis. Flares up were observed following each 3 deliveries. At age of 31 she presented with diarrhea and weight loss. Abdominal tumor was detected by ultrasound. The surgically removed tumor was histologically a benign mesenteric multicystic lymphangioma. Simultaneously, celiac disease was diagnosed. Gluten-free diet resulted in a significant improvement of celiac disease, but not of autoimmune hepatitis. Autonomic neuropathy was proven by standard cardiovascular tests. The patient was a homozygous carrier for HLA DQ2 Antigen characteristic for celiac disease and heterozygous for HLA DR3 B8 frequent in autoimmune liver diseases. Our novel observation on association of Holmes-Adie syndrome with autoimmune hepatitis and celiac disease is suggestive for a common immunological background for all three entities present in a patient with mesenteric multicystic lymphangioma.