The Experts below are selected from a list of 33 Experts worldwide ranked by ideXlab platform
Janet S Sinsheimer - One of the best experts on this subject based on the ideXlab platform.
-
using the maternal fetal genotype incompatibility test to assess non inherited maternal HLA DRB1 Antigen coding alleles as rheumatoid arthritis risk factors
BMC proceedings, 2007Co-Authors: Hsinju Hsieh, Christina G S Palmer, Sinead Harney, Hsiuwen Chen, Lara Bauman, Matthew A Brown, Janet S SinsheimerAbstract:Non-inherited maternal Antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
Hsinju Hsieh - One of the best experts on this subject based on the ideXlab platform.
-
using the maternal fetal genotype incompatibility test to assess non inherited maternal HLA DRB1 Antigen coding alleles as rheumatoid arthritis risk factors
BMC proceedings, 2007Co-Authors: Hsinju Hsieh, Christina G S Palmer, Sinead Harney, Hsiuwen Chen, Lara Bauman, Matthew A Brown, Janet S SinsheimerAbstract:Non-inherited maternal Antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.
Florentino Sánchez-garcía - One of the best experts on this subject based on the ideXlab platform.
-
Pocket 4 in the HLA-DRB1 Antigen-binding groove: an association with atopy.
Allergy, 2000Co-Authors: María José Torres-galván, Joaquín Quiralte, C. Blanco, R. Castillo, Teresa Carrillo, P. Perez-aciego, Florentino Sánchez-garcíaAbstract:Background: Many studies have attempted to identify an association between HLA genes and atopy, given the role of HLA molecules in the regulation of the immune response. In the case of house-dust mites, it is difficult to find an association with a particular HLA allele, due to the complexity of the allergen. The objective was to investigate whether HLA-DRB1 functional groups are better correlated with the atopic disease in our population than DRB1 alleles. Methods: The method was reanalysis of the HLA-DRB1 data of a previous case/control study. Results: The “Dr” group was found to be associated with the atopic disease in our population. Conclusions: Grouping HLA-DRB1 alleles into functional categories may assist in the search for predictive factors in relation to atopic disease.
Takahiro Ochi - One of the best experts on this subject based on the ideXlab platform.
-
Elderly-onset rheumatoid arthritis and its association with HLA-DRB1 alleles in Japanese.
British journal of rheumatology, 1998Co-Authors: Masao Yukioka, Shigeyuki Wakitani, Norikazu Murata, Yoshitaka Toda, Ryokei Ogawa, T Kaneshige, Takahiro OchiAbstract:SUMMARY To assess the association between HLA-DRB1 and elderly-onset rheumatoid arthritis (RA) (EORA) in Japanese people, we analysed the HLA-DRB1 Antigen frequencies of EORA patients. The age at onset distribution of 852 Japanese RA patients was analysed, and EORA was defined as an age at onset of 60 yr or older. Among the 852 RA patients, 120 (14.1%) were EORA patients. Their HLA-DRB1 Antigen frequencies were assessed for significant deviation from those of the control (n = 652) and adult-onset RA (AORA; disease onset between 16 and 59 yr; n = 732) groups. The Japanese EORA patients were positively associated with DRB1*0101, *0405 and *1502, and the relative risks were 2.7, 1.9 and 2.2, respectively. The frequency of DRB1*1502 was also significantly higher among the EORA patients than in the AORA patients. The EORA patients showed diAerent trends from the AORA patients in their frequency of HLA-DRB1 alleles, which suggests that EORA may be a diAerent subset from AORA in light of its immunogenetic background.
Christina G S Palmer - One of the best experts on this subject based on the ideXlab platform.
-
using the maternal fetal genotype incompatibility test to assess non inherited maternal HLA DRB1 Antigen coding alleles as rheumatoid arthritis risk factors
BMC proceedings, 2007Co-Authors: Hsinju Hsieh, Christina G S Palmer, Sinead Harney, Hsiuwen Chen, Lara Bauman, Matthew A Brown, Janet S SinsheimerAbstract:Non-inherited maternal Antigens encoded by specific HLA-DRB1 alleles (NIMA) have been implicated as a rheumatoid arthritis (RA) risk factor. Using genotype data from North American Rheumatoid Arthritis Consortium study participants and the maternal-fetal genotype incompatibility (MFG) test, we find evidence for offspring allelic effects but no evidence for NIMA as a RA risk factor. We discuss possible reasons why our result conflicts with several previous studies (including one of our own) that used RA patients from northern Europe.